Tag: 100-200

Azadioxatriangulenium: Synthesis and Photophysical Properties of Reactive Dyes for Bioconjugation was written by Bora, Ilkay;Bogh, Sidsel A.;Santella, Marco;Rosenberg, Martin;Sorensen, Thomas Just;Laursen, Bo W.. And the article was included in European Journal of Organic Chemistry in 2015.Name: Pyridinehydrochloride This article mentions the following:

Azadioxatriangulenium (ADOTA) is a fluorescent triangulenium dye with a long fluorescence lifetime, highly polarized transitions and emission in the red part of the visible spectrum. These properties make the chromophore suited for application in fluorescence polarization/anisotropy assays. To be useful for these applications, reactive forms of the dyes must be available in significant quantities. Here, the synthesis and photophys. properties of amine-reactive N-hydroxysuccinimide (NHS) esters and a thiol-reactive maleimide derivative of ADOTA are reported. The synthesis involves two steps of nucleophilic bridge-forming reactions starting from tris(2,6-dimethoxyphenyl)methylium tetrafluoroborate, which can readily be prepared on a 100 g scale. In the third and final step the reactive NHS or maleimide groups are formed. The beneficial photophys. properties of the ADOTA chromophore are maintained in these derivatives, and we conclude that these systems are ideal to study protein motion and protein-protein interactions for systems of up to 1000 kDa. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Name: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Name: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Complexes of 4- and 5-bromo derivatives of 2-(hydroxymethyl)pyridine with copper(II) and cobalt(II) salts: Synthesis and X-ray crystal structures was written by Hubrich, Michael;Peukert, Max;Seichter, Wilhelm;Weber, Edwin. And the article was included in Polyhedron in 2010.Quality Control of (4-Bromopyridin-2-yl)methanol This article mentions the following:

Four copper(II) complexes (1–4) and a cobalt(II) complex (5) derived from 4-bromo-2-(hydroxymethyl)pyridine (L¹) or 5-bromo-2-(hydroxymethyl)pyridine (L²) with Cu(NO₃)₂·3H₂O, CuCl₂·2H₂O and CoCl₂·6H₂O have been synthesized and their resp. crystal structures studied. They show specific influences owing to the different kind of metal cations and counter anions, the hydration as well as the different position of the bromine substitution on both the coordination of the complex unit and the network structure of the crystal lattice. The Cu(II) complexes of L¹ are five-coordinate [Cu(L¹)₂NO₃]NO₃·H₂O (1) and [Cu(L¹)₂Cl]Cl·H₂O (2) species with distorted quadratic pyramidal and trigonal bipyramidal coordination geometries of the N₂O₃ and N₂O₂Cl donor atoms around the Cu(II), resp. The Cu(II) complexes of L² are six-coordinate [Cu(L²)₂(NO₃)₂] (3) and [Cu(L²)₂Cl(H₂O)]Cl·H₂O (4) species with distorted octahedral coordination geometries of the N₄O₂ and N₂O₃Cl donor atoms. A distorted octahedral coordination geometry of the N₂O₂Cl₂ donor atoms is also found in the complex unit [Co(L²)₂Cl₂] of the Co(II) complex 5 but showing the oxygen atoms of the chelating ligand as well as the chloride ions in a cis-position. Depending on the complex, water mols. and chloride anions are shown to act as stabilizing components of the crystal structure. The comparative structural investigation includes also known structures of the bromine-free ligand analog 2-(hydroxymethyl)pyridine, illustrating the basic implication of the bromine substitution, mostly perceptible in the different modes of crystal packing. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Quality Control of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ionic liquids as solvents for rhodium and platinum catalysts used in hydrosilylation reaction was written by Zielinski, Witold;Kukawka, Rafal;Maciejewski, Hieronim;Smiglak, Marcin. And the article was included in Molecules in 2016.Related Products of 628-13-7 This article mentions the following:

A group of imidazolium and pyridinium based ionic liquids has been synthesized, and their ability to dissolve and activate the catalysts used in hydrosilylation reaction of 1-octane and 1,1,1,3,5,5,5-heptamethyltrisiloxane was investigated. An organometallic catalyst as well as inorganic complexes of platinum and rhodium dissolved in ionic liquids were used, forming liquid solutions not miscible with the substrates or with the products of the reaction. The results show that application of such a simple biphasic catalytic system enables reuse of ionic liquid phase with catalysts in multiple reaction cycles reducing the costs and decreasing the amount of catalyst needed per mol of product. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Enantioselective Catalytic Dearomative Addition of Grignard Reagents to 4-Methoxypyridinium Ions was written by Guo, Yafei;Castineira Reis, Marta;Kootstra, Johanan;Harutyunyan, Syuzanna R.. And the article was included in ACS Catalysis in 2021.Electric Literature of C7H9NO This article mentions the following:

The enantioselective dearomative alkylation of pyridine derivatives with Grignard reagents, allowing direct access to nearly enantiopure chiral dihydro-4-pyridones I [R¹ = H, Me; R² = H, Me, Et, etc.; R³ = Et, (CH₂)₂Ph, (CH₂)₅, etc.; R⁴ = OMe, OEt, OBn, etc.] with yields up to 98% was reported. The methodol. involved dearomatization of in situ-formed N-acylpyridinium salts, employing alkyl organomagnesium reagents as nucleophiles and a chiral copper (I) complex as the catalyst. Computational and mechanistic studies provided insights into the origin of the reactivity and enantioselectivity of the catalytic process. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Electric Literature of C7H9NO).

4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of zidovudine impurity 3′-chloro-3′-deoxythymidine was written by Wang, Rui;Zhong, Xiao-feng;Zou, Hui;Tian, Lei. And the article was included in Anhui Huagong in 2015.SDS of cas: 628-13-7 This article mentions the following:

3′-Chloro-3′-deoxythymidine was synthesized from thymidine through ring closing which then opened by chloro, finally deprotection. The impurity could be used as the reference substance of the related substances in the quality control of Zidovudine. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7SDS of cas: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Derivatives of 1,2,3,4-tetrahydro-6-aminocarbazole, a serotonin antimetabolite was written by Kotler-Brajtburg, Janina. And the article was included in Acta Poloniae Pharmaceutica in 1963.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:

To ascertain whether the pharmacol. properties of 1,2,3,4-tetrahydro-6-aminocarbazole (I) depend on the presence of the NH₂ group, several substitution products were prepared In tests with isolated rat uterus, they showed no antiserotonin activity. I (1.86 g.) suspended in 20 ml. 70% MeOH was treated with 2 g. AcONa.₃H₂O and, with stirring, 2.28 g. p-MeC₆H₄SO₂Cl, and the mixture stirred 30 min. at room temperature, 15 min. at 40-5°, and cooled to yield 2.7 g. N-[6-(1,2,3,4-tetrahydrocarbazolyl)]-p-toluenesulfonamide, m. 219-20° (80% Me₂CO). A solution of 3.72 g. I in 40 ml. 40% AcOH was treated at 5-8° with alternate portions of 1.4 g. NaNO₂ in 3 ml. H₂O and 1 ml. HCl, the mixture stirred 30 min., treated with 2.2 g. 2,6-diaminopyridine (II) in 40 ml. 20% Ac0H, stirred 1 hr. at 10-12°, and filtered, and the filtrate alkalized with NH₄OH to give 2.5 g. III, m. 196-8°, purified via the hydrochloride. When 3.06 g. III in 100 ml. AcOH was stirred 1 hr. at room temperature with 10 ml. AcCl, 72% mono-Ac derivative of III was obtained, m. 196-8°. Similarly acetylated, II gave 93% 2-amino-6-acetylaminopyridine-HCl, m. 245° (decomposition) (MeOH); the free base (IV) m. 156-7° (H₂O). Coupling IV with a diazo derivative of I gave an orange dye whose purification was unsuccessful. I-HCl did not melt up to 350°. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and characterization of a new energy material: Pyridinium dinitramide (Py-DN) was written by Kim, Wooram;Kwon, Younja;Adelodun, Adedeji A.;Jo, Youngmin. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2017.COA of Formula: C5H6ClN This article mentions the following:

A solid oxidizer pyridinium dinitramide (Py-DN) has been newly synthesized as a low toxic chlorine-free energetic oxidizer. The reaction yield increased by 10% higher than the other dinitramide such as ADN because Py-DN was directly converted without sequential precipitation of intermediates. A thermal analyzer, a UV-visible spectrometer and a Fourier transform-infra-red spectrometer were used to characterize the phys. and chem. properties of the synthesized Py-DN, and the results were compared with previously prepared salts of ammonium dinitramide (ADN, NH₄N(NO₂)₂) and guanidine dinitramide [GDN, NH₂C(NH₂)NH₂N(NO₂)₂]. The characteristic endothermic and exothermic decomposition temperatures of Py-DN were 77.4°C and 144.7°C, resp., and the material had a combustion caloric value of 1,739 J/g. These low values indicate that Py-DN is more thermally sensitive than the conventional dinitramides. Furthermore, it enables to decrease the decomposition temperature, which can reduce preheating temperature required for thruster operation. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7COA of Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development was written by Zhuo, Lin-Sheng;Xu, Hong-Chuang;Wang, Ming-Shu;Zhao, Xing-E.;Ming, Zhi-Hui;Zhu, Xiao-Lei;Huang, Wei;Yang, Guang-Fu. And the article was included in European Journal of Medicinal Chemistry in 2019.Reference of 65169-38-2 This article mentions the following:

As part of our effort to develop new mol. targeted antitumor drug, a novel 2,7-naphthyridone-based MET kinase inhibitor, I, was identified. Knowledge of the binding mode of BMS-777607 in MET led to the design of new inhibitors that utilize novel 2,7-naphthyridone scaffold to conformationally restrain the key pharmacophoric groups (block C). Detailed SAR studies resulted in the discovery of a new MET inhibitor I, displaying favorable in vitro potency and oral bioavailability. More importantly, I exhibited excellent in vivo efficacy (tumor growth inhibition/TGI of 114% and 95% in 50 mg/kg, resp.) both in the U-87 MG and HT-29 xenograft models. The favorable drug-likeness of I indicated that 2,7-naphthyridinone may be used a promising novel scaffold for antitumor drug development. The preclin. studies of I are under way. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Reference of 65169-38-2).

2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 65169-38-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metal(II) chloride complexes containing a tridentate N-donor Schiff base ligand: syntheses, structures and antimicrobial activity was written by Munshi, Sadeka J.;Saini, Jaswinder Kaur;Ingle, Sanjay;Kumar, Sujit Baran. And the article was included in Journal of Coordination Chemistry in 2021.Electric Literature of C12H9NO This article mentions the following:

One new tridentate N-coordinate ligand, N’-phenyl-N”-(phenyl(pyridin-2-yl)methylene)ethane-1,2-diamine (L), were synthesized and characterized. The tridentate N₃-coordinate ligand L were used in the synthesis of a series of three mononuclear complexes [M(L)Cl₂] [M = Cu(II), Co(II), and Zn(II)] and one polynuclear Cd(II) complex [Cd(L)Cl₂]_n and these complexes were characterized by spectroscopic techniques. The structure of all the complexes has been solved by single-crystal X-ray diffraction studies and the data reveal that all mononuclear complexes have distorted square pyramidal geometry and the polynuclear Cd(II) complex has distorted octahedral geometry. The antimicrobial activity of all complexes was investigated against Gram-pos. (Bacillus subtilis, Staphylococcus aureus) and Gram-neg. (Escherichia coli, Proteus vulgaris) bacteria by disk diffusion method. The compounds demonstrated significant antimicrobial activity while [Cu(L)Cl₂] exhibited the best antibacterial activity among all the synthesized complexes. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Electric Literature of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach was written by Cardinale, Luana;Konev, Mikhail O.;Jacobi von Wangelin, Axel. And the article was included in Chemistry – A European Journal in 2020.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1-mol., carbon dioxide, makes alternative carboxylation reactions with CO₂-surrogates especially important. A photoredox-catalyzed protocol for alkene carbamoylations has been reported. Readily accessible 4-carboxamido-Hantzsch esters I (R¹R² = -(CH₂)₂O(CH₂)₂-, -(CH₂)₅-, Ph, cyclopropane, etc.) serve as convenient starting materials that generate carbamoyl radicals R¹N(R²)C(O)CH(R³)CH(R⁴)(R⁵)(R³ = 4-cyanophenyl, cyclohexyl, pyridin-3-yl, thiophen-2-yl, etc.; R⁴ = CN, 4-methylphenyl, pyridin-2-yl, etc.; R⁵ = SO₂C₆H₅, CN, Ph, 4-methylphenyl, 4-chlorophenyl; R⁴R⁵ = 1,3-dioxo-2,3-dihydro-1H-inden-2-yl, 1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-yl, 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl) upon visible light-mediated single-electron transfer. Addition to various alkenes R³CH=C(R⁴)(R⁵) proceeded with high levels of regio- and chemoselectivity. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem