Tag: 100-200

Parallel and Antiparallel Triple Helices of Naphthyridine Oligoamides was written by Ferrand, Yann;Kendhale, Amol M.;Garric, Joachim;Kauffmann, Brice;Huc, Ivan. And the article was included in Angewandte Chemie, International Edition in 2010.Electric Literature of C7H9N3O This article mentions the following:

In summary, the authors have characterized a and robust artificial triple helix architecture. The principles governing these assemblies may allow the design of multistranded structures with even higher multiplicity resembling protein β-barrel architectures, for example, upon further increasing the monomer size and helix diameter In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Electric Literature of C7H9N3O).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Electric Literature of C7H9N3O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel NNO pincer type Schiff base ligand and its complexes of Fe(IIl), Co(II) and Ni(II): Synthesis, spectroscopic characterization, DFT, antibacterial and anticorrosion study was written by Shukla, Satyendra Nath;Gaur, Pratiksha;Raidas, Mohan Lal;Chaurasia, Bhaskar;Bagri, Sanjay Singh. And the article was included in Journal of Molecular Structure in 2021.Application of 91-02-1 This article mentions the following:

A novel NNO pincer type ligand (E)-N’-(phenyl(pyridin-2-yl)methylene)isonicotinohydrazide, PPMINH, was synthesized by condensation of 2-benzoyl pyridine and isonicotinylhydrazide. The ligand PPMINH on reaction with metal ions Fe(III), Co(II) and Ni(II) yielded six metal derivatives Different anal. tools like; Elemental analyses, ESI-MS, FTIR, molar conductivity, UV-spectra, magnetic susceptibility, NMR and EPR measurement were used. Theor. FTIR, ¹H NMR and ¹³C NMR of ligand and complex 6 exhibits quite a good correlation coefficient EPR spectrum of complex 6 at LNT suggests octahedral geometry around Ni(II). The ligand and complexes were screened for antibacterial activity. DFT was carried out to optimize the geometry of the ligand and complexes. The properties most relevant to their potential action as corrosion inhibitors was calculated all parameters of DFT from the inhibitor mol. to the metal atom. The corrosion inhibition effect of compounds on mild steel in an acidic medium was studied for 24, 48, 72 h using weight loss measurement. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application of 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A novel bio-based AB₂ monomer for preparing hyperbranched polyamides derived from levulinic acid and furfurylamine was written by Yang, Meng-Ling;Wu, Yue-Xiao;Liu, Yun;Qiu, Jin-Jun;Liu, Cheng-Mei. And the article was included in Polymer Chemistry in 2019.Electric Literature of C5H6ClN This article mentions the following:

A new AB₂ type bio-based monomer (FDA-E) with two amino functional groups and one ester functional group was prepared from renewable levulinic acid and furfurylamine using a three-step reaction. The AB₂ monomer underwent self-polycondensation under melt conditions to form a hyperbranched bio-polyamide. Polyamides show excellent solubility in a strong polar solvent and acidic solution In pure water, the rigid polyamides form a stable elastic gel by absorbing water instead of dissolving in it. Their glass transition temperatures are in the range 97-102°C and their char yields at 800°C are greater than 40%. The XRD results indicate that the three polyamides are amorphous polymers. In addition, the hyperbranched polyamides are fluorescent polymers and their photoluminescence properties depend on mol. weight, solvent, excitation wavelength, and excitation time. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Electric Literature of C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Electric Literature of C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Methylpyridine derivatives. II. Synthesis of 2-cyanomethylpyridines was written by Suzuki, Yasuyuki. And the article was included in Pharmaceutical Bulletin in 1957.Product Details of 1620-76-4 This article mentions the following:

In general, alkyl derivatives of 2-chloropyridine (I) were heated 10 hrs. in an autoclave with the calculated amount of Na₂SO₃ in H₂O, and the resulting alkyl derivative of Na 2-pyridinesulfonate fused (without previous isolation) with KCN over an open flame to give the corresponding alkyl derivatives of 2-cyanopyridine (II) (derivative of I used, temperature of autoclave, b.p. and m.p. of corresponding II derivative, yield given): I itself, 150-60°, b₂₄ 114-16°, -, 49.7%; 6-Me, 170-80°, b₃₈ 135-6°, m. 69-71°, 39%; 5-Me, 200-10°, b₂₈ 135-8°, m. 72-4°, 36.8%; 4-Me, 180-90°, b₃₈ 145-8°, m. 88-9°, 39.1%; 3-Me, 170-80°, b₃₈ 139-42°, m. 87-8°, 59%; 4,6-Me₂, 200-10°, b₁₆ 125-30°, m. 51-2°, 32.6%; 3,6-EtMe (III), 210-20°, b₃₂ 145-51°, -, 49.7%. Similarly, the 4-Cl derivative (IV) of III heated only 3 hrs. with Na₂SO₃ in an autocalve at 180-200° and fused with KCN yielded 60.6% 4-cyano derivative of III, b₁₇ 107-10°; picrate, m. 123-4°. 3-Ethyl-4-nitro-6-methylpyridine 1-oxide (9.1 g.) (Berson and Cohen, C.A. 50, 9405i) in 30 cc. CHCl₃ treated dropwise in the cold with 17.8 cc. AcCl, stirred an addnl. 30 min. at 50°, 8.8 cc. PCl₃ added dropwise in the cold, the mixture stirred 30 min. at room temperature, warmed 1 hr. at 60-70° on a H₂O bath, cooled, poured into 100 cc. ice H₂O, the aqueous layer (plus the washings from the organic layer) washed with 30 cc. ether, made alk. with Na₂CO₃, steam-distilled, and the distillate saturated with K₂CO₃ and extracted with ether yielded 5.27 g. IV, b₂₀ 92-5°; picrate, m. 133-4.5°. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Product Details of 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic rearrangement of O,S-dialkyl dithiocarbonates to S,S-dialkyl dithiocarbonates by pyridine N-oxides. The reaction mechanism was written by Harano, Kazunobu;Shinohara, Ikuo;Sugimoto, Shinichiro;Matsuoka, Toshikazu;Hisano, Takuzo. And the article was included in Chemical & Pharmaceutical Bulletin in 1989.Electric Literature of C7H9NO This article mentions the following:

The reaction of O-alkyl S-Me dithiocarbonates (xanthates) (I) with pyridine N-oxides (II) gave the corresponding S-alkyl S-Me dithiocarbonates (III) together with the sym. S,S-dialkyl and S,S-di-Me dithiocarbonates in good yields. Pyridine N-oxides bearing electron-donating substituents are efficient catalysts for rearrangement of I to III. The reaction is pseudo-first-order and the apparent first-order rate constant is proportional to the concentration of II. The role of pyridine N-oxides and the reaction behavior of O,S-dialkyl dithiocarbonates are discussed on the basis of kinetic and MO calculation data. The rearrangement may proceed by nucleophilic attack of ^–SCOSR derived from a complex of I and II on the O-alkyl group of xanthates. The reaction provides a useful preparation method for alkanethiols by aminolysis of the products with ethanolamine. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Electric Literature of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors was written by Lee, Lily;Kreutter, Kevin D.;Pan, Wenxi;Crysler, Carl;Spurlino, John;Player, Mark R.;Tomczuk, Bruce;Lu, Tianbao. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application of 199296-39-4 This article mentions the following:

2-(2-Chloro-6-fluorophenyl)acetamides having 2,2-difluoro-2-aryl/heteroaryl-ethylamine P3 and oxyguanidine P1 substituents are potent thrombin inhibitors (K_i = 0.9-33.9 nM). 2-(5-Chloropyridin-2-yl)-2,2-difluoroethylamine was the best P3 substituent, yielding the most potent inhibitor (K_i = 0.7 nM). Replacing the P3 heteroaryl group with a Ph ring or replacing the difluoro substitution with di-Me or cyclopropyl groups in the linker reduced the affinity for thrombin significantly. The aminopyridine P1s also provided an increase in potency. In the experiment, the researchers used many compounds, for example, 2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4Application of 199296-39-4).

2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 199296-39-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identifying specific conformations by using a carbohydrate scaffold: Discovery of subtype-selective LPA-receptor agonists and an antagonist was written by Tamaruya, Yoko;Suzuki, Masato;Kamura, Goshu;Kanai, Motomu;Hama, Kotaro;Shimizu, Kumiko;Aoki, Junken;Arai, Hiroyuki;Shibasaki, Masakatsu. And the article was included in Angewandte Chemie, International Edition in 2004.Computed Properties of C10H17NO2 This article mentions the following:

Stable and potent subtype-selective lysophosphatidic acid (LPA) analogs (agonists and an antagonist) were developed by using carbohydrates as a core structure. An array of mols. with the recognition motifs of LPA (a phosphate anion, an oleoyl group, and a hydrogen-bond acceptor) attached to carbohydrate isomers in different three-dimensional arrangements were tested for LPA-receptor activation or inhibition. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Practical routes toward the synthesis of 2-halo- and 2-(alkylamino)-4-pyridinecarboxaldehydes was written by Frey, L. F.;Marcantonio, K.;Frantz, D. E.;Murry, J. A.;Tillyer, R. D.;Grabowski, E. J. J.;Reider, P. J.. And the article was included in Tetrahedron Letters in 2001.Electric Literature of C6H3FN2 This article mentions the following:

We recently required an efficient synthesis of 2-halo- and 2-(alkylamino)-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Electric Literature of C6H3FN2).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Solvent-dependent oxidations of 5- and 6-azaindoles to trioxopyrrolopyridines and functionalised azaindoles was written by Mahiout, Zahia;Lomberget, Thierry;Goncalves, Sylvie;Barret, Roland. And the article was included in Organic & Biomolecular Chemistry in 2008.Synthetic Route of C6H7NO2 This article mentions the following:

A regioselective synthesis of 4,7-dimethoxy 5- and 6-azaindoles has been achieved, based on the appropriate choice of ortho-directing or ortho-repulsing groups in the formylation of a pyridine ring. Studies on the regioselectivity of the formylation step and on the preparation of azidoacrylate intermediates are described in this paper. The reactivity of the 5- and 6-azaindole structures towards BBr₃-mediated selective monodemethylation and oxidative demethylation reactions were also investigated. The regioselectivity of the deprotection was confirmed using a chem. approach. Oxidation reactions were then carried out on either dimethoxy- or hydroxymethoxyazaindoles, in different solvents, using [bis(trifluoroacetoxy)iodo]benzene. In acetonitrile-water, trioxopyrrolopyridines, e.g., I, were obtained, whereas the formation of functionalised azaindoles, e.g., II, were observed in acetonitrile-methanol. The tautomeric structure of the trioxopyrrolopyridines was proved by X-ray diffraction anal. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Synthetic Route of C6H7NO2).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C6H7NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anchoring a Molecular Iron Catalyst to Solar-Responsive WO₃ Improves the Rate and Selectivity of Photoelectrochemical Water Oxidation was written by Klepser, Benjamin M.;Bartlett, Bart M.. And the article was included in Journal of the American Chemical Society in 2014.Quality Control of (4-Bromopyridin-2-yl)methanol This article mentions the following:

Mol. catalysts help overcome the kinetic limitations of H₂O oxidation and generally result in faster rates for H₂O oxidation than do heterogeneous catalysts. However, mol. catalysts typically function in the dark and therefore require sacrificial oxidants such as Ce⁴⁺ or S₂O₈^2- to provide the driving force for the reaction. In this Communication, covalently anchoring a phosphonate-derivatized complex, Fe(tebppmcn)Cl₂ (1), to WO₃ removes the need for a sacrificial oxidant and increases the rate of photoelectrochem. H₂O oxidation on WO₃ by 60%. The dual-action catalyst, 1-WO₃, also gives rise to increased selectivity for H₂O oxidation in pH 3 Na₂SO₄ (56% on bare WO₃, 79% on 1-WO₃). This approach provides promising alternative routes for solar H₂O oxidation In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Quality Control of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem