Tag: 100-200

2,6-Diaminopyridine and Acrylamide-Based Copolymers with Upper Critical Solution Temperature-type Behavior in Aqueous Solution was written by Asadujjaman, Asad;Ahmadi, Vahid;Michel Claude Franc, Antoine;Bertin, Annabelle. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2019.Application of 1075-62-3 This article mentions the following:

A novel copolymer based on supramol. motif 2,6-diaminopyridine and water-soluble acrylamide, poly[N-(6-acetamidopyridin-2-yl) acrylamide-co-acrylamide], was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization with various monomer compositions The thermoresponsive behavior of the copolymers was studied by turbidimetry and dynamic light scattering. The obtained copolymers showed an upper critical solution temperature (UCST)-type phase transition behavior in water and electrolyte solution The phase transition temperature was found to increase with decreasing amount of acrylamide in the copolymer and increasing concentration of the solution Furthermore, the phase transition temperature varied in aqueous solutions of electrolytes according to the nature and concentration of the electrolyte in accordance with the Hoffmeister series. A dramatic solvent isotope effect on the transition temperature was observed in this study, as the transition temperature was almost 10-12 鎺矯 higher in D₂O than in H₂O at the same concentration and acrylamide composition The size of the aggregates below the transition temperature was larger in D₂O compared to that in H₂O that can be explained by deuterium isotope effect. The thermoresponsive behavior of the copolymers was also investigated in different cell medium and found to be exhibited UCST-type phase transition behavior in different cell medium. Such behavior of the copolymers can be useful in many applications including biomedical, microfluidics, optical materials, and in drug delivery. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Application of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stimuli-responsive supramolecular materials: photo-tunable properties and molecular recognition behavior was written by Huang, Cheng-Wei;Wu, Pei-Wei;Su, Wei-Hung;Zhu, Chao-Yuan;Kuo, Shiao-Wei. And the article was included in Polymer Chemistry in 2016.Related Products of 1075-62-3 This article mentions the following:

A new homopolymer of polystyrene (PS) presenting pendant diaminopyridine (DAP) moieties was prepared using controlled free radical polymerization and a CuAAC click reaction. Through directional complementary multiple H bonding, this PVB-DAP polymer underwent complexation with a thymine-functionalized azobenzene (Azo-T). The resulting supramol. complex exhibited amorphous and chromophoric behavior without microphase separation This strategy allowed the fabrication of homogeneous stimuli-responsive thin films with photocontrollable behavior through photoinduced trans-cis isomerization. The PVB-DAP/Azo-T supramol. complex facilitated the dispersion of an azo-dye through noncovalent interactions; the resulting complex was used to fabricate a surface relief grating displaying an interference pattern. The recordability and rewritability of these supramol. complexes suggest that they are promising materials for optical applications and therefore advance the pathway for supramol. development. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Related Products of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Merging Visible Light Photoredox Catalysis with Metal Catalyzed C-H Activations: On the Role of Oxygen and Superoxide Ions as Oxidants was written by Fabry, David C.;Rueping, Magnus. And the article was included in Accounts of Chemical Research in 2016.Name: 2-Phenoxypyridine This article mentions the following:

Visible light photoredox catalysis as a new alternative to conventionally applied regeneration/oxidation procedures was examined This account summarizes these recent advances in this expanding area and will highlight the new concept of merging distinct redox catalytic processes for C-H functionalizations through the application of visible light photoredox catalysis. Photoredox catalysis can be considered as catalytic electron-donating or -accepting processes, making use of visible-light absorbing homogeneous and heterogeneous metal-based catalysts, as well as organic dye sensitizers or polymers. As a consequence, photoredox catalysis is, in principle, an ideal tool for the recycling of any given metal catalyst via a coupled electron transfer (ET) process. Here we describe our first successful endeavors to address the above challenges by combining visible light photoredox catalysis with different ruthenium, rhodium, or palladium catalyzed C-H activations. Since only small amounts of the oxidant are generated and are immediately consumed in these transformations, side reactions of substrates or products can be avoided. Thus, usually oxidant-sensible substrates can be used, which makes these methods highly suitable for complex mol. structure syntheses. Moreover, mechanistic studies shed light on new reaction pathways, intermediates, and in situ generated species. The successful development of our dual catalysis concept, consisting of combined visible light photoredox catalysis and metal catalyzed C-H functionalization, provides many new opportunities for further explorations in the field of C-H functionalization. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Name: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents was written by Song, Lijun;Risseeuw, Martijn D. P.;Froeyen, Matheus;Karalic, Izet;Goeman, Jan;Cappoen, Davie;Van der Eycken, Johan;Cos, Paul;Munier-Lehmann, Helene;Van Calenbergh, Serge. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Reference of 85838-94-4 This article mentions the following:

We report the design and synthesis of a series of non-nucleoside MtbTMPK inhibitors (1-14) based on the gram-pos. bacterial TMPK inhibitor hit compound 1. A practical synthesis was developed to access these analogs. Several compounds show promising MtbTMPK inhibitory potency and allow the establishment of a structure-activity relationship, which is helpful for further optimization. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Reference of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

MINDO/3-derived geometries and energies of alkylpyridines and the related N-methylpyridinium cations was written by Seeman, Jeffrey I.;Schug, John C.;Viers, Jimmy W.. And the article was included in Journal of Organic Chemistry in 1983.Category: pyridine-derivatives This article mentions the following:

The structures of 25 alkyl-substituted pyridines and their corresponding N-methylpyridinium cations were calculated by using GEOMO/RV, utilizing semiempirical all-valence electron (MINDO/3) self-consistent-field procedures. The effects of substituents on the ring systems were examined with particular attention focused on the changes in the aromatic ring bond angles. The energy of methylation for these 25 pyridines was calculated by subtracting the total energy of each pyridine-free base from the total energy of the corresponding N-methylpyridinium cation. An excellent correlation was obtained between this calculated energy of methylation and Brown’s exptl. heats of trifluoroboronations for the same pyridines; implications of this correlation are discussed. Nonadditive structural parameters and energetic effects are calculated and evaluated. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Category: pyridine-derivatives).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A convenient synthesis of 3-substituted pipecolic acid methyl esters was written by Subramanyam, Chakrapani;Chattarjee, Sankar;Mallamo, John P.. And the article was included in Tetrahedron Letters in 1996.Recommanded Product: 59718-84-2 This article mentions the following:

A practical synthesis of the title compounds from com. available 3-hydroxy-2-pyridinecarboxylic acid is reported. The key step involves a Pd-catalyzed cross-coupling reaction of triflate I with the appropriate alkyl or aryl derivatives to generate substituted picolinic acid esters. Catalytic reduction of these esters provides the title compounds in good yields. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Recommanded Product: 59718-84-2).

Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 59718-84-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cytotoxicity estimation of ionic liquids based on their effective structural features was written by Fatemi, Mohammad H.;Izadiyan, Parisa. And the article was included in Chemosphere in 2011.Product Details of 17281-59-3 This article mentions the following:

Cytotoxicity of a diverse set of 227 ionic liquids (taken from UFT/Merck Ionic Liquids Biol. Effects Database) containing 94 imidazolium, 53 pyridinium, 23 pyrrolidinium, 22 ammonium, 15 piperidinium, 10 morpholinium, 5 phosphanium, and 5 quinolinium cations in combination with 25 different types of anions to Leukemia Rat Cell Line (IPC-81) was estimated from their structural parameters using quant. structure – toxicity relationship “QSTR” methodol. Linear and nonlinear models were developed using genetic algorithm (GA), multiple linear regressions (MLR) and multilayer perceptron neural network (MLP NN) approaches. Robustness and reliability of the constructed models were evaluated through internal and external validation methods. Furthermore, chem. applicability domain was determined via leverage approach. In this work, it was revealed that the cationic moieties make the major contribution to cytotoxicity and the anionic parts play a secondary role in cytotoxicity of the ionic liquids studied here. Structural information represented in this work, can be used for a rational design of safer ILs. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Product Details of 17281-59-3).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 17281-59-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An improved procedure for the preparation of aromatic heterocyclic N-oxides was written by Rhie, Soo Young;Ryu, Eung K.. And the article was included in Heterocycles in 1995.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Nitrogen-containing heterocyclic compounds gave their N-oxides in excellent yields by reaction with m-chloroperbenzoic acid in DMF/MeOH in the presence of HF. The presence of HF and MeOH is crucial for the reaction. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An interpenetrating network poly(diethylene glycol carbonate)-based polymer electrolyte for solid state lithium batteries was written by Liu, Xiaochen;Ding, Guoliang;Zhou, Xinhong;Li, Shizhen;He, Weisheng;Chai, Jingchao;Pang, Chunguang;Liu, Zhihong;Cui, Guanglei. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2017.Related Products of 628-13-7 This article mentions the following:

Polycarbonate-based polymer electrolytes possess superior ionic conductivity at room temperature, higher Li ion transference number and wider electrochem. stability window when compared with conventional poly(ethylene oxide)-based polymer electrolytes. Here, the poly(diethylene glycol carbonate) dimethacrylate macromonomer (PDEC-DMA) was synthesized and the resultant interpenetrating network IPN-PDEC polymer electrolyte was developed via free radical in situ polymerization for polymer electrolyte Li metal batteries. This IPN-PDEC polymer electrolyte exhibited a decent ionic conductivity of 1.64 鑴?10^-4 S/cm at room temperature and a wide electrochem. stability window (閳?.5 V vs. Li⁺/Li). The LiFePO₄/IPN-PDEC/Li and LiFe_0.2Mn_0.8PO₄/IPN-PDEC/Li cells delivered excellent rate capability and cycling performance at room temperature An all solid state Li battery was also demonstrated by applying the as-prepared solid polymer electrolyte (SPE-PDEC) at 100鎺? which displayed a superior cycling performance. Therefore, the IPN-PDEC network is a promising polymer electrolyte for solid state Li batteries. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Copper-catalyzed cyanation of heterocycle C-H bonds with ethyl(ethoxymethylene)cyanoacetate as a cyanating agent and its mechanism was written by Li, Ze-lin;Sun, Kang-kang;Cai, Chun. And the article was included in Organic Chemistry Frontiers in 2018.Application of 1620-76-4 This article mentions the following:

A method for synthesis of benzothiazole-2-carbonitriles such as I [R = H, 5-Cl, 6-Br, etc.; X = O, S], indole-3-carbonitriles II [R¹ = H, 6-MeO, 6-Cl; R² = H, Me; R³ = H, Me] and pyridine-2-carbonitriles III [R⁴ = H, 6-Me, 3-Br, etc.] was developed via copper-catalyzed cyanation of benzothiazoles/indoles/pyridines with ethyl(ethoxymethylene)cyanoacetate as a nontoxic and easily available cyanating agent. This transformation proceeded smoothly in the presence of di-tert-Bu peroxide (DTBP) with a wide substrate scope under ligand-free conditions. Mechanistic details were also described. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Application of 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application of 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem