Tag: 1000-1100

Li, Yanru; Miyamoto, Shoto; Torigoe, Takeru; Kuninobu, Yoichiro published an article in 2021, the title of the article was Regioselective C(sp3)-H alkylation of a fructopyranose derivative by 1,6-HAT.Formula: C36H22F16IrN4P And the article contains the following content:

Regioselective C(sp3)-H alkylation of a fructopyranose derivative using electron-deficient alkenes as alkylation reagents was achieved. The reaction proceeded via 1,6-hydrogen atom transfer under photoredox iridium catalysis. Several functional groups were introduced into the fructopyranose derivative The experimental process involved the reaction of 4,4′-Bis(trifluoromethyl)-2,2′-bipyridinebis[3,5-difluoro-2-[5-methyl-2-pyridinyl)phenyl] iridium(III) hexafluorophosphate(cas: 2229858-27-7).Formula: C36H22F16IrN4P

The Article related to regioselective alkylation catalyst alkene fructopyranose glycoside preparation, photoredox iridium catalysis hydrogen transfer alkylation, Carbohydrates: Glycosides and other aspects.Formula: C36H22F16IrN4P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 1, 2018, Le, Chip; Chen, Tiffany Q.; Liang, Tao; Zhang, Patricia; MacMillan, David W. C. published an article.Synthetic Route of 2229858-27-7 The title of the article was A radical approach to the copper oxidative addition problem: Trifluoromethylation of bromoarenes. And the article contained the following:

Transition metal-catalyzed arene functionalization was widely used for mol. synthesis over the past century. In this arena, copper catalysis has long been considered a privileged platform due to the propensity of high-valent copper to undergo reductive elimination with a wide variety of coupling fragments. However, the sluggish nature of oxidative addition has limited copper’s capacity to broadly facilitate haloarene coupling protocols. Here, this copper oxidative addition problem can be overcome with an aryl radical-capture mechanism, wherein the aryl radical was generated through a silyl radical halogen abstraction. This strategy was applied to a general trifluoromethylation of aryl bromides through dual copper-photoredox catalysis. Mechanistic studies support the formation of an open-shell aryl species. The experimental process involved the reaction of 4,4′-Bis(trifluoromethyl)-2,2′-bipyridinebis[3,5-difluoro-2-[5-methyl-2-pyridinyl)phenyl] iridium(III) hexafluorophosphate(cas: 2229858-27-7).Synthetic Route of 2229858-27-7

The Article related to copper oxidative addition trifluoromethylation bromoarene, Physical Organic Chemistry: General and other aspects.Synthetic Route of 2229858-27-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 15, 2022, Zhen, Guangjin; Wang, Furong; Yin, Biaolin published a patent.Electric Literature of 2229858-27-7 The title of the patent was Preparation of cyclobutane fused spiro indoline compounds as antitumor agents. And the patent contained the following:

The invention discloses the preparation of cyclobutane fused spiro indoline compounds with general formula I or II as antitumor agents [where X=O, S, CH = CH; R1=H, halogen group, ether group, aryl, siloxane or alkyl; R2=alkyl, siloxane, alkynyl or heterocyclic; R3=acetyl, p-methoxybenzyl, methylthiomethyl, tervaleryl, benzyloxycarbonyl, tert butoxycarbonyl, benzyl or p-methoxyphenyl], which has the advantages of simple preparation method, mild conditions, environmental protection and suitable for large-scale preparation For example, compound I (X=S, R1=H, R2=CH2CH2OCH3, R3=Ac) was prepared by photocatalytic cyclization of 1-acetyl-N-(2-methoxyethyl)-N-(thiophen-2-ylsulfonyl)-1H-indole-2-carboxamide. The title compounds have good inhibitory activity on hcc1806 cells and can be used to prepare anticancer agents. The experimental process involved the reaction of 4,4′-Bis(trifluoromethyl)-2,2′-bipyridinebis[3,5-difluoro-2-[5-methyl-2-pyridinyl)phenyl] iridium(III) hexafluorophosphate(cas: 2229858-27-7).Electric Literature of 2229858-27-7

The Article related to photocatalysis cyclization fused indoline isothiazole preparation treatment human cancer, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 2229858-27-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 15, 2022, Zhen, Guangjin; Wang, Furong; Yin, Biaolin published a patent.Electric Literature of 2229858-27-7 The title of the patent was Preparation of cyclobutane fused spiro indoline compounds as antitumor agents. And the patent contained the following:

The invention discloses the preparation of cyclobutane fused spiro indoline compounds with general formula I or II as antitumor agents [where X=O, S, CH = CH; R1=H, halogen group, ether group, aryl, siloxane or alkyl; R2=alkyl, siloxane, alkynyl or heterocyclic; R3=acetyl, p-methoxybenzyl, methylthiomethyl, tervaleryl, benzyloxycarbonyl, tert butoxycarbonyl, benzyl or p-methoxyphenyl], which has the advantages of simple preparation method, mild conditions, environmental protection and suitable for large-scale preparation For example, compound I (X=S, R1=H, R2=CH2CH2OCH3, R3=Ac) was prepared by photocatalytic cyclization of 1-acetyl-N-(2-methoxyethyl)-N-(thiophen-2-ylsulfonyl)-1H-indole-2-carboxamide. The title compounds have good inhibitory activity on hcc1806 cells and can be used to prepare anticancer agents. The experimental process involved the reaction of 4,4′-Bis(trifluoromethyl)-2,2′-bipyridinebis[3,5-difluoro-2-[5-methyl-2-pyridinyl)phenyl] iridium(III) hexafluorophosphate(cas: 2229858-27-7).Electric Literature of 2229858-27-7

The Article related to photocatalysis cyclization fused indoline isothiazole preparation treatment human cancer, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 2229858-27-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem