Tag: 200-300

Syntheses of [¹¹C]2- and [¹¹C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases was written by Ramos-Torres, Karla M.;Zhou, Yu-Peng;Yang, Bo Yeun;Guehl, Nicolas J.;Sung-Hyun, Moon;Telu, Sanjay;Normandin, Marc D.;Pike, Victor W.;Brugarolas, Pedro. And the article was included in RSC Medicinal Chemistry in 2020.Recommanded Product: 257937-08-9 This article mentions the following:

Trifluoromethyl groups are of great interest in PET radiopharmaceuticals. Radiolabeled 4-aminopyridine (4AP) derivatives have been proposed for imaging demyelinating diseases. Here, we describe methods for producing ¹¹C-trifluoromethylated derivatives of 4AP and present early imaging results with [¹¹C]3-trifluoromethyl-4AP in a rhesus macaque. This study shows the utility of [¹¹C]CuCF₃ for labeling pyridines and provides initial evidence for the potential use of [¹¹C]3-trifluoromethyl-4AP as a PET radioligand. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9Recommanded Product: 257937-08-9).

tert-Butyl (3-bromopyridin-4-yl)carbamate (cas: 257937-08-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 257937-08-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL) was written by Mayer, Nicole;Schweiger, Martina;Fuchs, Elisabeth;Migglautsch, Anna K.;Doler, Carina;Grabner, Gernot F.;Romauch, Matthias;Melcher, Michaela-Christina;Zechner, Rudolf;Zimmermann, Robert;Breinbauer, Rolf. And the article was included in Bioorganic & Medicinal Chemistry in 2020.SDS of cas: 89978-52-9 This article mentions the following:

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alc. fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure-activity relationship (SAR) studies of small mol. inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9SDS of cas: 89978-52-9).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule 婵?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 89978-52-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Designing Functionally Selective Noncatechol Dopamine D₁ Receptor Agonists with Potent In Vivo Antiparkinsonian Activity was written by Martini, Michael L.;Ray, Caroline;Yu, Xufen;Liu, Jing;Pogorelov, Vladimir M.;Wetsel, William C.;Huang, Xi-Ping;McCorvy, John D.;Caron, Marc G.;Jin, Jian. And the article was included in ACS Chemical Neuroscience in 2019.Reference of 175205-82-0 This article mentions the following:

Dopamine receptors are important G protein-coupled receptors (GPCRs) with therapeutic opportunities for treating Parkinson’s Disease (PD) motor and cognitive deficits. Biased D₁ dopamine ligands that differentially activate G protein over 闁?arrestin recruitment pathways are valuable chem. tools for dissecting pos. vs. neg. effects in drugs for PD. Here, we reveal an iterative approach toward modification of a D₁-selective noncatechol scaffold critical for G protein-biased agonism. This approach provided enhanced understanding of the structural components critical for activity and signaling bias and led to the discovery of several novel compounds with useful pharmacol. properties, including three highly G_S-biased partial agonists. Administration of a potent, balanced, and brain-penetrant lead compound from this series results in robust antiparkinsonian effects in a rodent model of PD. This study suggests that the noncatechol ligands developed through this approach are valuable tools for probing D₁ receptor signaling biol. and biased agonism in models of neurol. disease. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Reference of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A simple approach for assessment of the corrosion inhibition efficiency of triazole, oxadiazole and thiadiazole derivatives as a function of their concentrations without using complex computer codes was written by Shirazi, Zeinab;Keshavarz, Mohammad Hossein;Esmaeilpour, Karim;Golikand, Ahmad Nozad. And the article was included in Protection of Metals and Physical Chemistry of Surfaces in 2017.SDS of cas: 15420-02-7 This article mentions the following:

A new approach is introduced to predict the corrosion inhibition efficiency of triazole, oxadiazole and thiadiazole derivatives In contrast to the available predictive methods, there is no need to use complex computer codes and unusual complicated mol. descriptors. The new method is based on the number of carbon, hydrogen and nitrogen atoms as well as the contribution of some effective structural parameters in the corrosion inhibition efficiency. The effect of concentration of inhibitors is inserted in the new model to predict the corrosion inhibition efficiency of a desired triazole, oxadiazole and thiadiazole derivative as a function of its concentration For 19 compounds of these derivatives, where the computed results of four complex quantum mech. models were available, the root mean squared (RMS) deviations of the new method is 3.23, which is lower than the computed outputs of four models. High reliability of the new method is also tested for further several compounds In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7SDS of cas: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 闂?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H闂佹椿浜滈妴鍗l criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Borane-Catalyzed Reduction of Pyridines via a Hydroboration/Hydrogenation Cascade was written by Yang, Zhao-Ying;Luo, Heng;Zhang, Ming;Wang, Xiao-Chen. And the article was included in ACS Catalysis in 2021.Reference of 89978-52-9 This article mentions the following:

A method for a B(C₆F₅)₃-catalyzed hydroboration/hydrogenation cascade reduction of 2,3-disubstituted pyridines to afford piperidine derivatives I [R = Me, Ph, 2-furyl, etc.; R¹ = Me, OH, Ph, etc.; R² = H, nosyl; R³ = H, Me; R⁴ = H, Me, Ph, etc.] in high yields with high cis selectivity was reported. Mechanistic studies indicated that the pyridine substrates and the piperidine products sequentially acted as bases in cooperation with B(C₆F₅)₃ to split H₂. The broad functional group tolerance of the method allowed its use for the synthesis of some biol. active mols. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Reference of 89978-52-9).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 89978-52-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Corrosion inhibitors. Part II: Quantum chemical studies on the corrosion inhibition of steel in acidic medium by some triazole, oxadiazole and thiadiazole derivatives was written by El Ashry, El Sayed H.;El Nemr, Ahmed;Esawy, Sami A.;Ragab, Safaa. And the article was included in Electrochimica Acta in 2006.SDS of cas: 15420-02-7 This article mentions the following:

The corrosion inhibition efficiencies of some triazole, oxadiazole and thiadiazole derivatives for steel in an acid medium have been studied by using AM1, PM3, MINDO/3 and MNDO semi-empirical SCF MO methods. Geometric structures, total neg. charge on the mol., highest occupied mol. energy level, lowest unoccupied mol. energy level, core-core repulsion, dipole moment, linear solvation energy terms, mol. volume and dipolar-polarization were correlated with the corrosion inhibition efficiency. Four equations were proposed to calculate the corrosion inhibition efficiency. The agreement with exptl. data was satisfactory, and the standard deviation between the calculated and exptl. results ranged between 闂?.03 and 闂?.18. The inhibition efficiency was closely related to the orbital energies and dipole moment. The correlation between quantum parameters and exptl. inhibition efficiency has been validated by single point calculations for the semi-empirical AM1 structures using B3LYP/6-31G** as a higher level of theory. The proposed equations were used to predict the corrosion inhibition efficiency of some related structures to select mols. of possible activity from a presumable library of compounds In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7SDS of cas: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Spectral and ionization constant studies of substituted 2-hydroxypyridines(1,2-dihydro-2-oxopyridines) was written by Spinner, E.;White, J. C. B.. And the article was included in Journal of the Chemical Society [Section] B: Physical Organic in 1966.HPLC of Formula: 13472-81-6 This article mentions the following:

The uv and ir spectra and the ionization constants of the title compounds containing substituents (3-, 4-, 5-, and 6-Me; 3- and 5-Cl; 3,5-Cl₂; 3- and 5-Br; 3,5-Br₂; 5-I; 3,5-I₂; 3- and 6-OH; 3- and 6-O^–; 3- and 5-NO₂) have been determined For all the compounds examined the pyridone form predominates. A number of the corresponding 2-methoxypyridines were also studied for reference. 34 references. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6HPLC of Formula: 13472-81-6).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 13472-81-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and biological evaluation of some pyridine derivatives as antimicrobial agents was written by Ali Hussen, Dagim;Bekhit, Adnan A.;Hymete, Ariaya. And the article was included in Ethiopian Pharmaceutical Journal in 2009.Formula: C12H8N4O This article mentions the following:

In this study, several pyridine derivatives were prepared and evaluated for their in-vitro antimicrobial activity against Gram-pos. bacteria (Bacillus cereus and Staphylococcus aureus), Gram-neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Aspergillus niger and Candida albicans). The synthesis of the target compounds was achieved using 1-phenylethanone and 1-(4-chlorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde and 1-(4-methylphenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde as starting materials and a second series was obtained using 4-pyridinecarboxaldehyde and amines or hydrazides as starting materials. The products thus obtained [i.e., 1,2-dihydro-4-[1-(aryl)-3-phenyl-1H-pyrazol-4-yl]-2-oxo-6-phenyl-3-pyridinecarbonitrile derivatives and Schiff base imines and hydrazides] were confirmed by IR, ¹H-NMR, ¹³C-NMR and elemental anal. An evaluation of the toxicity profile revealed that oral and parenteral LD₅₀s are more than 300 mg/kg and 100 mg/kg, resp., and it was discovered that the title compounds displayed antimicrobial activity. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Facile preparation of thiophene C2-ethers using the Mitsunobu reaction was written by Harris, Craig S.;Germain, Herve;Pasquet, Georges. And the article was included in Tetrahedron Letters in 2008.Formula: C12H18N2O2 This article mentions the following:

The preparation of thiophene ethers generally requires forcing conditions thus limiting the choice of alkyl substituent. Herein, we report the first successful generally applicable conditions for the selective O-alkylation of 2(5H)-thiophenone. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Formula: C12H18N2O2).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 闂?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H闂佹椿浜滈妴鍗l criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H18N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Insights into the inhibition mechanism of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole for carbon steel corrosion in hydrochloric acid pickling via experimental and computational approaches was written by Nadi, I.;Bouanis, M.;Benhiba, F.;Nohair, K.;Nyassi, A.;Zarrouk, A.;Jama, C.;Bentiss, F.. And the article was included in Journal of Molecular Liquids in 2021.Electric Literature of C12H8N4O This article mentions the following:

The addition of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (4-POX) as organic corrosion inhibitor of carbon steel (CS) in 1 M HCl solution was assessed exploiting weight loss and electrochem. measurements as well as surface anal. The gravimetric results showed that the 4-POX presents excellent anticorrosive properties on CS substrate, and its inhibition performance, 闂?(%), augmented with the 4-POX concentration to reach a maximum value of 93.6% at 1 mM afterwards 6 h embedding in 1 M HCl at 303 K. The AC impedance findings revealed that the addition of 4-POX to the corrosive medium leads to a decrease of the charge capacitance resulting in a systematic improve of the interface charge/discharge function and forms an adsorbed layer over the metal surface. Furthermore, SEM, water contact angle and XPS methods supported the development of a protective film over CS substrate surface afterwards addition of 4-POX. DFT calculations and MD simulations of 2,5-bis(n-pyridyl)-1,3,4 oxadiazole (n = 2, 3 and 4) derivatives were exploited to get better insight, about structural and electronic effects in relation to the anticorrosion properties and to envisage the interactions of the investigated inhibitors with metal surface atoms along with corrosive species. The cytotoxicity of 4-POX was also determined using the cell culture system. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Electric Literature of C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem