Tag: 200-300

Synthetic Route of C10H9ClN4O2S《Validation of the QuEChERSER mega-method for the analysis of pesticides, veterinary drugs, and environmental contaminants in tilapia (Oreochromis Niloticus)》 was published in 2022. The authors were Monteiro, Sergio H.;Lehotay, Steven J.;Sapozhnikova, Yelena;Ninga, Ederina;Moura Andrade, Graziela C. R.;Lightfield, Alan R., and the article was included in《Food Additives & Contaminants, Part A》. The author mentioned the following in the article:

To meet this need, the development and implementation of more efficient and effective anal. methods to monitor residues (pesticides and veterinary drugs) and contaminants in food is important. In this study, we report the validation results for a simple high-throughput mega-method for residual anal. of 213 pesticides and veterinary drugs, including 15 metabolites, plus 12 environmental contaminants (polychlorinated biphenyls) in tilapia muscle for implementation in routine laboratory analyses. The generic sample preparation method and anal. approach are known as QuEChERSER. A small portion of the initial extract (204μL) is taken for anal. by ultrahigh-performance liquid chromatog. (UHPLC) tandem mass spectrometry (MS/MS) covering 145 analytes, and the remaining extract undergoes a salting out step followed by an automated robotic instrument top sample preparation (ITSP) cleanup, also known as micro-solid-phase extraction (μSPE), plus fast low-pressure gas chromatog. LPGC-MS/MS for 134 analytes (66 pesticides are targeted in both UHPLC-MS/MS and LPGC-MS/MS). No significant matrix effects were observed for the analytes in LPGC-MS/MS, and only 5% of the analytes exceeded ±20% matrix effect in UHPLC-MS/MS. Anal. of standard reference materials (NIST SRMs 1946 and 1947) for contaminants in freeze-dried fish showed acceptable results, further demonstrating that the QuEChERSER mega-method can be implemented to expand anal. scope and increase laboratory efficiency compared to the QuEChERS method. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Lin;Sim, Siong Fong;Lin, Sen;Wan, Jiang;Zhang, Wei;Li, Qiannan;Peng, Cheng published 《Integrated structural and chemical analyses for HCl-supported hydrochar and their adsorption mechanisms for aqueous sulfachloropyridazine removal》. The research results were published in《Journal of Hazardous Materials》 in 2021.Recommanded Product: 80-32-0 The article conveys some information:

In this study, various HCl-supported hydrochar made from root powder of long-root Eichhornia crassipes were applied to adsorb aqueous sulfachloropyridazine (SCP). Adsorption capacity (q_e μg g^-1) was pos. correlated with combined severity-CS. With CS increasing, carbonization degree, hydrophobicity, porosity and isoelec. point of hydrochar increased, but content of polar functional groups decreased. Hydrophobic interaction was important for SCP adsorption. A 24 x 36 peak area table was generated from 24 FT-IR absorbance spectra computed by peak detection algorithm. Afterwards, correlation anal. between qe μg g^-1 and FT-IR peak area were conducted, indicating that wavenumbers at 555.4, 1227.47, 1374.51, 1604.5, 2901.4/2919.2 and 3514.63 cm-1 were helpful for SCP adsorption. Further, multivariate linear regression analyses showed that aromatic skeleton and phenolic hydroxyl were the two biggest contributors. Electrostatic attraction did not exist during the SCP adsorption process. Under strong acid condition, protonated amino groups in cationic SCP acting as a hydrogen donator interacted with electron-rich functional groups onto hydrochar by Hydrogen interaction. Under weak acid condition, neutral SCP served as an π electron donor to bond with hydrochar by π-π electron donator-acceptor interaction. This work could guide the functional groups modification strategy of hydrochar to make better use of it in water purification field. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Recommanded Product: 80-32-0 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Xu;Zhao, Wenhao;Ji, Baocheng;Han, Yu;Xu, Gaigai;Jie, Mingsha;Wu, Nan;Wu, Yongmei;Li, Junguang;Li, Ke;Zhao, Dianbo;Bai, Yanhong published 《Application of silanized melamine sponges in matrix purification for rapid multi-residue analysis of veterinary drugs in eggs by UPLC-MS/MS》. The research results were published in《Food Chemistry》 in 2022.Synthetic Route of C10H9ClN4O2S The article conveys some information:

Fast and convenient matrix purification is an important prerequisite for high-throughput anal. of drug multiresidues in food. In this study, a silanized melamine sponge was prepared and first applied in the rapid determination of multiclass veterinary drugs in eggs by ultrahigh-performance liquid chromatog.-tandem mass spectrometry. Within five seconds, fast, convenient and efficient matrix separation could be achieved through simple soaking and squeezing. Compared to other matrix adsorbents, the developed material demonstrated equivalent or better purification performance. Good validation results were obtained in terms of drug recoveries (61.5%∼97.0%, relative standard deviation (RSD) ≤ 10.8%), and linearities (R2 ≥ 0.999), as well as low limits of quantitation (0.3 ∼ 10.9μg·kg-1) and detection (0.1 ∼ 3.8μg·kg-1). By analyzing 52 egg samples, high concentrations of ofloxacin, trimethoprim, metronidazole, and dimetridazole were found at 542.9, 121.2, 66.1 and 58.0μg·kg-1, resp. The silanized melamine sponge has shown its great potential for rapid anal. of multiclass residues in food safety. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C10H9ClN4O2SIn 2021, Ivanov, Evgeniy V. published 《A negative partial volume of methanol in aqueous solutions: How plausible is it? Some comments on “Intermolecular interactions between methanol and some sulphonamide drugs in aqueous medium using thermodynamics approach” by indra Bahadur et al. [J. Mol. Liquid 283 (2019) 451-461]》. 《Journal of Molecular Liquids》published the findings. The article contains the following contents:

The authors of the above paper came recently to the inference that the apparent (down to infinite dilution) molar volumes of methanol in water and aqueous sulfonamides are neg. in sign and unusually large in magnitude. In this regard, two main points relating to the given “phenomenon” were considered here: how plausible is it and what exptl. “features” did the authors apply to achieve such a result. Based on the recalculated authors data and reliable literature data of interest, it is concluded here on the scientific absurdity of results reported in the paper being commented. The main reasons for this could be the sloppy performing exptl. procedures as well as the incorrect using well-known thermodn. relations by the authors (Bahadur et al.). To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Campos, Victoria M.;Andrade, Mariane A.;Maciel, Edvaldo V. S.;de Toffoli, Ana Lucia;Lancas, Fernando M. published 《Environmentally friendly analysis of sulphonamides in Brazilian honey through automated and miniaturised sample preparation coupled with LC-MS/MS》 in 2022. The article was appeared in 《Food Additives & Contaminants, Part A》. They have made some progress in their research.Formula: C10H9ClN4O2S The article mentions the following:

Increased use of environmentally friendly practices has become a trend in science because of the current awareness regarding climate change and related issues. Similarly for anal. chem., considering the development of greener methods for reducing the use of reagents and samples and also toxic waste generation. To meet such goals, automation, and miniaturization of sample preparation-a well-recognized laborious and time-consuming anal. step-are two promising strategies. This work associates the greener aspects of miniaturization and the performance of automated sample preparation Therefore, we proposed an anal. method using a miniaturized extraction column for pre-concentrating sulphamerazine, sulphamethazine, sulphamethoxazole, sulphadimethoxine, sulphathiazole, and sulphachlorpyridazine from honey and cleaning-up the samples. Several variables were optimized: extractive phase, loading flow, loading phase, and loading time. Under optimized conditions, the method showed adequate linearity between 5.0 and 60 ng g-1 with R > 0.99, and also good selectivity and recovery (114.6-124.1%) which are acceptable according to Brazilian legislation. Intra and inter-day precision were in the range 3.0-5.0%. Although sulfonamides were detected in one of the eight com. honey samples, the value was below the established MRL. The method showed efficiency, while also exhibiting greener characteristics resulting from miniaturization and automation, representing a promising environmentally friendly alternative for conventional sample preparation methods. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Formula: C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C15H11F3N2OIn 2017, Chen, Junjie;Han, Xiuling;Lu, Xiyan published 《Atom-Economic Synthesis of Pentaleno[2,1-b]indoles via Tandem Cyclization of Alkynones Initiated by Aminopalladation》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:

An atom-economic Pd(OAc)₂-catalyzed tandem cyclization of alkynones to synthesize pentaleno[2,1-b]indoles was developed efficiently. In the formed tetracyclic indole framework, two neighboring stereocenters, one being all-carbon quaternary, are constructed in a single process with excellent diastereoselectivity. This reaction was initiated by aminopalladation of alkynes and quenched by addition to the intramol. carbonyl groups. To complete the study, the researchers used (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1835671-08-3) .

N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So (R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole(cas: C15H11F3N2O) can also undergo this reaction.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shahriman, Mohamad Shariff;Mohamad, Sharifah;Mohamad Zain, Nur Nadhirah;Alias, Yatimah;Chandrasekaram, Kumuthini;Raoov, Muggundha published 《Paper-based polymeric ionic liquid for thin film micro extraction of sulfonamides in environmental water samples prior to HPLC-DAD analysis》. The research results were published in《Microchemical Journal》 in 2021.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article conveys some information:

Paper-based polymeric ionic liquid (p-Poly-(MMA-IL)) was successfully developed by grafting the polymeric ionic liquid on the surface of com. filter paper by using dipping method, presenting a new cost-effective film. The newly developed p-Poly-(MMA-IL) was then applied as a paper-based thin film microextraction (p-TFME) to extract four representative sulfonamides (SAs) drugs, which were sulfadiazine, sulfachloropyridazine, sulfamethoxazole, and sulfadimethoxine in environmental water samples. Besides, p-Poly-(MMA-IL) was successfully characterised by FTIR, FESEM, and XRD techniques and underwent significant parameters optimization, which affected the extraction efficiency. Under optimal conditions, the proposed method (p-Poly-(MMA-IL)-TFME) was evaluated and applied to analyze SAs in environmental water samples by using a high-performance liquid chromatog.-diode array detector (HPLC-DAD). The validation method showed that a good linearity (0.50 μg L^-1 -500 μg L^-1) was noted (R² > 0.999, n = 3). Detection and quantification limits were within 0.14 μg L^-1 – 0.52 μg L^-1 and 0.41 – 1.57 μg L^-1, resp., the preconcentraction factors were > 14.95, and the matrix effect was less than 2.64%, an acceptable percentage for real samples anal. The extraction recoveries of environmental water samples were ranged from 90.4% to 109.9% with a relative standard deviation (RSD) of less than 9.8%. The newly developed paper-based polymeric ionic liquid p-Poly-(MMA-IL) for anal. of SAs under the p-TFME procedure was successfully achieved with limited sample volume and organic solvent, fast extraction, and practicable in the daily anal. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C10H9ClN4O2SIn 2021, Hu, Yaru;Jin, Lei;Zhao, Yi;Jiang, Lei;Yao, Shijie;Zhou, Wang;Lin, Kuangfei;Cui, Changzheng published 《Annual trends and health risks of antibiotics and antibiotic resistance genes in a drinking water source in East China》. 《Science of the Total Environment》published the findings. The article contains the following contents:

The extensive pollution of antibiotics and antibiotic resistance genes (ARGs) in drinking water has aroused worldwide concern. Successive monitoring of these pollutants has noteworthy significance for drinking water safety. Accordingly, this study conducted successive monitoring of antibiotics and ARGs from 2015 to 2017 in a drinking water source in East China. The total antibiotic concentration ranged from 19.68 ng/L to 497.00 ng/L, and decreased slightly from 2015 to 2017. Eighteen out of forty-one ARG subtypes showing resistance to six antibiotic classes and one class I integrase gene intI1, were detected in the drinking water source at concentrations ranging from 6.5 x 104 copies/mL to 1.6 x 106 copies/mL. Importantly, the total ARG concentration increased on an annual basis from 2015 to 2017 with an average annual increment of 0.25 orders of magnitude, which was mainly attributed to the increase in specific ARG subtypes, such as sul1, sul2, sul3, tetA, qnrB, and ermB. Most ARGs was pos. correlated with the intI1 genes (r = 0.47-0.55, P < 0.01). Furthermore, the variation of antibiotics and ARGs appeared to be related to the water indexes, particularly of the values of COD, BOD₅, NO₂-N (P < 0.05). This study provides basic data on antibiotic and ARG pollution in the studied drinking water source. Importantly, the findings expound that although the residual antibiotics in this drinking water source decreased slightly from 2015 to 2017, while its biol. effect, the antibiotic resistance, increased annually, which give a warning of the antibiotic resistance pollution in the drinking water source. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Electric Literature of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Chunmeng;Shi, Jiaqi;Zhang, Xuesheng;Qin, Li;Jiang, Zhongguan;Wang, Jinhua;Li, Yucheng;Liu, Bingxiang published 《Occurrence and bioaccumulation of sulfonamide antibiotics in different fish species from Hangbu-Fengle River, Southeast China》 in 2021. The article was appeared in 《Environmental Science and Pollution Research》. They have made some progress in their research.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

As a class of synthetic sulfur drugs, sulfonamides (SAs) have been used to treat diseases and promote organism growth. Different concentrations of SAs have been detected in the water environment, which has threatened the ecol. environment. In this study, the contamination of 9 SAs in water, sediments, and 8 fish species from the Hangbu-Fengle River, China, were analyzed using UPLC-MS/MS. The total SA concentrations in surface water, sediments, and fish were ND-5.064 ng/L, ND-5.052 ng/g dry weight (d.w.), and ND-1.42 ng/g wet weight (w.w.), resp. The major compounds were sulfadiazine (SDZ), sulfamerazine (SMZ), and sulfamethoxazole (SMX) in water and fish. The SA levels of in fish from different habitat preferences revealed a spatial difference, with the order of demersal species > pelagic species. Moreover, the SA concentrations were affected by trophic guilds, indicating their decrease in the order of piscivorous fish > omnivorous fish > planktivorous fish > herbivorous fish. The obtained bioaccumulation factors showed that SMZ and SMX have strong bioenrichments in Ophiocephalus argus Cantor and Pelteobagrus fulvidraco. The risk assessment indicated that SAs did not pose significant health threats to the organisms. This research is the first report of SA contamination in the Hangbu-Fenle River, which can provide an important scientific basis for their pollution prevention and ecol. risk assessment in the aquatic environment.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Ruidong;Mu, Shuhe;Feng, Tengwang;Liu, Huan;Sun, Huiwu;Li, Jincheng published 《Development of a vortex oscillating clean-up column for high-throughput semi-automatic sample preparation of drug residues in fish muscle tissues》 in 2022. The article was appeared in 《Journal of Food Composition and Analysis》. They have made some progress in their research.Recommanded Product: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

A novelty high-throughput semi-automatic sample clean-up method was developed and used for rapid anal. of 9 drug residues in fish muscle tissues combined with high-performance liquid chromatog./quadrupole-linear ion trap mass spectrometry (HPLC-QTRAP-MS/MS). The target compounds were extracted by Quick, Easy, Cheap, Effective, Rugged and Safe multiresidue (QuEChERS) method with acetonitrile. A vortex oscillating clean-up column was proposed for single step purification firstly. After centrifugation, 1 mL of acetonitrile layer was transferred into a 3 mL vortex oscillating clean-up column which packed with 150 mg C₁₈ sorbent. The column was covered with piston, placed on a column-tube rack, vigorously agitated on a multi-tube vortex mixer. After vortex oscillation, purified extract was obtained for anal. by pushing the piston of oscillating clean-up column. The performance of the developed method was validated by analyzing 9 analytes in spiked grass carp muscle tissues. The limits of quantification (LOQs) ranged from 1.0 to 5.0 μg kg^-1. The recoveries were in the range of 101-119% at the four concentration levels (2.0, 5.0, 10.0, 20.0 μg kg^-1). Inter-day and intra-day relative standard deviations (RSDs) were lower than 16% for all analytes. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Recommanded Product: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem