Tag: 200-300

A new bitrack sinusoid-like chain templated by Wells-Dawson type polyoxometalate was written by Wang, Xiuli;Hu, Hailiang;Tian, Aixiang;Lin, Hongyan;Li, Jin;Shi, Limin. And the article was included in Inorganic Chemistry Communications in 2010.Name: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

A new Wells-Dawson type polyoxometalate (POM)-templated compound, [Cu₄(娓?sub>2-O)₂(4,4′-bpo)₄(INA)₂(H₂O)₄][(P₂W₁₈O₆₂)]璺疕₂O (I, 4,4′-bpo = 2,5-bis(4-pyridyl)-1,3,4-oxadiazole; INA = pyridine-4-carboxylic acid), has been hydrothermally synthesized. I contains a novel bitrack sinusoid-like chain constructed from alternating dicopper units and non-linear rigid 4,4′-bpo linkers. Induced by POM templates, the adjacent chains formed elliptical spaces to accommodate the Wells-Dawson type anions. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Name: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermodynamic study on carbon dioxide and methane permeability in polyvinylchloride/ionic liquid blends was written by Noorani, Narmin;Mehrdad, Abbas;Chakhmaghi, Farnoosh. And the article was included in Journal of Chemical Thermodynamics in 2020.Category: pyridine-derivatives This article mentions the following:

In the present study, to improve separation proficiency of polyvinyl chloride (PVC) membrane, polyvinyl chloride is combined with 1-butyl-4-methylpyridinium ionic liquids ([B4MPyr][X]) with different anions bromide, [Br]^–, chloride, [Cl]^–, thiocyanate, [SCN]^–, and tetrafluoroborate, [BF₄]. The prepared PVC/[B4MPyr][X] blend membranes were characterized by differential scanning calorimetry (DSC) analyses. The prepared membrane morphol. was investigated by Scanning Electron Microscope (SEM). The effects of feed pressure, temperature and, different of anions on the performance of blend membrane were surveyed. The results reveal that the permeability of methane and carbon dioxide gases in the PVC/[B4MPyr][X] blevapornd membranes were reduced with an increase in feed pressure while the ideal selectivity of CO₂/CH₄ was increased with an increase in feed pressure. Moreover, the permeability of CH₄ and CO₂ gases in the PVC/[B4MPyr][X] blend membranes are increased with an increase in temperatures while the ideal selectivity of CO₂/CH₄ was decreased with increasing temperatures Also, the PVC/[B4MPyr][SCN] membrane has a higher performance for the separation of CO₂ and CH₄ gases in comparing with others membranes. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Category: pyridine-derivatives).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions was written by Huang, Binbin;Guo, Lin;Xia, Wujiong. And the article was included in Green Chemistry in 2021.Category: pyridine-derivatives This article mentions the following:

A general electrochem. system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et₃N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate e.g., 9-bromophenanthrene scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an ethanol. as a co-solvent. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Category: pyridine-derivatives).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery and optimization of adamantyl carbamate inhibitors of 11灏?HSD1 was written by Tice, Colin M.;Zhao, Wei;Krosky, Paula M.;Kruk, Barbara A.;Berbaum, Jennifer;Johnson, Judith A.;Bukhtiyarov, Yuri;Panemangalore, Reshma;Scott, Boyd B.;Zhao, Yi;Bruno, Joseph G.;Howard, Lamont;Togias, Jennifer;Ye, Yuan-Jie;Singh, Suresh B.;McKeever, Brian M.;Lindblom, Peter R.;Guo, Joan;Guo, Rong;Nar, Herbert;Schuler-Metz, Annette;Gregg, Richard E.;Leftheris, Katerina;Harrison, Richard K.;McGeehan, Gerard M.;Zhuang, Linghang;Claremon, David A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Category: pyridine-derivatives This article mentions the following:

Synthesis of 2-adamantyl carbamate derivatives of piperidines and pyrrolidines led to the discovery of 2-adamantanyl (3R)-3-tert.-butoxycarbonylaminopyrrolidine-1-carboxylate with an IC₅₀ of 15.2 nM against human 11灏?HSD1 in adipocytes. Optimization for increased adipocyte potency, metabolic stability and selectivity afforded 1-carbamoyladmanatan-4-yl (3R)-(3-cyano- and 5-cyanopyrdinylamino)pyrrolidine-1-carboxylate, both of which were >25% orally bioavailable in rat. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Category: pyridine-derivatives).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficacy of difenoconazole emulsifiable concentrate with ionic liquids against cucumbers powdery mildew was written by Peng, Qingrong;Liu, Fengmao;Zhang, Chunrong. And the article was included in International Journal of Chemical Engineering in 2017.Category: pyridine-derivatives This article mentions the following:

Among eight ionic liquids (ILs) examined, 1-n-butyl-4-methyl-pyridinium bromide (BMPyBr, 5) was used in this study as an appropriate alternative to benzene homologs and derivatives to be used in 10 wt% water-insoluble difenoconazole emulsifiable concentrate (EC). Moreover, 10 wt% difenoconazole EC with BMPyBr (5) exhibited the same efficacy as 10 wt% difenoconazole wettable powder (WP) against powdery mildew on cucumbers under field conditions.The results revealed that difenoconazole EC with BMPyBr (5) had excellent stability at 268K and 327K after 14 days through high-performance liquid chromatog. (HPLC). Therefore, ILs can be considered as promising environment-friendly adjuvants for pesticides that are com. processed as EC formulation. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Category: pyridine-derivatives).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chain-walking cycloisomerization of 1,n-dienes catalyzed by pyridine-oxazoline palladium catalysts and its application to asymmetric synthesis was written by Hamasaki, Taro;Kakiuchi, Fumitoshi;Kochi, Takuya. And the article was included in Chemistry Letters in 2016.Quality Control of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole This article mentions the following:

Palladium catalysts possessing pyridine-oxazoline ligands, e.g., I, were found to catalyze the chain-walking cycloisomerization of 1,n-dienes, e.g., II, to form five-membered rings and were particularly effective for the reaction of 1,14-dienes, e.g., III. Asym. synthesis of cyclopentane derivatives was also achieved for the reaction of 1,n-dienes using chiral pyridine-oxazoline ligands. In the experiment, the researchers used many compounds, for example, (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2Quality Control of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole).

(S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electrostatically Self-Assembled Polyoxometalates on Molecular-Dye-Functionalized Diamond was written by Zhong, Yu Lin;Ng, Wibowo;Yang, Jia-Xiang;Loh, Kian Ping. And the article was included in Journal of the American Chemical Society in 2009.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

The authors have successfully immobilized phosphotungstic acid (PTA), a polyoxometalate, on the surface of B-doped diamond (BDD) surface through electrostatic self-assembly of PTA on pyridinium dye-functionalized-BDD. The inorganic/organic bilayer structure on BDD is found to exhibit fast surface-confined reversible electron transfer. The mol. dye-grafted BDD can undergo controllable elec. stripping and regeneration of PTA which can be useful for electronics or sensing applications. Also, the authors demonstrated the use of PTA as a mol. switch in which the direction of photocurrent from diamond to Me viologen is reversed by the surface bound PTA. Robust photocurrent converter based on such mol. system-diamond platform can operate in corrosive medium which is not tolerated by In Sn oxide electrodes. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361) was written by Smolinski, Michael P.;Bu, Yahao;Clements, James;Gelman, Irwin H.;Hegab, Taher;Cutler, David L.;Fang, Jane W. S.;Fetterly, Gerald;Kwan, Rudolf;Barnett, Allen;Lau, Johnson Y. N.;Hangauer, David G.. And the article was included in Journal of Medicinal Chemistry in 2018.Category: pyridine-derivatives This article mentions the following:

The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an elusive goal. Herein we describe the discovery of two such clin. candidates that inhibit the tyrosine kinase Src. Compound 1 is a phase 3 clin. trial candidate that is likely to provide a first in class topical treatment for actinic keratosis (AK) with good efficacy and dramatically less toxicity compared to existing standard therapy. Compound 2 is a phase 1 clin. trial candidate that is likely to provide a first in class treatment of malignant glioblastoma and induces 30% long-term complete tumor remission in animal models. The discovery strategy for these compounds iteratively utilized mol. modeling, along with the synthesis and testing of increasingly elaborated proof of concept compounds, until the final clin. candidates were arrived at. This was followed with mechanism of action (MOA) studies that revealed tubulin polymerization inhibition as the second MOA. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Category: pyridine-derivatives).

Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of EST73502, a Dual 娓?Opioid Receptor Agonist and 锜?sub>1 Receptor Antagonist Clinical Candidate for the Treatment of Pain was written by Garcia, Monica;Virgili, Marina;Alonso, Monica;Alegret, Carles;Farran, Joan;Fernandez, Begona;Bordas, Magda;Pascual, Rosalia;Burgueno, Javier;Vidal-Torres, Alba;Fernandez de Henestrosa, Antonio R.;Ayet, Eva;Merlos, Manuel;Vela, Jose Miguel;Plata-Salaman, Carlos R.;Almansa, Carmen. And the article was included in Journal of Medicinal Chemistry in 2020.Formula: C7H9Br2N This article mentions the following:

The synthesis and pharmacol. activity of a new series of 4-alkyl-1-oxa-4,9-diazaspiro[5.5]undecane derivatives as potent dual ligands for the 锜?sub>1 receptor (锜?sub>1R) and the 娓?opioid receptor (MOR) are reported. A lead optimization program over the initial 4-aryl analogs provided 4-alkyl derivatives with the desired functionality and good selectivity and ADME profiles. Compound I (EST73502) showed MOR agonism and 锜?sub>1R antagonism and a potent analgesic activity, comparable to the MOR agonist oxycodone in animal models of acute and chronic pain after single and repeated administration. Contrary to oxycodone, I produces analgesic activity with reduced opioid-induced relevant adverse events, like intestinal transit inhibition and naloxone-precipitated behavioral signs of opiate withdrawal. These results provide evidence that dual MOR agonism and 锜?sub>1R antagonism may be a useful strategy for obtaining potent and safer analgesics and were the basis for the selection of I as a clin. candidate for the treatment of pain. In the experiment, the researchers used many compounds, for example, 2-(2-Bromoethyl)pyridine hydrobromide (cas: 72996-65-7Formula: C7H9Br2N).

2-(2-Bromoethyl)pyridine hydrobromide (cas: 72996-65-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C7H9Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of G protein-coupled receptor 119 agonist MBX-2982 was written by Ding, Lu;Luo, Tang;Song, Kai-zhen;Gong, Ping;Han, Jing. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2012.Synthetic Route of C11H20N2O2S This article mentions the following:

Type 2 diabetes is emerging as a disease of staggering proportions in twenty-first century. MBX-2982, discovered by Metabolex company, is a potential oral first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119. According to the synthetic methods of MBX-2982 in literature, a new route was developed. The target compound was prepared from 4-cyanopiperidine-1-carboxylic tert-Bu ester via five steps including sulfidation, condensation, etherification, deprotection and substitution. The overall yield was 42.8% (based on 4-cyanopiperidine-1-carboxylic tert-Bu ester), which was 12% higher than that reported in the literature. The synthetic methods of intermediate 2, 6 and MBX-2982 were improved. The final structure and some intermediates were confirmed by ¹H-NMR and MS. Compared with the synthetic process in literature, this route has an economic advantage in view of application to in-depth study. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Synthetic Route of C11H20N2O2S).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C11H20N2O2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem