Tag: 300-400

High Throughput Screening of Transdermal Formulations was written by Karande, Pankaj;Mitragotri, Samir. And the article was included in Pharmaceutical Research in 2002.SDS of cas: 104-73-4 This article mentions the following:

Applications of transdermal drug delivery are limited by low skin permeability. Many chems. have been used to enhance skin permeability, however, only a handful are actually used in practice. Combinations of chems. are likely to be more efficient in enhancing skin permeability compared to individual enhancers. However, identification of efficient enhancer combinations is quite challenging because many chem. enhancers interact with each other and with the skin in a complex manner. In the absence of a fundamental knowledge of such interactions, we need to rely on rapid methods to screen various enhancer combinations for their effectiveness. In this paper, we report a novel high throughput (HTP) method that is at least 50-fold more efficient in terms of skin utilization and up to 30-fold more efficient in terms of holdup times than the current methods for formulation screening (Franz diffusion cells). A high throughput method was developed based on skin conductivity and mannitol penetration into the skin. This method was used to perform at least 100 simultaneous tests per day. Detailed studies were performed using two model enhancers, sodium lauryl sulfate (SLS) and dodecyl pyridinium chloride (DPC). The predictions of the high throughput method were validated using Franz diffusion cells. High throughput screening revealed that mixtures of SLS and DPC are significantly more effective in enhancing transdermal transport compared to each of them alone. Maximum efficiency was observed with near-equimolar mixtures of SLS/DPC. The predictions of the HTP method compared well against those made using Franz diffusion cells. Specifically, the effect of surfactant mixtures on skin conductivity and mannitol permeability measured using Franz cells also showed a maximum at near-equimolar mixtures of SLS/DPC. Thus, the novel HTP method allows rapid screening of enhancer formulations for transdermal applications. This method can be used to discover new and effective enhancer mixtures At the same time, these data may also broaden our understanding of the effect of enhancers on skin permeability. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4SDS of cas: 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. SDS of cas: 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The effects of surfactant concentration, adsorption, aggregation, and solution conditions on steel corrosion inhibition and associated modeling in aqueous media was written by Zhu, Yakun;Free, Michael L.;Yi, Gaosong. And the article was included in Corrosion Science in 2016.Quality Control of 1-Dodecylpyridin-1-ium bromide This article mentions the following:

A potential model for the prediction of metal corrosion inhibition using relevant pure and mixed surfactants in salt solution was developed and validated. This model is based on the combination of Langmuir adsorption (LA) and a newly-developed critical micelle concentration (cmc) prediction model for various pure and mixed surfactants. The collected data from benzalkonium chloride (BAC) surfactants was used for model illustration and derivation. The effects of surfactant concentration, adsorption, aggregation, and solution temperature on steel corrosion inhibition were investigated. The adsorption mechanism is discussed based on temperature, concentration, potential of zero charge, and d. functional theory (DFT) calculation In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Quality Control of 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adsorption of dodecylpyridinium bromide and Triton X-100 from individual and mixed solutions on alumina was written by Kharitonova, T. V.;Ivanova, N. I.;Rudnev, A. V.;Summ, B. D.. And the article was included in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya in 2003.Recommanded Product: 104-73-4 This article mentions the following:

Adsorption of dodecylpyridinium bromide (DDPB) and Triton X-100 on alumina was investigated by UV spectroscopy and capillary electrophoresis at pH 6.5, 8.7 and 10. The adsorption of DDPB was weak and it weakly increased with increasing pH. No significant adsorption was observed for Triton X-100. The low adsorption values were confirmed by the contact angle data. No DDPB-Triton X-100 interaction effects were observed during their adsorption on alumina. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Recommanded Product: 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Superactivity induced by micellar systems as the key for boosting the yield of enzymatic reactions was written by Sintra, Tania E.;Ventura, Sonia P. M.;Coutinho, Joao A. P.. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2014.Electric Literature of C17H30BrN This article mentions the following:

The superactivity phenomenon is a concept that expresses a significant increase on the enzymic activity by common surfactants or ionic liquids emulsions. In this context, this work presents an overview of the literature on this subject, focused on the type, and characteristics of the surfactants and ILs reported in literature as superactivity inductors and the enzymes and reactions hitherto investigated in the superactivity context. It intends to emphasize the necessity of a multidisciplinary approach to this subject bringing together scientific communities of different fields to foster the understanding of this phenomenon, and to identify the type of reactions and processes that could and should be improved by it, having into account its potential application at industrial level. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Electric Literature of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Electric Literature of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design and Synthesis of Quinazolinone-Triazole Hybrids as Potent Anti-Tubercular Agents was written by Dutta, Apurba;Trivedi, Priyanka;Gehlot, Praveen Singh;Gogoi, Dipshikha;Hazarika, Roktopol;Chetia, Pankaj;Kumar, Arvind;Chaliha, Amrita Kashyap;Chaturvedi, Vinita;Sarma, Diganta. And the article was included in ACS Applied Bio Materials in 2022.Computed Properties of C17H30BrN This article mentions the following:

A straightforward and convenient methodol. had been developed for the reaction of 2-aminobenzamide and carbonyls affording 2,3-dihydroquinazolin-4(1H)-ones I [R¹ = Ph, 4-BrC₆H₄, 2-thienyl, etc.; R² = H; R¹R² = (CH₂)₄, (CH₂)₅, (CH₂)₆] using aqueous solution of [C₁₂Py][FeCl₃Br]. The developed methodol. was applied for the synthesis of quinazolinone-triazole hybrids II [R³ = H, MeO; R⁴ = 4-FC₆H₄, 2-OHC₆H₄, 4-ClC₆H₄, etc.] and III [R⁵ = 4-FC₆H₄, 2-OHC₆H₄, 4-CH₃SC₆H₄,4-CHF₂OC₆H₄, 3,4-di-FC₆H₃] followed by evaluation of their in vitro anti-TB activity. The results revealed that quinazolinone-triazole hybrids displayed promising activity having MIC values 0.78-12.5μg/mL. The compound II [R³ = H, R⁴ = 2,4-di-FC₆H₃] with MIC 0.78μg/mL was found to be the lead nominee among the series, better than Ethambutol, a first line anti-TB drug and comparable with Rifampicin. The active compounds with MIC values ≤ 6.25μg/mL were subjected to in vitro cytotoxicity and found nontoxic. In drug-drug interaction, compounds II [R³ = H, R⁴ = 4-FC₆H₄, 3,4-di-FC₆H₃] interacted synergistically with all the three anti-TB drugs, INH, RFM and EMB. Important information on the binding interaction of the target compounds with the active sites of 1DQY Antigen 85C from Mycobacterium tuberculosis and Enoyl acyl carrier protein reductase (InhA) enzymes were obtained from mol. docking studies. Screening of the drug-likeness properties and bioactivity score indicated that synthesized mols. could be projected as potential drug candidates. Based on the current study, quinazolinone-triazole hybrids framework could be useful in drug development for tuberculosis. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Computed Properties of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Physicochemical properties and surface tension prediction of mixed surfactant systems: Triton X-100 with dodecylpyridinium bromide and Triton X-100 with sodium dodecylsulfonate was written by Song, Shi-Li;Hu, Zhi-Guo;Wang, Quan-kun;Cheng, Gang;Liu, Xin-Hua. And the article was included in Journal of Dispersion Science and Technology in 2008.Synthetic Route of C17H30BrN This article mentions the following:

Dependences of the surface tension of aqueous solutions of ionic (dodecylpyridinium bromide, sodium dodecylsulfonate) and nonionic (Triton X-100) surfactants and their mixtures on total surfactant concentration and solution composition were studied, and the surface tension of the mixed systems were predicted using different Miller’s model. It was found how to select the model for calculation of ω is corresponding to the degree of the deviation from the ideality during the adsorption of mixed surfactants. The compositions of micelles and adsorption layers at air-solution interface as well as parameters (βm, βads) of headgroup-headgroup interaction between the mols. of ionic and nonionic surfactants were calculated based on Rubingh model. The parameters (B1) of chain-chain interaction between the mols. of ionic and nonionic surfactants were calculated based on Maeda model. The free energy of micellization calculated from the phase separation model (ΔG2m), and by Maeda’s method (ΔG1m) agree reasonably well at high content of nonionic surfactant. The excess free energy ΔGadsE and ΔGmE (except α = 0.4) for TX-100/SDSn system are more neg. than that TX-100/DDPB system. These can be probably explained with the EO groups of TX-100 surfactant carrying partial pos. charge. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Synthetic Route of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effects of head group of cationic surfactants on the hydrolysis of p-nitrophenyl acetate catalyzed by α-chymotrypsin was written by Ghosh, Kallol K.;Verma, Santosh Kumar. And the article was included in International Journal of Chemical Kinetics in 2009.Synthetic Route of C17H30BrN This article mentions the following:

The search for activity enhancement (superactivity) has been an important aspect of in vitro micellar enzymol. The present kinetic study was undertaken to investigate the effect of different cationic surfactants which might improve the hydrolytic activity of chymotrypsin (I). Here, the kinetics of hydrolysis of p-nitrophenyl acetate catalyzed by I was studied in the presence of several cationic surfactants having different head groups maintaining the dodecyl hydrophobic residue and bromide counterion. I activity was tested in the presence of dodecyl trimethylammonium bromide (DTAB), dodecylpyridinium bromide (DPB), dodecyldimethylethanolammonium bromide (DDMEAB), dodecyldiethylethanolammonium bromide (DDEEAB), benzyldimethyldodecylammonium bromide (BDDAB), and dodecyltriphenylphosphonium bromide (DTPB) surfactants. The extent of superactivity depended upon the head groups of the surfactants. I activity also depended on the surfactant concentration and it varied with the surfactant head group dimensions (DTPB > DDEEAB > DTAB > BDDAB > DDMEAB > DPB). For all surfactants, DTPB exhibited the highest superactivity. The effects of the surfactants on apparent kinetic parameters such as the K_m and k_cat were determined In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Synthetic Route of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Smart Shell-by-Shell Nanoparticles with Tunable Perylene Fluorescence in the Organic Interlayer was written by Stiegler, Lisa M. S.;Klein, Stefanie;Kryschi, Carola;Neuhuber, Winfried;Hirsch, Andreas. And the article was included in Chemistry – A European Journal in 2021.Quality Control of 1-Dodecylpyridin-1-ium bromide This article mentions the following:

A new series of shell-by-shell (SbS)-functionalized Al₂O₃ nanoparticles (NPs) containing a perylene core in the organic interlayer as a fluorescence marker is introduced. Initially, the NPs were functionalized with both, a fluorescent perylene phosphonic acid derivative, together with the lipophilic hexadecylphosphonic acid or the fluorophilic (1 H,1 H,2 H,2H-perfluorodecyl)phosphonic acid. The lipophilic first-shell functionalized NPs were further implemented with amphiphiles built of aliphatic chains and polar head-groups. However, the fluorophilic NPs were combined with amphiphiles consisting of fluorocarbon tails and polar head-groups. Depending on the nature of the combined phosphonic acids and the amphiphiles, tuning of the perylene fluorescence can be accomplished due variations of supramol. organization with the shell interface. Because the SbS-functionalized NPs dispose excellent dispersibility in water and in biol. media, two sorts of NPs with different surface properties were tested with respect to biol. fluorescent imaging applications. Depending on the agglomeration of the NPs, the cellular uptake differs. The uptake of larger agglomerates is facilitated by endocytosis, whereas individualized NPs cross directly the cellular membrane. Also, the larger agglomerates were preferentially incorporated by all tested cells. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Quality Control of 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

3D QSAR studies of long chain quartenary ammonium derivatives as soft anti-bacterial agents was written by Jacob, Blessy;Bisht, Lata K.;Naveen, S.;David, Deena;Antony, Anjana. And the article was included in International Journal of Applied Pharmaceutical and Biological Research in 2016.Synthetic Route of C17H30BrN This article mentions the following:

Quant. structure activity relationship studies have been conducted on a series (19 compounds) of long chain quaternary ammonium derivatives using Chem Office v 8.0 software. The best predictions have been obtained for antibacterial activity (r= 0.9, r2=0.91, Boots strapping r2=0.8). Both equations are validated by a test set of compounds and give satisfactory predictive r2 values of 0.9 resp. The equations selected emphasized the importance of Dipole, Non Vander Wall energy on biol. activity i.e. Dipole moment, and Non VDW energy of mol. might be influencing the selective antibacterial activity. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Synthetic Route of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adsorption of alkylpyridinium bromides from aqueous solutions on metalized (Cu) glass fibers was written by Skokina, R. E.;Voronchikhina, L. I.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2002.Product Details of 104-73-4 This article mentions the following:

Adsorption of cationic surfactants n-alkylpyridinium bromides from their aqueous solutions on copper-plated glass fibers was investigated. The form of the adsorption isotherm for all compounds under investigation was quite similar. With increasing length of alkyl radical, the saturation concentration of surfactant shifted to the region of lower concentrations In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Product Details of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Product Details of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem