Tag: 300-400

Category: pyridine-derivativesOn October 15, 2021 ,《Cobalt-Catalyzed Remote Hydroboration of Alkenyl Aminesã€?was published in Organic Letters. The article was written by Lei, Yaqin; Huang, Jiaxin; Zhao, Wanxiang. The article contains the following contents:

The authors here present a generally applicable Co-catalyzed remote hydroboration of alkenyl amines, providing a practical strategy for the preparation of borylamines and aminoalcs. This method shows broad substrate scope and good functional group tolerance, tolerating alkenyl amines, including alkyl-alkyl amines, alkyl-aryl amines, aryl-aryl amines, and amides. Of note, this protocol is also compatible with a variety of natural products and drug derivatives Preliminary mechanistic studies suggest that this transformation involves an iterative chain walking and hydroboration sequence.4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Category: pyridine-derivatives) was used in this study.

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Category: pyridine-derivativesThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Improved Effect of Metal Coordination on Molecular Oxygen Activation for Selective Aerobic Photooxidationã€?was written by Cui, Jing-Wang; Rao, Cai-Hui; Jia, Meng-Ze; Yao, Xin-Rong; Zhang, Jie. Electric Literature of C20H14N4 And the article was included in ChemSusChem on April 22 ,2022. The article conveys some information:

A pyridinium-based complex with environment-friendly and earth-abundant ZnII ion was synthesized and explored as a green catalyst applied in activating mol. oxygen for the simple and efficient photooxidation of alcs. into aldehydes under additive-free and mild conditions. The metal coordination was conducive to promoting the electron transfer efficiency and introducing the heavy-atom effect for the increased generation of ·O2- and 1O2. Accordingly, improved photocatalytic performance of this complex compared to its precursor, no matter activity or selectivity, was obtained, facilitating the transformation of alcs. into aldehydes in a sustainable way. After reading the article, we found that the author used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Electric Literature of C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Electric Literature of C20H14N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A bifunctional small molecular photocatalyst with a redox center and a Lewis acid site for one-pot tandem oxidation-acetalization》 were Rao, Cai-Hui; Ma, Shuai; Cui, Jing-Wang; Jia, Meng-Ze; Yao, Xin-Rong; Zhang, Jie. And the article was published in Green Chemistry in 2022. Electric Literature of C20H14N4 The author mentioned the following in the article:

By combining the double identity of a redox center and a Lewis acid site of the pyridinium derivative, the first bifunctional small mol. photocatalyst was developed for the one-pot tandem oxidation-acetalization reaction. A mechanism study revealed that pyridinium-mediated electron transfer and the photoactivation of mol. oxygen greatly facilitate the transformation of benzyl alcs. into the corresponding aldehydes, while the Lewis acid site of this bifunctional photocatalyst promoted a highly efficient acetalization reaction without any significant loss in activity after multiple reaction cycles, thus achieving the direct conversion of various alcs. into either cyclic or acyclic acetals in good yields under mild conditions without any additives. After reading the article, we found that the author used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Electric Literature of C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Electric Literature of C20H14N4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A chitosan-based fluorescent hydrogel for selective detection of Fe2+ ions in gel-to-sol mode and turn-off fluorescence mode》 was published in Polymer Chemistry in 2019. These research results belong to Fan, Kaiqi; Wang, Xiaobo; Yu, Shuyan; Han, Guanglu; Xu, Die; Zhou, Liming; Song, Jian. Product Details of 112881-51-3 The article mentions the following:

A novel chitosan-based fluorescent hydrogel has been synthesized by chem. bonding terpyridine-bearing aldehydes onto chitosan via an acid condensation reaction. More interestingly, such a hydrogel works as a dual-mode chemosensor for selective, rapid, gel-to-sol, and turn-off fluorescence sensing of Fe2+ ions. In the gel-to-sol mode, the detection limit for Fe2+ ions is 0.28 ppm, and in the turn-off fluorescence mode, the detection limit is 3.8 ppb. Such hydrogel-based fluorescent chemosensors are potentially suitable for the monitoring of Fe2+ in biol. and environmental applications. In the part of experimental materials, we found many familiar compounds, such as 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Product Details of 112881-51-3)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Product Details of 112881-51-3 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Wei-Zhen; Lin, Hui-An; Bai, Chyi-Huey; Lin, Sheng-Feng published an article in 2021, the title of the article was Posterior circulation acute stroke prognosis early CT scores in predicting functional outcomes: A meta-analysis.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

Background and purpose: Patients with posterior circulation acute ischemic stroke exhibit varied clin. presentations and functional outcomes. Whether posterior circulation acute stroke prognosis early computed tomog. scores (PC-ASPECTS) predict unfavorable functional outcomes (UFO) for patients treated with different therapeutic regimens is unclear. Methods: According to PRISMA guidelines, we performed a systematic search of electronic databases for studies assessing the functional outcomes of posterior circulation acute ischemic stroke using baseline PC-ASPECTS. The following three scales of PC-ASPECTS were retrieved: UFO prediction by using PC-ASPECTS per score decrease, UFO prediction by using binary PC-ASPECTS with a cut-off value, and the difference in PC-ASPECTS between patients with unfavorable and favorable functional outcomes. Moreover, a subgroup anal. was conducted for patients treated with intra-arterial endovascular treatment (IA-EVT) only. Sensitivity anal. with different definition of UFO and image modalities were also conducted. Results: In total, 25 studies were included. In scale 1, PC-ASPECTS significantly predicted UFO (odds ratio [OR]: 1.66 per score decrease, 95% confidence interval [CI]: 1.32-2.07). In scale 2, binary PC-ASPECTS with a cut-off value between 6 and 9 significantly predicted UFO (OR: 3.91, 95% CI: 2.54-6.01). In scale 3, patients with UFO had lower PC-ASPECTS than those with favorable outcomes (standardized mean difference [SMD]: -0.67, 95% CI: -0.8 to -0.55). For patients treated with IA-EVT only, the scales demonstrated consistent results. Sensitivity anal. showed PC-ASPECTS significantly predicted UFO in both definitions of modified Rankin Scale ≥ 3 and ≥ 4, and magnetic resonance imaging was preferred imaging modality for PC-ASPECTS evaluation. Conclusion: Baseline PC-ASPECTS is effective in predicting UFO for patients with posterior circulation acute ischemic stroke treated with different therapeutic regimens. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas:132-20-7) belongs to pyridine-derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 31, 2022, Sravanthi, A. L.; Ratnakumar, P.; Reddy, S. Narender; Eswari, K. B.; Pandey, Brij B.; Manikanta, ChLN; Ramya, K. T.; Sonia, E.; Mohapatra, Shruti; Gopika, K.; Anusha, P. L.; Yadav, Praduman published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Morpho-physiological, quality traits and their association with seed yield in sesame (Sesamum indicum L.) indigenous collection under deficit moisture stress. And the article contained the following:

Abstract: A field experiment was conducted to investigate the effect of deficit moisture stress on eleven sesame genotypes viz., IC-132171, IC-132186, IC-204445, IC-131500, IC-132207, IC-205471, IC-203962, IC-205353, IC-96229, and IC-204966 along with a national check (GT-10). The deficit moisture stress (WS) was imposed for a period of 50-55 days from flowering to physiol. maturity. The morphol., physiol., and yield traits under WS significantly decreased in comparison with irrigated conditions (WW). Based on the mean trait performance studied among the genotypes, IC-204966 was found significantly superior with respect to plant height, capsules number, seed weight, total dry matter, leaf area, relative water content and reduced canopy temperature under WS conditions. The correlation anal. of different traits with seed yield indicated that the plant height and number of capsules/plant were highly and pos. correlated with seed yield under both WW and WS conditions. The principal component anal. (PCA) revealed that among the traits studied, number of capsules/ plant, total dry matter, stomatal conductance, transpiration rate and fatty acid i.e., palmitic acid were the most important traits that accounted for more than half of the total variation among the sesame genotypes studied. Furthermore, the scatter plot revealed that two genotypes, IC 132,207 and IC 205,471 were stable performers under both stress and irrigated conditions, whereas the performance of check GT-10 varied depending upon conditions. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas:132-20-7) belongs to pyridine-derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 11, 2018, Yamada, Kentaro; Satoh, Shigenobu; Hashizume, Hiroshi; Yoshimura, Noriko; Kagotani, Ryohei; Ishimoto, Yuyu; Abe, Yuichiro; Toyoda, Hiromitsu; Terai, Hidetomi; Masuda, Takeshi; Muraki, Shigeyuki; Nakamura, Hiroaki; Yoshida, Munehito published an article.Category: pyridine-derivatives The title of the article was Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery.. And the article contained the following:

Factors related to the onset and progression of lumbar spinal stenosis (LSS) have not yet been identified. Diffuse idiopathic skeletal hyperostosis (DISH) increases mechanical loading on the non-fused lumbar levels and may therefore lead to LSS. This cross-sectional study aimed to identify associations between LSS and DISH. This study included 2363 consecutive patients undergoing surgery for LSS and 787 general inhabitants without symptoms of LSS as participants of the population-based cohort study, Research on Osteoarthritis/Osteoporosis Against Disability. Standing whole-spine radiographs were used to diagnose DISH based on the criteria proposed by Resnick and Niwayama. The prevalence of DISH showed a significant step-wise increase among asymptomatic inhabitants without radiographic LSS, asymptomatic inhabitants with radiographic LSS, and patients with LSS requiring surgery (14.4, 21.1, and 31.7%, respectively; p < 0.001). The distribution of DISH was similar between the groups, but the lower thoracic and upper-middle lumbar spine regions were more frequently involved in patients with LSS requiring surgery. Multivariate analysis indicated that DISH was an independent associated factor for LSS requiring surgery (adjusted odds ratio 1.65; 95% confidence interval 1.32-2.07) after adjustment for age, sex, body mass index, and diabetes mellitus. Among patients with LSS requiring surgery, a higher occurrence of stenosis at the upper lumbar levels and multi-level stenosis were observed in patients with DISH requiring surgery than in patients without DISH. In conclusion, DISH is independently associated with LSS requiring surgery. The decrease in the lower mobile segments by DISH may increase the onset or severity of LSS. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to diffuse idiopathic skeletal hyperostosis, general inhabitants, lumbar spinal stenosis, prevalence, standing whole-spine radiographs, and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 4, 2019, Maghsoudlou, Siavash; Beyene, Joseph; Yu, Zhijie Michael; McDonald, Sarah D published an article.SDS of cas: 132-20-7 The title of the article was Phenotypic Classification of preterm Birth Among Multiparous Women: A Population-Based Cohort Study.. And the article contained the following:

OBJECTIVE: The Global Alliance to Prevent Prematurity and Stillbirth developed a phenotypic classification for preterm birth using clinical presentation (rather than risk factors) to improve surveillance. The objective of this study was to determine distributions of preterm birth phenotypes and associations with Caesarean section, low Apgar score, and neonatal death in multiparous women, stratifying by first versus recurrent preterm births. METHODS: This population-based cohort study used the Better Outcomes Registry and Network (BORN) of multiparous women giving birth in hospital with a singleton after 20 weeks in Ontario from 2012 to 2014 (Canadian Task Force Classification II-2). RESULTS: In multiparous women with preterm birth, 29.6% had a history of recurrence, of whom 66.2% had at least one clinical condition associated with the phenotypic model, compared with 63.5% of first preterm births. In recurrent preterm births, criteria for maternal, fetal, and placental conditions were met in 44.5%, 37.9%, and 8.2%, respectively, compared with 36.8%, 39.0%, and 10.4%, respectively, of first preterm births. Associations of preterm birth with Caesarean section, low Apgar score, and neonatal death varied across clinical conditions but were similar between first and recurrent preterm births; for example, for recurrent preterm birth, Caesarean section for maternal, fetal, and placental conditions had odds ratios of 1.66 (95% confidence interval [CI] 1.32-2.07), 1.09 (95% CI 0.80-1.49), and 3.92 (95% CI 1.98-7.78), compared with first preterm birth odds ratios of 1.21 (95% CI 1.03-1.41), 0.92 (95% CI 0.77-1.10), and 6.24 (95% CI 4.07-9.56). CONCLUSION: This study provides novel evidence of the utility of the preterm birth phenotypic classification model by using stratification for previous preterm birth, a robust predictor-with variation in phenotypes in initial and recurrent preterm births. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to preterm birth, prematurity, phenotyping, clinical presentations, risk factors, population-based, cohort study, and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Getahun, Darios; Strickland, Daniel; Zeiger, Robert S; Fassett, Michael J; Chen, Wansu; Rhoads, George G; Jacobsen, Steven J published an article in 2010, the title of the article was Effect of chorioamnionitis on early childhood asthma..Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

OBJECTIVE: To examine the association between chorioamnionitis and childhood asthma based on gestational age at birth and race/ethnicity. DESIGN: A retrospective cohort study using the Kaiser Permanente Southern California (KPSC) Matched Perinatal records. SETTING: Kaiser Permanente Southern California, Pasadena, California. PARTICIPANTS: All singleton children born in KPSC hospitals between 1991 and 2007 (N = 510 216). MAIN EXPOSURE: Clinically diagnosed chorioamnionitis. MAIN OUTCOME MEASURES: Physician-diagnosed asthma in children aged 8 years or younger. RESULTS: The incidence rates of asthma among preterm- and full term-born children of pregnancies complicated by chorioamnionitis were 100.7 and 39.6 per 1000 person-years, respectively (incidence rate ratio, 2.9; 95% confidence interval [CI], 2.6-3.3). Children aged 8 years or younger with asthma were more likely to be born to women who were aged 35 years or older, African American, had 13 or more years of education, had maternal asthma, used antibiotics, had chorioamnionitis during the pregnancy, and had a male child. Multivariable Cox regression analysis revealed that children born at 23 to 28, 29 to 33, and 34 to 36 weeks’ gestation after pregnancies complicated by chorioamnionitis had a 1.23-fold (95% CI, 1.02-1.49), 1.51-fold (95% CI, 1.26-1.80), and 1.20-fold (95% CI, 1.03-1.47), respectively, increased risk of asthma compared with children of similar gestational age born after pregnancies not complicated by chorioamnionitis. A preterm pregnancy complicated by chorioamnionitis was associated with increased risk of asthma among white (hazard ratio [HR], 1.66; 95% CI, 1.32-2.07), African American (HR, 1.98; 95% CI, 1.60-2.44), and Hispanic (HR, 1.70; 95% CI, 1.45-2.00), but not Asian/Pacific Islander (HR, 1.15; 95% CI, 0.83-1.58) women. CONCLUSION: Findings suggest that chorioamnionitis at preterm gestation is independently associated with increased risk of childhood asthma. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to asthma: epidemiology, child, child, preschool, chorioamnionitis: diagnosis, chorioamnionitis: epidemiology, cohort studies, ethnicity: statistics & numerical data, female, fetal diseases: epidemiology, fetal membranes, premature rupture, gestational age, health status, humans, infant, infant, newborn, male, maternal age, pregnancy and other aspects.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Riise, Øystein Rolandsen; Laake, Ida; Vestrheim, Didrik; Flem, Elmira; Moster, Dag; Riise Bergsaker, Marianne Adeleide; Storsæter, Jann published an article in 2017, the title of the article was Risk of Pertussis in Relation to Degree of Prematurity in Children Less Than 2 Years of Age..Electric Literature of 132-20-7 And the article contains the following content:

BACKGROUND: A few previous studies reported increased risk of pertussis in children with birth weight less than 2500 g. The risk of pertussis by degree of prematurity has not been determined in a cohort study. The vaccine effectiveness (VE) against reported pertussis in preterm infants is unknown. METHODS: Data were obtained from the Medical Birth Registry of Norway (1998-2010) and linked to other national registries. In total, 713,166 children were included in our study and followed until 2 years of age. Incidence rate ratios (IRRs) and confidence intervals (CIs) were estimated with Poisson regression. RESULTS: We identified 999 reported cases of pertussis. We observed a higher rate of reported pertussis in preterm than in full-term infants, IRR = 1.65 (95% CI: 1.32-2.07). Compared to full-term infants, the risk of reported pertussis in infants born at gestational age (GA) 35-36, 32-34 and 23-27 weeks were higher [IRRs = 1.49 (95% CI: 1.11-2.01), 1.63 (95% CI: 1.06-2.51) and 4.49 (95% CI: 2.33-8.67), respectively]. Moreover, preterm infants had a higher rate of pertussis-related hospitalization than full-term infants [IRR = 1.99 (95% CI: 1.47-2.71)]. The VE against reported pertussis for the third dose was 88.8% (95% CI: 84.3-92.0) in full-term infants and 93.0% (95% CI: 85.8-96.5) in preterm infants. CONCLUSIONS: In this cohort study, preterm infants including those born at GA 35 and 36 weeks had increased risk of reported pertussis. The VE was similar in preterm and full-term infants. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Electric Literature of 132-20-7

The Article related to birth weight, child, preschool, cohort studies, female, gestational age, hospitalization: statistics & numerical data, humans, infant, infant, low birth weight, infant, newborn, infant, premature: immunology, male, norway, pertussis vaccine: administration & dosage, registries, risk, vaccine potency, whooping cough: diagnosis and other aspects.Electric Literature of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem