Tag: 300-400

On April 15, 2013, Wirasorn, Kosin; Ngamprasertchai, Thundon; Chindaprasirt, Jarin; Sookprasert, Aumkhae; Khantikaew, Narong; Pakkhem, Ake; Ungarereevittaya, Piti published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Prognostic factors in resectable cholangiocarcinoma patients: Carcinoembryonic antigen, lymph node, surgical margin and chemotherapy.. And the article contained the following:

AIM: To evaluate outcomes in resectable cholangiocarcinoma patients and to determine prognostic factors. METHODS: A retrospective study was conducted among newly-diagnosed cholangiocarcinoma patients from January 2009 to December 2011 who underwent curative resection in Srinakarind Hospital (a 1000-bed university hospital). Two hundred and sixty-three cholangiocarcinoma patients with good performance were enrolled. These patients had pathological reports with clear margins or microscopic margins. Prognostic factors which included clinical factors, serum liver function test as well as serum tumor makers at presentation, tumor data, and receiving adjuvant chemotherapy were determined by uni- and multivariate analysis. RESULTS: The median overall survival time was 17 mo (95%CI: 13.2-20.7); and 1-, 2-, and 3- year survival rates were 65.5%, 45.2% and 35.4%. Serum albumin levels, serum carcinoembryonic antigen (CEA) levels, staging classifications by American Joint Committee on cancer, pathological tumor staging, lymph node metastases, tumor grading, surgical margin status, and if adjuvant chemotherapy was administered, were shown to be significant prognostic factors of resectable cholangiocarcinoma by univariate analysis. Multivariate analysis, however, established that only abnormal serum CEA [hazard ratio (HR) 1.68; P = 0.027] and lymph node metastases (HR 2.27; P = 0.007) were significantly associated with a decrease in overall survival, while adjuvant chemotherapy (HR 0.71; P = 0.067) and surgical margin negative (HR 0.72; P = 0.094) tended to improve survival time. CONCLUSION: Serum CEA and lymph node metastases which were associated with advanced stage tumors become strong negative prognostic factors in cholangiocarcinoma. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to adjuvant, carcinoembryonic antigen, chemotherapy, cholangiocarcinoma, hepatectomy, lymph nodes, neoplasm metastasis, prognosis, surgical margin status, survival rate, and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kelani, Khadiga M.; Hegazy, Maha A.; Hassan, Amal M.; Tantawy, Mahmoud A. published an article in 2021, the title of the article was Determination of naphazoline HCl, pheniramine maleate and their official impurities in eye drops and biological fluid rabbit aqueous humor by a validated LC-DAD method.COA of Formula: C20H24N2O4 And the article contains the following content:

A simple RP-HPLC-DAD method was developed and validated, as per the ICH guidelines, for simultaneous determination of naphazoline HCl (NPZ) & pheniramine maleate (PHN) along with three of their official impurities. Chromatog. separation was performed on a hypersil ODS column (5 mm, 250-4.6 mm i.d.) with isocratic elution using phosphate buffer pH 6.0: acetonitrile (70 : 30, volume/volume) as mobile phase, at a flow rate of 1.0 mL min-1 and UV detection at 260.0 nm. The developed method was found to be linear over the concentration ranges of 5.00-45.00 Μg mL-1 for NPZ and NPZ impurity B and 10.00-110.00 Μg mL-1, 10-70 Μg mL-1 and 10-120 Μg mL-1 for PHN, and PHN impurity A and B, resp., with correlation coefficient values <0.999 for the five cited compounds The method was confirmed to be accurate, robust and precise with RSD >2.0%. LOD and LOQ values for the five cited compounds were calculated Moreover, the method was also validated in rabbit aqueous humor as per the US food and drug administration (FDA) bioanal. validation guidelines. Finally, the proposed method was applied for the anal. of the two drugs along with their impurities in dosage form and spiked aqueous humor samples. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).COA of Formula: C20H24N2O4

The Article related to naphazoline hcl pheniramine maleate eye drop biol fluid, Biochemical Methods: Immunological and other aspects.COA of Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2017, the title of the article was A validated titrimetric method for the determination of pheniramine maleate in pure form and in their pharmaceutical formulation.SDS of cas: 132-20-7 And the article contains the following content:

A simple, convenient and accurate visual titrimetric method for the determination of Pheniramine maleate (PM) in pure form and in their pharmaceutical formulations Avil (tablet and injection) using Pyridinium fluoro chromate (PFC) as an oxidant is described. The titrimetric method is based on the oxidation of the drugs in sulfuric acid medium by known excess of Pyridinium fluoro chromate and iodometric determination of the unreacted Pyridinium fluoro chromate (PFC). To examine the accuracy and precision of results percentage error, standard deviation (SD) and coefficient of variation (CV) were also calculated for each sample. Proposed method was validated by recovery anal. by drug addition method of drug. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate avil tablet titrimetry, Pharmaceutical Analysis: General and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 30, 2011, Borkar, Nitin; Sawant, Sakshi published an article.Application of 132-20-7 The title of the article was Review of simultaneous determination of analytes by high performance liquid chromatography (HLPC) in multicomponent cough and cold oral drug products. And the article contained the following:

A review. The objective of this article is to review the methodologies of determination of the most widely used analytes in cough and cold preparations by HPLC. This article studies the effect of all chromatog. parameters so as to provide a fast, reliable and cost effective methodol. of testing. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to review cough cold oral drug analysis hplc, Pharmaceutical Analysis: Reviews and other aspects.Application of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Eltsova, Natalia O.; Budko, Elena V.; Yampolskii, Leonid M.; Kulikov, Alexander L. published an article in 2016, the title of the article was UPLC study of inter-component interaction in the system “naproxen – pheniramine maleate”.Computed Properties of 132-20-7 And the article contains the following content:

The anal. was performed for the two-component system “naproxen – pheniramine maleate” using the method UPLC. It is concluded that strengthening the destructive processes in the presence of pheniramine maleate with naproxen based on the chromatogram initial substances at influence of stress factors and identified degradation products. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to naproxen pheniramine maleate inter component interaction uplc, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bukhari, Syed Majid Hanif; Khan, Samiullah; Rehanullah, Muhammad; Ranjha, Nazar Mohammad published an article in 2015, the title of the article was Synthesis and characterization of chemically cross-linked acrylic acid/gelatin hydrogels: effect of pH and composition on swelling and drug release.Category: pyridine-derivatives And the article contains the following content:

This present work was aimed at synthesizing pH-sensitive cross-linked AA/Gelatin hydrogels by free radical polymerization Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as crosslinking agent, resp. Different feed ratios of acrylic acid, gelatin, and EGDMA were used to investigate the effect of monomer, polymer, and degree of crosslinking on swelling and release pattern of the model drug.The swelling behavior of the hydrogel samples was studied in 0.05M USP phosphate buffer solutions of various pH values pH 1.2, pH 5.5, pH 6.5, and pH 7.5.The prepared samples were evaluated for porosity and sol-gel fraction anal. Pheniraminemaleate used for allergy treatment was loaded as model drug in selected samples. The release study of the drug was investigated in 0.05M USP phosphate buffer of varying pH values (1.2, 5.5, and 7.5) for 12 h. The release data was fitted to various kinetic models to study the release mechanism. Hydrogels were characterized by Fourier transformed IR (FTIR) spectroscopy which confirmed formation of structure. Surface morphol. of unloaded and loaded samples was studied by surface electron microscopy (SEM), which confirmed the distribution of model drug in the gel network. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to acrylic acid gelatin hydrogel drug delivery system, Pharmaceuticals: Formulation and Compounding and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 31, 2010, Rajalakshmi, G.; Damodharan, N.; Chaudhary, Abhinav; Maheswara Reddy, D. published an article.COA of Formula: C20H24N2O4 The title of the article was Formulation and evaluation of Orodispersible tablets of Pheniramine maleate. And the article contained the following:

In the present study an attempt has been made to formulate Pheniramine maleate a selective H1 receptor antagonist into orodispersible tablet. The tablets were prepared by direct compression method using super disintegrants like croscarmellose sodium, crospovidone, sodium starch glycollate, low hydroxyl pr cellulose and pre gelatinized starch in different ratios. The blend was examined for various pre compression parameters. Tablets were evaluated by measuring hardness, friability, content uniformity, weight variation and drug release pattern. All the tablets met the pharmacopoeial requirements for phys. tests. Almost in all the formulations with increase in concentration of superdisintegrants, the drug release was rapid. Stability studies were also performed. Dissolution studies indicated that the tablets containing crospovidone and croscarmellose sodium showed rapid dissolution compared to other disintegrants releasing almost 100% of the drug in six minutes. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).COA of Formula: C20H24N2O4

The Article related to pheniramine maleate orodispersible tablet, Pharmaceuticals: Formulation and Compounding and other aspects.COA of Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Petkova, Valentina; Hadzhieva, Bozhidarka Radoslavova published an article in 2021, the title of the article was Pilot study of over-the-counter drugs applied among the pediatric population in Bulgaria.Application of 132-20-7 And the article contains the following content:

Herbal medicines have evolved through their traditional use in a specific or cultural context. The pharmacol. effects of herbal medicines are not due to their “natural” origin, but to the complex character of biol. active substances. Pediatricians have begun to integrate the use of complementary / alternative medical therapies with conventional health care. The first aim of the study was to make an anal. of over-the-counter (OTC) drugs (OTCDs) with a plant component. The secondary aim was to investigate OTCDs in terms of composition and nosol. for use by the pediatric population in Bulgaria. Registered OTC drugs with a herbal component for children are prescribed for the treatment of colds, pain, gastrointestinal diseases, mild sleep disorders, neurovegetative dystonias and kinetosis, urinary tract inflammation, liver disease, and are also applied topically to inflammation, trauma, urticaria and scars. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to herbal medicine counter drug pediatric population pain gastrointestinal disease, Placeholder for records without volume info and other aspects.Application of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Zeyang; Lu, Song; Fu, Yan; Wang, Hui; Zhao, Guannan published an article in 2016, the title of the article was Sodium borohydride promotes drug molecules preparation.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

Sodium borohydride reduction is an excellent performance of “universal reducing agent”, which commonly used in a variety of reduction of organic functional groups, After the modified sodium borohydride reduction was greatly expanded in the field of application, can be used to restore the carboxylic acids, carboxylic acid esters, alcs., indole, enyne other substances, under certain reduction system, when compared with a sodium borohydride reduction good reduction On the other hand, due to the high amount of sodium borohydride hydrogen storage, mild reaction conditions, making it the people developed “green energy” hot hydrogen raw materials, and therefore there are many catalytic hydrogen production catalysts are finding out, it was discover the advantages of composite sodium borohydride hydrogen production The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to sodium borohydride drug mol reduction, Placeholder for records without volume info and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gasior, Justyna; Kawa-Rygielska, Joanna; Kucharska, Alicja Z. published an article in 2020, the title of the article was Carbohydrates profile, polyphenols content and antioxidative properties of beer worts produced with different dark malts varieties or roasted barley grains.Synthetic Route of 132-20-7 And the article contains the following content:

The aim of this study was to assess the possibility of shaping properties of beers at the stage of brewing wort production with the use of various types of special malts (chocolate pale, chocolate dark, wheat chocolate, brown barley) and roasted barley grains. The carbohydrate profile, polyphenols content, antioxidant capacity, 5-hydroxymethylfurfural content, and the browning index level were analyzed. Statistical anal. showed significant differences in the values of the examined features between the samples. The sugars whose content was most affected by the addition of special malts were maltose and dextrins. The polyphenol content in worts with 10% of additive was 176.02-397.03 mg GAE/L, ferric reducing antioxidant power (FRAP) 1.32-2.07 mmol TE/L, and capacity to reduction radical generated from 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS•+) 1.46-2.70 mmol TE/L. Wort with 40% dark malt showed the highest content of polyphenolic compounds and antioxidant activity (FRAP and ABTS•+). The HMF content and the browning index value were higher for wort with the addition of darker-colored malts (EBC) and increased with increasing dark malt dose. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to carbohydrate polyphenol antioxidative beer wort malt barley grain, antioxidants, barley, beer, dark malt, malt, melanoidins, polyphenols, roasting, specialty malt, wort, Pharmaceuticals: Pharmacognostic Products and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem