Tag: 300-400

On August 31, 2010, Phatthiyaphaibun, K.; Som-Aum, W.; Srisa-ard, M.; Threeprom, J. published an article.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Chiral separation of pheniramine by capillary electrophoresis partial-filling technique using hydroxypropyl-β-cyclodextrin as chiral selector. And the article contained the following:

A simple capillary electrophoresis partial-filling technique for the enantioseparation of pheniramine is presented. Phosphate buffer and hydroxypropyl-β-cyclodextrin (HP-β-CD) were used as the electrolyte and chiral selector, resp. Several exptl. parameters such as HP-β-CD concentration, HP-β-CD plug length, CE temperature and applied voltage were studied. Under the selected conditions, pheniramine enantiomers can be separated within <14 min. The assay was validated for linearity (5.0 × 10-6 - 5.0 × 10-4 M; R2 = 0.9987), limit of detection (5.0 × 10-7 M), limit of quantitation (5.0 × 10-6 M), anal. precision (%RSD ≤ 9.8) and accuracy (%recovery = 101 ± 3). The proposed methodol. was then applied to the anal. of a com. available pharmaceutical eye drop preparation The results are in good agreement with that declared by the manufacturer. The proposed methodol. provides adequate results in terms of simplicity, cost, sample throughput, repeatability and accuracy for quality control of pheniramine enantiomers in pharmaceutical preparations The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pheniramine enantiosepn capillary electrophoresis partial filling technique hydroxypropylcyclodextrin selector, Organic Analytical Chemistry: Separations and other aspects.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Eltsova, Natalia O.; Budko, Elena V.; Yampolskii, Leonid M.; Kulikov, Alexander L. published an article in 2016, the title of the article was UPLC study of inter-component interaction in the system “naproxen – pheniramine maleate”.Computed Properties of 132-20-7 And the article contains the following content:

The anal. was performed for the two-component system “naproxen – pheniramine maleate” using the method UPLC. It is concluded that strengthening the destructive processes in the presence of pheniramine maleate with naproxen based on the chromatogram initial substances at influence of stress factors and identified degradation products. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to naproxen pheniramine maleate inter component interaction uplc, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bukhari, Syed Majid Hanif; Khan, Samiullah; Rehanullah, Muhammad; Ranjha, Nazar Mohammad published an article in 2015, the title of the article was Synthesis and characterization of chemically cross-linked acrylic acid/gelatin hydrogels: effect of pH and composition on swelling and drug release.Category: pyridine-derivatives And the article contains the following content:

This present work was aimed at synthesizing pH-sensitive cross-linked AA/Gelatin hydrogels by free radical polymerization Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as crosslinking agent, resp. Different feed ratios of acrylic acid, gelatin, and EGDMA were used to investigate the effect of monomer, polymer, and degree of crosslinking on swelling and release pattern of the model drug.The swelling behavior of the hydrogel samples was studied in 0.05M USP phosphate buffer solutions of various pH values pH 1.2, pH 5.5, pH 6.5, and pH 7.5.The prepared samples were evaluated for porosity and sol-gel fraction anal. Pheniraminemaleate used for allergy treatment was loaded as model drug in selected samples. The release study of the drug was investigated in 0.05M USP phosphate buffer of varying pH values (1.2, 5.5, and 7.5) for 12 h. The release data was fitted to various kinetic models to study the release mechanism. Hydrogels were characterized by Fourier transformed IR (FTIR) spectroscopy which confirmed formation of structure. Surface morphol. of unloaded and loaded samples was studied by surface electron microscopy (SEM), which confirmed the distribution of model drug in the gel network. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to acrylic acid gelatin hydrogel drug delivery system, Pharmaceuticals: Formulation and Compounding and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 31, 2010, Rajalakshmi, G.; Damodharan, N.; Chaudhary, Abhinav; Maheswara Reddy, D. published an article.COA of Formula: C20H24N2O4 The title of the article was Formulation and evaluation of Orodispersible tablets of Pheniramine maleate. And the article contained the following:

In the present study an attempt has been made to formulate Pheniramine maleate a selective H1 receptor antagonist into orodispersible tablet. The tablets were prepared by direct compression method using super disintegrants like croscarmellose sodium, crospovidone, sodium starch glycollate, low hydroxyl pr cellulose and pre gelatinized starch in different ratios. The blend was examined for various pre compression parameters. Tablets were evaluated by measuring hardness, friability, content uniformity, weight variation and drug release pattern. All the tablets met the pharmacopoeial requirements for phys. tests. Almost in all the formulations with increase in concentration of superdisintegrants, the drug release was rapid. Stability studies were also performed. Dissolution studies indicated that the tablets containing crospovidone and croscarmellose sodium showed rapid dissolution compared to other disintegrants releasing almost 100% of the drug in six minutes. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).COA of Formula: C20H24N2O4

The Article related to pheniramine maleate orodispersible tablet, Pharmaceuticals: Formulation and Compounding and other aspects.COA of Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Petkova, Valentina; Hadzhieva, Bozhidarka Radoslavova published an article in 2021, the title of the article was Pilot study of over-the-counter drugs applied among the pediatric population in Bulgaria.Application of 132-20-7 And the article contains the following content:

Herbal medicines have evolved through their traditional use in a specific or cultural context. The pharmacol. effects of herbal medicines are not due to their “natural” origin, but to the complex character of biol. active substances. Pediatricians have begun to integrate the use of complementary / alternative medical therapies with conventional health care. The first aim of the study was to make an anal. of over-the-counter (OTC) drugs (OTCDs) with a plant component. The secondary aim was to investigate OTCDs in terms of composition and nosol. for use by the pediatric population in Bulgaria. Registered OTC drugs with a herbal component for children are prescribed for the treatment of colds, pain, gastrointestinal diseases, mild sleep disorders, neurovegetative dystonias and kinetosis, urinary tract inflammation, liver disease, and are also applied topically to inflammation, trauma, urticaria and scars. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to herbal medicine counter drug pediatric population pain gastrointestinal disease, Placeholder for records without volume info and other aspects.Application of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2011, Murahdharan, Balathandapani; Gopu, Gopalakrishnan; Laya, Saraswathy; Vedhi, Chinnapiyan; Manisankar, Paramasivam published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was A study on preparation and use of nano poly pyrrole and nano poly (3,4-ethylenedioxythiophene) coated glassy carbon electrode for the determination of antihistamine in pharmaceutical and urine sample. And the article contained the following:

Pheniramine maleate (PA), an antihistamine, was determined by Differential Pulse Stripping voltammetry using nano polypyrrole (Ppy) and nano poly (3,4-ethylenedioxythiophene) (PEDOT) modified glassy carbon electrodes. The cyclic voltammetric behavior of pheniramine was studied in aqueous acidic, neutral and alk. conditions. One well-defined oxidation peak was observed in the cyclic voltammograms at all pHs. The influence of pH, scan rate and concentration revealed irreversible electron transfer and the oxidation was diffusion controlled adsorption. The SEM anal. confirmed good accumulation of PA on the electrode surface. A systematic study of influence of various exptl. parameters that affect the stripping voltammetric response was carried out and the maximum peak current conditions were arrived at. Calibration was made under maximum peak current conditions. The range of study was 0.05 to 0.4 μg/mL on Ppy/GCE and 0.025 to 0.4 μg/mL on PEDOT/GCE and the lower limit of determination were 0.035 μg/mL on Ppy/GCE and 0.016 μg/mL on PEDOT/GCE. The suitability of the method for the determination of PA in pharmaceutical preparations and urine samples was also ascertained. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to polypyrrole ethylenedioxythiophene glassy carbon electrode nanoparticle antihistamine pheniramine maleate, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2022, Kelani, Khadiga M.; Hegazy, Maha A.; Hassan, Amal M.; Tantawy, Mahmoud A. published an article.Recommanded Product: 132-20-7 The title of the article was A green TLC densitometric method for the simultaneous detection and quantification of naphazoline HCl, pheniramine maleate along with three official impurities. And the article contained the following:

Impurity profiling of a pharmaceutical compound is now taking great attention during quality assessment of pharmaceuticals, as presence of small amount of impurities may affect safety and efficacy. In this work, a novel TLC chromatog. method coupled with densitometric detection was established for the simultaneous quantification of naphazoline HCl, pheniramine maleate and three of their official impurities, namely; naphazoline impurity B, pheniramine impurities; A & B. Chromatog. separation was carried out on TLC aluminum silica plates F254, as a stationary phase, using methanol: Et acetate: 33.0% ammonia (2.0: 8.0: 1.0, by volume), as a mobile phase. Plates were examined at 260.0 nm and International Council for Harmonisation (ICH) guidelines were followed for method’s validation. Important factors, such as; composition of mobile phase and detection wavelengths were optimized. Linearity was achieved over the ranges of 2.0-50.0μg band-1 for naphazoline, 10.0-110.0μg band-1 for pheniramine, 0.1-10.0μg band-1 for naphazoline impurity B and 2.0-50.0μg band-1 for both pheniramine impurities. The proposed method was assessed in terms of accuracy, precision and robustness where satisfactory results (recovery % ≈ 100% and RSD < 2) were obtained. The method was also applied for the simultaneous determination of naphazoline HCl and pheniramine maleate, in Naphcon-A eye drops, with resp. recoveries of 101.36% and 100.94%. Method greenness was evaluated and compared to the reported HPLC one via environmental, health and safety tool. The developed method has much potential over the reported one of being simple, selective, economic and time saving for the anal. of the five cited compounds The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: 132-20-7

The Article related to green tlc densitometric method naphazoline hcl pheniramine maleate, ehs tool, impurities, naphazoline, pheniramine, tlc, Pharmaceutical Analysis: Natural Drug Materials and other aspects.Recommanded Product: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 25, 2012, Lai, Yonghua; Huang, Taomin; Wang, Donglei; Chen, Nianzu published an article.HPLC of Formula: 132-20-7 The title of the article was Determination of pheniramine maleate content in pheniramine maleate-naphazoline hydrochloride eye drops by reverse-phase high performance liquid chromatography. And the article contained the following:

The purpose of the research is to develop a reverse-phase high performance liquid chromatog.(RP-HPLC) method to determine pheniramine maleate concentration in the pheniramine maleate-naphazoline hydrochloride eye drops. The HPLC separation was carried out on an Agilent C18(150 mm*4.6 mm, 5μm) column, using a UV detector with 262 nm wavelength. The mobile phase was 0.1 mol·L-1 ammonium acetate buffer(0.5% triethylamine, adjusted to pH 4.0 with acetic acid)-methanol solution=97:3(V/V), with velocity of 1 mL·min-1 and column temperature of 20°C. The good linearity of pheniramine maleate under chromatog. was found(r>0.999, n=7). The recovery values were between 97% and 103%(n=3). The RSD values were below 2.0%(n=3). The sample was stable in 24 h. The samples reached standardized qualification. RP-HPLC is proved to be a simple, swift, accurate and reliable method and has good reproducibility. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to pheniramine maleate content rp hplc, Pharmaceutical Analysis: Natural Drug Materials and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 31, 2020, Rodriguez-Medina, Carlos; Martinez-Cuadron, David; Cano, Isabel; Gil, Cristina; Tormo, Mar; Martinez-Sanchez, Maria del Pilar; Bernal del Castillo, Teresa; Serrano-Lopez, Josefina; Benavente, Celina; Herrera-Puente, Pilar; Garcia-Boyero, Raimundo; Lavilla-Rubira, Esperanza; Amigo, Ma. Luz; Sayas-Lloris, Ma. ose; Bergua-Burgues, Juan M.; Perez-Simon, Jose Antonio; Rodriguez, Gabriela; Espadana, Ana; Vidriales-Vicente, Belen; Fernandez, Rosa; Lopez-Lorenzo, Jose Luis; Lopez, Maria; Garcia-Fortes, Maria; Labrador Gomez, Jorge; Colorado-Araujo, Mercedes; Sossa-Melo, Claudia Lucia; Aguilar, Eliana; Montesinos Fernandez, Pau published an article.HPLC of Formula: 132-20-7 The title of the article was Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study. And the article contained the following:

Selection of elderly patients (aged ≥60 years) for intensive chemotherapy treatment of acute myeloblastic leukemia (AML) remains challenging. Several cooperative groups such as Acute Leukemia French Association (ALFA), Haematol. Oncol. Clin. Studies Group (HOCSG) and MD Anderson Cancer Center (MDACC) have developed predictive models to select those patients who can benefit from intensive chemotherapy. Our purpose is to validate and compare these three models in a cohort of patients treated in real-life setting. For this, a total of 1724 elderly AML patients and treated with intensive chemotherapy regimens were identified in the PETHEMA registry. Median age was 67.2 years (range, 60-84,9) and median overall survival [OS] 9 mo (95% confidence interval [CI], 8.2-9.7). Taking into account the ALFA group’s model, patients likely to benefit from intensive chemotherapy had longer OS (14 mo, 95% CI 12.3-15.7) than those unlikely to benefit (5 mo, 95% CI 4.1-5.9; p < 0.001). Significant differences in OS were observed between patients with favorable risk (17 mo, 95% CI 13.2-20.7), intermediate risk (11 mo, 95% CI 9.3-12.6) and adverse risk (6 mo, 95% CI 5.1-6.4; p < 0.001) according to the HOCSG model. No significant differences in OS were observed between patients with 0, 1, 2 or ≥3 points according to the MDACC model. However, when patients with ≥1 point were compared with those with 0 points, median OS was significantly longer in the latter [15 mo (95% CI 12.1-17.8) vs 7 (95% CI 5.7-8.5)]. This retrospective study validates predictive models proposed by the ALFA, HOCSG and MDACC groups in this real-life cohort. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to human acute myeloid leukemia prognosis intensive chemotherapy, acute myeloid leukemia, elderly, intensive chemotherapy, overall survival, prognosis, Mammalian Pathological Biochemistry: Oncology and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 30, 2014, Kouki, Noura; Tayeb, Rafik; Dhahbi, Mahmoud published an article.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Recovery of acetaminophen from aqueous solutions using a supported liquid membrane based on a quaternary ammonium salt as ionophore. And the article contained the following:

A flat sheet-supported liquid membrane (FSSLM) system, consisting of an ionic liquid, tricapryl-methylammonium chloride (Aliquat 336) in octan-2-ol, is proposed as a means of recovering acetaminophen (Ac) from aqueous solutions; Ac is an active ingredient widely used in many pharmaceutical preparations Several parameters which could affect the transport efficiency were examined, i.e., the strippant nature and concentration in the receiving solution, the diluent nature, carrier concentration, initial acetaminophen concentration in the feed solution, and the polymeric support type. A facilitated transport was obtained by impregnating the polymeric support with 10 volume ^of Aliquat 336 in octan-2-ol, 1 M NaOH as a receiving solution, and a feed solution of Ac dissolved in ultrapure water. The study was completed by using the FSSLM thus developed for extracting Ac from some drugs in frequent use in Tunisia (Analgan, Doliprane, and Fervex). The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to acetaminophen aqueous liquid membrane quaternary ammonium salt ionophore, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem