Tag: 300-400

On August 31, 2011, Mehul, Dave; Senthil, A.; Hardik, Thakkar R.; Ravikumar; Tejas, Lad published an article.SDS of cas: 132-20-7 The title of the article was Formulation and evaluation of orodispersible tablets of pheniramine maleate. And the article contained the following:

Orodispersible tablets of pheniramine maleate were prepared by direct compression method using three super disintegrants, viz., croscarmellose sodium, crospovidone and sodium starch glycolate at different concentrations with microcrystalline cellulose were used along with sodium bicarbonate and citric acid as effervescent agent. Orodispersible tablet is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing Pheniramine maleate is a member of alkylamine class of H1 receptor antagonists. It is an antihistamine used in the treatment of allergic conditions including urticaria and angioedema. It is completely absorb after oral administration. The bland were examined for angle of repose, bulk d., tapped d., compressibility index and hausner’s ratio. The prepared tablets were evaluated for thickness, hardness, friability, and weight variation, content uniformity, wetting time, Water absorption ratio, in-vitro dispersion time, dissolution studies and FTIR studies. Twelve formulations F1 to F12 were prepared with three super disintegrants with different concentration The optimum formulation was chosen and their optimum results were found to be in close agreement with exptl. finding. Among three super disintegrants crospovidone F5 emerged as overall best formulation. Short-term stability studies on the formulations indicated no significant changes in the drug content and in vitro dispersion time (p < 0.05). The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate orodispersible tablet formulation superdisintegrant, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 132-20-7

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Pyridine – Wikipedia,
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Kaji, Ayumi; Hashimoto, Yoshitaka; Sakai, Ryosuke; Okada, Hiroshi; Hamaguchi, Masahide; Ushigome, Emi; Majima, Saori; Yamazaki, Masahiro; Fukui, Michiaki published an article in 2019, the title of the article was Frequent usage of convenience stores is associated with low diet quality.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

In Japan, convenience stores are more common, and it is thus more important to assess whether people use convenience stores than the d. or availability of the convenience stores. In this cross-sectional study of patients with type 2 diabetes, the association between the usage of the convenience stores and dietary habits or the prevalence of hypertension was evaluated. Among the 206 men and 161 women in the study, 24 men and 9 women used convenience stores three or more times per wk. Fruit and vegetable intake (men, 132 (102-191) vs. 192 (128-267) g/1000 kcal, p = 0.019; and women, 178 (132-207) vs. 239 (172-313) g/1000 kcal, p = 0.063) of patients who frequently use convenience stores was lower compared to those who did not. Net endogenous acid production score (men, 55.2 (45.4-65.2) vs. 48.9 (42.3-56.8) mEq/day, p = 0.013; and women, 56.9 (52.6-59.8) vs. 46.3 (40.9-54.0) mEq/day, p = 0.050) and intake of carbohydrate to fiber ratio (men, 21.5 (20.0-29.3) vs. 19.9 (15.7-25.0), p = 0.052; and women, 21.0 (18.9-23.9) vs. 16.2 (13.8-20.3), p = 0.017) of patients who frequently use convenience stores were higher compared to those who did not. Addnl., frequent usage of convenience stores was associated with the prevalence of hypertension after adjusting for covariates (5.01; 95% confidence interval, 1.12-22.50; p = 0.035). In conclusion, frequent usage of convenience stores is associated with low diet quality and the prevalence of hypertension. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to diabetes convenience store low diet quality, convenience store, diet quality, food environment, habitual diet intake, lifestyle, type 2 diabetes, Animal Nutrition: Carbohydrates, Fiber, and Energy and other aspects.Application In Synthesis of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

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Pyridine – Wikipedia,
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Bhagat, Rakshanda; Sheikh, Amir Amin; Dar, Rouf Rashid; Dogra, Pooja; Islam, Sheikh Tajamul published an article in 2017, the title of the article was A clinical case of ear canker and alopecia in a rabbit.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

A two year old male rabbit was presented with history of itching; rough hair coat and hair fall from last 15 days with reddish brown crust formation on ears, paws and around eyes. Skin scraping revealed the presence of Psoroptes cuniculi (ear mite) thus diagnosing the case of ear canker. Treatment with Ivermectin (Ivomec) @ 0.02mg/kg S.c. weekly for 4 wk, Pheniramine maleate (Avil) @ 0.5 mg/kg I.m. and topical application of honey and turmeric mix daily for 1 wk was accomplished which resulted in substantial clin. improvement recorded in terms of decreased frequency of itching, regained smooth hair coat and lusture of hair and skin. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to ear canker alopecia rabbit, Mammalian Pathological Biochemistry: Skin Diseases and other aspects.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

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On November 30, 2013, Raghu, M. S.; Basavaiah, K.; Abdulrahaman, Sameer A. M.; Prashanth, K. N.; Vinay, K. B. published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Sensitive and selective spectrophotometric methods for the determination of pheniramine maleate in bulk drug and in its formulations using sodium hypochlorite. And the article contained the following:

Two simple, selective and sensitive spectrophotometric methods for the determination of pheniramine maleate (PAM; H1 histamine receptor antagonist) in pharmaceutical pure and dosage forms are described. The methods are based on the reaction of PAM with Na hypochlorite in Kolthoff phosphate-borate buffer pH 7.0 leading to the PAM chloro derivative, subsequent decomposition of excess hypochlorite by Na nitrite (the PAM chloro derivative is not affected under optimized conditions), followed by the oxidation of K iodide with the PAM chloro derivative to iodine (I3-) colored product, which is measured either directly at 355 (method A; yellow product) or after reaction with starch at 590 nm (method B; blue product). The optimal conditions for the PAM-hypochlorite reaction were detd; under these conditions the linear relationship was found in the concentration ranges of 2-50 and 1-25 μg PAM/mL with methods A and B, resp. The calculated molar absorptivity values were 7.26 × 103 and 1.28 × 104 L/(mol cm) for methods A and B, resp. Sandell sensitivity values, limits of detection (LOD), and limits of quantification (LOQ) were calculated The proposed methods were used for the determination of PAM in tablets and injection solutions with good accuracy and precision and without interferences from common pharmaceutical additives. The obtained results compared favorably with those of the reference method. The accuracy and reliability of the proposed methods were further checked by recovery studies via standard addition procedure. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pharmaceutical analysis pheniramine maleate spectrophotometry sodium hypochlorite reagent, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

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Pyridine – Wikipedia,
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Caglar, Hatice; Bueyuektuncel, Ebru published an article in 2014, the title of the article was HPLC method development and validation: simultaneous determination of active ingredients in cough and cold pharmaceuticals.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

Objective: This study aimed to develop a simple reversed-phase high performance chromatog. method for simultaneous determination of pseudoephdrine HCI, pheniramine maleate, acetaminophen, guaifenisin, pyrilamine maleate, chlorpheniramine maleate, triprolidine HCI, dextromethorphan HBr, diphenhydramine HCI in cough and cold pharmaceuticals. Methods: The separation of these compounds was achieved within 37.9 min on a Nucleodur gravity C18 column (250 x 4.0 mm, 5μm). The chromatog. separation of these compounds performed in a single run by using isocratic mobile phase consisting of methanol:buffer mixture (38:62, volume/volume) at room temperature, with flow rate of 0.75 mL.min-1. An UV absorption at 210 nm was monitored. 2,4,6-trimethoxybenzaldehyde was used as an internal standard (ISTD). The selectivity, linearity of calibration, accuracy, intraday and interday precision and forced degradation studies were examined as parts of the method validation. Results: The concentration-response relationship was linear over a concentration range of 0.2-250 μg.mL-1 for acetaminophen, 0.5-250 μg.mL-1 for pseudoephdrine HCI and pheniramine maleate, 1-250 μg.mL-1 for guaifenisin, 2.5-250 μg.mL-1 for chlorpheniramine maleate and triprolidine HCI, 5-250 μg.mL-1 for pyrilamine maleate and diphenhydramine HCI, 10-20 μg.mL-1 for dextromethorphan HBr with correlation coefficients better than 0.9993. The relative standard deviations of the intraday and interday were all less than 4%. Conclusion: The proposed liquid chromatog. method was successfully applied for the routine anal. of these compounds in different cough and cold pharmaceutical preparations such as syrups and tablets. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to reversed phase high performance chromatog, cough cold pharmaceutical active ingredient, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

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Pyridine – Wikipedia,
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Huang, Taomin; Chen, Nianzu; Wang, Donglei; Lai, Yonghua; Cao, Zhijuan published an article in 2014, the title of the article was A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations.Computed Properties of 132-20-7 And the article contains the following content:

Background: A simple, rapid, and accurate stability-indicating reverse phase liquid chromatog. method was developed and validated for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in bulk drugs and pharmaceutical formulations. Results: Optimum chromatog. separations among pheniramine maleate, naphazoline hydrochloride and stress-induced degradation products have been achieved within 10 min by using an Agilent zorbax eclipse XDB C18 column (150 mm × 4.6 mm, 5 μm) as the stationary phase with a mobile phase consisted of 10 mM phosphate buffer pH 2.8 containing 0.5% triethlamine and methanol (68:32, volume/volume) at a flow rate of 1 mL min-1. Detection was performed at 280 nm using a diode array detector. Theor. plates for pheniramine maleate and naphazoline hydrochloride were calculated to be 6762 and 6475, resp. The method was validated in accordance with ICH guidelines with respect to linearity, accuracy, precision, robustness, specificity, limit of detection and quantitation. Regression anal. showed good correlations (R2 > 0.999) for pheniramine maleate in the concentration range of 150-1200 μg mL-1 and naphazoline hydrochloride in 12.5-100 μg mL-1. The method results in excellent separation of both the analytes and degradation products. The peak purity factor is ≥980 for both analytes after all types of stress, indicating complete separation of both analyte peaks from the stress induced degradation products. Conclusions: Overall, the proposed stability-indicating method was suitable for routine quality control and drug anal. of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to naphazoline hydrochloride pharmaceutical formulation quality control rphplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

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Pyridine – Wikipedia,
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Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2019, the title of the article was Oxidative determination of some antihistamine drugs in pure form and their pharmaceutical preparations by using Pyridinium fluoro chromate (PFC) reagent.Computed Properties of 132-20-7 And the article contains the following content:

In this paper Chromium (VI) based Pyridinium fluoro chromate (PFC) reagent has been used as an oxidant for the determination of some antihistamine drugs e.g. Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and their pharmaceutical preparations such as Phenergan (Injection and tablet) and Avil (Tablet and injection) resp. The main principle of this method is based on the fact, that each pharmaceutical drug contains a specific organic functional group, which on oxidation in the presence of selected oxidant (Here PFC is used as an oxidant) provides the new oxidized product. This type of oxidation reaction between the drug mol. and an oxidant establishes a stoichiometric relationship between the drug mol. and an oxidant. This relationship is the basis of quant. estimation of drugs in pure form and their pharmaceutical preparations In this research, oxidizing reagent Pyridinium fluoro chromate (PFC) oxidizes the sulfur atom of Promethazine hydrochloride (PMH) to the corresponding sulfoxide, whereas in case of Pheniramine maleate (PM) it oxides one hydroxyl (-OH) group of carboxylic (-COOH) group to corresponding aldehydic (-CHO) group. Thus an oxidant PFC establishes a 1:1 ratio with both Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) drug. Oxidative determination of these drugs was carried out by adopting the iodometric titration (Visual volumetric) method. The applied technique was very simple, convenient, accurate, precise and economical. To examine the accuracy and precision of results various statistical anal. such as percentage error, standard deviation (SD) and coefficient of variation (CV) was also calculated for each sample. The proposed method was validated by recovery anal., by drug addition method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to antihistamine oxidation pyridinium fluoro chromate iodometric titration, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

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Pyridine – Wikipedia,
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Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2018, the title of the article was Titrimetric assay of some antihistamines with pyridinium fluoro chromate (PFC) reagent.Computed Properties of 132-20-7 And the article contains the following content:

In the present paper, simple, convenient accurate, precise and cost effective titrimetric (Visual volumetric) method has been reported for the estimation of some antihistamine drugs e.g. Cyproheptadine hydrochloride (CPH), Fexofenadine hydrochloride (FFH), Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and in their pharmaceutical preparations such as Ciplactin (Tab), Allegra (Tab), Phenergan (Tab and Inj) and Avil (Tab and Inj) with Pyridinium fluoro chromate (PFC) reagent. The principle of this method is based on the fact, that each pharmaceutical drug consists of certain organic functional group which on oxidation by a known excess of potassium iodate in sulfuric acid medium followed by iodometric titration in presence of reagent Pyridinium fluoro chromate (PFC) establishes stoichiometric relationship between drug mol. and an oxidising reagent Pyridinium fluoro chromate (PFC). Different results obtained for each drug during experiment, has been validated by different statistical parameters such as percentage error, standard deviation (SD) and coefficient of variation (CV). Results obtained from these statistical parameters proves the accuracy and precision of adopted method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to titrimetry ciplactin allegra phenergan avil pyridinium fluoro chromate, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

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Pyridine – Wikipedia,
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Mehmood, Yasir; Saleem, Noviara; Mahmood, Rana Khalid; Riaz, Humayun; Atif, Raza Syed published an article in 2016, the title of the article was Analytical method development and validation of pheniramine maleate injection.SDS of cas: 132-20-7 And the article contains the following content:

Pheniramine Maleate assay in its injection formulation was performed using spectrophotometric estimation in UV/Vis-region and non-aqueous titration method. The method have been developed and validated in spectrophotometric Method and water was used as diluent which does not shows any interference in spectrophotometric estimations ICH guidelines were used to determine the anal. parameter. RSD and %RSD were obtained statistically along with neat chromatograms. Precision and accuracy of the results were obtained also which showed that the method is very accurate for quant. estimation of Pheniramine Maleate in injection dosage forms. Another simple titrimetric method is described for the determination of Pheniramine Maleate (PM) in pure form and in injection dosage forms. The principle involved in the method is simple acid-base reaction in which the perchloric acid is used as titrant and naphthol benzene as indicator. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate injection dosage form uv visible spectrophotometry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.SDS of cas: 132-20-7

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Pyridine – Wikipedia,
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Franco, Marina; Jasionowska, Renata published an article in 2013, the title of the article was Quick single run Capillary Zone Electrophoresis determination of active ingredients and preservatives in pharmaceutical products.Product Details of 132-20-7 And the article contains the following content:

The paper deals with the development of a rapid and efficient Capillary Zone Electrophoresis (CZE) method for Quality Control anal. of pharmaceutical preparations containing antihistamines, decongestants, anticholinergic remedies and preservatives. Active ingredients of interest are: ChlorPheniramine Maleate (CPM), DiPhenhydramine Hydrochloride (DPH), Ephedrine hydrochloride (E), Isopropamide Iodide (II), Pheniramine Maleate (PM), Lidocaine hydrochloride (L), Tetracaine hydrochloride (T), Clopamide Hydrochloride (CH) , DiHydroErgochristine (DHE), PhenylEphrine hydrochloride (PE) and Acetaminophen (A). Preservatives studied are: MethylParaben (MeP), EthylParaben (EtP), PropylParaben (PrP), ButylParaben (BuP), p-HydroxyBenzoic Acid (p-HBA). All these analytes were separated in a single run using 60 mM tetraborate buffer solution (TBS) pH = 9.2 as a BackGround Electrolyte (BGE) by an uncoated fused silica capillary of I.D. = 50 μm and applying a voltage of 25 kV in the first part of the electrophoretic run (up to 5.8 min) and 30 kV for the remaining time. The hydrodynamic pressurization of the inlet vial was 20 psi at 7.2 min. up to the end of anal. Total separation time was of 7.5 min. The method was then successfully validated and applied to the simultaneous determination of active ingredients and preservatives. Good repeatability, linearity, and sensitivity were demonstrated. Precision of migration time ™ was RSD% <0.53% and of corrected peak area (Ac) was RSD% <6.15%. The linearity evaluation gave 0.9928 < r2 < 1.000. LOD and LOQ, accuracy (recovery) and ruggedness were evaluated for each analyte demonstrating the good reliability of the method. Analyses of some pharmaceutical real samples were performed. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Product Details of 132-20-7

The Article related to pharmaceutical preservative analysis capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Product Details of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem