Tag: 600-700

In 2019,Advanced Synthesis & Catalysis included an article by Li, Lixin; Ma, Yan-Na; Tang, Mi; Guo, Jing; Yang, Zhen; Yan, Yizhe; Ma, Xiantao; Tang, Lin. Electric Literature of C33H24IrN3. The article was titled 《Photoredox-Catalyzed Oxydifluoroalkylation of Styrenes for Access to Difluorinated Ketones with DMSO as an Oxidant》. The information in the text is summarized as follows:

By taking advantage of DMSO (DMSO) as an oxidant, the photoredox-catalyzed alkene oxydifluoroalkylation for formal C(sp3)-CF2R and C(sp2)=O formation is disclosed for the first time. This difunctionalization reaction employs readily available styrenes as the substrates and bromodifluoro compounds as the difluoroalkylating reagents, which can afford the difluorinated ketones in acceptable yields with excellent regioselectivity. Experiments indicate that fac-Ir(ppy)3-catalyzed oxydifluoroalkylation can proceed smoothly under base-free conditions in the presence of AgTFA. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Promoted Oxo-difluoroalkylation of Alkenes with DMSO as the Oxidant》 was written by Xia, Zi-Hao; Gao, Zhong-Hua; Dai, Lei; Ye, Song. Product Details of 94928-86-6This research focused onvisible light promoted oxo difluoroalkylation alkene DMSO oxidant. The article conveys some information:

Visible-light-promoted oxo-difluoroalkylation (acetylation and acetamidation) of alkenes with DMSO as both the solvent and the oxidant was developed, affording the corresponding α,α-difluoro-γ-ketoacetates and acetamides in modest yields. Both terminal and internal alkenes worked well for the reaction. This reaction features simple starting materials, a green oxidant, mild reaction conditions, and highly functional products. The experimental part of the paper was very detailed, including the reaction process of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Product Details of 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Pu; Chen, Zan; Xiong, Bi-Quan; Liang, Yun; Tang, Ke-Wen; Xie, Jun; Liu, Yu published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Visible-light-mediated cascade cyanoalkylsulfonylation/cyclization of alkynoates leading to coumarins via SO2 insertion》.Formula: C33H24IrN3 The article contains the following contents:

A visible-light-mediated tandem cyanoalkylsulfonylation/cyclization of alkynoates with cycloketone oxime compounds for the preparation of 3-cyanoalkylsulfonylcoumarins I [R1 = H, 6-Me, 7-OMe, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = H, Ph, 4-MeC6H4, etc.; R4 = H, Me; R5 = H, Bn] via SO2 insertion was reported. The difunctionalization of carbon-carbon triple bonds includes a radical mechanism and involved the formation of an iminyl radical, ring-opening of the cycloketone, insertion of SO2, addition of the sulfonyl radical to carbon-carbon triple bonds, ipso-cyclization and ester migration. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Formula: C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wang, Yu-Zhao; Lin, Wu-Jie; Liu, Hong-Chao; Yu, Wei published an article in Organic Chemistry Frontiers. The title of the article was 《Visible-light-promoted radical amidoarylation of arylacrylamides towards amidated oxindoles》.Product Details of 94928-86-6 The author mentioned the following in the article:

A visible-light-promoted intermol. radical amidation/cyclization of arylacrylamides was realized by using N-aminopyridinium salts as the source of amidyl radicals. The reaction exhibited a broad scope and good functional group tolerance and a variety of amide-tethered-oxindoles were prepared in this way in moderate to good yields. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Product Details of 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Product Details of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C33H24IrN3In 2021 ,《Photocatalytic Radical Ortho-Dearomative Cyclization: Access to Spiro[4.5]deca-1,7,9-trien-6-ones》 was published in Journal of Organic Chemistry. The article was written by Dong, Wuheng; Yuan, Yao; Liang, Caiyun; Wu, Feng; Zhang, Siyuan; Xie, Xiaomin; Zhang, Zhaoguo. The article contains the following contents:

A highly efficient ortho-dearomative cyclization reaction between alkynes and 2-bromo-2-(2-methoxybenzyl)malonates via visible light-induced photoredox catalysis has been reported. In the presence of 1 mol% fac-Ir(ppy)3, a variety of spiro[4.5]deca-1,7,9-trien-6-ones, e.g., I, was obtained in moderate to excellent yields under mild conditions. Under the optimized reaction conditions, a sample reaction of 3 mmol scale proceeded smoothly to give the desired products in 84% yield with a low catalyst loading of 0.1 mol%. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Induced Intermolecular Dearomative Cyclization of Furans: Synthesis of 1-Oxaspiro[4.4]nona-3,6-dien-2-one》 was written by Dong, Wuheng; Yuan, Yao; Gao, Xiaoshuang; Keranmu, Miladili; Li, Wanfang; Xie, Xiaomin; Zhang, Zhaoguo. Recommanded Product: fac-Tris(2-phenylpyridine)iridiumThis research focused onvisible light intermol dearomative cyclization furan iridium catalyst alkyne; spirolactone preparation. The article conveys some information:

A fac-Ir(ppy)3-catalyzed intermol. dearomative cyclization of 2-bromo-2-((5-bromofuran-2-yl)methyl)malonate and alkynes affording substituted spirolactones, e.g. I, in yields of 19-91% via a 5-exo-dig radical cyclization under visible light is presented. This method provides a new access to the synthesis of spirocycle skeletons applying water as an external oxygen source under mild reaction conditions. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Recommanded Product: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis of Functionalized Spirocyclic Indolines by Visible Light-Induced One-Pot Sequential Difluoromethylative Dearomatization, Hydroxylation, and Substitution Reactions》 were Wang, Qiang; Qu, Yi; Liu, Yuxiu; Song, Haibin; Wang, Qingmin. And the article was published in Advanced Synthesis & Catalysis in 2019. Name: fac-Tris(2-phenylpyridine)iridium The author mentioned the following in the article:

Herein an one-pot protocol for visible light-induced synthesis of functionalized spirocyclic indolines I [R = P(O)Ph2, 2-pyrrolyl, 3-indolyl, etc.; R1 = H, 5-F, 6-Me, etc.] was described under mild conditions by means of a process involving sequential difluoromethylative dearomatization, hydroxylation and substitution reactions of indole derivatives The transformation proceeded via a hydroxylated “”acetal pool”” intermediate that could react with various nucleophiles. Several of the phosphine-oxide and indole-substituted products showed good fungicidal activity, suggesting that this protocol might be useful in the agrochem. field. The results came from multiple reactions, including the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ji, Wen-Zhe; Shi, Hao-Nan; Wei, Ping; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Photocatalytic Annulation-Carbohalogenation of 1,7-Enynes for Atom-Economic Synthesis of Functionalized 3,4-dihydronaphthalen-1(2H)-ones》.Reference of fac-Tris(2-phenylpyridine)iridium The article contains the following contents:

A general and efficient photocatalytic annulation-carbohalogenation of 1,7-enynes with a wide variety of alkyl halides were reported, which resulted in atom-economic synthesis of functionalized 3,4-dihydronaphthalen-1(2H)-ones with good yields and high stereoselectivity under the mild and oxidant-free conditions. The reaction demonstrated remarkable compatibility regarding alkyl halides as a bifunctional reagents, such as ethyl-2-bromo-2,2-difluoroacetate, ethyl-2,2-difluoro-2-iodoacetate, perfluorobutyl iodide, bromotrichloromethane, and diethyl-2-bromomalonate, and which provided wide substrate scope, high functional group tolerance, and 100% atom utilization.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Reference of fac-Tris(2-phenylpyridine)iridium) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 828918-24-7On June 7, 2019, Sattar, Moh.; Patidar, Krishna; Thorat, Raviraj Ananda; Kumar, Sangit published an article in Journal of Organic Chemistry. The article was 《Copper-Mediated Selective Mono- and Sequential Organochalcogenation of C-H Bonds: Synthesis of Hybrid Unsymmetrical Aryl Ferrocene Chalcogenides》. The article mentions the following:

A 8-aminoquinoline directed Cu/1,10-phenanthroline-mediated selective mono-organothiolation of C-H bond in ferroceneamide was developed using aryl/alkyl-disulfide substrates. The sequential ferrocene C-H organochalcogenation (chalcogen = S, Se, and Te) also was established for the synthesis of novel hybrid unsym. aryl chalcogenides with the aid of a catalytic amount of Cu(OAc)2 under ambient reaction conditions. The developed protocol exhibits a broad functional group tolerance to allow alkyl, aryl, hetero-aryl, bromo, chloro, and nitro containing diorgano dichalcogenides as a coupling partner. Further, the 8-aminoquinoline directing group is easily removed to afford the aldehyde functionality after C-H organochalcogenation. A mechanistic understanding of the Cu-mediated selective mono-organothiolation reaction suggests that rigid bi-coordinated 1,10-phenanthroline ligand and freshly generated Cu(II) from Cu(I) in the less polar solvent MeCN seem crucial for the selective mono-C-H functionalization of ferroceneamide. In the experiment, the researchers used many compounds, for example, 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7SDS of cas: 828918-24-7)

2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. SDS of cas: 828918-24-7 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineOn June 3, 2016, Suneja, Arun; Bisai, Vishnumaya; Singh, Vinod K. published an article in Journal of Organic Chemistry. The article was 《Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related Structures》. The article mentions the following:

A unified approach for the asym. syntheses of medicinally important isoindolinones (S)-PD 172938 and (R)-JM 1232 has been accomplished via a Cu(I)-PYBOX-diPh catalyzed highly enantioselective (up to 99% ee) alkynylation/lactamization sequence in a one-pot fashion. The overall sequence involves one C-C and two C-N bond forming events in one pot starting from inexpensive starting material in ambient reaction conditions. The results came from multiple reactions, including the reaction of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7Reference of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem