Tag: M.W=0-100

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Dalton Transactions called Energetic C-trinitromethyl-substituted pyrazoles: synthesis and characterization, Author is Zhang, Yiying; Li, Yanan; Hu, Jianjian; Ge, Zhongxue; Sun, Chenghui; Pang, Siping, which mentions a compound: 948552-36-1, SMILESS is O=CC1=CC=NN1, Molecular C4H4N2O, Quality Control of 1H-Pyrazole-5-carbaldehyde.

A new family of C-trinitromethyl-substituted pyrazoles was designed and obtained in good yields by the reaction of N2O4 with the pyrazolecarbaldehyde oxime followed by further N-nitration and C-nitration. All of the new compounds were fully characterized by IR and NMR spectroscopy, elemental anal. and differential scanning calorimetry (DSC). Compounds 2 and 3 were further confirmed by X-ray crystallog. These pyrazole derivatives have good densities, pos. enthalpies of formation and acceptable sensitivity values. Theor. calculations carried out using Gaussian 03 and EXPLO5 program demonstrate good to excellent detonation velocities and pressures in the range of ADN and HMX. Compound 3 exhibiting a pos. oxygen balance, high specific impulse and moderate thermal stability is a promising high energy d. oxidizer.

This compound(1H-Pyrazole-5-carbaldehyde)Quality Control of 1H-Pyrazole-5-carbaldehyde was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pfeifer, David; Russegger, Andreas; Klimant, Ingo; Borisov, Sergey M. published the article 《Green to red emitting BODIPY dyes for fluorescent sensing and imaging of carbon dioxide》. Keywords: dipyrrometheneboron difluoride preparation fluorescent imaging emitting carbon dioxide sensor.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).COA of Formula: C6H9N. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.

Several new BODIPY pH indicators are prepared and tested as transducers in polymer-based optical carbon dioxide sensors. Apart from classical BODIPY chromophore absorbing at around 505 nm, π-extended analogs showing absorption maxima at around 635 and 665 nm are prepared All the dyes possess excellent brightness due to combination of high molar absorption coefficients and fluorescence quantum yields. Addnl., the π-extended BODIPYs show unmatched photostability whereas the classical 1,3,5,7-tetramethyl-8-aryl-4,4-difluoroboradiazaindacene is found to be photolabile. The phenol receptors render BODIPY dyes pH sensitive inducing fluorescence quenching in the phenolate form. Carbon dioxide sensors are prepared via immobilization of the dyes into Et cellulose along with tetraoctylammonium hydrogencarbonate. The sensitivity of these sensors is mainly guided by the nature of the receptor and to a smaller extent by the nature of the chromophore, and can be tuned over a very wide range covering all important applications. Introduction of the receptor bearing carboxylic group in the o-position towards OH group of the receptor enables highly sensitive sensors resolving ambient CO2 levels (LOD 0.009 hPa). Sensors based on other indicators show optimal response from 0.2 to 60 hPa and from 20 to 400 hPa, making them attractive for medical and food packaging applications, resp. Materials for referenced sensing with phase fluorometry and ratiometric imaging with RGB cameras have also been prepared

This compound(2,4-Dimethyl-1H-pyrrole)COA of Formula: C6H9N was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 625-82-1, is researched, SMILESS is CC1=CNC(C)=C1, Molecular C6H9NJournal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called An Ethacrynic Acid-Brominated BODIPY Photosensitizer (EA-BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor-Targeted Photodynamic Therapy, Author is Won, Miae; Koo, Seyoung; Li, Hao; Sessler, Jonathan L.; Lee, Jin Yong; Sharma, Amit; Kim, Jong Seung, the main research direction is ethacrynic acid brominated BODIPY preparation photosensitizer PDT hypoxic cancer; BODIPY; Hypoxia; ethacrynic acid; glutathione S-transferase-pi; photodynamic therapy.Application of 625-82-1.

Despite being a clin. approved intervention for cancer, photodynamic therapy (PDT) still suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen dependent. This limits the utility of PDT in treating hypoxic tumors since lower levels of cytotoxic reactive oxygen species (ROS) are generated in regions of low oxygen tension. Glutathione-pi (GST-pi) is a key enzyme that militates against ROS-mediated apoptosis. We report herein a new construct, EA-BPS, that contains both a brominated BODIPY photosensitizer (BPS) and an ethacrynic acid (EA) GST-pi inhibitor. Photoirradiation of EA-BPS induces a synergistic antitumor effect that results from the combination of ROS production and GST-pi inhibition. Relative to BPS alone, an enhanced cell-killing effect is seen under hypoxic conditions both in vitro and in vivo. We conclude that by making better use of the available oxygen in tumor environments, improved therapeutic PDT outcomes should be achievable even under hypoxic conditions.

This compound(2,4-Dimethyl-1H-pyrrole)Application of 625-82-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 948552-36-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Synthesis of pyrrolo[1,2-c]imidazol-5-one, pyrrolo[1,2-a]imidazol-5-one, and pyrrolo[1,2-b]pyrazol-6-one (three isomeric azapyrrolizinones) by pyrolysis of Meldrum’s acid derivatives. Author is McNab, Hamish.

Reaction of Meldrum’s acid with 4- or 2-imidazolecarboxaldehyde or 3-pyrazolecarboxaldehyde gave condensation products, which were pyrolyzed in the gas phase to give the title aza analogs I-III, resp., of 3-pyrrolizinone, as air-sensitive yellow solids.

This compound(1H-Pyrazole-5-carbaldehyde)Product Details of 948552-36-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 948552-36-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Cytotoxic activity of new cerium (III) complexes of bis-coumarins. Author is Kostova, Irena; Manolov, Ilia; Momekov, Georgi; Tzanova, Tzvetomira; Konstantinov, Spiro; Karaivanova, Margarita.

Complexes of Ce (III) with bis-coumarins, 3,3′-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) and bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-(1H-pyrazol-3-yl)methane, were synthesized by reaction of Ce(III) salt and the ligands, in amounts equal to metal/ligand molar ratio of 1:2. The complexes were prepared by adding an aqueous solution of Ce (III) salt to an aqueous solution of the ligand subsequently raising the pH of the mixture gradually to ∼5.0 by adding dilute solution of NaOH. The Ce (III) complexes with bis-coumarins were characterized by different physicochem. methods-elemental anal., IR-, 1H- and 13C-NMR-spectroscopies and mass-spectral data. The spectral data of Ce (III) complexes were interpreted from comparison with the spectra of the free ligands. This anal. showed that in the Ce (III) complexes the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. From the ν(C=O) red shift observed, participation of the carbonyl groups in the coordination to the metal ion was also suggested. Cytotoxic screening by MTT assay was carried out. The authors performed comparative evaluation of the cytotoxic effects of the two newly synthesized Ce complexes against the acute myeloid leukemia derived HL-60 and the chronic myeloid leukemia (CML)-derived BV-173. The cytotoxic effects of Ce (III) complex with 3,3′-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) were evaluated on the CML-derived K-562 and LAMA-84 cells, characterized by relative low responsiveness to chemotherapy. The DNA isolated from the cytosolic fraction of BV-173 cells after 24 h treatment with the same complex (at 100 and 200 μM) demonstrated a laddering phenomenon that is indicative for apoptotic cell death.

This compound(1H-Pyrazole-5-carbaldehyde)Product Details of 948552-36-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 625-82-1. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment. Author is Zhang, Yuandong; Yang, Zhiyu; Zheng, Xiaohua; Chen, Li; Xie, Zhigang.

BODIPYs are highly potential photoactive agents for cancer theragnostics. The rational design of BODIPY-based photoactive nanodrugs with high efficiency and near-IR (NIR) absorption is imperative. Herein, we developed a donor-acceptor-donor (D-A-D) organic photosensitizer (PS) (BODIPY, named NBB), which possessed strong absorption in the NIR region due to the multi-intersection of intramol. charge transfer (ICT), photoinduced electron transfer (PET), and heavy atom effects. Through a nanopptn. method, NBB nanoparticles (NPs) were facilely prepared The as-prepared NBB NPs exhibited favorable water-stability and photostability. In particular, the outstanding photon absorption capacity endows the NPs with high photothermal conversion efficiency (η = 53.8%) and active singlet oxygen (1O2) generation ability upon 808 nm laser irradiation, and promotes their tumor inhibition efficiency via the combination of photothermal/photodynamic therapy (half-maximal inhibitory concentration IC50 = 8.11 and 7.77 μM for HeLa and HepG2 cells, resp.). Together with the favorable synthetic yield and excellent antitumor effect, we envision that this exploration can provide beneficial guidance for the clin. translation of BODIPY-based PSs for phototherapy.

《Highly efficient near-infrared BODIPY phototherapeutic nanoparticles for cancer treatment》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4-Dimethyl-1H-pyrrole)HPLC of Formula: 625-82-1.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 625-82-1, is researched, Molecular C6H9N, about Highly Phototoxic Transplatin-Modified Distyryl-BODIPY Photosensitizers for Photodynamic Therapy, the main research direction is preparation transplatin distyryl BODIPY PDT photosensitizer cancer PDT; Cancer; intramolecular charge transfer; photophysics; photosensitizer; singlet oxygen.Product Details of 625-82-1.

We report the synthesis of the first transplatin-BODIPY conjugates for application in photodynamic therapy (PDT). The distyryl BODIPYs containing two iodine atoms were designed to absorb in the red region, easily undergo intersystem crossing for efficient singlet oxygen generation, and addnl. offer the possibility for coordination with mono-activated transplatin. We were able to demonstrate that coordination of the BODIPYs with a mono-activated transplatin increases the phototoxic index of the photosensitizers significantly, giving rise to highly phototoxic distyryl BODIPY derivatives, of which one was shown to have the highest ever reported phototoxic index against any cell line. Furthermore, the photophys. mechanism of singlet oxygen generation in distyryl BODIPYs undergoing intramol. charge transfer was studied exptl. and using time-dependent d. functional theory.

《Highly Phototoxic Transplatin-Modified Distyryl-BODIPY Photosensitizers for Photodynamic Therapy》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4-Dimethyl-1H-pyrrole)Product Details of 625-82-1.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 625-82-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about A glutathione-responsive photosensitizer with fluorescence resonance energy transfer characteristics for imaging-guided targeting photodynamic therapy. Author is Cao, Jing-Jing; Zhang, Ming-Shan; Li, Xiao-Qiang; Yang, De-Chao; Xu, Gan; Liu, Jian-Yong.

Here, we have synthesized and characterized a novel activatable photosensitizer (PS) 8a in which two well-designed boron dipyrromethene (BODIPY) derivatives are utilized as the photosensitizing fluorophore and quencher resp., which are connected by a disulfide linker via two successive Cu (I) catalyzed click reactions. The fluorescence emission and singlet oxygen production of 8a are suppressed via intramol. fluorescence resonance energy transfer (FRET) from the excited BODIPY-based PS part to quencher unit, but both of them can be simultaneously switched on by cancer-related biothiol glutathione (GSH) in phosphate buffered saline (PBS) solution with 0.05% Tween 80 as a result of cleavage of disulfide. Also, 8a exhibits a bright fluorescence image and a substantial ROS production in A549 human lung adenocarcinoma, HeLa human cervical carcinoma and H22 mouse hepatoma cells having a relatively high concentration of GSH, thereby leading to a significant photocytotoxicity, with IC50 values as low as 0.44 μM, 0.67 μM and 0.48 μM, resp. In addition, the photosensitizer can be effectively activated and imaged in H22 transplanted hepatoma tumors of mice and shows a strong inhibition on tumor growth. All these results suggest that such a GSH-responsive photosensitizer based on FRET mechanism may provide a new strategy for tumor-targeted and fluorescence imaging-guided cancer therapy.

This compound(2,4-Dimethyl-1H-pyrrole)HPLC of Formula: 625-82-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ) is researched.Reference of 2,4-Dimethyl-1H-pyrrole.Shao, Shuai; Gobeze, Habtom B.; Bandi, Venugopal; Funk, Christiane; Heine, Brian; Duffy, Maddie J.; Nesterov, Vladimir; Karr, Paul A.; D’Souza, Francis published the article 《Triplet BODIPY and AzaBODIPY Derived Donor-acceptor Dyads: Competitive Electron Transfer versus Intersystem Crossing upon Photoexcitation》 about this compound( cas:625-82-1 ) in ChemPhotoChem. Keywords: azadipyrromethene donor acceptor dyad electron transfer photoexcitation. Let’s learn more about this compound (cas:625-82-1).

The bis-iodo β-pyrrole-substituted BF2-chelated dipyrromethene, I2BODIPY, and its structural analog BF2-chelated aza dipyrromethene, I2azaBODIPY, carrying a nitrogen at the meso-position instead of carbon, were. These sensitizers were further functionalized with fullerene, C60, at the central boron atom to build donor-acceptor conjugates. Using spectral, electrochem., and computational methods, these conjugates were characterized,energy levels were established. The energetics, kISC, and position of HOMO and LUMO levels was found to control the ability of the dyad to undergo electron transfer, although the donor-acceptor distances were virtually the same in both I2BODIPY-C60 and I2azaBODIPY-C60 conjugates. Free-energy calculations revealed that the photoinduced electron transfer process was thermodynamically feasible from only the singlet excited states in both conjugates. Consequently, electron transfer from the 1I2BODIPY* in competition with intersystem crossing was witnessed in the case of I2BODIPY-C60 dyad while in the case of I2azaBODIPY-C60 dyad, excitation of azaBODIPY led to a short-lived charge transfer state involving the catechol bridge followed by populating the low-lying 3I2azaBODIPY* state without promoting the process of charge separation involving C60.

This compound(2,4-Dimethyl-1H-pyrrole)Reference of 2,4-Dimethyl-1H-pyrrole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Nature Catalysis called Real-time fluorescence imaging of a heterogeneously catalysed Suzuki-Miyaura reaction, Author is Costa, Paolo; Sandrin, Deborah; Scaiano, Juan C., which mentions a compound: 625-82-1, SMILESS is CC1=CNC(C)=C1, Molecular C6H9N, Recommanded Product: 625-82-1.

The palladium-catalyzed Suzuki-Miyaura reaction is one of the most important methods for C-C cross-coupling, yet the heterogeneous version of this reaction remains poorly understood. More specifically, the question of whether the reaction occurs on the surface of the catalyst (heterogeneous process) or is promoted by leaching of palladium species in solution (homogeneous phase) is still under debate. Here, we use real-time high spatial resolution microscopy to monitor a palladium-catalyzed coupling reaction that produces a highly fluorescent BODIPY dye. We show catalyst migration during the reaction, which we attribute to a dissolution/redeposition mechanism where migrating palladium species become true active sites after attachment to the catalyst support. The observed process is heterogeneous, but the active catalysts (atoms or small clusters) have important mobility, as revealed by the observation of migrating catalytic sites. Our report shows the strength of single-mol. studies for unveiling fundamental mechanisms in heterogeneously catalyzed reactions that are otherwise difficult to explore with classical ensemble experiments [graphic not available: see fulltext]

This compound(2,4-Dimethyl-1H-pyrrole)Recommanded Product: 625-82-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem