Tag: M.W=0-100

Related Products of 108-99-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-99-6, name is 3-Methylpyridine, molecular formula is C6H7N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Catalyst (0.03 mmol), H2O (3 ml), substrate (4 mmol), and H2O2 (20 mmol, 30% aq.) were charged in the reaction flask, which was first bathed in cold water (about 283 K). The mixture was then stirred at room temperature for 16-24 h. The reaction was detected by thin-layer chromatography (TLC). After the reaction, the system was concentrated by evaporation, and the catalyst precipitated from the mixture after the addition of anhydrous ethyl alcohol. The recovered catalyst, obtained by filtration, was washed with anhydrous ethyl alcohol and diethyl ether and then used for the next oxidation after drying. The filtrate was extracted with dichloromethane. The combined organic layers were dried over anhydrous Na2SO4, and the pure products were obtained by evaporation or column chromatography. The products were analyzed by 1H NMR and 13C NMR.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-99-6, 3-Methylpyridine.

Reference:
Article; Zhao, Wei; Wang, Xing; Yang, Chunxia; Synthetic Communications; vol. 44; 1; (2014); p. 150 – 160;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 504-29-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Manufacturing Example 1-2-1 2,2-Dimethyl-N-pyridin-2-yl-propionamide To a methylene chloride solution (500 mL) of 2-aminopyridine (50.0 g, 531 mmol) were added triethylamine (81.4 mL, 584 mmol) and pivaloyl chloride (71.9 mL, 584 mmol) at 0 C., which was stirred for 4 hours and 30 minutes at room temperature. The reaction solution was partitioned into water and methylene chloride. The organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. Potassium carbonate (73.4 g, 531 mmol) was added to 300 mL of thus obtained residue methanol solution at 0 C., which was stirred at room temperature for 90 minutes. This reaction solution was partitioned into water and ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, the solvent was evaporated under a reduced pressure. Heptane (300 mL) was added to the residue, the precipitated solids were collected by filtering, which gave the titled compound (80.2 g, 85%). The filtrate was then concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1), which gave the titled compound (12.2 g, 13%). 1H-NMR spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1H, m), 8.01-8.03 (1H, m), 8.29-8.31 (1H, m), 9.71 (1H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-29-0, Pyridin-2-amine.

Reference:
Patent; MATSUKURA, Masayuki; US2010/331282; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 626-64-2, Pyridin-4-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 626-64-2, blongs to pyridine-derivatives compound. Recommanded Product: 626-64-2

1,7-dibromo perylene diimide (7, 56 mg, 0.1 mmol) was dissolved into 5 mL of DMF. To which 4-hydroxypyridine (47.6 mg, 0.5 mmol) and potassium carbonate (K2CO3, 70 mg, 0.5 mmol) were added. The resulted mixture was then allowed reacted under 80C for 1 hours. The reaction mixture was then powered into 50 mL of water and the red solid was then re-dissolved in 50 mL DCM and washed with 50 mL of 1N hydrochloric acid and then 50 mL of water each for 3 times. Then, DCM layer was dried over Na2SO4. After removal of DCM, the residue was applied to chromatography with CH2Cl2/ethyl acetate (100:0-100:2) as eluents to afford the desired products 9 as red solid (68.7 mg, 0.93 mmol, yield = 93%). 1H-NMR (400MHz, CDCl3) d ppm: 8.66 (s, 1H), 8.63 (s, 1H), 8.56 (d, J = 8.00 Hz, 2H), 7.60 (m, J = 8.00 Hz, 5H), 7.44 (d, J = 7.20 Hz, 1H), 6.69 (d, J = 8.00 Hz, 4H), 5.01 (t, 2H), 2.53 (q, J = 10.32 Hz, 4H), 1.93 (d, J = 10.00 Hz, 4H), 1.75 (d, J = 10.32 Hz, 6H), 1.48 -1.32 (m, J = 13.2 Hz, 12.00 Hz, 10.60 Hz, 11.60 Hz, 11.72 Hz, 6H). 13C-NMR (100 MHz, CDCl3) d ppm: 163.7, 163.4, 162.9, 155.5, 152.7, 152.5, 148.4, 148.3, 133.4, 130.2, 129.1, 128.7, 127.7, 126.5, 125.0, 123.8, 123.7, 123.6, 122.6, 122.1, 119.5, 119.3, 114.9, 59.6, 59.4, 30.8, 30.6, 26.1, 25.9, 24.5, 24.3. TOF MS: m/z = 740.2 [M+H]+.

The synthetic route of 626-64-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Xin; Pang, Shufeng; Zhang, Zhigang; Ding, Xunlei; Zhang, Shanlin; He, Shenggui; Zhan, Chuanlang; Tetrahedron Letters; vol. 53; 9; (2012); p. 1094 – 1097;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 142-08-5, name is Pyridin-2(1H)-one, the common compound, a new synthetic route is introduced below. Formula: C5H5NO

(128-2) Under nitrogen atmosphere, to a solution of 2-hydroxypyridine (2.66 g) and NEt3 (4.05 mL) in THF (80 mL) was added dropwise SOCl2 (1.05 mL) under ice-cooling, and the mixture was stirred for one hour. The mixture was filtered, and the solvent was evaporated under reduced pressure to give di-2-pyridyl sulfite (3.02 g, 91 %).

The synthetic route of 142-08-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1479384; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 504-24-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-24-5, name is 4-Aminopyridine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 6 Compounds of the following general formula II-6 may be synthesised, for example, by the following methods. 3-Bromo-4-aminopyridine (1). 4-Aminopyridine (3.0 g, 31.9 mmol) was dissolved in 100 mL of DCM and 60 mL CH3CN. Bromine (5.1 g, 31.9 mmol) was added to this solution dropwise and the solution was stirred for 2 h. Sodium carbonate (6.2 g, 73.8 mmol) was added to the mixture and the reaction was stirred overnight. TLC (EtOAc) analysis of the reaction mixture showed two major spots, the higher running was 4-amino-3,5-dibromopyridine and the lower running one was the desired product (Rf=0.4, EtOAc). The reaction mixture was filtered and the filtrate was concentrated and chromatographed on a minimum amount of silica gel to yield 1.4 g (26%) of the desired product. 1H NMR (CDCl3): delta 8.39 (s, 1H), 8.10 (d, 1H), 6.60 (d, 1H), 4.74 (bs, 2H).

According to the analysis of related databases, 504-24-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ferraris, Dana V.; Li, Jia-He; Kalish, Vincent J.; Zhang, Jie; US2003/22883; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-64-2, name is Pyridin-4-ol, molecular formula is C5H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C5H5NO

4-Hydroxypyridine 1.88g (0.02 mol) and 4,6-dimethoxypyrimidine-2-yl methyl sulfone 4.36g (0.02 mol) were dissolved in DMF 100 ml, and K2CO3 3.3g (1.2 eq) was added thereto. Then, the temperature was maintained at 95C while the mixture was stirred over night. The reacted solution was added to water 100 ml, extracted with diethyl ether, dried with MgSO4, and distilled under reduced pressure to obtain residue. Through purification with silica gel column chromatography, a solid material 3.73g (80%) was obtained: 1H NMR (CDCl3); 3.73 (s, 6H), 5.49 (s, 1H), 6.85-8.42 (m, 4H).

With the rapid development of chemical substances, we look forward to future research findings about 626-64-2.

Reference:
Patent; SNU R&DB Foundation; Korea Research Institute Of Chemical Technology; EP2497768; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 504-24-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 504-24-5, name is 4-Aminopyridine. A new synthetic method of this compound is introduced below.

(1) Bromination reaction:In a 100 ml three-necked flask, 3.76 g (0.04 mol)4-aminopyridineAnd 0.04 g of azobisisobutyronitrile were dissolved in 36 ml of carbon tetrachloride,14.95g (0.084mol) of N-bromosuccinimide was added portionwise at 25 C, the reaction was carried out for 20h,After the liquid-phase central control monitored the conversion of 4-aminopyridine and intermediate 3-bromo-4-aminopyridine into the target product 3,5-dibromo-4-aminopyridine,The reaction mixture was cooled to room temperature with stirring, poured into 50ml carbon tetrachloride and stirred, filtered, the filter cake was washed twice with 2 × 30ml carbon tetrachloride, the filtrate was washed once with aqueous sodium bicarbonate solution, saturated salt Water once, spin-dried to remove carbon tetrachloride, and then recrystallized from petroleum ether,9.28 g of a white solid was obtained,Namely 3,5-dibromo-4-aminopyridine,Yield 92.10%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-24-5, 4-Aminopyridine, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Wohua Chemical Co., Ltd.; Hu Yadong; Yang Benmei; (5 pag.)CN106957259; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 504-29-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Manufacturing Example 1-2-1: 2,2-Dimethyl-N-pyridin-2-yl-propionamide To a methylene chloride (500 mL) solution of 2-aminopyridine (50 g) were added triethylamine (81 mL) and pivaloyl chloride (72 mL) at 0C, which was stirred for 4 hours and 30 minutes at room temperature. Water was added to the reaction solution, and then extraction was performed with methylene chloride. The organic layer was washed with water and saturated brine, and dried over anhydrous magnesium sulfate and filtered, and then the filtrate was concentrated under a reduced pressure. Potassium carbonate (73 g) was added at 0C to a methanol (300 mL) solution of the residue thus obtained, which was stirred for 90 minutes at room temperature. Water was added to the reaction solution, and then extraction was performed with ethyl acetate. The organic layer was washed with saturated brine, then dried over anhydrous magnesium sulfate, and filtered, after which the filtrate was concentrated under a reduced pressure. Heptane (300 mL) was added to the residue, and the precipitated solids were filtered off to obtain the titled compound (80 g). The filtrate was then further concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate = 2:1) to obtain the titled compound (12 g). 1H-NMR spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1 H, m), 8.01-8.03 (1 H, m), 8.29-8.31 (1 H, m), 9.71 (1 H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-29-0, Pyridin-2-amine.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2065377; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 504-24-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.504-24-5, name is 4-Aminopyridine, molecular formula is C5H6N2, molecular weight is 94.12, as common compound, the synthetic route is as follows.

To a solution of 4-aminopyridine (50.0 g, 531 mmol) in triethylamine/CH2Cl2 (1:1, 200 mL) at 0°C was slowly added a solution of di-t-butyl-dicarbonate (116 g, 531 mmol) in CH2Cl2 (150 mL). The resulting mixture was allowed to warm to it overnight then was concentrated. The crude product was taken up in hot EtOAc, filtered and precipitated with hexanes. The precipitate was collected by filtration, washed with hexanes and dried under vacuum to give 91.0 g (88percent yield) of pure t-butyl carbamate.

The chemical industry reduces the impact on the environment during synthesis 504-24-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PURDUE RESEARCH FOUNDATION; WO2007/61554; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 108-99-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 108-99-6 as follows.

10 g of catalyst B was taken into a cylindrical fixed bed reactor with an inner diameter of 25 mm, and the plunger pump was pumped into a solution of 3-methylpyridine in carbon tetrachloride. The mass ratio of 3- methylpyridine to carbon tetrachloride was 1: The weight hourly space velocity of 10,3-methylpyridine is 6h, the chlorine gas flow rate is 2L/min, and the 3-methylpyridine and chlorine gas are vaporized by the preheating tube and then passed into the fixed bed reactor. The fixed bed reactor is used. The temperature was 400 C, the reaction was carried out for 4 h, the reaction product was passed through a condenser, and 2987 g of the reaction product mixture was obtained in a receiving tank. The ammonia solution was added to adjust to neutrality, and the pear-shaped funnel was separated to obtain an organic phase. 30 g of anhydrous sulfuric acid was added to the organic phase. Magnesium is dehydrated, suction filtered, and then rotary evaporated to remove carbon tetrachloride to give a pale yellow liquid. After analysis and detection, the product is a mixture of 2-chloro-5-trichloromethylpyridine, 2,3-dichloro-5-trichloromethylpyridine and 2,3,6-trichloropyridine, respectively. 77%, 16%, 7%. It is indicated that it is difficult to remove trichloromethyl group under the reaction conditions in the absence of water

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-99-6, its application will become more common.

Reference:
Patent; Chongqing Zhong Bang Technology Co., Ltd.; Xue Yi; Li Xueyong; Mu Dengyou; Chen Honglong; Qian Yong; (7 pag.)CN109734657; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem