Tag: M.W=0-100

Reference of 626-64-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 626-64-2, Name is Pyridin-4-ol, SMILES is OC1=CC=NC=C1, belongs to pyridine-derivatives compound. In a article, author is Daware, Gaurav B., introduce new discover of the category.

Removal of pyridine using ultrasound assisted and conventional batch adsorption based on tea waste residue as biosorbent

The current study deals with comparison of ultrasound assisted adsorption and conventional batch adsorption using biosorbent based on tea waste residue (TWR) with an objective to develop novel treatment approach for effective removal of pyridine. The characterization of TWR was performed using FTIR and SEM to get clear insight into the associated functional groups and the morphology. In addition, point of zero charge was also established and oxygen functional groups were detected using Boehm titration method. Ultrasound assisted adsorption was studied in ultrasonic bath (25 kHz frequency) under varying conditions of pH (2-10), TWR dose (0.5-4 g/L) treatment time (0 to 120 min for ultrasound assisted and 0 to 200 min for conventional approach), temperature (283 K-313 K), power (15 W-150 W) and initial concentration (10 mg/L150 mg/L). Maximum removal and pyridine uptake obtained for ultrasound assisted adsorption was 98.2% and 37.38 mg/g respectively at optimized conditions of pH of 6, TWR loading of 2.5 g/L, temperature of 303 K, treatment time of 90 min and power of 120 W. Conventional batch adsorption studies performed at fixed 150 rpm as shaking speed revealed that maximum removal and maximum pyridine uptake was obtained as 92.25% and 33.72 mg/g respectively under similar optimum conditions but in treatment time of 160 min required to reach equilibrium. Pseudo second order kinetic model was the best fit for both adsorption approaches. Langmuir adsorption isotherm model for conventional batch adsorption and both Langmuir and Temkin isotherm for ultrasound assisted adsorption were also found suitable. Thermodynamic parameters as AG, AH and AS were evaluated for both adsorption approaches and it was established that the AG and AS values for ultrasound assisted adsorption for all temperatures and isotherms are higher compared to conventional batch adsorption. Overall, ultrasound was demonstrated as effective means to improve adsorption leading to enhanced extent of adsorption and lower treatment time. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 626-64-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 626-64-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 142-08-5, name is Pyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 142-08-5

3-l3romo-pyridin-2-ol. A stirred suspension of 2-pyridone (77-0, 19 g, 200 mmol) in 200 mE of 1 M aqueous K13r at room temperature was treated over 15 mm with bromine (32 g, 200 mmol; CAUTION: Large quantities of 13r2 should be handled careffilly) in 200 mE of 1 M aqueous K13r, then stirred vigorously at room temperature 0/N. After 24 h, this solution deposited crystals which were filtered off and then recrystallized from acetonitrile to give 27.2 g (78%) of 3-bromo- pyridin-2-ol. (77-1) [J. Am. Chem. Soc. 1982, 104, 4142- 4146; Bioorg. Med. Chem. Lett. 2002, 12, 197-200; JMed Chem. 1979, 22, 1284-1290.] Molecular weight calcd. for C5H4I3rNO: 173; (M+H) found: 174

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 142-08-5, Pyridin-2(1H)-one.

Reference:
Patent; Ocera Therapeutics, Inc.; Hoveyda, Hamid R.; Fraser, Graeme L.; Peterson, Mark; (171 pag.)US2018/110824; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 108-96-3, Adding some certain compound to certain chemical reactions, such as: 108-96-3, name is Pyridin-4(1H)-one,molecular formula is C5H5NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108-96-3.

I Oa. 3,5-Diiodo-pyridin-4-ol Into a 3 L three necked round bottom flask I ,4-dihydropyridin-4-one (50.0 g, 0.50 mol) and N-iodosuccinimide (232 g, 1.00 mmol) were suspended inacetonitrile (1 L). The reaction mixture was refluxed for 3h. The mixture was cooled down with an ice bath and then filtered and washed with acetonitrile (150 mL). The light yellow solid was dried at 60C under reduced pressure for 15 hr to obtain 165 g (95 %) of the title compound as a light yellow solid. LC/MS (Method B): Rt 1.34 mm, (M+H) 348.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 108-96-3, Pyridin-4(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 462-08-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 462-08-8, name is Pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of pyridin-3-ylamine (20 g, 212.49 mmol, CAS RN 462-08-8) in a mixture of THF:Et2O (175 mL; 2.5:1 v/v) was added slowly a solution of pivaloyl chloride (26 mL, 212.5 mmol, CAS RN 3282-30-2) in THF (50 mL) and Et3N (44 mL, 318.7 mmol) at 0 C. and left stirring at that temperature for 1 h. After the completion of reaction, the reaction mixture was filtered, and the filtrate was evaporated in vacuo. The crude filter cake was washed with n-hexane to yield the title compound. Colorless crystalline solid (32 g, 85%). MS (ESI): m/z=179.4 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 462-08-8, Pyridin-3-amine.

Reference:
Patent; Bissantz, Caterina; Dehmlow, Henrietta; Erickson, Shawn David; Karnachi, Prabha Saba; Kim, Kyungjin; Martin, Rainer E.; Mattei, Patrizio; Sander, Ulrike Obst; Pietranico-Cole, Sherrie Lynn; Richter, Hans; Ullmer, Christoph; US2012/232051; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-24-5, name is 4-Aminopyridine, molecular formula is C5H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 4-Aminopyridine

To a solution of 4-aminopyridine (1a, 37.65 g, 0.4 mole) in HOAc (200 mL) was added iodine monchloride (130 g, 0.8 mole) portionwise. The reaction mixture was stirred at 45 C. for 20 h, then diluted with water (500 mL). The mixture was cooled to 0 C., and basified 30% NaOH to pH=9-10. The solution was extracted with EtOAc (1 L¡Á2) and the combined extracts were washed with 15% Na2S2O3 (400 mL¡Á2), water, brine, dried over Na2SO4, and evaporated in vacuo to give 1b (62 g) as a light yellow solid. ES-MS m/z 221 (MH+). [0185] Into a pressure flask was added 1b (4.4 g, 20 mmol), cupric iodide (228 mg, 1.2 mmol), (trimethylsilyl)acetylene (7.08 g, 72 mmol), triethylamine (200 mL) and DMF (80 mL). The mixture was stirred under nitrogen for 10 min, followed by addition of Pd(PPh3)2Cl2 (0.84 g, 1.2 mmol). The mixture was then stirred to 70 C. for 5 h, and then diluted with ethyl acetate (600 mL). The solution was washed with H2O (250 mL¡Á2), brine (250 mL), dried over Na2SO4, and evaporated in vacuo to give crude product which was purified by flash chromatography (100% CH2Cl2 to 2% MeOH in CH2Cl2) to afford Compound 1c (2. 97 g, 78%) as a light brown solid. 1H NMR (CDCl3) delta 8.37 (s, 1H), 8.13 (d, J=5.7 Hz, 1H), 6.53 (d, J=5.6 Hz, 1H), 4.67 (bs, 2H), 0.27 (s, 9H). ES-MS m/z 191 (MH+). [0186] Into an ice-cold solution of 1c (1.35 g, 7.1 mmol) in THF (50 mL) was added 95% NaH (1.86 g, 8.5 mmol). The mixture was stirred at 0 C. for 10 min, rt for 10 min, then cooled back to 0 C. (Boc)2O (1.86 g, 8.5 mmol) was added and the mixture was stirred at 0 C. for 30 min and then rt for 2 h. Additional 95% NaH (0.08 g, 3.5 mmol) and (Boc)2O (0.2 g, 0.92 mmol) were added and the mixture was stirred at rt for another 2 h. The reaction was then quenched slowly with saturated NaHCO3 (10 mL), extracted with ethyl acetate (200 mL¡Á2). The organic layer was washed with brine, dried over Na2SO4, and evaporated in vacuo. The crude product was purified by flash chromatography (EtOAc/hexane; 1:3) to give 1d (0.67 g). ES-MS m/z 219 (MH+). [0187] To a solution of 1d (1.3 g, 4.5 mmol) in DMF (20 mL) was added cupric iodide (0.85 g, 4.5 mmol). The mixture was stirred at 80 C. for 6 h and then filtered. The filtrate was extracted with ethyl acetate (100 mL¡Á3), and the organic layer was washed with H2O, brine, dried (Na2SO4) and concentrated. The residue was purified by flash chromatography (Ethyl acetate/hexane; 1:3) to give Compound 1e (0.25 g, 26%). 1H NMR (CDCl3) delta 8.89 (s, 1H), 8.47 (d, J=5.8 Hz, 1H), 7.98 (d, J=5.7 Hz, 1H), 7.62 (d, J=3.7 Hz, 1H), 6.66 (d, J=3.7 Hz, 1H), 1.69 (s, 9H). ES-MS m/z 219 (MH+). [0188] To a solution of 1e (0.178 g, 0.82 mmol) in methylene chloride (5 mL) was added TFA (1.0 mL) slowly. The mixture was stirred at rt for 1.5 h, and The solvent was evaporated to obtain 5-azaindole 1f as a white solid (0.18 g, 95%). 1H NMR (CDCl3) delta 8.97 (s, 1H), 8.31 (d, J=5.7 Hz, 1H), 7.35 (d, J=5.7 Hz, 1H), 7.29 (m, 1H), 6.68 (d, J=3.3 Hz, 1H). ES-MS m/z 119 (MH+). [0189] A mixture of Compound 1f (0.26 g, 2.2 mmol) and cesium carbonate (1.43 g, 4.4 mmol) in DMF (10 mL) was stirred at rt for 10 min, and then 3-methoxypropylbromide (0.40 g, 2.64 mmol) was added. The reaction mixture was stirred at 60 C. for 3 h. The solvent was evaporated and the residue was partitioned between EtOAc (150 mL) and water (100 mL). The organic layer was washed with water (3¡Á50 mL), brine (2¡Á50 mL), then dried (Na2SO4) and evaporated in vacuo to give a brown oil. The crude product was purified by flash column chromatography (from 100% DCM to DCM/MeOH/NH4OH; 97:3:0.3) to afford Compound 1g (0.26 g, 62%) as light brown oil. 1H NMR (CDCl3) delta 8.91 (s, 1H), 8.31 (d, J=5.8 Hz, 1H), 7.27 (s, 1H), 7.11 (d, J=3.2 Hz, 1H), 6.60 (d, J=3.3 Hz, 1H), 4.25 (t, J=6.7 Hz, 2H), 3.32 (s, 3H), 3.25 (t, J=5.7 Hz, 2H), 2.05 (m, 2H). ES-MS m/z 191(MH+). [0190] Oxalyl chloride (3 mL) was added slowly to a solution of compound 1g (0.22 g, 1.14 mmol) in ether (5 mL). The mixture was heated to 48 C. in a pressure tube overnight. TLC shown that some starting materials were still present. Additional 0.5 mL of oxalyl chloride was added and stirring was continuted at 48 C. for another night. The mixture was then cooled down to rt, to which methanol (3 mL) was added. The mixture was heated to 48 C. and stirred for 2 h. The volatiles removed under vacuo and the residue was purified by flash chromatography (from 100% DCM to DCM/MeOH/NH4OH; 97:3:0.3) to afford Compound 1h (0.15 g, 48%) as a white solid. 1H NMR (CDCl3) delta 8.51 (d, J=5.8 Hz, 1H), 8.44 (s, 1H), 7.37 (m, 1H), 4.34 (t, J=6.8 Hz, 2H), 3.97 (s, 3H), 3.35 (s, 3H), 3.30 (t, J=5.7 Hz, 2H), 2.12 (m, 2H). ES-MS m/z 277 (MH+). [0191] The alpha-ketoester Compound 1h (53.8 mg, 0.20 mmol) and amide Compound 1i (23 mg, 0.14 mmol) were combined in dry THF (3 mL) under argon and cooled with an ice bath as a solution of 1.0 M potassium t-butoxide in THF (1 mL, 1 mmol) was added dropwise. The mixture was stirred at 0 C. for 30 …

With the rapid development of chemical substances, we look forward to future research findings about 504-24-5.

Reference:
Patent; Zhang, Han-Cheng; Maryanoff, Bruce E.; Ye, Hong; US2004/192718; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 108-99-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.108-99-6, name is 3-Methylpyridine, molecular formula is C6H7N, molecular weight is 93.13, as common compound, the synthetic route is as follows.

Example 7 The preparation of the catalyst of the present invention and the process for preparing nicotinic acid by using the catalyst 6.43 g of ammonium meta-vanadate were added into 500 ml water and the solution was heated at 70C to dissolve ammonium meta-vanadate. Then, 8.2 g of zinc sulfate were added into the solution and stirred for 30 minutes. Into the resultant solution were added 92.68 g titanium oxide (Hembitec K-03) and stirred for 1 hour. The mixture was heated to evaporate water and then calcined in an oven at a temperature of 600C to obtain the catalyst of the present invention, whose composition was shown in Table 1. After calcination, the catalyst was observed by electronic microscopy and found that the crystal size of the active ingredients on the surface of the carrier is from 40 to 60 nm. Subsequently, 30g of the prepared catalyst were fed into a tube reactor having a diameter of 1 inch and a length of 5 centimeter to obtain a catalyst bed. 3-Methylpyridine was first mixed with air and then with H2O vapor and then continuously fed into the catalyst bed at a mole ratio of 1:30:70 (3-methylpyridine: oxygen: H2O) and where the bed temperature was controlled at 320C . The feed speed of 3-methylpyridine is 0.025 hr-1. The product was collected at the outlet of the catalyst bed and analyzed by HPLC and GC. It was found that a conversion of 3-methylpyridine is 88.10%, a selectivity of nicotinic acid is 88.32%, and a selectivity of carbon dioxide is 9.25%.

The chemical industry reduces the impact on the environment during synthesis 108-99-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Chang Chun Petrochemical Co. Ltd.; EP1584618; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 504-29-0, Adding some certain compound to certain chemical reactions, such as: 504-29-0, name is Pyridin-2-amine,molecular formula is C5H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 504-29-0.

2-Aminopyridine (4.7 g,50 mmol) was dissolved in a mixture of water (6 mL),glacial acetic acid (120 mL), and concentrated sulfuricacid (1 mL) preliminarily cooled to room temperature. Upon mixing, iodine (6 g, 23.6 mmol) and NaIO4(1.6 g, 7.5 mmol) were added. The mixture was kept at80C for 4 h, then 200 mL of 10% sodium thiosulfate solution was added and extracted with ethyl acetate(3 ¡Á 150 mL). The organic phase was washed with10% sodium hydroxide solution (3 ¡Á 60 mL) and brine(2 ¡Á 50 mL), dried over anhydrous Na2SO4, evaporated,and purified by flash chromatography (chloroform-ethanol, 50 : 1). Violet powder (10.3 g, 94%);1H NMR: 8.04 (d, J2 2.1, 1H), 7.58 (dd, J2 8.6, 2.2,1H), 6.35 (d, J2 8.6, 1H), 6.10 (br, 2H).

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Baleeva, N. S.; Baranov, M. S.; Smirnov, A. Yu.; Zaitseva, E. R.; Zaitseva, S. O.; Russian Journal of Bioorganic Chemistry; vol. 46; 1; (2020); p. 120 – 123; Bioorg. Khim.; vol. 46; 1; (2020); p. 120 – 123,4;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 372-47-4, Adding some certain compound to certain chemical reactions, such as: 372-47-4, name is 3-Fluoropyridine,molecular formula is C5H4FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 372-47-4.

EXAMPLE 28A 2-chloro-3-fluoropyridine 1,4-Diazabicyclo[2.2.2]octane (5.78 g, 51.5 mmol) in diethyl ether (130 mL) was treated dropwise with n-butyllithium (32.2 mL, 51.5 mmol, 1.6M solution in hexanes) at -78 C. The reaction mixture was warmed to -20 C. for 1 hour and then recooled to -78 C. The recooled mixture was treated with 3-fluoropyridine (5.0 g, 51.5 mmol) in diethyl ether (5 mL) dropwise. After stirring for 2 hours at -78C, the mixture was treated with hexachloroethane (12.2 g, 51.5 mmol) in tetrahydrofuran (24 mL). After stirring for one hour at -78 C., the reaction mixture was treated with a solution of water (15 mL) and tetrahydrofuran (25 mL). The reaction mixture was warmed to 0 C. and, after 30 minutes, additional water and diethyl ether were added to the mixture. The layers were separated and the aqueous phase extracted with diethyl ether (2*). The combined ethereal layers were dried over Na2SO4, filtered, and the filtrate concentrated under reduced pressure. The residue was chromatographed on flash silica gel (10% ethyl acetate/hexanes) to afford 3.5 g (52% yield) of the title compound. 1H NMR (300 MHz, DMSO-d6) delta 7.54 (m, 1H), 7.96 (m, 1H), 8.31 (m, 1H); MS (ESI) m/e 154 (M+Na)+.

According to the analysis of related databases, 372-47-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cowart, Marlon D.; Patel, Meena V.; Kolasa, Teodozyi; Brioni, Jorge D.; Rohde, Jeffrey J.; Engstrom, Kenneth M.; Stewart, Andrew O.; Daanen, Jerome F.; Bhatia, Pramila A.; US2004/127504; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

626-64-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-64-2, name is Pyridin-4-ol, molecular formula is C5H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Hydroxypyridine (15 g, 157.7 mmol) was suspended in mineral oil (220 mL) under argon atmosphere, sodium amide (24.6 g, 630.8 mmol, 4 eq) was added and stirred over night at room temperature. The homogeneous suspension was heated within 25 min to 70 C for 15 min. At 65 C ammonia was released. The temperature was raised stepwise within 30 min to 140C, whereupon the orange color of the suspension changed to brown. Within 20 min the mixture was heated to 190 C, and hydrogen was released at 130 C. The color change to dark brown and a foam was formed. The mixture was heated within 25 min to 220 C, the reaction was controlled by TLC(MeOH/AcOH 1:0.1). After 2 h at 220 C the hydrogen release stopped, and the reaction was cooled to room temperature. The suspension was filtered, washed with petroleum ether (4x 100 mL)and Et2O (2x 100 mL). The brown solid was transferred to an Erlenmeyer flask, the salt was quenched carefully with water (50 mL), activated charcoal was added, stirred for 30 min and filtrated over Celite. Nitric acid 65 % was added until a pH of one was reached and a brown precipitate was formed. Then thesolid was filtrated, washed with ice water (50 mL), acetone/Et2O (1:1; 3x 50 mL) and Et2O (2x 50 mL). Thesolid was dried under vacuum affording 22.9 g (77 %) of 8 as brown solid. 1H NMR (DMSO-d6) delta: 11.33 (s,2H), 6.85 (s, 4H, NH2), 5.38 (s, 2H, Py). 13C{1H} NMR (DMSO-d6) delta: 170.3 (Py), 152.8 (Py), 82.9 (Py).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-64-2, Pyridin-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mastalir, Matthias; Pittenauer, Ernst; Allmaier, Guenter; Kirchner, Karl; Tetrahedron Letters; vol. 57; 3; (2016); p. 333 – 336;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-99-6, name is 3-Methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. 108-99-6

Example 5 The preparation of the catalyst of the present invention and the process for preparing nicotinic acid by using the catalyst 6.43 g of ammonium meta-vanadate were added into 500 ml water and the solution was heated at 70C to dissolve ammonium meta-vanadate. Then, 13.54 g of ferric nitrate were added into the solution and stirred for 30 minutes. Into the resultant solution were added 92.31 g titanium oxide (Hembitec K-03) and stirred for 1 hour. The mixture was heated to evaporate water and then calcined in an oven at a temperature of 700C to obtain the catalyst of the present invention, whose composition was shown in Table 1. After calcination, the catalyst was observed by electronic microscopy and found that the crystal size of the active ingredients on the surface of the carrier is from 60 to 80 nm, as shown in Figure 11. Subsequently, 30g of the prepared catalyst were fed into a tube reactor having a diameter of 1 inch and a length of 5 centimeter to obtain a catalyst bed. 3-Methylpyridine was first mixed with air and then with H2O vapor and then continuously fed into the catalyst bed at a mole ratio of 1:35:330 (3-methylpyridine: oxygen: H2O) and where the bed temperature was controlled at 310C. The feed speed of 3-methylpyridine is 0.02 hr-1. The product was collected at the outlet of the catalyst bed and analyzed by HPLC and GC. It was found that a conversion of 3-methylpyridine is 96.78%, a selectivity of nicotinic acid is 93.13%, and a selectivity of carbon dioxide is 5.56%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 108-99-6, 3-Methylpyridine.

Reference:
Patent; Chang Chun Petrochemical Co. Ltd.; EP1584618; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem