Tag: M.W=0-100

626-64-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-64-2, name is Pyridin-4-ol, the common compound, a new synthetic route is introduced below.

To a solution of tert-butyl 3-hydroxyazetidine-1-carboxylate 1 (4.55 g, 26.3 mmol) inTHF (100 mL) was added pyridin-4-ol (2.0 g, 21.0 mmol), PPh3 (6.89 g, 26.3 mmol)and DEAD (4.57 g, 26.3 mmol). The resulting reaction mixture was stirred at 70 Covernight. TLC indicated that the reaction was complete. The reaction mixture wasconcentrated in vacuum. The resulting oil was dissolved in 1 .0 M aqueous HCI solution C 20 mL) and extracted with DCM (50 mL x 3), The combined organic phases were washed with HCI (aq) solution (0.5 M, 150 mL). The aqueous fractions were combined and basified to pH12 using NaOH (1.0 M) and extracted with DCM(100 mL x 3) . The combined organic phases were dried over anhydrous Na2SO4,filtered and concentrated in vacuum. The residue was purified by column chromatography on silica gel to afford to afford 4 (2.81 91 53% yield) as a solid.1HNMR (400 MHz, DMSO-d6): 5 8.41 (d, J 6.0 Hz, 2 H), 6.88 (d, J = 6.0 Hz, 2 H),5.07-5.09 (m, 1 H), 4.32-4.33 (m, 2 H), 3.80-3.82 (m, 2 H)3 1.39 (s, 9 H). MS Calcd.:250; MS Found: 251 ([M+Hfl.

Statistics shows that 626-64-2 is playing an increasingly important role. we look forward to future research findings about Pyridin-4-ol.

Reference:
Patent; H. LUNDBECK A/S; SVENSTRUP, Niels; WEN, Kate; WANG, Yazhou; (78 pag.)WO2017/5786; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

462-08-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 462-08-8, name is Pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

Reference Example 69 tert-Butyl N-(3-pyridyl)carbamate Sodium bis(trimethylsilyl)amide (1.0M tetrahydrofuran solution 800 mL, 0.80M) was added to a solution of 3-aminopyridine (34.2 g, 0.36 mmol) in tetrahydrofuran (800 mL), followed by stirring for two hours. A solution of di-tert-butyl dicarbonate in tetrahydrofuran (200 mL) was added thereto and stirred for 30 minutes. Water was added, extracted with ethyl acetate, and the organic layer was washed with 1N hydrochloric acid, water and brine, dried over anhydrous magnesium sulfate and evaporated. The resulting crystals were washed with hexane, to give the title compound (55.0 g) as white crystals. 1H NMR (400 MHz, CDCl3) delta1.52 (s, 9H), 6.85 (br s, 1H), 7.24 (ddd, J=8.4 Hz, 4.8 Hz, 0.8 Hz, 1H), 7.95-8.04 (m, 1H), 8. 28 (dd, J=4.8 Hz, 1.6 Hz, 1H), 8.35 (dd, J=2.8 Hz, 0.8 Hz, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 462-08-8, Pyridin-3-amine.

Reference:
Patent; Hibi, Shigeki; Hoshino, Yorihisa; Yoshiuchi, Tatsuya; Shin, Kogyoku; Kikuchi, Kouichi; Soejima, Motohiro; Tabata, Mutsuko; Takahashi, Yoshinori; Shibata, Hisashi; Hida, Takayuki; Hirakawa, Tetsuya; Ino, Mitsuhiro; US2003/78277; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

504-29-0 , The common heterocyclic compound, 504-29-0, name is Pyridin-2-amine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Manufacturing Example 39-1-1 2,2-Dimethyl-N-pyridin-2-yl-propionamide; To a solution of 2-aminopyridine (50.0 g, 531 mmol) in methylene chloride (500 mL) were added triethylamine (81.4 mL, 584 mmol) and pivaloyl chloride (71.9 mL, 584 mmol) at 0 C., which was stirred for 4 hours and 30 minutes at room temperature. The reaction solution was partitioned into water and methylene chloride. The organic layer was washed with water and saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. To a solution of the resulting residue in methanol (300 mL) was added potassium carbonate (73.4 g, 531 mmol) at 0 C., which was stirred for 90 minutes at room temperature. The reaction solution was partitioned into water and ethyl acetate at room temperature. The organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. Heptane (300 mL) was added to the residue, and the precipitated solids were filtered to obtain the title compound (80.2 g, 85%). The filtrate was then concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1) to obtain the title compound (12.2 g, 13%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1H, m), 8.01-8.03 (1H, m), 8.29-8.31 (1H, m), 9.71 (1H, s).

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

626-64-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-64-2, name is Pyridin-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

9.5 g (0.10 mol) of 4-hydroxypyridine,, 21.5 g (0.11 mol) of 4-bromobutyric acid ethyl ester,0.5 g of 5% Pd / C catalyst,80 ml of ethanol was placed in a 300 ml autoclave, and the interior of the container was replaced with hydrogen.While introducing hydrogen gas into the vessel, the reactor was heated to 100 C. while stirring, and the reaction was carried out at a hydrogen pressure of 4.9 ¡Á 10 5 Pa for 9 hours.After allowing the reactor to cool down, disappearance of 4-hydroxypyridine was confirmed by TLC. The catalyst was removed by filtration, and the obtained reaction solution was concentrated.To the residue was added 100 ml of water and extracted with 60 ml of ethyl acetate, and the organic layer was dried and concentrated. After drying the obtained solid under reduced pressure, 18.3 g (85 mmol, yield 85%) of (4-hydroxy) -4-piperidinobutanoic acid ethyl ester was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 626-64-2, Pyridin-4-ol.

Reference:
Patent; TOKUYAMA CORPORATION; SEKI, MASAHIKO; YAMAMOTO, HIROMASA; (13 pag.)JP2018/24593; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

504-29-0 , The common heterocyclic compound, 504-29-0, name is Pyridin-2-amine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

75.2 g (0.80 mol) Of 2-aminopyridine was dissolved in 88.0 g (0.88 mol) of ethyl acrylate and 20 mL of acetic acid. The mixture was heated to 80C and stirred for 24 hours at the same temperature. -Solvent was removed under vacuum, and the title compound was isolated by vacuum distillation to obtain 77.0 g of ethyl 3-(2- pyridylamino)propionate as a white solid.Yield: 77.Og (49.67%); Purity by HPLC: 98.5%.

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MEGAFINE PHARMA (P) LTD.; MATHAD, Vijayavitthal Thippannachar; SOLANKI, Pavankumar Vrajlal; UPPELLI, Sekhar Babu; SARODE, Ganesh Gitaram; WO2015/128875; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

626-64-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-64-2, name is Pyridin-4-ol, molecular formula is C5H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a mixture of chlorinated derivatives of dihydropyrimidinonederivatives 4a-i (1 equiv.), potassium carbonate (2.5 equiv.) in acetonitrile,under 80 C was added different aryl/ heteroaryl alcohols(5a-k, 0.75 equiv.) and stirred under reflux till complete consumptionof the starting materials as determined by TLC. The solvent was thenremoved using rotary evaporator and extracted using ethyl acetate(25 mL¡Á3) and water. The organic layer was concentrated under invacuo and the residue obtained was chromatographed on silica gel(elution with hexane/EtOAc=7:3-5:5) to provide the 2-oxo-6-(aryloxymethyl)-4-aryl/heteroaryl-1,2,3,4-tetrahydropyrimidine-5-carboxylatederivatives 6a-s in moderate to good yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-64-2, Pyridin-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sana, Sravani; Tokala, Ramya; Bajaj, Deepti Madanlal; Nagesh, Narayana; Bokara, Kiran Kumar; Kiranmai, Gaddam; Lakshmi, Uppu Jaya; Vadlamani, Swapna; Talla, Venu; Shankaraiah, Nagula; Bioorganic Chemistry; vol. 93; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem