Tag: M.W=0-100

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Yifeng; Ma, Chenggong; Zheng, Xuwei; Ju, Minzi; Fu, Yongqian; Zhang, Xing; Shen, Baoxing researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Reference of 2,4-Dimethyl-1H-pyrrole.They published the article 《A red emission multiple detection site probe for detecting carboxylesterase 1 based on BODIPY fluorophore》 about this compound( cas:625-82-1 ) in Journal of Photochemistry and Photobiology, A: Chemistry. Keywords: BODIPY fluorophore carboxylesterase red emission multiple detection. We’ll tell you more about this compound (cas:625-82-1).

In this work, a BODIPY-based multi-site red emission fluorescent probe MRS-BOD for the detection of carboxylesterase 1 (CES1) was designed and synthesized. MRS-BOD showed good biocompatibility and could be used to monitor the activity of CES1 in living cells. MRS-BOD emission is located in the red emission region, which has the advantages of less background interference and less damage to biol. samples. MRS-BOD has multiple CES1 recognition sites, and the ultra-sensitive quantification of CES1 has been successfully achieved. The low detection limit of MRS-BOD was calculated as 2.5 ng/mL, and the fluorescence quantum yield was calculated as 0.49. This study can promote the development of CES1 fluorescent probes and help the identification of related diseases.

Although many compounds look similar to this compound(625-82-1)Reference of 2,4-Dimethyl-1H-pyrrole, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C4H4N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Synthesis of 2-(3-pyrazolyl)imidazo[4,5-f][1,10]phenanthroline. Author is Lin, Long; Wu, Jian-fang; Pan, Wen-long; Wu, Jian-zhong.

A new ligand, 2-(1H-pyrazol-3-yl)imidazo[4,5-f][1,10]phenanthroline (I), was synthesized from 1,10-phenanthrolinequinone (i.e., 1,10-phenanthroline-5,6-dione) and 1H-pyrazole-3-carboxaldehyde. The structure was characterized by 1H NMR, IR and MS (ESI). The electronic absorption and fluorescence spectra of I were also measured.

Although many compounds look similar to this compound(948552-36-1)Computed Properties of C4H4N2O, numerous studies have shown that this compound(SMILES:O=CC1=CC=NN1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 625-82-1. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Author is Jin, Meng; Ji, Xiuna; Stoika, Rostyslav; Liu, Kechun; Wang, Lizhen; Song, Yang.

Berberine is a naturally occurred isoquinoline alkaloid that shows great potential for developing anticancer drugs. However, the problem stays of poor understanding of the mechanisms of anticancer action of berberine. It depends on evaluation of berberine’s pharmacokinetics, namely monitoring of its uptake and distribution in cells, tissues and organs. In order to address these problems, we have designed and synthesized a novel berberine derivative BBR-BODIPY bearing a fluorescent tag that allows screening its interaction with the targeted cells. It was shown that the synthesized fluorescent derivative could penetrate into human breast carcinoma MCF7 cells, and then induced apoptosis detected by the Western Blot anal. as changed expression of apoptosis-related proteins, including Bax, Bcl2, and Cyto C released from mitochondria, Cleaved Caspase 9, Cleaved PARP, Pro-Caspase 3, and Cleaved Caspase 3. The results of MitoTracker anal. followed by the confocal microscopy of sub-cellular localization of BBR-BODIPY in the MCF7 cells demonstrated excellent cell-penetrating ability of this compound even at low concentrations, and mitochondria was the main site of its accumulation. Together with the results of Western Blot anal., these data indicated that the mitochondria pathway might be involved in berberine-induced apoptosis.

Although many compounds look similar to this compound(625-82-1)HPLC of Formula: 625-82-1, numerous studies have shown that this compound(SMILES:CC1=CNC(C)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ou, Changjin; Zhang, Yewei; Ge, Wei; Zhong, Liping; Huang, Yong; Si, Weili; Wang, Wenjun; Zhao, Yongxiang; Dong, Xiaochen published the article 《A three-dimensional BODIPY-iron(III) compound with improved H2O2-response for NIR-II photoacoustic imaging guided chemodynamic/photothermal therapy》. Keywords: BODIPY iron compound preparation photoacoustic imaging photothermal chemotherapy cancer.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).Electric Literature of C6H9N. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.

3D boron dipyrromethene (BODIPY)-Fe(III) coordination polymer nanoparticles can extend absorption to 1300 nm for enhanced ligand-to-metal transfer. The nanoparticles show good cytotoxic hydroxyl radical ( ̇OH) generation ability, high photothermal conversion, and outstanding NIR-II photoacoustic imaging, displaying synergistic chemodynamic/photothermal therapy.

In some applications, this compound(625-82-1)Electric Literature of C6H9N is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C4H4N2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Highly sensitive ruthenium complex-based fluorescent probe for copper ion detection. Author is Xia, Xiao Li; Zhang, Dao Bin; Zhang, Jiu Long; Pu, Shou Zhi.

A Ru(II) complex 1 ([Ru(bpy)2(L)](PF6)2 (L = 2-(1H-pyrazol-5-yl)-1H-imidazo-[4,5-f] [1,10] phenanthroline, bpy = 2,2′-bipyridine)), which included adjacent imidazole and pyrazole moieties as responsive bidentate ligand, had been designed and synthesized as a ‘turn-off’ fluorescent probe for sensitively and selectively detecting Cu2+ in methanol and test strips. It displayed easy synthesis, large Stokes shift (178 nm) and long emission wavelength (633 nm). After addition of Cu2+, the probe 1 exhibited obvious fluorescence quenching (ca. 83%) and color change from red to dark. The detection limit of Cu2+ ions was as low as 1.78 x 10-8 M, which was far lower than the permissible level of copper ion (∼20μM) in drinking water set by the EPA (Environmental Protection Agency). Moreover, the results of test strip experiments and real water sample detection experiments demonstrated the probe 1 possesses potential application of ions recognition in environment.

In some applications, this compound(948552-36-1)COA of Formula: C4H4N2O is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1H-Pyrazole-5-carbaldehyde. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2 kinase with selectivity against a panel of selected kinases in enzymic assays and specificity in cell-based phosphorylation assays in LPS-treated human monocytes were identified. Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFα release when administered i.p. in mice.

In some applications, this compound(948552-36-1)Reference of 1H-Pyrazole-5-carbaldehyde is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C6H9N. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Chitosan based macromolecular probes for the selective detection and removal of Fe3+ ion.

Chitosan has been widely used due to its biodegradable, cost-effective and environmentally friendly properties. Modification of chitosan attracts much attention as promising methods to detect and remove organic and inorganic pollutants. In this work, chitosan-based macromol. probes were designed and synthesized. The probes can detect Fe3+ in the presence of other metal ions. The detection mechanism is investigated as well. The prob′s fluorescence quenching upon the addition of Fe3+ ion could be ascribed to the complexation between the electron-deficient ion Fe3+ and ′C=N′ (electron-rich group) of fluorescent chitosan probes. What′s more, the obtained fluorescent macromol. probes can be used for the removal of Fe3+ in solution The probes could adsorb the Fe3+ in solution and the removal efficiency can reach as high as 62.0% while the removal efficiency of original chitosan is only 16.0%. μThe probes have good selective detection for Fe3+ and the detection limit reaches 1.2 M.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Fluorescence activation, patterning and enhancement with photogenerated radicals, a prefluorescent probe and silver nanostructures, the main research direction is fluorescent probe optical reflection silver nanoparticles.Application In Synthesis of 2,4-Dimethyl-1H-pyrrole.

We synthesized a dual fluorogenic system based on a boron-dipyrromethene (BODIPY) dye coupled with a paramagnetic 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) nitroxide. Electron exchange facilitates the non-radiative relaxation of the singlet state of the chromophore, partially quenching the fluorescence from the BODIPY moiety. Nonetheless, the system can be activated in solution or thin polymer films by UV (UVA) light in the presence of a free radical initiator. UVA illumination promotes the decomposition of the initiator, resulting in the release of a carbon-centered free radical. The dye-TEMPO probe can concomitantly trap the radical or undergo H-abstraction. Both processes consequently turn on the fluorescence and are reversible in nature. We used this protocol to optically imprint a fluorescent pattern on a surface. Moreover, we investigated metal-enhanced fluorescence (MEF) effects by silver nanostructures (AgNP) as a means to improve the performance of our mol. strategy for fluorescence activation. Overall, this work contributes toward the development of improved nanoparticle-dye systems for applications of light-activated fluorescence such as multicolor fluorescence patterning and microscopy, where shorter reaction times, milder conditions, reversibility and a more diverse selection of both excitation sources and emission wavelengths are beneficial.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 625-82-1. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Cu-catalyzed click conjugation of cobalamin to a BODIPY-based fluorophore: A versatile tool to explore the cellular biology of vitamin B12. Author is Haghdoost, Mohammad Mehdi; Sauvageau, Etienne; Oguadinma, Paul; Tran, Hoang-Van; Lefrancois, Stephane; Castonguay, Annie.

The Cu-catalyzed click conjugation of an azide-functionalized vitamin B12 (cobalamin) and an alkyne-labeled 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) gave a highly stable fluorescent BODIPY-labeled vitamin B12 (λex/λem = 495/508 nm). The formation of what has been identified as an iodine adduct of the conjugate was also observed as a side-product during this reaction and could be removed using HPLC. BODIPY-labeled vitamin B12 was characterized by NMR and HR-ESI-MS. In vitro studies on wild-type human fibroblasts indicated that BODIPY-labeled vitamin B12 could internalize in a manner similar to that of untagged vitamin B12. ATP-binding cassette sub-family D member 4 (ABCD4) is a lysosomal localized transporter required to export vitamin B12 from the lysosomal lumen to the cytosol. Mutations in this transporter result in the accumulation of vitamin B12 in lysosomes. In human fibroblasts harbouring a mutation in ABCD4, BODIPY-labeled vitamin B12 accumulated in the lumen of lysosomes. The authors′ data suggests the potential use of BODIPY-labeled vitamin B12 to study the intracellular behavior of the vitamin in the context of disorders related to the abnormal cellular use of the vitamin. Moreover, results presented here demonstrate that click chem. could be exploited for the conjugation of vitamin B12 to various other fluorophores.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 625-82-1. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2,4-Dimethyl-1H-pyrrole, is researched, Molecular C6H9N, CAS is 625-82-1, about Boron-dipyrromethene derivatives bearing N-alkyl phthalimide and amine substituents of potential application in the photoinactivation of bacteria. Author is Piskorz, Jaroslaw; Dlugaszewska, Jolanta; Porolnik, Weronika; Teubert, Anna; Mielcarek, Jadwiga.

Novel boron-dipyrromethene derivatives with N-alkyl phthalimide and amine substituents, including iodinated derivative, were synthesized and characterized using UV-Vis spectrophotometry, mass spectrometry (HRMS) and NMR spectroscopy. Non-iodinated analogs revealed high emission properties with fluorescence quantum yields (ΦF) between 0.48 and 0.58. But singlet oxygen generation quantum yields (ΦΔ) were low with values in the range of 0.01-0.06. Iodinated derivative revealed a strong heavy atom effect resulted in the red-shifted absorption and emission bands, fluorescence quenching with ΦF values of about 0.02, but increased singlet oxygen generation abilities with excellent ΦΔ values of 0.97 and 0.85 in methanol and ethanol, resp. In vitro photodynamic inactivation activity was evaluated on Gram-pos. cocci of Staphylococcus aureus and Gram-neg. rods of Escherichia coli. Novel BODIPY derivatives showed promising inactivation efficiency on S. aureus, with the highest activity for iodinated derivative, which reduced the number of bacteria by 3.6 logs10 at low 0.5 μM concentration However, none of the tested derivatives showed a satisfactory ability to eradicate E. coli. Only non-iodinated derivative with amine substituent, at high concentrations, showed some significant activity with log10 reduction values of 2.0 and 1.1 at 500 and 50 μM, resp. Nevertheless, the presented approach enabled to obtain novel BODIPY derivatives with promising photoinactivation activity and properties such as fluorescence and singlet oxygen generation efficacy, easy to modify by the heavy atom substitution. Also, peripheral phthalimide or amine groups can be used for further structural modifications.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem