Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article Additive- and Oxidant-Free Expedient Synthesis of Benzimidazoles Catalyzed by Cobalt Nanocomposites on N-Doped Carbon published in 2019.0. Category: pyridine-derivatives, Reprint Addresses Yang, Y (corresponding author), Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key CAS Lab Biobased Mat, Qingdao 266101, Shandong, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A one-pot direct synthesis of a wide range of biologically active benzimidazoles through coupling of phenylenediamines and aldehydes catalyzed by a highly recyclable nonnoble cobalt nanocomposite was developed. A broad set of benzimidazoles can be efficiently synthesized in high yields and with good functional-group tolerance under additive- and oxidant-free mild conditions. The catalyst can be easily recycled for successive uses, and the process permits gram-scale syntheses of benzimidazoles.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles WOS:000455286100019 published article about CROSS-COUPLING REACTIONS; DIRECT C-2 ARYLATION; INTRAMOLECULAR CYCLIZATION; BIOLOGICAL EVALUATION; BOND FORMATION; ARYL HALIDES; INDOLES; GENERATION; AMINES; CONSTRUCTION in [Bzeih, Tourin; Zhang, Kena; Alami, Mouad; Hamze, Abdallah] Univ Paris Sud, Fac Pharm, CNRS, LabEx LERMIT,Lab Chim Therapeut,BioCIS UMR 8076, Rue JB Clement, F-92296 Chatenay Malabry, France; [Bzeih, Tourin; Khalaf, Ali; Hachem, Ali] Lebanese Univ, Lab Med Chem & Nat Prod, Fac Sci 1, Hadath, Lebanon; [Bzeih, Tourin; Khalaf, Ali; Hachem, Ali] Lebanese Univ, PRASE EDST, Hadath, Lebanon in 2019, Cited 65. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A one-pot Barluenga coupling between N-tosylhydrazones and nitro-benzyl bromide, followed by deoxygenation of ortho-nitrostyrenes, and subsequent cyclization has been developed, providing a new way to synthesize various C2-arylindoles. This method exhibits a good substrate scope and functional group tolerance, and it allows an access to NH-free indoles, which can present a potential utility in medicinal chemistry applications.

Recommanded Product: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Bzeih, T; Zhang, KN; Khalaf, A; Hachem, A; Alami, M; Hamze, A or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Iodine-DMSO-Catalyzed Chemoselective Biomimetic Aromatization of Tetrahydro-beta-carbolines-3-carboxylic Acid: Mechanism Study with DFT-Calculation WOS:000490895800024 published article about TETRAHYDRO-BETA-CARBOLINES; EUDISTOMIN-U; BIOLOGICAL EVALUATION; ASSISTED SYNTHESIS; ALKALOIDS; NORHARMANE; HARMANE; DERIVATIVES; UTILITY; OXIDATIONS in [Gaikwad, Sunil, V; Devkate, Manisha; Joshi, Rekha; Shinde, Rohit G.; Nikalje, Milind D.; Lokhande, Pradeep D.] Savitribai Phule Pune Univ, Ctr Adv Studies, Dept Chem, Pune 411007, Maharashtra, India; [Nadimetla, Dinesh N.; Bhosale, Sheshanath, V] Goa Univ, Sch Chem Sci, Taleigao Plateau 403206, Goa, India; [Al Kobaisi, Mohammad] Swinburne Univ Technol, Dept Chem & Biotechnol, FSET, Hawthorn, Vic 3122, Australia; [Gaikwad, Milind, V] Dr DY Patil ACS Coll, Dept Chem, Pune 411018, Maharashtra, India in 2019.0, Cited 57.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

A new protocol for the chemoselective aromatization of tetrahydro-beta-carboline-3-carboxylic acids to direct biomimetic one step synthesis of beta-carboline-3-carboxylic acids 2 A-L using catalytic amount of I-2 in DMSO/H+ produces very good yield. This method was also successfully extended for the aromatization of tetrahydro-beta-carboline-3-methyl esters 5 A-G as well as one-step synthesis of Marinacarbolines-D analog, respectively. Further, the mechanism and role of iodine-DMSO in aromatization has been studied by Density Functional Theory Calculation.

Recommanded Product: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Gaikwad, SV; Nadimetla, DN; Al Kobaisi, M; Devkate, M; Joshi, R; Shinde, RG; Gaikwad, MV; Nikalje, MD; Bhosale, SV; Lokhande, PD or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C6H5NO. In 2020.0 BIOORGAN MED CHEM published article about ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; ORIENTED SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; 1-METHYL-3-OXIDOPYRIDINIUM; CHEMISTRY; DISCOVERY; PRODUCTS; KETONES in [Lowe, Robert A.; Nelson, Adam] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England; [Lowe, Robert A.; Nelson, Adam; Marsden, Stephen P.] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England; [Taylor, Dale] Univ Cape Town, H3D Drug Discovery & Dev Ctr, ZA-7700 Rondebosch, South Africa; [Chibale, Kelly] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa; [Chibale, Kelly] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7701 Rondebosch, South Africa; [Chibale, Kelly] Univ Cape Town, South African Med Res Council, Drug Discovery & Dev Res Unit, ZA-7701 Rondebosch, South Africa in 2020.0, Cited 50.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxy-pyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-related scaffolds were formed by addition of substituents to, cyclisation reactions of, and fusion of additional ring(s) to the key bicyclic intermediates. A set of 53 screening compounds was designed, synthesised and evaluated in order to determine the biological relevance of the scaffolds accessible using the synthetic approach. Two inhibitors of Hedgehog signalling, and four compounds with weak activity against the parasite P. falciparum, were discovered. Three of the active compounds may be considered to be indotropane or pyrrotropane pseudo natural products in which a tropane is fused with a fragment from another natural product class. It was concluded that the unified synthetic approach had yielded diverse scaffolds suitable for the design of performance-diverse screening libraries.

Welcome to talk about 500-22-1, If you have any questions, you can contact Lowe, RA; Taylor, D; Chibale, K; Nelson, A; Marsden, SP or send Email.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Ramaiah, MM; Shivananju, NS; Shubha, PB in [Ramaiah, Manjunatha M.; Shubha, Priya Babu] Univ Mysore, Dept Studies Chem, Mysuru 570006, Karnataka, India; [Shivananju, Nanjunda Swamy] JSS Sci & Technol Univ, Dept Biotechnol, JSS Tech Inst Campus, Mysuru 570006, Karnataka, India published A Facile, Efficient and Solvent-Free Titanium (IV) Ethoxide Catalysed Knoevenagel Condensation of Aldehydes and Active Methylenes in 2020.0, Cited 65.0. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Titanium ethoxide has been employed as a novel and efficient reagent for the Knoevenagel condensation of aldehydes with active methylenes such as diethyl malonate and ethyl cyanoacetate under solvent free conditions to afford substituted olefins in high to excellent yields. The reaction is suitable for a variety of aromatic, aliphatic and heteroaromatic aldehydes with various active methylenes. Parallel to this, microwave irradiation has been utilized to achieve improved reaction rates and enhanced yields. Herein, we illustrated a convenient method for the preparation of alpha,beta-unsaturated compounds using both conventional and microwave irradiation methods. An efficient and solvent free Knoevenagel condensation between aldehydes and active methylenes was developed using titanium ethoxide. The procedure proved to be successful with a wide range of substrates such as aromatic, aliphatic and heterocyclic aldehydes and various active methylenes to afford substituted olefins. The reaction was also carried out under microwave irradiation to accomplish the corresponding olefins with improved reaction rates, yields and cleaner reaction profiles.We have developed an efficient and novel methodology for the synthesis of olefinic compounds by Knoevenagel condensation under solvent-free conditions using titanium ethoxide, for the first time, as a reagent as well as a solvent. This method is appropriate for the synthesis of a variety of aromatic aldehydes containing various electron-donating and withdrawing groups, aliphatic and heteroaromatic aldehydes. The significant advantages offered by this methodology could be applied to various active methylenes in order to offer the corresponding Knoevenagel products. Thus, we believe that this method delivers high conversions, cleaner reaction profiles under solvent-free reaction conditions and shorter reaction times, all of which make it a very useful and attractive approach for the preparation of a wide range of substituted olefins.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis and biological evaluation of novel N-9-heterobivalent beta-carbolines as angiogenesis inhibitors WOS:000454743400001 published article about ANTICANCER ACTIVITY; DNA-BINDING; HARMINE DERIVATIVES; TRIOXANE DIMERS; IN-VITRO; DESIGN; CYTOTOXICITY; APOPTOSIS; EFFICACY; B-9-3 in [Guo, Liang; Zhang, Jie; Dai, Bin] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn XinJiang Bingtuan, Shihezi 832000, Peoples R China; [Ma, Qin; Chen, Wei; Fan, Wenxi] XinJiang Huashidan Pharmaceut Res Co Ltd, Urumqi, Peoples R China in 2019.0, Cited 34.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives

A series of novel N-9-heterobivalent beta-carbolines has been synthesized. All the novel compounds were tested for their anticancer activity against six tumour cell lines in vitro. Among these molecules, compounds 5b, and 5w exhibited strong cytotoxic activities with IC50 value of lower than 20 mu M. Acute toxicities and antitumor efficacies of the selected compounds in mice were also evaluated, compounds 5b and 5w exhibited that tumour inhibition rate of over 40% in the Sarcoma 180 and Lewis lung cancer animal models. Preliminary structure-activity relationships (SARs) analysis indicated that: (1) C-1-methylation and C-7-methoxylation were favorable for increased activities; (2) 3-Pyridyl or 2-thienyl group substituent into position-1 of the beta-carboline core, and the aryl substituent into another beta-carboline ring might be detrimental to cytotoxic effects of this class compounds. Investigation of the preliminary mechanism of action demonstrated that compound 5b had obvious angiogenesis inhibitory effects in the chicken chorioallantoic membrane (CAM) assay.

Category: pyridine-derivatives. Welcome to talk about 500-22-1, If you have any questions, you can contact Guo, L; Ma, Q; Chen, W; Fan, WX; Zhang, J; Dai, B or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 500-22-1. Kurva, M; Kerim, MD; Gamez-Montano, R; El Kaim, L in [Kurva, Mahanandaiah; Kerim, Mansour Dole; El Kaim, Laurent] Ecole Polytech, Inst Polytech Paris, Lab Synth Organ, CNRS,ENSTA Paris,UMR 7652, 828 Bd Marechaux, F-91128 Palaiseau, France; [Kurva, Mahanandaiah; Gamez-Montano, Rocio] Univ Guanajuato, Dept Quim, Noria Alta S-N, Guanajuato 36050, Gto, Mexico published Straightforward access to complex isoindolinones from the Ugi reaction of o-nitrobenzoic acid derivatives in 2019.0, Cited 36.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The Ugi reaction of 2-nitrobenzoic acid derivatives has been used for a diversity oriented synthesis of complex isoindolinones via a SNAr reaction involving the peptidyl position. When the cyclization is triggered by strong bases such as potassium tert-butylate, the SNAr reaction is followed by a deamidification/oxidation sequence leading to 2-hydroxyisoindolinones. The latter may be further transformed into polycyclic fused isoindolinones via Pictet-Spengler type cyclization or O-alkylation/metathesis sequences.

SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kurva, M; Kerim, MD; Gamez-Montano, R; El Kaim, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. In 2020.0 CHEMMEDCHEM published article about CAFFEIC ACID-ESTERS; ANTILEISHMANIAL ACTIVITIES; TRYPANOSOMA-BRUCEI; PHENOLIC-COMPOUNDS; IN-VITRO; ASSAY; ESTERIFICATION; RHODESIENSE; SENSITIVITY; CATALYSTS in [Bernal, Freddy A.; Schmidt, Thomas J.] Westfalische Wilhelms Univ Munster, IPBP, Corrensstr 48, D-48149 Munster, Germany; [Kaiser, Marcel] Swiss Trop & Publ Hlth Inst Swiss TPH, Socinstr 57, CH-4051 Basel, Switzerland; [Kaiser, Marcel] Univ Basel, Peterspl 1, CH-4003 Basel, Switzerland; [Wuensch, Bernhard] Westfalische Wilhelms Univ Munster, Inst Pharmazeut & Med Chem, Corrensstr 48, D-8149 Munster, Germany in 2020.0, Cited 51.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Protozoal infections are still a global health problem, threatening the lives of millions of people around the world, mainly in impoverished tropical and sub-tropical regions. Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure-activity relationships. In general, Leishmania donovani and Trypanosoma brucei were quite susceptible to the compounds in a structure-dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro-aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high in vitro potency of catechol-type compounds against T. brucei could not be extrapolated to an in vivo mouse model.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. Fouda, AM; Youssef, AMS; Afifi, TH; Mora, A; El-Agrody, AM in [Fouda, Ahmed M.; Youssef, Ayman M. S.] King Khalid Univ, Fac Sci, Chem Dept, Abha 61413, Saudi Arabia; [Youssef, Ayman M. S.] Fayoum Univ, Fac Sci, Chem Dept, Al Fayyum, Egypt; [Afifi, Tarek H.] Taibah Univ, Fac Sci, Chem Dept, Al Madinah Al Munawarah 30002, Saudi Arabia; [Mora, Ahmed; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Nar City 11884, Cairo, Egypt published Cell cycle arrest and induction of apoptosis of newly synthesized pyranoquinoline derivatives under microwave irradiation in 2019, Cited 47. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A set of 2-amino-4-aryl-4H-pyrano[3,2-h]quinoline-3-carbonitrile derivatives were prepared via a one-pot, three-component condensation reaction between the substituted hydroxyquinoline derivatives, some aryl and/or hetaryl aldehydes, and malononitrile in an ethanol/piperidine solution in a microwave irradiation environment. The structure of the prepared compounds was instituted on the foundations of their spectral data: IR, H-1 NMR, C-13 NMR, and MS. Four human cancer cell lines, MCF-7, HCT-116, HepG-2, and A549 were utilized to evaluate the antiproliferative properties of the target compounds in comparison to the positive controls, Vinblastine and Colchicine using the MTT viability assay. The cell cycle arrest behavior, detected by propidium iodide as well as the apoptosis induction, which was monitored by the flow cytometer, using the Annexin V-FITC kits, was investigated. The results illustrated that the potent cytotoxic compounds induce cell cycle arrest at the G2/M phases and trigger apoptosis in the different tested cancer cells. Finally, the structure-activity relationship (SAR) study showcases the substitution of some specific groups at the 4-, 6-, and 9-positions in the prepared 2-amino-4H-pyrano[3,2-h]quinoline derivatives, which indicates that the lipophilicity manipulates the ability of these moieties against the diverse cell lines.

Quality Control of 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 500-22-1. I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Application of the Cu(i)/TEMPO/O-2 catalytic system for aerobic oxidative dehydrogenative aromatization of pyrrolidines published in 2019.0, Reprint Addresses Hu, HY (corresponding author), Huaiyin Normal Univ, Jiangsu Key Lab Chem Lowdimens Mat, Sch Chem & Chem Engn, Huaian 223300, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

A Cu(i)/TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy)-catalyzed aerobic oxidative dehydrogenative aromatization reaction of fully saturated pyrrolidines to synthesize multi-substituted pyrroles was developed for the first time. The use of a non-precious metal catalyst, green oxidant and environmentally friendly solvent made the reaction more sustainable.

Welcome to talk about 500-22-1, If you have any questions, you can contact Luo, Z; Liu, Y; Wang, C; Fang, DJ; Zhou, JY; Hu, HY or send Email.. SDS of cas: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem