Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article Selective oxidation of alcohols by porphyrin-based porous polymer-supported manganese heterogeneous catalysts published in 2020.0. Name: 3-Pyridinecarboxaldehyde, Reprint Addresses Zhu, DJ; Li, T (corresponding author), Huazhong Univ Sci & Technol, Hubei Key Lab Mat Chem & Serv Failure, 1073 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China.; Zhu, DJ; Li, T (corresponding author), Huazhong Univ Sci & Technol, Minist Educ, Key Lab Mat Chem Energy Convers & Storage, 1073 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China.; Zhu, DJ; Li, T (corresponding author), Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, 1073 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A series of porphyrin-based porous polymers to support Mn heterogeneous catalysts (Mn/TFP-DPM, Mn/TFP-DPM-2, Mn/TFP-DPM-3, and Mn/TFP-DPM-4) in the selective oxidation of alcohols were designed. TFP-DPM and TFP-DPM-2 demonstrated micro/nanoscale spherical morphology, whereas TFP-DPM-3 and TFP-DPM-4 exhibited nanosheets structure. According to surface area and porosity analysis results, the specific surface areas of these catalysts were less than 300 m(2) g(-1). Thermogravimetric analysis indicated that the synthesized catalysts maintain their stability even at 300 degrees C. Catalysts Mn/TFP-DPM and Mn/TFP-DPM-3, which had the smallest and largest specific surface area among the four catalysts, respectively, were used to perform selective oxidation reaction of alcohols, with experimental results indicating that both have excellent catalytic performance. As these catalysts possess good catalytic performance despite their low specific surface area, we suggest that porphyrin-based porous polymer-supported Mn heterogeneous catalysts are promising materials for selective oxidation of alcohols.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Chen, J; Zhang, Y; Zhu, DJ; Li, T or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Son, WS; Jeong, KS; Lim, SM; Pae, AN in [Son, Woo Seung; Lim, Sang Min; Pae, Ae Nim] Korea Inst Sci & Technol, Convergence Res Ctr Diag Treatment & Care Syst De, 5,Hwarang Ro 14 Gil, Seoul 02792, South Korea; [Son, Woo Seung; Jeong, Kyu-Sung] Yonsei Univ, Dept Chem, 50 Yonsei Ro, Seoul 03722, South Korea; [Lim, Sang Min; Pae, Ae Nim] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, 5,Hwarang Ro 14 Gil, Seoul 02792, South Korea published Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model in 2019.0, Cited 30.0. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Highly effective and safe drugs for the treatment of neuropathic pain are urgently required and it was shown that blocking T-type calcium channels can be a promising strategy for drug development for neuropathic pain. We have developed pyrrolidine-based T-type calcium channel inhibitors by structural hybridization and subsequent assessment of in vitro activities against Ca(v)3.1 and Ca(v)3.2 channels. Profiling of in vitro ADME properties of compounds was also carried out. The representative compound 17h showed comparable in vivo efficacy to gabapentin in the SNL model, which indicates T-type calcium channel inhibitors can be developed as effective therapeutics for neuropathic pain.

Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Son, WS; Jeong, KS; Lim, SM; Pae, AN or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. In 2020.0 ORG BIOMOL CHEM published article about PURE LITHIUM AMIDES; TERT-BUTANESULFINYL IMINES; AZA-MICHAEL REACTION; ASYMMETRIC-SYNTHESIS; DIASTEREOSELECTIVE ADDITION; AMMONIA EQUIVALENTS; ENANTIOSELECTIVE SYNTHESIS; MEDIATED ALLYLATION; ALKALOIDS; ACCESS in [Vasse, Jean-Luc] CNRS, Inst Chim Mol Reims, UMR 7312, F-51687 Reims 2, France; Univ Reims, F-51687 Reims 2, France in 2020.0, Cited 66.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The diastereoselective conjugate addition of secondary homo-allylamines, obtained in the enantioenriched form via allylmetallation of imines, to alpha,beta-unsaturated esters is reported. This method allows access to valuable building blocks as well as heterocyclic skeletons, providing tertiary amines bearing two chains integrating a stereogenic center adjacent to the nitrogen atom.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Rogier, J; Anani, L; Coelho, A; Massicot, F; Machado-Rodrigues, C; Behr, JB; Vasse, JL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article A [bmim]Cl-promoted domino protocol using an isocyanide-based [4+1]-cycloaddition reaction for the synthesis of diversely functionalized 3-alkylamino-2-alkyl/aryl/hetero-aryl indolizine-1-carbonitriles under solvent-free conditions WOS:000518019300009 published article about IONIC LIQUID; MULTICOMPONENT SYNTHESIS; EFFICIENT CATALYST; C-C; INDOLIZINES; DERIVATIVES; ALKYNES; ACCESS; AMINES; CYCLIZATION in [Atar, Amol Balu; Kang, Jongmin] Sejong Univ, Dept Chem, Seoul 143747, South Korea; [Jadhav, Arvind H.] Jain Univ, CNMS, Jain Global Campus, Bangalore 562112, Karnataka, India in 2020.0, Cited 63.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A domino protocol involving aldehydes, isocyanides and 2-pyridylacetonitrile in the presence of [bmim]Cl as a promoter and solvent for the synthesis of 3-alkylamino-2-alkyl/arylindolizine-1-carbonitriles is described. A wide range of alkyl, aryl and hetero-aryl aldehydes reacted with 2-pyridylacetonitrile and isocyanides, leading to indolizine derivatives with high selectivity, high atom economy, and good to excellent yields. This straight-forward and highly efficient method allows the synthesis of bis-indolizine-1-carbonitrile derivatives.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Atar, AB; Kang, J; Jadhav, AH or concate me.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Reduction of Aldehydes with Formic acid in Ethanol using Immobilized Iridium Nanoparticles on a Triazine-phosphanimine Polymeric Organic Support WOS:000546724300001 published article about EFFICIENT HETEROGENEOUS CATALYST; CHEMOSELECTIVE REDUCTION; SELECTIVE HYDROGENATION; LIGAND; COMPLEXES; DEHYDROGENATION; ADSORPTION; KETONES; DESIGN; CARBON in [Panahi, Farhad; Haghighi, Fatemeh; Khalafi-Nezhad, Ali] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 71454, Iran in 2020.0, Cited 59.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A novel triazine-phosphanimine polymeric organic support (TPA) was synthesized successfully by a controllable one-pot method using melamine (1,3,5-triazine-2,4,6-triamine) and trichlorophosphane (PCl3). The TPA substrate is a material incorporating P and N atoms which can coordinate with metals as a pincer ligand to stabilize them, providing an efficient heterogeneous support to prepare recyclable transition metal catalyst systems. In this study, TPA was used as support to immobilize iridium nanoparticles in the range of similar to 8 nm on its surface, resulting in the generation of a novel iridium nanocatalyst system (INP-TPA-POP). This catalyst system was characterized using different microscopic and spectroscopic techniques such as FT-IR, TEM, XPS, XRD, SEM, EDX, elemental analysis, ICP and BET analysis. The INP-TPA-POP nanocatalyst exhibited remarkable activity in reduction of aldehydes to alcohols using formic acids as reducing agent in ethanol as solvent.

COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Panahi, F; Haghighi, F; Khalafi-Nezhad, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Latham, DE; Polidano, K; Williams, JMJ; Morrill, LC in AMER CHEMICAL SOC published article about ASYMMETRIC ISOMERIZATION; REDOX ISOMERIZATION; COMPLEXES SYNTHESIS; ORGANIC-SYNTHESIS; N-ALKYLATION; METHANOL; HYDROGENATION; AMINES; FUNCTIONALIZATION; HYDROMETHYLATION in [Latham, Daniel E.; Polidano, Kurt; Morrill, Louis C.] Cardiff Univ, Cardiff Catalysis Inst, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3AT, S Glam, Wales; [Williams, Jonathan M. J.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England in 2019.0, Cited 83.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A one-pot iron-catalyzed conversion of allylic alcohols to alpha-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentad-ienone)iron(0) carbonyl complex as precatalyst and methanol as the Cl source. A diverse range of allylic alcohols undergoes isomerization-methylation to form alpha-methyl ketones in good isolated yields (up to 84% isolated yield).

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Latham, DE; Polidano, K; Williams, JMJ; Morrill, LC or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about MULTICOMPONENT REACTIONS; CONVERTIBLE ISOCYANIDE; RAPID ACCESS; CONDENSATION, Saw an article supported by the CONACYTConsejo Nacional de Ciencia y Tecnologia (CONACyT) [632715/338546, 285622 CB-2016-28562]; Laboratorio Nacional de Caracterizacion de Propiedades Fisicoquimicas y Estructura Molecular (CONACYT-Mexico) [123732]; ENSTA Paris. Product Details of 500-22-1. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Kurva, M; Kerim, MD; Gamez-Montano, R; El Kaim, L. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The Ugi reaction of 2-nitrobenzoic acid derivatives has been used for a diversity oriented synthesis of complex isoindolinones via a SNAr reaction involving the peptidyl position. When the cyclization is triggered by strong bases such as potassium tert-butylate, the SNAr reaction is followed by a deamidification/oxidation sequence leading to 2-hydroxyisoindolinones. The latter may be further transformed into polycyclic fused isoindolinones via Pictet-Spengler type cyclization or O-alkylation/metathesis sequences.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kurva, M; Kerim, MD; Gamez-Montano, R; El Kaim, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo WOS:000500420100020 published article about GONADOTROPIN; EXPRESSION; OVARIAN; CELLS; PATHOGENESIS; SOLUBILITY; INHIBITORS; GENE in [Wortmann, Lars; Lindenthal, Bernhard; Muhn, Peter; Walter, Alexander; Nubbemeyer, Reinhard; Heldmann, Dieter; Sobek, Lothar; Moosmayer, Dieter; Guenther, Judith; Kuhnke, Joachim; Koppitz, Marcus; Luecking, Ulrich; Roehn, Ulrike; Schaefer, Martina; Nowak-Reppel, Katrin; Weinmann, Hilmar; Langer, Gernot] Bayer AG, Res & Dev, Pharmaceut, D-13353 Berlin, Germany; [Morandi, Federica; Schrey, Anna K.; Kuehne, Ronald] Leibniz Forsch Inst Mol Pharmakol FMP, Robert Rossle Str 10,Campus Berlin Buch, D-13125 Berlin, Germany in 2019.0, Cited 56.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The human luteinizing hormone receptor (hLH-R) is a member of the glycoprotein hormone family of G-protein-coupled receptors (GPCRs), activated by luteinizing hormone (hLH) and essentially involved in the regulation of sex hormone production. Thus, hLH-R represents a valid target for the treatment of sex hormone dependent cancers and diseases (polycystic ovary syndrome, uterine fibroids, endometriosis) as well as contraception. Screening of the Bayer compound library led to the discovery of tetrahydrothienopyridine derivatives as novel, small molecule (SMOL) hLH-R inhibitors and to the development of BAY-298, the first nanomolar hLH-R antagonist reducing sex hormone levels in vivo. Further optimization of physicochemical, pharmacokinetic, and safety parameters led to the identification of BAY-899 with an improved in vitro profile and proven efficacy in vivo. BAY-298 and BAY-899 serve as valuable tool compounds to study hLH-R signaling in vitro and to interfere with the production of sex hormones in vivo.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wortmann, L; Lindenthal, B; Muhn, P; Walter, A; Nubbemeyer, R; Heldmann, D; Sobek, L; Morandi, F; Schrey, AK; Moosmayer, D; Gunther, J; Kuhnke, J; Koppitz, M; Lucking, U; Rohn, U; Schafer, M; Nowak-Reppel, K; Kuhne, R; Weinmann, H; Langer, G or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Lin, SS; Zhang, LY; Zhang, X; Yu, ZL; Huang, XW; Xu, JH; Liu, Y; Chen, LM; Wu, LX in [Lin, Shanshan; Zhang, LingYu; Zhang, Xiao; Yu, Zelei; Huang, Xiuwang; Xu, Jianhua; Wu, Lixian] FMU, Sch Pharm, Dept Pharmacol, Fuzhou, Peoples R China; [Lin, Shanshan; Zhang, LingYu; Zhang, Xiao; Yu, Zelei; Xu, Jianhua; Liu, Yang; Chen, Limin; Wu, Lixian] FMU, Inst Mat Med, Fuzhou, Peoples R China; [Lin, Shanshan; Zhang, LingYu; Zhang, Xiao; Yu, Zelei; Huang, Xiuwang; Xu, Jianhua; Liu, Yang; Chen, Limin; Wu, Lixian] FMU, Fujian Key Lab Nat Med Pharmacol, Fuzhou, Peoples R China; [Huang, Xiuwang] FMU, Dept Publ Technol Serv Ctr, Fuzhou, Peoples R China; [Liu, Yang; Chen, Limin] FMU, Sch Pharm, Dept Pharmacochem, Fuzhou, Peoples R China published Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities in 2020.0, Cited 21.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Poly (ADP-ribose) polymerase (PARP) inhibitors have achieved great success in clinical application, especially for the prolonged survival of cisplatin-sensitive ovarian cancer patients. However, there are still many patients who do not respond to PARP inhibitors. Novel PARP inhibitors with higher activity are urgently needed. Herein we report a series of compounds by molecular hybridization PARP-1 inhibitor Olaparib (Ola) with HSP90 inhibitor C0817 (one curcumin derivative). All synthesized compounds were evaluated for their antiproliferative activity in vitro, and some were further assessed for their inhibitory activities of the PARP enzyme and HSP90 affinity. Our results indicated that compound 4 could bind to HSP90 and cause static quenching, indicating that compound 4 was able to bind to HSP90, moreover, downstream molecular breast cancer 1 (BRAC-1) was reduced. In conclusion, dual target inhibitors of PARP and HSP90 exhibited stronger selective cytotoxicities against cancer.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Lin, SS; Zhang, LY; Zhang, X; Yu, ZL; Huang, XW; Xu, JH; Liu, Y; Chen, LM; Wu, LX or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 3-Pyridinecarboxaldehyde. Recently I am researching about UNACTIVATED ALKYL-HALIDES; GRIGNARD-TYPE ADDITION; C-H BONDS; CARBONYL-COMPOUNDS; ORGANIC-REACTIONS; ALPHA,BETA-UNSATURATED KETONES; QUATERNARY CENTERS; IN-SITU; ORGANOINDIUM REAGENTS; ASYMMETRIC-SYNTHESIS, Saw an article supported by the Nanjing Tech University [39837118]; Yancheng Teachers University; Nanjing Forestry University. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Wu, Z; Feng, XX; Wang, QD; Liu, XY; Rao, WD; Yang, JM; Shen, ZL. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

An efficient water-based bismuth-mediated addition reaction of carbonyl compound with cyclic allylic halide was developed. The reactions proceeded smoothly in aqueous DMF in the presence of ammonium iodide to afford the corresponding syn-homoallylic alcohols in moderate to good yields with excellent diastereoselectivities (>99:1 syn:anti). Reversal of product diastereoselectivity was observed when heteroaryl aldehyde possessing an adjacent chelating nitrogen atom was employed as substrate. 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Recommanded Product: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wu, Z; Feng, XX; Wang, QD; Liu, XY; Rao, WD; Yang, JM; Shen, ZL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem