Tag: M.W=100-150

COA of Formula: C6H5NO. Recently I am researching about SOLID PHARMACEUTICAL FORMULATIONS; RECEPTOR-BINDING-AFFINITY; MOLECULAR-DYNAMICS; DRUG DISCOVERY; ANTIMYCOBACTERIAL ACTIVITY; ANTITUBERCULAR ACTIVITY; ANTIPLATELET ACTIVITY; METHYL CELLULOSE; DESIGN; AMINOETHERS, Saw an article supported by the . Published in FUTURE SCI LTD in LONDON ,Authors: Papageorgiou, A; Foscolos, AS; Papanastasiou, IP; Vlachou, M; Siamidi, A; Vocat, A; Cole, ST; Kellici, TF; Mavromoustakos, T; Tsotinis, A. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Aim: There is a necessity for new drugs to be more efficient than today’s standard due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) Results/methodology: 12 new isoniazid-based adamantane derivatives were synthesized and tested for their antitubercular activity. The pharmacological test results and the aqueous dissolution profile of representative examples of the new molecules are in agreement with the computational results obtained from docking poses and molecular dynamics simulations on the tested compounds. Conclusion: Among their congeners, the adamantane isonicotinoyl hydrazones Ia and Ih exhibit the best antitubercular activity (MIC = 0.04 mu g/ml) and the lowest cytotoxicity (selectivity index >= 2500). These results are useful for in future in vivo studies.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Papageorgiou, A; Foscolos, AS; Papanastasiou, IP; Vlachou, M; Siamidi, A; Vocat, A; Cole, ST; Kellici, TF; Mavromoustakos, T; Tsotinis, A or concate me.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. In 2020.0 EUR J MED CHEM published article about NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; RAW 264.7; CHALCONE DERIVATIVES; BIOLOGICAL EVALUATION; SUPEROXIDE-DISMUTASE; CELL; KAVA; SUPPRESSION; ARTHRITIS in [Yang, Youzhe; Teichmann, Alexander Tobias; Wieland, Frank Heinrich] Southwest Med Univ, Sichuan Prov Ctr Gynaecol & Breast Dis, Affiliated Hosp, Luzhou 646000, Peoples R China; [Yang, Youzhe; Wei, Zhe; Chen, Lijuan] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China; [Yang, Youzhe; Wei, Zhe; Chen, Lijuan] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China; [Yang, Youzhe; Wei, Zhe; Chen, Lijuan] Collaborat Innovat Ctr, Chengdu 610041, Peoples R China; [Yang, Youzhe; Fan, Tiantian; Zhou, Li; Wang, Chao] Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Peoples R China; [Wang, Amu; Lei, Xiangui; Zhu, Yue; Yin, Jinxiang] Xihua Univ, Sch Sci, Chengdu 610039, Peoples R China in 2020.0, Cited 68.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Inflammation is a complex biological response to stimuli. Activated macrophages induced excessively release of pro-inflammatory cytokines and mediators such as endogenous radical nitric oxide (NO) play a significant role in the progression of multiple inflammatory diseases. Both natural and synthetic chalcones possess a wide range of bioactivities. In this work, thirty-nine chalcones and three related compounds, including several novel ones, based on bioactive kava chalcones were designed, synthesized and their inhibitory effects on NO production in RAW264.7 cells were evaluated. The novel compound (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3-methoxy-4-(3-morpholinopropoxy)phenyl)prop-2-en-1-one (53) exhibited a better inhibitory activity (84.0%) on NO production at 10 mu M (IC50 = 6.4 mu M) with the lowest cytotoxicity (IC50 > 80 mu M) among the tested compounds. Besides, western blot analysis indicated that compound 53 was a potent down-regulator of inducible nitric oxide synthase (iNOS) protein. Docking study revealed that compound 53 also can dock into the active site of iNOS. Furthermore, at the dose of 10 mg/kg/day, compound 53 could both significantly suppress the progression of inflammation on collagen-induced arthritis (CIA) and adjuvant-induced arthritis (AIA) models. In addition, the structure-activity relationship (SAR) of the kava chalcones based analogs was also depicted. (c) 2020 Elsevier Masson SAS. All rights reserved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Yang, YZ; Wei, Z; Teichmann, AT; Wieland, FH; Wang, A; Lei, XG; Zhu, Y; Yin, JX; Fan, TT; Zhou, L; Wang, C; Chen, LJ or concate me.. Computed Properties of C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Ling, F; Chen, JC; Xie, Z; Hou, HC; Pan, ZT; Feng, C; Shen, HW; Zhong, WH in WILEY published article about FRUSTRATED LEWIS PAIRS; METAL-FREE HYDROGENATIONS; DERIVATIVES; ANTAGONISTS; REDUCTION; INSIGHTS; KETONES in [Ling, Fei; Chen, Jiachen; Xie, Zhen; Hou, Huacui; Pan, Zhentao; Feng, Cong; Shen, Haiwei; Zhong, Weihui] Zhejiang Univ Technol, Coll Pharmaceut Sci, Minist Educ, Key Lab Green Pharmaceut Technol & Related Equipm, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 44.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A metal-free method to construct quinoline derivatives via B(C6F5)(3)-catalyzed cyclization of anilines with aldehyde derivatives and pyruvates is described. This three-component cascade reaction provides an efficient approach for the easy access to various substituted quinoline-4-carboxylic esters with 71% to 92% yield. The utility of this methodology was further demonstrated by gram-scale formal synthesis of the antimalarial drug DDD107498.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ling, F; Chen, JC; Xie, Z; Hou, HC; Pan, ZT; Feng, C; Shen, HW; Zhong, WH or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 3-Pyridinecarboxaldehyde. I found the field of Chemistry very interesting. Saw the article CO2-switchable Pickering emulsions: efficient and tunable interfacial catalysis for alcohol oxidation in biphasic systems published in 2019.0, Reprint Addresses Wang, JL (corresponding author), Zhejiang Univ Technol, Coll Chem Engn, Biodiesel Lab China Petr & Chem Ind Federat, Zhejiang Prov Key Lab Biofuel,State Key Lab Breed, Hangzhou 310014, Zhejiang, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

CO2-responsive Pickering emulsions were fabricated on the basis of polymeric nanoaggregates with adjustable surface wettability. The static Pickering emulsion system provides an efficient and sustainable platform for in situ separation and reuse of catalysts in biphasic reactions.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Tang, J; Cao, SX; Wang, JL or concate me.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about CYCLOOXYGENASE; CELECOXIB; SAFETY; PYRIDAZIN-3(2H)-ONES; NSAIDS; DRUGS; RISK, Saw an article supported by the . Application In Synthesis of 3-Pyridinecarboxaldehyde. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Ahmed, EM; Hassan, MSA; El-Malah, AA; Kassab, AE. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

New pyridazinone and pyridazinthione derivatives were designed, synthesized and identified through performing H-1 NMR, C-13 NMR, IR and MS spectroscopic techniques. All the newly synthesized derivatives were evaluated for cyclooxygenase inhibitory activity and COX-2 selectivity using celecoxib and indomethacin, as reference drugs. All compounds showed highly potent COX-2 inhibitory activity with IC50 values in nano-molar range. Moreover, they demonstrated higher selectivity towards COX-2 inhibition compared to indomethacin. Compounds 3d, 3g and 6a exhibited significantly increased potency towards COX-2 enzyme compared to celecoxib with IC50 values of 67.23, 43.84 and 53.01 nM, respectively. They were 1.1-1.7 folds more potent than celecoxib (IC50 = 73.53 nM) and extremely much more potent than indomethacin (IC50 = 739.2 nM). Of particular interest, Compound 3g showed SI of 11.51 which was as high as that of celecoxib (SI 11.78). This compound was further challenged by in vivo anti-inflammatory activity assay and gastric ulcerogenic effect. It showed comparable anti-inflammatory activity to indomethacin as positive control. Moreover, the anti-inflammatory activity of compound 3g was found to be equipotent to celecoxib. Furthermore, the selective COX-2 inhibitor 3g exhibited a superior gastrointestinal safety profile compared to the reference drugs celecoxib and indomethacin with less number of ulcers and milder ulcer score. The molecular docking study of this compound with COX-2 protein revealed more favorable binding mode compared to celecoxib, explaining its remarkable COX-2 inhibitory potency.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ahmed, EM; Hassan, MSA; El-Malah, AA; Kassab, AE or concate me.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article The magnetic graphene oxide/NHC catalyzed aerobic direct amidation and cross-dehydrogenative coupling of aldehydes WOS:000493080000015 published article about N-HETEROCYCLIC CARBENES; AMIDE BOND FORMATION; OXIDATIVE AMIDATION; BRESLOW INTERMEDIATE; EFFICIENT; AMINES; REDUCTION; CYCLOHEXADIENONES; DESYMMETRIZATION; HYDROACYLATION in [Sepahvand, Heshmatollah; Ghasemi, Elnaz; Shahverdizadeh, Gholam Hossein] Islamic Azad Univ, Dept Chem, Tabriz Branch, Tabriz, Iran; [Sharbati, Mohammad] Univ Tehran, Sch Met & Mat Engn, Coll Engn, Tehran, Iran; [Mohammadi, Melika Sadat; Pirlar, Maghsoud Arshadi] Shahid Beheshti Univ, Dept Phys, Tehran, Iran in 2019.0, Cited 53.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

In this paper, the synthesis of a novel imidazolium based N-heterocyclic carbene (NHC) containing imidazopyridine substitutes using a three-component reaction is described. This compound was immobilized on magnetic graphene oxide (GO) to make a heterogeneous catalyst for the direct aerobic amidation of benzaldehyde derivatives under solvent-free conditions, as well as the intra- and intermolecular cross dehydrogenative coupling of aldehydes. In addition, the catalytic activity of the NHC catalyst was homogeneously studied in the presence of Fe3O4 nanoparticles under the same conditions, and showed good activity with lower yields than the heterogeneous catalyst.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Sepahvand, H; Ghasemi, E; Sharbati, M; Mohammadi, MS; Pirlar, MA; Shahverdizadeh, GH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Pyridinecarboxaldehyde. I found the field of Chemistry very interesting. Saw the article 2-Hydroxyethyl-1-ammonium 3-hydroxypropane-1-sulfonate: a biodegradable and recyclable ionic liquid for the one-pot synthesis of 2-amino-3-cyano-4H-pyrans published in 2019.0, Reprint Addresses Honarmand, M (corresponding author), Birjand Univ Technol, Fac Min Civil & Chem Engn, Dept Chem Engn, Birjand 97175569, Iran.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

2-Hydroxyethyl-1-ammonium 3-hydroxypropane-1-sulfonate HAHS’ was synthesized as a novel ionic liquid and characterized by various techniques. HAHS’ ionic liquid was efficiently applied as a multifunctional promoter for the three-component synthesis of 2-amino-3-cyano-4H-pyrans. The 2-amino-3-cyano-4H-pyrans were produced not only in high to excellent yields but also no toxic solvent or catalyst was used. HAHS’ ionic liquid was recovered and reused four times without the considerable decreasing in its activity. The effect of hydroxyl groups in the structure of HAHS’ ionic liquid on its catalytic activity was studied. Moreover, the biodegradability potential of the ionic liquid was examined using the 5-day biological oxygen demand closed bottle test and the results showed that HAHS’ has remarkable biodegradability potential.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Honarmand, M; Tzani, A; Detsi, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds WOS:000545862800029 published article about PHOTOREDOX CATALYSIS; CARBOXYLIC-ACIDS; TRIFLUOROMETHYLATION; ACTIVATION; ALCOHOLS; ALKYLATION; ALDEHYDES; CLEAVAGE; ESTERS in [Zhu, Xianjin; Liu, Yong; Liu, Can; Yang, Haijun; Fu, Hua] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China in 2020, Cited 59. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Visible light-induced organic reactions are important chemical transformations in organic chemistry, and their efficiency highly depends on suitable photocatalysts. However, the commonly used photocatalysts are precious transition-metal complexes and elaborate organic dyes, which hamper large-scale production due to high cost. Here, for the first time, we report a novel strategy: light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds, allowing high-value-added aromatic ketones and carboxylic acids to be easily prepared in high-to-excellent yields using readily available alkyl arenes, methyl arenes and aldehydes as materials. The mechanistic investigations showed that the treatment of inexpensive and readily available sodium trifluoromethanesulfinate with oxygen under irradiation of light couldin situform a pentacoordinate sulfide intermediate as an efficient photosensitizer. The method represents a highly efficient, economical and environmentally friendly strategy, and the light and oxygen-enabled sodium trifluoromethanesulfinate photocatalytic system represents a breakthrough in photochemistry.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zhu, XJ; Liu, Y; Liu, C; Yang, HJ; Fu, H or concate me.. Quality Control of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. In 2020 J HETEROCYCLIC CHEM published article about FLUORESCENCE in [Horak, Radim; Koristek, Kamil; Samsulova, Veronika; Slaninova, Ludmila; Grepl, Martin; Kvapil, Lubomir; Funk, Petr; Hradil, Pavel; Soural, Miroslav] Palacky Univ, Dept Organ Chem, Fac Sci, 17 Listopadu, Olomouc, Czech Republic in 2020, Cited 37. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Compounds bearing [1,3]dioxolo-quinoline scaffolds have been found in quinoline-based natural products; the only exception is the [1,3]dioxolo[4,5-c]quinoline moiety with a rare occurrence in both natural and synthetic derivatives. In this article, we report the preparation of diversely substituted and functionalized [1,3]dioxolo[4,5-c]quinolines using [1,3]dioxolo[4,5-c]quinoline-4-carbaldehyde (DQC) as the common intermediate. DQC was synthesized on a large scale from anthranilic acid and chloroacetone as the starting materials, with the rearrangement of acetonyl-anthranilate as the key step. The developed method allows for the simple preparation of [1,3]dioxolo[4,5-c]quinolines with various C2 substituents on the quinoline scaffold. Additionally, the synthetic route was successfully applied to the preparation of 3-hydroxyquinoline-4(1H)-ones. The target compounds were tested against representative Gram-positive/negative bacteria, and two derivatives exhibited submicromolar minimum inhibitory concentrations against Micrococcus luteus.

Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Horak, R; Koristek, K; Samsulova, V; Slaninova, L; Grepl, M; Kvapil, L; Funk, P; Hradil, P; Soural, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Umpolung Difunctionalization of Carbonyls via Visible-Light Photoredox Catalytic Radical-Carbanion Relay published in 2020.0. SDS of cas: 500-22-1, Reprint Addresses Konig, B (corresponding author), Univ Regensburg, Fac Chem & Pharm, Inst Organ Chem, D-93040 Regensburg, Germany.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The combination of photoredox catalysis with the Wolff-Kishner (WK) reaction allows the difunctionalization of carbonyl groups by a radical-carbanion relay sequence (photo-Wolff-Kishner reaction). Photoredox initiated radical addition to N-sulfonylhydrazones yields alpha-functionalized carbanions following the WK-type mechanism. With sulfur-centered radicals, the carbanions are further functionalized by reaction with electrophiles including CO2 and aldehydes, whereas CF3 radical addition furnishes a wide range of gem-difluoroalkenes through beta-fluoride elimination of the generated alpha-CF3 carbanions. More than 80 substrate examples demonstrate the broad applicability of this reaction sequence. A series of investigations including radical inhibition, deuterium labeling, fluorescence quenching, cyclic voltammetry, and control experiments support the proposed radical-carbanion relay mechanism.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, S; Cheng, BY; Srsen, M; Konig, B or concate me.. SDS of cas: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem