Tag: M.W=100-150

Ramu, S; Srinath, S; Kumar, AA; Baskar, B; Ilango, K; Balasubramanian, KK in [Ramu, S.; Srinath, S.; Kumar, A. Aswin; Baskar, B.] SRM Inst Sci & Technol, Dept Chem, Lab Sustainable Chem, Kattankulatur 603203, Tamil Nadu, India; [Ilango, K.] SRM Inst Sci & Technol, IIISM, Kattankulathur 603203, Tamil Nadu, India; [Ilango, K.] SRM Inst Sci & Technol, SRM Coll Pharm, Dept Pharmaceut Chem, Kattankulathur 603203, Tamil Nadu, India; [Balasubramanian, K. K.] Indian Inst Technol Madras, Dept Biotechnol, Chennai 600036, Tamil Nadu, India published Metal free one pot synthesis of beta-carbolines via a domino Pictet-Spengler reaction and aromatization in 2019.0, Cited 79.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A convenient and efficient metal free, atom economical flexible synthesis of beta-carbolines involving a domino Pictet-Spengler reaction and aromatization in oxygen atmosphere in N-methyl-2-pyrollidone (NMP) is described. Variety of aryl, heteroaryl and aliphatic aldehydes were found to be good substrates for this methodology. Several beta-carbolines (6a-6t) and beta-carboline methyl esters (7a-7e) were synthesized using this methodology. The same reaction carried out in argon atmosphere in the presence of catalytic amount of acid in NMP furnished, tetrahydro-beta-carbolines (4a-4g).

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ramu, S; Srinath, S; Kumar, AA; Baskar, B; Ilango, K; Balasubramanian, KK or concate me.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Pyridinecarboxaldehyde. Siddiqui, IR; Neha, S; Waseem, MA; Sagir, H in [Siddiqui, I. R.; Neha, Shamshun; Waseem, Malik Abdul; Sagir, Hozeyfa] Univ Allahabad, Dept Chem, Lab Green Synth, Allahabad 211002, Uttar Pradesh, India published Aqua mediated multicomponent reaction under phase transfer catalysis: A novel and green approach to access fused pyrazoles in 2019.0, Cited 71.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

An environmentally benign multicomponent strategy for the synthesis of fused pyrazole derivatives has been developed. The present strategy provides a rapid access to construct a diversity-oriented library of fused pyrazoles by using three simple and readily available substrates viz. aromatic aldehyde, tetronic acid and aryl hydrazine as amine source. Further, the employment of molecular iodine, phase transfer catalyst and water altogether served as a green attribute to the present protocol. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Siddiqui, IR; Neha, S; Waseem, MA; Sagir, H or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C6H5NO. In 2020.0 MOLECULES published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; CRYSTAL-STRUCTURE; PYRAZOLINES; ANTICANCER; ANTIBACTERIAL; ANALOGS in [Shaik, Afzal B.] Jawaharlal Nehru Technol Univ, Vignan Pharm Coll, Dept Pharmaceut Chem, Vadlamudi 522213, India; [Bhandare, Richie R.; Edis, Zehra] Ajman Univ, Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, POB 346, Ajman, U Arab Emirates; [Tangirala, N. Ravikiran] Jawaharlal Nehru Technol Univ, Narasaraopeta Inst Pharmaceut Sci, Dept Pharmaceut Chem, Narsaraopet 522601, India; [Shahanaaz, Shaik] Victoria Coll Pharm, Dept Pharmaceut Chem, Nallapadu 522001, India; [Rahman, M. Mukhlesur] Univ East London, Sch Hlth Sports & Biosci, Med Res Grp, Stratford Campus,Water Lane, London E15 4LZ, England in 2020.0, Cited 47.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally. Therefore, there is an urgent need for the development of novel agents to combat the deadly problems of cancer, tuberculosis, and also fungal infections. Hence, in the present study, we designed, synthesized, and characterized 30 compounds including 15 chalcones (2-16) and 15 dihydropyrazoles (17-31) containing dichlorophenyl moiety and also screened these compounds for their antifungal, antitubercular, and antiproliferative activities. Among these compounds, the dihydropyrazoles showed excellent antifungal and antitubercular activities whereas the chalcones exhibited promising antiproliferative activity. Among the dihydropyrazoles, compound31containing 2-thienyl moiety showed promising antifungal activity (MIC 5.35 mu M), whereas compounds22and24containing 2,4-difluorophenyl and 4-trifluoromethyl scaffolds revealed significant antitubercular activity with the MICs of 3.96 and 3.67 mu M, respectively. Compound16containing 2-thienyl moiety in the chalcone series showed the highest anti-proliferative activity with an IC(50)value of 17 +/- 1 mu M. The most active compounds identified through this study could be considered as starting points in the development of drugs with potential antifungal, antitubercular, and antiproliferative activities.

HPLC of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Shaik, AB; Bhandare, RR; Nissankararao, S; Edis, Z; Tangirala, NR; Shahanaaz, S; Rahman, MM or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 500-22-1. Leijendekker, LH; Weweler, J; Leuther, TM; Kratz, D; Streuff, J in [Leijendekker, Leonardus H.; Weweler, Jens; Leuther, Tobias M.; Streuff, Jan] Albert Ludwigs Univ Freiburg, Inst Organ Chem, Albertstr 21, D-79104 Freiburg, Germany; [Kratz, Daniel] Albert Ludwigs Univ Freiburg, Inst Anorgan & Analyt Chem, Albertstr 21, D-79104 Freiburg, Germany published Development, Scope, and Applications of Titanium(III)-Catalyzed Cyclizations to Aminated N-Heterocycles in 2019, Cited 121. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The exceptionally mild conditions of a titanium(III)-catalyzed cyclization reaction paired with a convenient acid/base extraction have enabled the straightforward synthesis, isolation, and direct N-functionalization of amino heterocycles such as 3-aminoindoles and -pyrroles. The unprotected heterocycles are ideal building blocks for the installation of aminated indoles and pyrroles into target molecules, but their sensitivity has previously impeded their synthesis by modern catalytic methods. This full paper presents the development and extended scope of the new cyclization methodology. The transformation of the products into fused bis-indoles is also demonstrated along with the discovery of an unusual palladium-catalyzed reductive biphenyl coupling reaction. The titanium(III)-catalyzed cyclization has also been applied to the synthesis of substituted 3-iminoindolines, which are of potential interest for applications in natural product synthesis and exhibit tunable blue-to-green fluorescence properties.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Leijendekker, LH; Weweler, J; Leuther, TM; Kratz, D; Streuff, J or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. Recently I am researching about SOLVENT-FREE HYDROBORATION; COMPLEXES SYNTHESES; MAGNESIUM, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772093]; Natural Science Foundation of Jiangsu Province, ChinaNatural Science Foundation of Jiangsu Province [BK20181421]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Wang, WF; Lu, K; Qin, Y; Yao, WW; Yuan, DD; Pullarkat, SA; Xu, L; Ma, MT. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Simple, commercially available Grignard reagents have been used as highly efficient precatalysts for the hydroboration of a wide range of aldehydes and ketones. The reaction employs very low catalyst loadings (aldehydes: 0.05 mol%, ketones: 0.5 mol%), and proceeds rapidly (aldehydes: 10 min, ketones: 20 min) under neat condition at room temperature. The Grignard reagent catalyst demonstrated good substrate scope, functional group tolerance, and high chemoselectivity in the carbonyl hydroboration. DFT calculations were performed to investigate the possible reaction mechanism. In contrast to the traditional stoichiometric use of Grignard reagents, this newly developed protocol provides a catalytic application of these reagents for molecular transformations. (C) 2020 Elsevier Ltd. All rights reserved.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, WF; Lu, K; Qin, Y; Yao, WW; Yuan, DD; Pullarkat, SA; Xu, L; Ma, MT or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. I found the field of Chemistry very interesting. Saw the article A Ba/Pd Catalytic System Enables Dehydrative Cross-Coupling and Excellent E-Selective Wittig Reactions published in 2019.0, Reprint Addresses Xie, PZ; Loh, TP (corresponding author), Nanjing Tech Univ, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Jiangsu, Peoples R China.; Loh, TP (corresponding author), Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

A Ba/Pd cooperative catalysis system was developed to enable the dehydrative cross-coupling of allylic alcohols with P-ylides to occur directly and promote a subsequent Wittig reaction in one pot. A variety of multisubstituted 1,4-dienes were isolated in good to excellent yields with broad P-ylides (stabilized by both ester and ketone carbonyl groups) and aldehyde (aliphatic and aromatic) substrates with excellent E selectivity.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Xie, PZ; Fu, WS; Cai, XY; Sun, ZL; Wu, Y; Li, SS; Gao, CQ; Yang, XB; Loh, TP or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Design, Synthesis, Molecular Docking and Biological Evaluation of 1-(benzo[d]thiazol-2-ylamino)(phenyl)methyl)naphthalen-2-ol Derivatives as Antiproliferative Agents published in 2019.0. Recommanded Product: 500-22-1, Reprint Addresses Nameta, B; Chavali, M (corresponding author), Vignans Fdn Sci Technol & Res Guntur, Dept Sci & Humanities, Div Chem, Guntur, India.; Reddy, BVS (corresponding author), Indian Inst Chem Technol, CSIR, Ctr Semiochem, Hyderabad 500007, Andhra Pradesh, India.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A class of 1-((benzo[d]thiazol-2-ylamino)(phenyl)methyl)naphthalen-2-ol derivatives (4a-t) has been synthesized in good yields through a three component coupling reaction. The newly synthesized compounds were evaluated for their in vitro antiproliferative activity against five cell lines such as DU145 (human prostate cancer), MDA-MB-B231 (human breast cancer), SKOV3 (human ovarian cancer), B16-F10 (mouse skin melanoma) and CHO-K1 (Chinese hamster ovary cells), a non-cancerous cell line. In vitro inhibitory activity indicates that compounds 4a, 4b, 4c, 4d, 4g, 4j, and 4o exhibited potent anti-proliferative behavior. Among them, compounds 4g, 4j and 4o found to be the most active members exhibiting remarkable growth inhibitory activity. Molecular docking facilitates to investigate the probable binding mode and key active site interactions in tubulins alpha and beta proteins. The docking results are complementary to experimental results.

Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Jonnala, S; Nameta, B; Chavali, M; Bantu, R; Choudante, P; Misra, S; Sridhar, B; Dilip, S; Reddy, BVS or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. Recently I am researching about ION-EXCHANGE-RESIN; ACETIC-ACID; CATALYZED ESTERIFICATION; LACTIC-ACID; CHEMICAL-EQUILIBRIUM; COSOLVENT INFLUENCE; REACTION-KINETICS; SOLVENTS; NITROMETHANE; REDUCTION, Saw an article supported by the DFGGerman Research Foundation (DFG)European Commission [VE 265/12-1, RE948/10-2, DFG-SA700/23-1, VE 265/14-1, SPP 1708] Funding Source: Medline. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Weinbender, T; Knierbein, M; Bittorf, L; Held, C; Siewert, R; Verevkin, SP; Sadowski, G; Reiser, O. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Thiourea-organocatalyzed Michael additions of diethyl malonate to various heteroaromatic nitroolefins (13 examples) have been studied under high-pressure (up to 800 MPa) and ambient pressure conditions. High pressure was conducive to enhanced product yields by a factor of 2-12 at a given reaction time, high reaction rates (reaction times were decreased from 72-24 h down to 4-24 h) and high enantioselectivity. Elucidating the effects of solvents for maximizing reaction rates and yields has been carried out using the Perturbed-Chain Polar Statistical Associating Fluid Theory (PCP-SAFT), allowing for the first time a prediction of the kinetic profiles under high-hydrostatic-pressure conditions.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Weinbender, T; Knierbein, M; Bittorf, L; Held, C; Siewert, R; Verevkin, SP; Sadowski, G; Reiser, O or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Gueret, R; Pelinski, L; Bousquet, T; Sauthier, M; Ferey, V; Bigot, A in AMER CHEMICAL SOC published article about PHOTOREDOX CATALYSIS; AQUEOUS-SOLUTIONS; SNAP REAGENTS; ACIDS; DECARBOXYLATION; RADICALS; CONSTRUCTION; HETEROCYCLES; CHEMISTRY; ARYLATION in [Gueret, Robin; Pelinski, Lydie; Bousquet, Till; Sauthier, Mathieu] Univ Artois, Univ Lille, Unite Catalyse & Chim Solide, ENSCL,UMR 8181,CNRS,Cent Lille, F-59000 Lille, France; [Bigot, Antony] Sanofi, Pre Dev Sci Chem Synth, F-94403 Vitry Sur Seine, France; [Ferey, Vincent] Sanofi, PDP Innovat, F-34184 Montpellier, France in 2020.0, Cited 51.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl piperazines. The iridium-based complex [Ir(ppy)(2)(dtbpy)]PF6 and carbazolyl dicyanobenzene 4CzIPN were found to be the photocatalysts of choice to efficiently perform the transformation under mild conditions, whether in batch or in continuous mode.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Gueret, R; Pelinski, L; Bousquet, T; Sauthier, M; Ferey, V; Bigot, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. Chen, YJ; Xiang, Y; He, YH; Guan, Z in [Chen, Yu-Jue; Xiang, Yang; He, Yan-Hong; Guan, Zhi] Southwest Univ, Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China published Anti-selective direct asymmetric Mannich reaction catalyzed by protease in 2019.0, Cited 69.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The anti-selective direct asymmetric Mannich reaction of (hetero) aromatic aldehydes, 4-anisidine and O-protected hydroxyacetones for the synthesis of stereodefined anti-beta-amino-alpha-hydroxycarbonyl compounds was developed. Protease type XIV from Streptomyces griseus (SGP) was used as a biocatalyst in 1,4-dioxane/phosphate buffer under mild reaction conditions. The excellent diastereoselectivities of up to >99:1 (anti/syn) and good enantioselectivities of up to 90% ee were achieved. This method provides a more sustainable complement to chemically catalyzed anti-selective direct asymmetric Mannich reactions. (C) 2019 Elsevier Ltd. All rights reserved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Chen, YJ; Xiang, Y; He, YH; Guan, Z or concate me.. Safety of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem