Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article Construction of Chiral beta-Trifluoromethyl Alcohols Enabled by Catalytic Enantioselective Aldol-Type Reaction of CF3CHN2 published in 2019.0. COA of Formula: C6H5NO, Reprint Addresses Zhang, FG; Ma, JA (corresponding author), Tianjin Univ, Dept Chem, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China.; Zhang, FG; Ma, JA (corresponding author), Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China.; Ma, JA (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A zinc-/quinine-mediated enantioselective Aldol-type reaction of trifluorodiazoethane (CF3CHN2) with various aldehydes is described. This study demonstrated the feasibility of utilizing CF3CHN2 as an effective hard nucleophile in catalytic asymmetric transformations. Furthermore, the synthetic utility of this protocol is exemplified by the construction of a diverse set of chiral beta-trifluoromethylated alcohols, including a valuable HDAC inhibitor precursor.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Rong, MY; Yang, LJ; Nie, J; Zhang, FG; Ma, JA or concate me.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Polyethylene glycol (PEG-400): An efficient one-pot green synthesis and anti-viral activity of novel alpha-diaminophosphonates WOS:000466645100001 published article about AMINO-PHOSPHONATES; 3-COMPONENT SYNTHESIS; ACID-DERIVATIVES; CATALYST; SOLVENT; AMINOPHOSPHONATES; INHIBITION; CHLORIDE; FACILE; KETONES in [Patnala, Harika] Andhra Loyola Inst Engn & Technol, Dept Chem, Vijayawada, Andhra Pradesh, India; [Abbo, Hanna S.; Titinchi, Salam J. J.] Univ Basrah, Dept Chem, Basrah, Iraq; [Abbo, Hanna S.; Titinchi, Salam J. J.] Univ Western Cape, Dept Chem, Cape Town, South Africa; [Potla, Krishna Murthy] Acharya Nagarjuna Univ, Post Grad Res Ctr, Bapatla Engn Coll, Dept Chem, Bapatla, Andhra Pradesh, India; [Chinnam, Sampath] BMS Coll Engn, Dept Chem, Bengaluru, Karnataka, India in 2019.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives

An efficient and eco-friendly protocol has been accomplished for a series of novel alpha-diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4,4 ‘-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80 degrees C. All products were obtained in good to excellent yields (80-95%). The identity of the new synthesized compounds was confirmed by IR, H-1, 13C, and 31P NMR, LC-MS and elemental analysis. In vivo anti-viral activity was evaluated against tobacco mosaic virus (TMV). Compounds 4b, 4c, 4j and 4k exhibited the highest anti-viral activities against tobacco mosaic virus (TMV) when compared with the standard drug ningnanmycin. [GRAPHICS] .

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Patnala, H; Abbo, HS; Potla, KM; Titinchi, SJJ; Chinnam, S or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. In 2020.0 INORG CHIM ACTA published article about IMIDAZOLATE-BRIDGED DICOPPER(II); CHEMOSELECTIVE AEROBIC OXIDATION; SELECTIVE OXIDATION; CRYSTAL-STRUCTURE; HETEROBIMETALLIC COMPLEX; P-HYDROXYBENZALDEHYDE; DINUCLEAR COMPLEXES; MACROCYCLIC LIGAND; BENZYLIC ALCOHOLS; AQUEOUS-MEDIUM in [Asthana, Mrityunjaya] TCG Lifesci Private Ltd, Kolkata 700091, W Bengal, India; [Syiemlieh, Ibanphylla; Lal, Ram A.] North Eastern Hill Univ, Ctr Adv Study, Dept Chem, Shillong 793022, Meghalaya, India; [Kumar, Arvind] Univ West Indies, Fac Sci & Technol, Dept Chem, St Augustine, Trinidad Tobago in 2020.0, Cited 106.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

We report herein a ligand and additive- free [CuNi(bz)(3)(bpy)(2)]ClO4 catalyst system that efficiently and selectively catalyses the oxidation of a range of primary and secondary benzylic alcohols, 1 – heteroaryl alcohols, cinnamyl alcohol, and aliphatic alcohols mediated by hydrogen peroxide to the corresponding aldehydes and ketones, respectively.

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Asthana, M; Syiemlieh, I; Kumar, A; Lal, RA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Novel access to 2-substituted quinolin-4-ones by nickel boride-mediated reductive ring transformation of 5-(2-nitrophenyl)isoxazoles WOS:000502890400010 published article about C-H AMIDATION; 4-QUINOLONES; ALKALOIDS; QUINOLONES; ALKYL; ARYL in [Lohrer, Bernhard; Bracher, Franz] Ludwig Maximilians Univ Munchen, Dept Pharm, Ctr Drug Res, Butenandtstr 5-13, D-81377 Munich, Germany in 2019.0, Cited 45.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reductive ring transformation of 3-substituted 5-(2-nitrophenyl)isoxazoles, readily accessible via 1,3-dipolar cycloaddition of 2-ethinylnitrobenzene with nitrile oxides, opens a novel access to 2-substituted quinolin-4-ones. Nickel boride, generated in situ from nickel chloride and sodium borohydride, allows, via simultaneous reduction of the nitro group and reductive cleavage of the isoxazole ring, the one-step conversion into the target quinolin-4-ones. This protocol tolerates various functional groups, except olefins, and thus is complementary to the reductive ring transformation with iron/acetic acid, which predominantly tolerates olefins. (C) 2019 Elsevier Ltd. All rights reserved.

Application In Synthesis of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Lohrer, B; Bracher, F or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Umpolung Difunctionalization of Carbonyls via Visible-Light Photoredox Catalytic Radical-Carbanion Relay published in 2020.0. Recommanded Product: 500-22-1, Reprint Addresses Konig, B (corresponding author), Univ Regensburg, Fac Chem & Pharm, Inst Organ Chem, D-93040 Regensburg, Germany.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The combination of photoredox catalysis with the Wolff-Kishner (WK) reaction allows the difunctionalization of carbonyl groups by a radical-carbanion relay sequence (photo-Wolff-Kishner reaction). Photoredox initiated radical addition to N-sulfonylhydrazones yields alpha-functionalized carbanions following the WK-type mechanism. With sulfur-centered radicals, the carbanions are further functionalized by reaction with electrophiles including CO2 and aldehydes, whereas CF3 radical addition furnishes a wide range of gem-difluoroalkenes through beta-fluoride elimination of the generated alpha-CF3 carbanions. More than 80 substrate examples demonstrate the broad applicability of this reaction sequence. A series of investigations including radical inhibition, deuterium labeling, fluorescence quenching, cyclic voltammetry, and control experiments support the proposed radical-carbanion relay mechanism.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, S; Cheng, BY; Srsen, M; Konig, B or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators WOS:000573916100021 published article about CELL-DEATH; ENDOPLASMIC-RETICULUM; DUAL ROLES; APOPTOSIS; EXPRESSION; STRESS; UBIQUITINATION; METABOLISM; ACTIVATION; INDUCTION in [Li, Baicun; Yao, Jie; Guo, Kaiqiang; He, Fengming; Chen, Kun; Lin, Zongxin; Liu, Shunzhi; Huang, Jiangang; Wu, Qiaoqiong; Fang, Meijuan; Zeng, Jinzhang; Wu, Zhen] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China; [Li, Baicun; Yao, Jie; Guo, Kaiqiang; He, Fengming; Chen, Kun; Lin, Zongxin; Liu, Shunzhi; Huang, Jiangang; Wu, Qiaoqiong; Fang, Meijuan; Zeng, Jinzhang; Wu, Zhen] Xiamen Univ, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China; [Li, Baicun] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Physiol, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China; [Li, Baicun] Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China in 2020.0, Cited 74.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Computed Properties of C6H5NO

Nur77 is a potential target for the treatment of cancer such as HCC. Herein, we detailed the discovery of a novel series of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as potential Nur77 modulators. The studies of antiproliferative activity and Nur77-binding affinity of target compounds resulted in the discovery of a lead candidate (10g), which was a good Nur77 binder (K-D = 3.58 +/- 0.16 mu M) with a broad-spectrum antiproliferative activity against all tested hepatoma cells (IC50 < 2.0 mu M) and was low toxic to normal LO2 cells. 10g could up-regulate Nur77 expression and mediate sub-cellular localization of Nur77 to induce apoptosis in hepatocellular carcinoma cell lines, which relied on 10g inducing Nur77-dependent autophagy and endoplasmic reticulum stress as the upstream of apoptosis. Moreover, the in vivo assays verified that 10g significantly inhibited xenograft tumor growth. These results indicate that 10g has the potential to be developed as a novel Nur77-targeting anti-hepatoma drug. (C) 2020 Elsevier Masson SAS. All rights reserved. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Li, BC; Yao, J; Guo, KQ; He, FM; Chen, K; Lin, ZX; Liu, SZ; Huang, JG; Wu, QQ; Fang, MJ; Zeng, JZ; Wu, Z or concate me.. Computed Properties of C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 500-22-1. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis of novel 4,5-dihydropyrrolo[1,2-a]quinoxalines, pyrrolo[1,2-a]quinoxalin]-2-ones and their antituberculosis and anticancer activity published in 2020.0, Reprint Addresses Rode, HB (corresponding author), CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, Telangana, India.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

A facile strategy was developed for the synthesis of biologically important 4,5-dihydropyrrolo[1,2-a]quinoxalines and pyrrolo[1,2-a]quinoxalin]-2-ones by treating 2-(1H-pyrrol-1-yl)anilines with imidazo[1,2-a]pyridine-3-carbaldehyde or isatin, using amidosulfonic acid (NH3SO3) as a solid catalyst in water at room temperature. The protocol has been extended to electrophile ninhydrin. The catalyst could be recycled for six times without the loss of activity. The compounds were evaluated for their antituberculosis, antibacterial, and anticancer activities. It is worth noting that compounds3dand3edemonstrated a minimum inhibitory concentration value of 6.25 mu M againstMycobacterium tuberculosisH37Rv, whereas compounds3d,3g,5d,5e, and5ishowed a remarkable inhibition of A549, DU145, HeLa, HepG2, MCF-7, and B16-F10 cell lines, respectively.Staphylococcus aureuswas inhibited by compounds5b,5e,5d,5g, and5lat 32 mu g/ml.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Makane, VB; Krishna, EV; Karale, UB; Babar, DA; Kalari, S; Rekha, EM; Shukla, M; Kaul, G; Sriram, D; Chopra, S; Misra, S; Rode, HB or concate me.. SDS of cas: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Coupling-Isomerization-Cycloisomerization Reaction (CICIR) – An Unexpected and Efficient Domino Approach to Luminescent 2-(Hydroxymethylene)indenones WOS:000490802100001 published article about SENSITIZED SOLAR-CELLS; NATURAL-PRODUCTS; C-C; MULTICOMPONENT; SEQUENCE; DYES in [Ghazvini, Helya Janatian; Mueller, Thomas J. J.] Heinrich Heine Univ Dusseldorf, Inst Organ Chem & Makromol Chem, Univ Str 1, D-40225 Dusseldorf, Germany; [Ghazvini, Helya Janatian; Balalaie, Saeed] KN Toosi Univ Technol, Peptide Chem Res Ctr, POB 15875-4416, Tehran, Iran; [Armaghan, Mahsa; Janiak, Christoph] Heinrich Heine Univ Dusseldorf, Inst Anorgan Chem & Strukturchem, Univ Str 1, D-40225 Dusseldorf, Germany in 2019.0, Cited 69.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A Pd/Cu-catalyzed base mediated domino process of ortho-halo (hetero)aryl carboxaldehydes and propargyl alcohols unexpectedly furnish 2-(hydroxymethylene)indenones in good to excellent yield as a result of a coupling-isomerization-cycloisomerization reaction (CICIR). In addition, the title compounds constitute an interesting class of luminophores with tunable emission solvatochromicity.

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ghazvini, HJ; Armaghan, M; Janiak, C; Balalaie, S; Muller, TJJ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article SAR of non-hydrolysable analogs of pyridoxal 5 ‘-phosphate against low molecular weight protein tyrosine phosphatase isoforms WOS:000546628500017 published article about LMW-PTP; ENZYMES in [DeSouza, Shirin R.; Olson, Maxwell C.; Tinucci, Samantha L.; Sinner, Erica K.; Flynn, Rebecca S.; Marshall, Quinlen F.; Jakubowski, Henry, V; McIntee, Edward J.] St Johns Univ, Coll St Benedict, Dept Chem, St Joseph, MN 56374 USA in 2020.0, Cited 15.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Kinases and phosphatases are key enzymes in cell signal transduction pathways. Imbalances in these enzymes have been linked to numerous disease states ranging from cancer to diabetes to autoimmune disorders. The two isoforms (IFA and IFB) of Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) appear to play a role in these diseases. Pyridoxal 5′-phosphate (PLP) has been shown to act as a potent but, impractical micromolar inhibitor for both isoforms. In this study, a series of non-hydrolysable phosphonate analogs of PLP were designed, synthesized and tested against the two isoforms of LMW-PTP. Assay results demonstrated that the best inhibitor for both isoforms was compound 5 with a K-is of 1.84 mu M (IFA) and 15.6 mu M (IFB). The most selective inhibitor was compound 16, with a selectivity of roughly 370-fold for IFA over IFB.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact DeSouza, SR; Olson, MC; Tinucci, SL; Sinner, EK; Flynn, RS; Marshall, QF; Jakubowski, HV; McIntee, EJ or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C6H5NO. In 2019.0 BIOORG CHEM published article about QUINOLINE BASED CHALCONES; MOLECULAR DOCKING; ADME EVALUATION; DRUG DISCOVERY; DESIGN; AGENTS; CYTOTOXICITY; PREDICTION; HYBRIDS; ELECTRONEGATIVITY in [Polo, Efrain; Ibarra-Arellano, Nicol; Prent-Penaloza, Luis; Gutierrez, Margarita] Univ Talca, Lab Sintesis Organ, Inst Quim Recursos Nat, Casilla 747, Talca 3460000, Chile; [Morales-Bayuelo, Alejandro] Univ Sinu, Ciencias Salud, Grp Invest Basicas & Clin Univ Sinu GIBACUS, Secc Cartagena, Cartagena, Colombia; [Henao, Jose] Univ Ind Santander, Grp Invest Quim Estruct GIQUE, Escuela Quim, Fac Ciencias, AA 678,Carrera 27,Calle 9 Ciudadela Univ, Bucaramanga, Colombia; [Galdamez, Antonio] Univ Chile, Dept Quim, Fac Ciencias, Santiago 7800003, Chile in 2019.0, Cited 90.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The chalcone and bis-chalcone derivatives have been synthesized under sonication conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20-89%). The structures were established on the basis of NMR, IR, Single-crystal XRD, and MS. The best compound 3u had inhibitory activity (IC50 = 7.50 mu M). The synthesis, the antioxidative properties, chemical reactivity descriptors supported in Density Functional Theory (DFT), acetylcholinesterase (AChE) inhibition and their potential binding modes, and affinity were predicted by molecular docking of a number of morpholine-chalcones and quinoline-chalcone. A series of bis-chalcones are also reported. Molecular docking and an enzyme kinetic study on compound 3u suggested that it simultaneously binds to the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. Moreover, the pharmacokinetic profile of these compounds was investigated using a computational method.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Polo, E; Ibarra-Arellano, N; Prent-Penaloza, L; Morales-Bayuelo, A; Henao, J; Galdamez, A; Gutierrez, M or concate me.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem