Tag: M.W=100-150

Name: 3-Pyridinecarboxaldehyde. de Salles, HD; da Silva, TL; Radatz, CS; Affeldt, RF; Benvenutti, EV; Schneider, PH in [de Salles, Helena D.; Benvenutti, Edilson, V; Schneider, Paulo H.] Univ Fed Rio Grande do Sul, Inst Quim, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil; [da Silva, Tiago L.] Univ Fed Rio de Janeiro, Inst Quim, Av Athos da Silveira Ramos 149,Bloco A, BR-21941909 Rio de Janeiro, RJ, Brazil; [Radatz, Catia S.] Univ Fed Pelotas UFPeI, CCQFA, BR-96010900 Pelotas, RS, Brazil; [Affeldt, Ricardo F.] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil published Imidazo[1,2-a]pyridine A(3)-Coupling Catalyzed by a Cu/SiO2 Material in 2019.0, Cited 60.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

In this work, we report the preparation of a copper-silica material (Cu/SiO2) by a sol-gel methodology and its characterization concerning composition and textural properties. The Cu/SiO2 material was successfully applied as a Lewis acid heterogeneous catalyst for the A(3)-coupling from 2-aminopyridine, aldehydes and alkynes to imidazo[1,2-a]pyridines (45-82%). which are relevant pharmacological scaffolds. The synthesis shows a number of advantages, such as easy separation from the reaction media and the minimal formation of metal aqueous wastes. Investigation of the mechanism supports the involvement of the formation of reaction intermediates inside the pores of the mesoporous material prior to 5-exo-dig cyclization.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact de Salles, HD; da Silva, TL; Radatz, CS; Affeldt, RF; Benvenutti, EV; Schneider, PH or concate me.. Name: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. Recently I am researching about IONIC LIQUIDS; HIGHLY EFFICIENT; HIGH-PERFORMANCE; BUILDING-BLOCK; CAPTURE; DESIGN; OXIDE, Saw an article supported by the NSAF [U1530262]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21875021, 21576026]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Hu, BP; Shi, QR; Lu, FP; Zhang, PC; Peng, PP; Zhao, CF; Du, Y; Su, H; Li, SH; Pang, SP; Nie, FD. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

We report a greener and more-general organic method for the synthesis of functional organic salts containing organic anions through a Schiff base reaction between readily available aldehydes and simple aminoguanidinium salts. This reaction is operationally simple, free of metal salts, and forms water as the sole byproduct. The broad scope and good functional-group compatibility of this method permit its use to provide ready access to a library of more than 70 distinct organic salts, including those of heterocyclic anions, complex pharmaceutical anions, and polyanions, which are difficult to obtain through classical inorganic methods. Moreover, choosing different aldehydes and organic anions provides a convenient method for modulating or improving the functional properties of the designed organic salts, such as their melting points, fluorescence, and energetic properties. We therefore expect that this method will open new opportunities for the discovery and functionalization of a wide variety of organic salts and functional materials.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Hu, BP; Shi, QR; Lu, FP; Zhang, PC; Peng, PP; Zhao, CF; Du, Y; Su, H; Li, SH; Pang, SP; Nie, FD or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. In 2019.0 BIOORG CHEM published article about QUINOLINE BASED CHALCONES; MOLECULAR DOCKING; ADME EVALUATION; DRUG DISCOVERY; DESIGN; AGENTS; CYTOTOXICITY; PREDICTION; HYBRIDS; ELECTRONEGATIVITY in [Polo, Efrain; Ibarra-Arellano, Nicol; Prent-Penaloza, Luis; Gutierrez, Margarita] Univ Talca, Lab Sintesis Organ, Inst Quim Recursos Nat, Casilla 747, Talca 3460000, Chile; [Morales-Bayuelo, Alejandro] Univ Sinu, Ciencias Salud, Grp Invest Basicas & Clin Univ Sinu GIBACUS, Secc Cartagena, Cartagena, Colombia; [Henao, Jose] Univ Ind Santander, Grp Invest Quim Estruct GIQUE, Escuela Quim, Fac Ciencias, AA 678,Carrera 27,Calle 9 Ciudadela Univ, Bucaramanga, Colombia; [Galdamez, Antonio] Univ Chile, Dept Quim, Fac Ciencias, Santiago 7800003, Chile in 2019.0, Cited 90.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The chalcone and bis-chalcone derivatives have been synthesized under sonication conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20-89%). The structures were established on the basis of NMR, IR, Single-crystal XRD, and MS. The best compound 3u had inhibitory activity (IC50 = 7.50 mu M). The synthesis, the antioxidative properties, chemical reactivity descriptors supported in Density Functional Theory (DFT), acetylcholinesterase (AChE) inhibition and their potential binding modes, and affinity were predicted by molecular docking of a number of morpholine-chalcones and quinoline-chalcone. A series of bis-chalcones are also reported. Molecular docking and an enzyme kinetic study on compound 3u suggested that it simultaneously binds to the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. Moreover, the pharmacokinetic profile of these compounds was investigated using a computational method.

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Polo, E; Ibarra-Arellano, N; Prent-Penaloza, L; Morales-Bayuelo, A; Henao, J; Galdamez, A; Gutierrez, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis, characterization, biological evaluation, and molecular docking studies of some piperonyl-based 4-thiazolidinone derivatives published in 2020.0, Reprint Addresses Bilgicli, HG (corresponding author), Sakarya Univ, Fac Arts & Sci, Dept Chem, TR-54050 Servidan, Sakarya, Turkey.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Heterocyclic compounds are of particular importance among pharmacologically active compounds. In this study, some piperonyl-based 4-thiazolidinone derivatives (2a-i) were synthesized and characterized by spectroscopic assays. All molecules were tested as enzyme inhibitory factors. These compounds were effective inhibitors of the enzymes acetylcholinesterase (AChE), alpha-glycosidase (alpha-Gly), and the human carbonic anhydrase I and II isoforms (hCA I and II), with K-i values in the range of 8.90-66.51 nM for alpha-Gly, 94.8-289.5 nM for hCA I, 106.3-304.6 nM for hCA II, and 0.55-2.36 nM for AChE. The synthesized molecules were also studied theoretically. Molecular docking calculations were performed to investigate the interaction between the target protein and molecules. CA inhibitor compounds have been clinically used for almost 60 years as antiglaucoma and diuretic drugs. The inhibition of the AChE enzyme results in the blockage of ACh hydrolysis. On the contrary, the design of inhibitor compounds or/and modulators for AChE is of major interest as it is one of the most popular tools to prevent Alzheimer’s disease.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Bilgicli, HG; Taslimi, P; Akyuz, B; Tuzun, B; Gulcin, I or concate me.. Quality Control of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 J MED CHEM published article about ACETYLCHOLINE-RECEPTORS; IN-VITRO; QUINOLINE DERIVATIVES; THERAPEUTIC TARGETS; LIGAND EFFICIENCY; FULL AGONIST; ALPHA-4-BETA-2; VARENICLINE; EPIBATIDINE; SUBTYPES in [Manetti, Dina; Bartolucci, Gianluca; Bellucci, Cristina; Chiaramonte, Niccolo; Dei, Silvia; Teodori, Elisabetta; Romanelli, Maria Novella] Univ Florence, Sect Pharmaceut & Nutraceut Sci, Dept Neurosci Psychol Drug Res & Childs Hlth NEUR, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Garifulina, Alexandra; Spirova, Ekaterina; Shelukhina, Irina; Tsetlin, Victor] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Dept Mol Basis Neurosignaling, Miklukho Maklaya St 16-10, Moscow 117997, Russia; [Bazzicalupi, Carla] Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 3, I-50019 Sesto Fiorentino, Italy; [Mannelli, Lorenzo Di Cesare; Ghelardini, Carla] Univ Florence, Sect Pharmacol & Toxicol, Dept NEUROFARBA, Viale G Pieraccini 6, I-50139 Florence, Italy; [Gratteri, Paola] Univ Firenze, Lab Mol Modeling Cheminformat, Dept NEUROFARBA, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Gratteri, Paola] Univ Firenze, QSAR, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Varani, Katia] Univ Ferrara, Inst Pharmacol, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy in 2019.0, Cited 64.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Formula: C6H5NO

A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands. The synthesized compounds were tested in radioligand binding assay on rat cortex against [H-3]-cytisine and [3H]-methyllycaconitine to measure their affinity for alpha 4 beta 2* and alpha 7* nicotinic receptors. The new derivatives showed some preference for the alpha 4 beta 2* over the alpha 7* subtype, with their affinity being dependent on the endo/exo isomerism and on the methylation degree of the basic nitrogen. The endo primary amines displayed the lowest K-i values on both receptor subtypes. Selected compounds (1a, 2a, 3a, and 6a) were tested on heterologously expressed alpha 4 beta 2, alpha 7, and alpha 3 beta 2 receptors and on SHSY-5Y cells. Compounds 1a and 2a showed alpha 4 beta 2 antagonistic properties while behaved as full agonists on recombinant alpha 7 and on SHSYSY cells. On the alpha 3 beta 2 subtype, only the chloro derivative 2a showed full agonist activity and submicromolar potency (EC50 = 0.43 mu M). The primary amines described here represent new chemotypes for the alpha 7 and alpha 3* receptor subtypes.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Manetti, D; Garifulina, A; Bartolucci, G; Bazzicalupi, C; Bellucci, C; Chiaramonte, N; Dei, S; Mannelli, LD; Ghelardini, C; Gratteri, P; Spirova, E; Shelukhina, I; Teodori, E; Varani, K; Tsetlin, V; Romanelli, MN or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. Zha, GF; Fang, WY; Leng, J; Qin, HL in [Zha, Gao-Feng; Fang, Wan-Yin; Leng, Jing; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China published A Simple, Mild and General Oxidation of Alcohols to Aldehydes or Ketones by SO2F2/K2CO3 Using DMSO as Solvent and Oxidant in 2019.0, Cited 67.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A practical, general and mild oxidation of primary and secondary alcohols to carbonyl compounds proceeds in yields of up to 99% using SO2F2 as electrophile in DMSO as both the oxidant and the solvent at ambient temperature. No moisture- and oxygen-free conditions are required. Stoichiometric amount of inexpensive K2CO3, which generates easy to separate by-products, is used as the base. Thus, 5-gram scale runs proceeded in nearly quantitative yields by a simple filtration as the work-up. The use of a polar solvent such as DMSO, which usually promotes competing Pummerer rearrangement, is also noteworthy. This protocol is compatible with a variety of common N-, O-, and S-functional groups on (hetero)arene, alkene and alkyne substrates (68 examples). The protocol was applied (99% yield) to a formal synthesis of the important cholesterol-lowering drug Rosuvastatin.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zha, GF; Fang, WY; Leng, J; Qin, HL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Visible-Light-Driven CarboxyLic Amine Protocol (CLAP) for the Synthesis of 2-Substituted Piperazines under Batch and Flow Conditions WOS:000547468700047 published article about PHOTOREDOX CATALYSIS; AQUEOUS-SOLUTIONS; SNAP REAGENTS; ACIDS; DECARBOXYLATION; RADICALS; CONSTRUCTION; HETEROCYCLES; CHEMISTRY; ARYLATION in [Gueret, Robin; Pelinski, Lydie; Bousquet, Till; Sauthier, Mathieu] Univ Artois, Univ Lille, Unite Catalyse & Chim Solide, ENSCL,UMR 8181,CNRS,Cent Lille, F-59000 Lille, France; [Bigot, Antony] Sanofi, Pre Dev Sci Chem Synth, F-94403 Vitry Sur Seine, France; [Ferey, Vincent] Sanofi, PDP Innovat, F-34184 Montpellier, France in 2020.0, Cited 51.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Safety of 3-Pyridinecarboxaldehyde

Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl piperazines. The iridium-based complex [Ir(ppy)(2)(dtbpy)]PF6 and carbazolyl dicyanobenzene 4CzIPN were found to be the photocatalysts of choice to efficiently perform the transformation under mild conditions, whether in batch or in continuous mode.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Gueret, R; Pelinski, L; Bousquet, T; Sauthier, M; Ferey, V; Bigot, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about SURFACTANT-TYPE CATALYST; ORGANIC-REACTIONS; KETONES; WATER; RUTHENIUM; ACID; REDUCTION; COMPLEXES; DENSITY; DESIGN, Saw an article supported by the MRS; Austrian Science FundAustrian Science Fund (FWF) [P29146-N34]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Palvolgyi, AM; Bitai, J; Zeindlhofer, V; Schroder, C; Bica, K. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Recommanded Product: 3-Pyridinecarboxaldehyde

We report the design and synthesis of novel ion-tagged chiral ligands for asymmetric transfer hydrogenation (ATH) in aqueous medium. Based on (R,R)-1,2-diphenylethylene diamine (DPEN) as structural motif, a straightforward three-step protocol was developed that gave access to novel chiral ligands with carbamate-substructure and pyridinium headgroup. The careful optimization of steric and electronic properties in combination with the adaption of solubility via choice of the anion gave a set of chiral and water-soluble ligands for use in ruthenium-catalyzed asymmetric transfer hydrogenations in aqueous medium. Eventually, a pool of aliphatic and aromatic ketones as well as two imine substrates were reduced with excellent isolated yields up to 95% and enantioselectivities >90% ee under environmentally benign conditions in the absence of additional surfactants.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Palvolgyi, AM; Bitai, J; Zeindlhofer, V; Schroder, C; Bica, K or concate me.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; CRYSTAL-STRUCTURE; PYRAZOLINES; ANTICANCER; ANTIBACTERIAL; ANALOGS, Saw an article supported by the Dean’s Office of the College of Pharmacy and Health Sciences, Ajman University, UAE. Application In Synthesis of 3-Pyridinecarboxaldehyde. Published in MDPI in BASEL ,Authors: Shaik, AB; Bhandare, RR; Nissankararao, S; Edis, Z; Tangirala, NR; Shahanaaz, S; Rahman, MM. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Infectious diseases caused by fungi and mycobacteria pose an important problem for humankind. Similarly, cancer is one of the leading causes of death globally. Therefore, there is an urgent need for the development of novel agents to combat the deadly problems of cancer, tuberculosis, and also fungal infections. Hence, in the present study, we designed, synthesized, and characterized 30 compounds including 15 chalcones (2-16) and 15 dihydropyrazoles (17-31) containing dichlorophenyl moiety and also screened these compounds for their antifungal, antitubercular, and antiproliferative activities. Among these compounds, the dihydropyrazoles showed excellent antifungal and antitubercular activities whereas the chalcones exhibited promising antiproliferative activity. Among the dihydropyrazoles, compound31containing 2-thienyl moiety showed promising antifungal activity (MIC 5.35 mu M), whereas compounds22and24containing 2,4-difluorophenyl and 4-trifluoromethyl scaffolds revealed significant antitubercular activity with the MICs of 3.96 and 3.67 mu M, respectively. Compound16containing 2-thienyl moiety in the chalcone series showed the highest anti-proliferative activity with an IC(50)value of 17 +/- 1 mu M. The most active compounds identified through this study could be considered as starting points in the development of drugs with potential antifungal, antitubercular, and antiproliferative activities.

Application In Synthesis of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Shaik, AB; Bhandare, RR; Nissankararao, S; Edis, Z; Tangirala, NR; Shahanaaz, S; Rahman, MM or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Functionalization of the Chalcone Scaffold for the Discovery of Novel Lead Compounds Targeting Fungal Infections published in 2019.0, Reprint Addresses Belluti, F (corresponding author), Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol, Via Belmeloro 6, I-40126 Bologna, Italy.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

The occurrence of invasive fungal infections represents a substantial threat to human health that is particularly serious in immunocompromised patients. The limited number of antifungal agents, devoid of unwanted toxic effects, has resulted in an increased demand for new drugs. Herein, the chalcone framework was functionalized to develop new antifungal agents able to interfere with cell growth and with the infection process. Thus, a small library of chalcone-based analogues was evaluated in vitro against C. albicans ATCC 10231 and a number of compounds strongly inhibited yeast growth at non-cytotoxic concentrations. Among these, 5 and 7 interfered with the expression of two key virulence factors in C. albicans pathogenesis, namely, hyphae and biofilm formation, while 28 emerged as a potent and broad spectrum antifungal agent, enabling the inhibition of the tested Candida spp. and non-Candida species. Indeed, these compounds combine two modes of action by selectively interfering with growth and, as an added value, weakening microbial virulence. Overall, these compounds could be regarded as promising antifungal candidates worthy of deeper investigation. They also provide a chemical platform through which to perform an optimization process, addressed at improving potency and correcting liabilities.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Bonvicini, F; Gentilomi, GA; Bressan, F; Gobbi, S; Rampa, A; Bisi, A; Belluti, F or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem