Tag: M.W=100-150

An article Palladium-Catalyzed Formal Hydroalkylation of Aryl-Substituted Alkynes with Hydrazones WOS:000537524300001 published article about C-H BONDS; OLEFIN SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; ALDEHYDES; ALKENYLATION; CARBANIONS; 1,3-DIENES; ALCOHOLS; ALKENES in [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, FRQNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Tan, Ze] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China in 2020.0, Cited 62.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

We have developed an unprecedented Pd-catalyzed formal hydroalkylation of alkynes with hydrazones, which are generated in situ from naturally abundant aldehydes, as both alkylation reagents and hydrogen donors. The hydroalkylation proceeds with high regio- and stereoselectivity to form (Z)-alkenes, which are more difficult to generate compared to (E)-alkenes. The reaction is compatible with a wide range of functional groups, including hydroxy, ester, ketone, nitrile, boronic ester, amine, and halide groups. Furthermore, late-stage modifications of natural products and pharmaceutical derivatives exemplify its unique chemoselectivity, regioselectivity, and synthetic applicability. Mechanistic studies indicate the possible involvement of Pd-hydride intermediates.

SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Yu, L; Lv, LY; Qiu, ZH; Chen, ZP; Tan, Z; Liang, YF; Li, CJ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Copper-Catalyzed Asymmetric Radical 1,2-Carboalkynylation of Alkenes with Alkyl Halides and Terminal Alkynes WOS:000537415600047 published article about CROSS-COUPLING REACTIONS; ENANTIOSELECTIVE 1,2-DIFUNCTIONALIZATION; IODIDES; TRIFLUOROMETHYLATION; FUNCTIONALIZATION; 1,2-ADDITION; ALKYNYLATION; STRATEGY; DIENES; LIGAND in [Dong, Xiao-Yang] Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Peoples R China; [Dong, Xiao-Yang; Cheng, Jiang-Tao; Zhang, Yu-Feng; Zhan, Tian-Ya; Chen, Ji-Jun; Wang, Fu-Li; Yang, Ning-Yuan; Liu, Xin-Yuan] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China; [Dong, Xiao-Yang; Cheng, Jiang-Tao; Zhang, Yu-Feng; Zhan, Tian-Ya; Chen, Ji-Jun; Wang, Fu-Li; Yang, Ning-Yuan; Liu, Xin-Yuan] Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China; [Li, Zhong-Liang; Ye, Liu; Gu, Qiang-Shuai] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China; [Li, Zhong-Liang; Ye, Liu; Gu, Qiang-Shuai] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China in 2020.0, Cited 73.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A copper-catalyzed intermolecular three-component asymmetric radical 1,2-carboalkynylation of alkenes has been developed, providing straightforward access to diverse chiral alkynes from readily available alkyl halides and terminal alkynes. The utilization of a cinchona alkaloid-derived multidentate N,N,P-ligand is crucial for the efficient radical generation from mildly oxidative precursors by copper and the effective inhibition of the undesired Glaser coupling side reaction. The substrate scope is broad, covering (hetero)aryl-, alkynyl-, and aminocarbonyl-substituted alkenes, (hetero)aryl and alkyl as well as silyl alkynes, and tertiary to primary alkyl radical precursors with excellent functional group compatibility. Facile transformations of the obtained chiral alkynes have also been demonstrated, highlighting the excellent complementarity of this protocol to direct 1,2-dicarbofunctionalization reactions with C(sp(2)/sp(3))-based reagents.

COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Dong, XY; Cheng, JT; Zhang, YF; Li, ZL; Zhan, TY; Chen, JJ; Wang, FL; Yang, NY; Ye, L; Gu, QS; Liu, XY or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Kazia, AK; Melngaile, RM; Mishnev, AM; Veliks, JV in [Kazia, Armands; Melngaile, Renate; Mishnev, Anatoly; Veliks, Janis] Latvian Inst Organ Synth, Aizkraukles 21, LV-1006 Riga, Latvia published Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes: scope and limitations in 2020.0, Cited 44.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Johnson-Corey-Chaykovsky fluorocyclopropanation of double activated alkenes utilizing S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate is an efficient approach to obtain a range of monofluorocyclopropane derivatives. So far, fluoromethylsulfonium salts have displayed the broadest scope for direct fluoromethylene transfer. In contrast to more commonly used fluorohalomethanes or freon derivatives, diarylfluoromethylsulfonium salts are bench stable, easy-to use reagents useful for the direct transfer of a fluoromethylene group to alkenes giving access to the challenging products – fluorocyclopropane derivatives. Interplay between the reactivity of the starting materials and stability of the fluorocyclopropanes formed determines the outcome of the process.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kazia, AK; Melngaile, RM; Mishnev, AM; Veliks, JV or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Highly diastereoselective and thermodynamically controlled nucleophilic addition of alpha-fluoro-alpha-phenylthio-alpha-phenylsulfonylmethane (FTSM) to aldehydes WOS:000512218200001 published article about FLUORINATED SULFONES; FLUOROALKYLATION; TRIFLUOROMETHYLATION; DI in [Ye, Wenchao; Zhu, Lingui; Luo, Qinyu; Ni, Chuanfa; Hu, Jinbo] Chinese Acad Sci, Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Key Lab Organofluorine Chem,Shanghai Inst Organ C, 345 Ling Ling Rd, Shanghai 200032, Peoples R China in 2020.0, Cited 18.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A thermodynamically controlled and reversible nucleophilic addition of a monofluorinated sulfone, alpha-fluoro-alpha-phenylthio-alpha-phenylsulfonylmethane (FTSM), to aldehydes has been developed, which allows the efficient synthesis of beta-fluorinated carbinols with high diastereoselectivity. Control experiments showed that the fluorine substitution not only promotes the addition process, but also improves the diastereoselectivity. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ye, WC; Zhu, LG; Luo, QY; Ni, CF; Hu, JB or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. Khalil, HSA; Sedky, NK; Amin, KM; Abd Elhafez, OM; Arafa, RK in [Khalil, Hazem S. A.] Armed Forces, Cairo, Egypt; [Sedky, Nada K.; Arafa, Reem K.] Zewail City Sci & Technol, Program Biomed Sci, Cairo 12578, Egypt; [Amin, Kamelia M.] Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt; [Abd Elhafez, Omaima M.] Natl Res Ctr, Cairo, Egypt published Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking in 2019.0, Cited 41.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A series of new visnagin and benzofuran scaffold-based molecules was designed and synthesized as anti-inflammatory and analgesic agents. Biological screening of these compounds showed that they exhibit potent anti-inflammatory/analgesic activity with a safer side effect profile in in vivo mouse models. In vitro cyclooxygenase (COX)inhibition assay showed that the compounds elicit their function through selective COX-2 inhibition. Molecular docking study also revealed the ability of the compounds to correctly recognize the active site and achieve noncovalent binding interactions with key residues therein. The best combined profile of anti-inflammatory, analgesic and COX-2 selective inhibition properties in association with low gastrotoxicity was displayed by the analogs 8, 11b and 19d, which can be considered as promising leads for further future optimization. [GRAPHICS] .

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Khalil, HSA; Sedky, NK; Amin, KM; Abd Elhafez, OM; Arafa, RK or concate me.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. In 2019.0 EUR J ORG CHEM published article about ONE-POT SYNTHESIS; HURD-MORI-REACTION; 1,3,4-THIADIAZOLE DERIVATIVES; MOLECULAR-IODINE; DEPRESSANT ACTIVITY; MEDIATED SYNTHESIS; N-TOSYLHYDRAZONES; C-N; BOND; 2-AMINO-1,3,4-THIADIAZOLES in [Zhu, Fuyuan; Yan, Zhaohua; Ai, Chengmei; Wang, Yanmei; Lin, Sen] Nanchang Univ, Coll Chem, 999 Xuefu Dadao, Nanchang 330031, Jiangxi, Peoples R China in 2019.0, Cited 56.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A new three-component strategy from aldehyde, p-toluenesulfonyl hydrazide and potassium thiocyanate for the synthesis of 2-aminothiadiazoles promoted by I-2 under metal-free conditions has been described. Potassium thiocyanate was used as an odorless and low-toxicity sulfur source. A wide range of aromatic aldehydes can smoothly undergo the three-component cyclization reaction under the optimized conditions to give the corresponding products in moderate to good yields.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zhu, FY; Yan, ZH; Ai, CM; Wang, YM; Lin, S or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Ajani, OO; Iyaye, KT; Aderohunmu, DV; Olanrewaju, IO; Germann, MW; Olorunshola, SJ; Bello, BL in ELSEVIER published article about QUINOLINE DERIVATIVES; ESCHERICHIA-COLI; BINDING; MECHANISMS; RESISTANCE; DOCKING; OVENS in [Ajani, Olayinka O.; Iyaye, King T.; Aderohunmu, Damilola V.; Olanrewaju, Ifedolapo O.] Covenant Univ, Dept Chem, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria; [Germann, Markus W.; Bello, Babatunde L.] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA; [Olorunshola, Shade J.] Covenant Univ, Dept Biol Sci, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria in 2020.0, Cited 53.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Microwave-assisted approach was utilized as green approach to access a series of 2-pro pylquinoline-4-carbohydrazide hydrazone derivatives 10a-j of aromatic and heteroaromatic aldehydes in highly encouraging yields. It involved four steps reaction which was initiated with ring opening reaction of isatin in a basified environment and subsequent cross-coupling with pentan-2-one to produce compound 7. Esterification of 7 in acid medium led to the formation of compound 8 which was reacted with hydrazine hydrate to access 9 which upon microwave-assisted condensed with aromatic and heteroaromatic aldehydes furnished the targeted compounds 10a-j. The structures of 10aj were confirmed by physico-chemical, elemental analyses and spectroscopic characterization which include UV, FT-IR, H-1 and C-13 NMR as well as DEPT-135. The targeted compounds 10a-j, alongside with gentamicin clinical standard, were investigated for their antibacterial efficacies using agar diffusion method. 2-Propyl-N’-(pyridine-3-ylmethylene) quinoline-4-carbohydrazide 10j emerged as the best antibacterial hydrazide-hydrazone with lowest MIC value of 0.39 +/- 0.02 – 1.56 +/- 0.02 mu g/ mL across all the organisms screened. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ajani, OO; Iyaye, KT; Aderohunmu, DV; Olanrewaju, IO; Germann, MW; Olorunshola, SJ; Bello, BL or concate me.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy WOS:000459358600010 published article about DEPENDENT KINASE INHIBITOR; MICROTUBULE POLYMERIZATION; CDK4-SPECIFIC INHIBITORS; BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; CRYSTAL-STRUCTURE; NONPLANAR ANALOG; CYCLIN D1-CDK4; IN-VITRO; PROTEIN in [Sonawane, Vinay; Chaudhuri, Bhabatosh] De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England; [Siddique, Mohd Usman Mohd; Sinha, Barij Nayan; Jayaprakash, Venkatesan] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India; [Jadav, Surender Singh] Indian Inst Chem Technol, CSIR, Hyderabad 500007, Telangana, India in 2019, Cited 79. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Safety of 3-Pyridinecarboxaldehyde

Inhibition of cyclin dependent kinase 4 (Cdk4) prevents cancer cells from entering the early G(0)/G(1) phase of the cell division cycle whereas inhibiting tubulin polymerization blocks cancer cells’ ability to undergo mitosis (M) late in the cell cycle. We had reported earlier that two non-planar and relatively non-toxic fascaplysin derivatives, an indole and a tryptoline, inhibit Cdk4 with IC50 values of 6.2 and 10 mu M, respectively. Serendipitously, we had also found that they inhibited tubulin polymerization. The molecules were efficacious in mouse tumor models. We have now identified Cink4T in a 59-compound quinazolinone library, designed on the basis of ligand-based virtual screening, as a compound that inhibits Cdk4 and tubulin. Its IC50 value for Cdk4 inhibition is 0.47 mu M and >50 mu M for inhibition of Cdk1, Cdk2, Cdk6, Cdk9. Cink4T inhibits tubulin polymerization with an IC50 of 0.6 mu M. Molecular modelling studies on Cink4T with Cdk4 and tubulin crystal structures lend support to these observations. Cancer cell cycle analyses confirm that Cink4T blocks cells at both G(0)/G(1) and M phases as it should if it were to inhibit both Cdk4 and tubulin polymerization. Our results show, for the very first time, that virtual screening can be used to design novel inhibitors that can potently block two crucial phases of the cell division cycle. (C) 2019 Elsevier Masson SAS. All rights reserved.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Sonawane, V; Siddique, MUM; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Kolli, MK; Palani, E; Govindasamy, C; Katta, VR in [Kolli, Murali Krishna; Palani, Elamathi; Govindasamy, Chandrasekar] VIT Univ, Sch Adv Sci, Div Chem, Chennai 600127, Tamil Nadu, India; [Govindasamy, Chandrasekar] Imam Abdulrahman Bin Faisal Univ, IRMC, Dammam 31441, Saudi Arabia; [Kolli, Murali Krishna; Katta, Vishweshwar Rao] GVK Biosci Pvt Ltd, Dept Med Chem, IDA Nacharam, Hyderabad 500076, Telangana, India published Highly efficient one-pot synthesis of alpha-aminophosphonates using nanoporous AlSBA-15 catalyst in a three-component system in 2020.0, Cited 89.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Nanoporous AlSBA-15 catalysts with different nSi/nAl ratios (41, 129, and 210) were synthesized using a hydrothermal method. These catalysts were characterized by XRD, N-2 sorption, TPD-NH3, FT-IR, SEM and TEM. XRD analyses of AlSBA-15 catalysts confirmed the presence of well-ordered crystalline structure with p6mm symmetry. The specific surface area and specific pore volume of the AlSBA-15 catalysts are in the range of 480 to 757 m(2)/g and 0.65 to 0.95 cm(3)/g, respectively. The catalytic performance of nanoporous AlSBA-15 catalysts are used as an outstanding catalytic system for one-pot synthesis of alpha-aminophosphonates via Kabachnik-Fields reaction in a three-component system using amines (primary/secondary), carbonyl compounds (aldehydes/ketones) and diethyl phosphite. The major advantages of the present contributions are excellent yields, short reaction time, simple experimental technique, high chemo-selectivity, catalyst recyclability, easy work-up procedure and green approach. Three-component synthesis of alpha-aminophosphonates follows first imine formation from amine and aldehyde/ketone followed by phosphate addition. The experimental findings suggest that the nanoporous AlSBA-15 catalysts can be recycled and reused up to six cycles without any loss in the catalytic performance.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kolli, MK; Palani, E; Govindasamy, C; Katta, VR or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Xia, XS; Lao, ZQ; Toy, PH in [Xia, Xuanshu; Lao, Zhiqi; Toy, Patrick H.] Univ Hong Kong, Dept Chem, Pokfulam Rd, Hong Kong, Peoples R China published Triphenylphosphine Oxide-Catalyzed Selective ,-Reduction of Conjugated Polyunsaturated Ketones in 2019.0, Cited 25.0. Application In Synthesis of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The scope of the triphenylphosphine oxide-catalyzed reduction of conjugated polyunsaturated ketones using trichlorosilane as the reducing reagent has been examined. In all cases studied, the ,-C=C double bond was selectively reduced to a C-C single bond while all other reducible functional groups remained unchanged. This reaction was applied to a large variety of conjugated dienones, a trienone, and a tetraenone. Additionally, a tandem one-pot Wittig/conjugate-reduction reaction sequence was developed to produce ,-unsaturated ketones directly from simple building blocks. In these reactions the byproduct of the Wittig reaction served as the catalyst for the reduction reaction. This strategy was then used in the synthesis of naturally occurring moth pheromones to demonstrate its utility in the context of natural-product synthesis.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Xia, XS; Lao, ZQ; Toy, PH or concate me.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem