Tag: M.W=100-150

Recently I am researching about ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; ANTIMICROBIAL ACTIVITIES; EFFICIENT; CA9.5MG0.5(PO4)(5.5)(SIO4)(0.5)F-1.5; ANTICONVULSANT; COMBINATORIAL; SCAFFOLDS; CHEMISTRY; REAGENTS, Saw an article supported by the Islamic Azad University, Khorasgan, and Fasa BranchesIslamic Azad University. Recommanded Product: 500-22-1. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Memar, FO; Khazdooz, L; Zarei, A; Abbaspourrad, A. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

In this study, we synthesize 2-amino-4-alkyl/aryl-6-(hydroxymethyl)-8-oxopyrano[3,2-b] pyran-3-carbonitriles derivatives using a multicomponent reaction featuring aromatic or aliphatic aldehydes, kojic acid, and malononitrile catalyzed by nano fluoroapatite doped with Si and Mg (Si-Mg-FA). All reactions were carried out in EtOH as the solvent under reflux and green condition. The process demonstrates various advantages, including high yields, short reaction times, and simple workup. In addition, toxic organic solvent is not used, nor is chromatographic purification of products required. We characterized the synthesized compounds by Fourier transform infrared,(CNMR)-C-13, and(1)HNMR spectroscopies. Additionally, the antibacterial properties of the pyrano[3,2-b]pyran derivatives were evaluated by determining the minimum inhibitory concentration on two gram-positive and gram-negative bacteria using the macro dilution method and compared with Penicillin and Tetracycline at the same conditions. The 2-amino-4-(2,4-dichlorophenyl)-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile and the 2-amino-4-hexyl-4,8-dihydro-6-(hydroxymethyl)-8-oxo-pyrano[3,2-b]pyran-3-carbonitrile show the best antibacterial activity with a MIC value of 62.5 mu g/ml againstStaphylococcus aureus(ATCC 25923). Moreover, the antioxidant properties of the pyrano[3,2-b] pyrans derivatives were evaluated. It is notable that pyrano[3,2-b] pyrans derivatives, synthesized with substituent groups on benzaldehyde such as-NO2, -COOCH3, -OMe show the best antioxidant activity measured by DPPH radical-scavenging method.

Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Memar, FO; Khazdooz, L; Zarei, A; Abbaspourrad, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Zhu, XJ; Liu, Y; Liu, C; Yang, HJ; Fu, H in [Zhu, Xianjin; Liu, Yong; Liu, Can; Yang, Haijun; Fu, Hua] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China published Light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds in 2020, Cited 59. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Visible light-induced organic reactions are important chemical transformations in organic chemistry, and their efficiency highly depends on suitable photocatalysts. However, the commonly used photocatalysts are precious transition-metal complexes and elaborate organic dyes, which hamper large-scale production due to high cost. Here, for the first time, we report a novel strategy: light and oxygen-enabled sodium trifluoromethanesulfinate-mediated selective oxidation of C-H bonds, allowing high-value-added aromatic ketones and carboxylic acids to be easily prepared in high-to-excellent yields using readily available alkyl arenes, methyl arenes and aldehydes as materials. The mechanistic investigations showed that the treatment of inexpensive and readily available sodium trifluoromethanesulfinate with oxygen under irradiation of light couldin situform a pentacoordinate sulfide intermediate as an efficient photosensitizer. The method represents a highly efficient, economical and environmentally friendly strategy, and the light and oxygen-enabled sodium trifluoromethanesulfinate photocatalytic system represents a breakthrough in photochemistry.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zhu, XJ; Liu, Y; Liu, C; Yang, HJ; Fu, H or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. I found the field of Chemistry very interesting. Saw the article Synthesis and Biological Evaluation of Heterocyclic Substituted Bis(indolyl)methanes published in 2020.0, Reprint Addresses Mao, ZW (corresponding author), Yunnan Univ Chinese Med, Coll Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China.; Wan, CP (corresponding author), Yunnan Univ Chinese Med, 1 Affiliated Hosp, Cent Lab, Kunming 650021, Yunnan, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Background: Bis(indolyl)methane derivatives are widely found in nature with a broad range of biological and pharmacological activities. The development of techniques for the synthesis and functionalization of bis(indolyl)methanes have attracted more and more attention in recent years. Objective: To study the synthesis and biological activity of heterocyclic substituted bis(indolyl)methanes. Materials and Methods: A series of heterocyclic substituted bis(indolyl)methanes (3a-3p) have been prepared by condensation reaction of indole and heterocyclic aldehydes catalyzed by boron trifluoride etherate with high yields. Preliminary in vitro anti-inflammatory in lipopolysaccharide (LIPS)-stimulated RAW-264.7 macrophages and cytotoxic activity against human tumor cell lines (A549, Hela and SGC7901) by MTT assay were tested. Results: The result indicated that heterocyclic substituted bis(indolyl)methanes showed good anti-inflammatory and selective cytotoxic activity. Especially, compounds 3o, 3p and 3q displayed similar inhibitory effect on the generation of NO to positive control dexamethasone, and compound 3q displayed similar selective cytotoxic activity to 5-FU. Conclusion: Heterocyclic substituted bis(indolyl)methanes may be used as potential anti-inflammatory and anticancer leads.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Li, MX; Pu, XJ; Zhang, X; Zheng, X; Gao, H; Xiao, WL; Wan, CP; Mao, ZW or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Khalil, HSA; Sedky, NK; Amin, KM; Abd Elhafez, OM; Arafa, RK in FUTURE SCI LTD published article about BIOLOGICAL EVALUATION; CHROMONES; KHELLIN; DISEASE; ANALOGS; AGENTS; RATS in [Khalil, Hazem S. A.] Armed Forces, Cairo, Egypt; [Sedky, Nada K.; Arafa, Reem K.] Zewail City Sci & Technol, Program Biomed Sci, Cairo 12578, Egypt; [Amin, Kamelia M.] Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo, Egypt; [Abd Elhafez, Omaima M.] Natl Res Ctr, Cairo, Egypt in 2019.0, Cited 41.0. Recommanded Product: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A series of new visnagin and benzofuran scaffold-based molecules was designed and synthesized as anti-inflammatory and analgesic agents. Biological screening of these compounds showed that they exhibit potent anti-inflammatory/analgesic activity with a safer side effect profile in in vivo mouse models. In vitro cyclooxygenase (COX)inhibition assay showed that the compounds elicit their function through selective COX-2 inhibition. Molecular docking study also revealed the ability of the compounds to correctly recognize the active site and achieve noncovalent binding interactions with key residues therein. The best combined profile of anti-inflammatory, analgesic and COX-2 selective inhibition properties in association with low gastrotoxicity was displayed by the analogs 8, 11b and 19d, which can be considered as promising leads for further future optimization. [GRAPHICS] .

Recommanded Product: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Khalil, HSA; Sedky, NK; Amin, KM; Abd Elhafez, OM; Arafa, RK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Wang, Y; Yang, RH; Luo, WY; Li, ZX; Zhang, Z; Wu, CD; Hadjichristidis, N in AMER CHEMICAL SOC published article about FUNCTIONALIZED POLYMERS; POLY(ETHYLENE GLYCOL); TOSYL AZIRIDINES; POLYSTYRENE; COPOLYMERS in [Wang, Ying; Yang, Ruhan; Luo, Wenyi; Li, Zhunxuan; Zhang, Zhen; Wu, Chuande] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China; [Wu, Chuande] Zhejiang Univ, Dept Chem, State Key Lab Silicon Mat, Hangzhou 310027, Zhejiang, Peoples R China; [Hadjichristidis, Nikos] KAUST, Polymer Synth Lab, KAUST Catalysis Ctr, Phys Sci & Engn Div, Thuwal 23955, Saudi Arabia in 2019.0, Cited 50.0. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Using the easily accessible 2-azaallyl anions as initiators, the one-pot synthesis of well-defined primary amine-ended telechelic polyaziridines (alpha-NH2 PAzs) has been achieved through the ring-opening polymerization (ROP) of N-sulfonyl aziridines followed by hydrolysis of the diphenylketimine moiety (-N=C-Ph-2). The 2-azaallyl anions were synthesized from the reaction of diphenylketimine or N-[aryl-methylene]-alpha-phenylbenzenemethanamine with potassium bis(trimethylsilyl) amide (KHMDS) in situ and used to initiate the ROP of aziridines leading to well-defined alpha-(Ph2C=N)-alpha’-aryl-omega-NH PAzs. Along with the diphenylketimine group (-N=C-Ph-2), aryl functionalities, such as pyridine and triphenylphosphine moieties, can also be incorporated to the chain end. Chain extension has been applied for the synthesis of poly(N-sulfonyl aziridine)-block-poly(epsilon-caprolactone) (PAz-b-PCL) block copolymers by utilization of the primary amine end group as initiating sites for the ROP of epsilon-caprolactone catalyzed by tin 2-ethyl hexanoate (SnOct(2)). Taking advantage of this synthetic approach, core cross-linked multiarm star (CCS) polymers with an outermost shell having amino and triphenylphosphine functionalities have been synthesized via arm-first strategy.

SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, Y; Yang, RH; Luo, WY; Li, ZX; Zhang, Z; Wu, CD; Hadjichristidis, N or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design and Synthesis of Pyrrolidine-based Fragments That Sample Three-dimensional Molecular Space published in 2019.0. Formula: C6H5NO, Reprint Addresses Garner, P (corresponding author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA.; Cox, PB (corresponding author), AbbVie Inc, Discovery Chem & Technol, 1 North Waukegan Rd, N Chicago, IL 60064 USA.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Fragment-based drug discovery (FBDD) is a well- established technology for lead compound generation in drug discovery. As this technology has evolved, the design of fragments for screening has also evolved to engender not just an understanding of the role of modulating the physicochemical properties of fragments (Rule of Three, Ro3) but also the importance and implications of incorporating shape and, in particular, 3D characteristics into fragments. Herein, we describe the design and synthesis of pyrrolidine-based fragments with good fragment-like (Ro3) physicochemical properties that effectively sample three-dimensional molecular space.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Garner, P; Cox, PB; Rathnayake, U; Holloran, N; Erdman, P or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity WOS:000467781700024 published article about H-3 RECEPTOR; NEURONAL HISTAMINE; H3 RECEPTOR; AGONIST; PROTEIN; SYSTEM; DISCOVERY; TARGET; 2-AMINOPYRIMIDINES; IDENTIFICATION in [Kumar, Ajeet; Yadav, Anubhav; Dogra, Shalini; Sona, Chandan; Umrao, Deepmala; Yadav, Prem N.] Cent Drug Res Inst, Pharmacol Div, Lucknow 226031, Uttar Pradesh, India; [Pasam, Venkata Reddy; Thakur, Ravi Kumar; Singh, Kartikey; Tripathi, Rama Pati] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India; [Singh, Maninder; Siddiq, Mohammad Imran] Cent Drug Res Inst, Mol & Struct Biol Div, Lucknow 226031, Uttar Pradesh, India; [Shukla, Mahendra; Jaiswal, Swati; Ahmad, Hafsa; Rashid, Mamunur; Singh, Sandeep K.; Wahajuddin, Muhammad; Dwivedi, Anil Kumar; Lal, Jawahar] Cent Drug Res Inst, Pharmaceut & Pharmacokinet Div, Lucknow 226031, Uttar Pradesh, India; [Shukla, Mahendra; Jaiswal, Swati; Ahmad, Hafsa; Rashid, Mamunur; Singh, Sandeep K.; Wahajuddin, Muhammad; Dwivedi, Anil Kumar; Lal, Jawahar] Cent Drug Res Inst, CSIR, Lucknow 226031, Uttar Pradesh, India; [Siddiq, Mohammad Imran; Tripathi, Rama Pati; Yadav, Prem N.] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India; [Tripathi, Rama Pati] Natl Inst Pharmaceut Educ & Res Raebareli, New Transit Campus,Bijnor Rd, Lucknow 226002, Uttar Pradesh, India in 2019.0, Cited 85.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

The histamine 3 receptor (H3R) is a presynaptic receptor, which modulates several neurotransmitters including histamine and various essential physiological processes, such as feeding, arousal, cognition, and pain. The H3R is considered as a drug target for the treatment of several central nervous system disorders. We have synthesized and identified a novel series of 4-aryl-6-methyl-5,6,7,8-tetrahydroquinazolinamines that act as selective H3R antagonists. Among all the synthesized compounds, in vitro and docking studies suggested that the 4-methoxy-phenyl-substituted tetrahydroquinazolinamine compound 4c has potent and selective H3R antagonist activity (IC50 < 0.04 mu M). Compound 4c did not exhibit any activity on the hERG ion channel and pan-assay interference compounds liability. Pharmacokinetic studies showed that 4c crosses the blood brain barrier, and in vivo studies demonstrated that 4c induces anorexia and weight loss in obese, but not in lean mice. These data reveal the therapeutic potential of 4c as an anti-obesity candidate drug via antagonizing the H3R. SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kumar, A; Pasam, VR; Thakur, RK; Singh, M; Singh, K; Shukla, M; Yadav, A; Dogra, S; Sona, C; Umrao, D; Jaiswal, S; Ahmad, H; Rashid, M; Singh, SK; Wahajuddin, M; Dwivedi, AK; Siddiq, MI; Lal, J; Tripathi, RP; Yadav, PN or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Gorodnicheva, NV; Vasil’eva, OS; Ostroglyadov, ES; Baichurin, RI; Makarenko, SV; Karamov, FA; Lodochnikova, OA; Litvinov, IA in [Gorodnicheva, N. V.; Vasil’eva, O. S.; Ostroglyadov, E. S.; Baichurin, R. I.; Makarenko, S. V.] Herzen State Pedag Univ Russia, 48 Nab R Moiki, St Petersburg 191186, Russia; [Karamov, F. A.] Kazan Natl Res Tech Univ, 10 Ul K Marksa, Kazan 420111, Russia; [Lodochnikova, O. A.; Litvinov, I. A.] Russian Acad Sci, Kazan Sci Ctr, Fed Res Ctr, AE Arbuzov Inst Organ & Phys Chem, 8 Ul Akad Arbuzova, Kazan 420088, Russia published 4-Het(aryl)-2-pyrrolidone-3(5)-carboxylic acid alkyl(hetaryl)idenecarbohydrazides: synthesis and structure in 2020.0, Cited 25.0. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

4-Het(aryl)-2-pyrrolidone-3(5)-carboxylic acid hydrazides react with aromatic aldehydes, acetone, and acetophenone to give new representatives of N ‘-alkyl(hetaryl)idenecarbohydrazides of (3R*,4S*)-4-het(aryl)-2-pyrrolidone-3- and (4R*,5R*)-4-het(aryl)-2-pyrrolidone-5-carboxylic acids.

Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Gorodnicheva, NV; Vasil’eva, OS; Ostroglyadov, ES; Baichurin, RI; Makarenko, SV; Karamov, FA; Lodochnikova, OA; Litvinov, IA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators published in 2020.0, Reprint Addresses Thakur, GA (corresponding author), Northeastern Univ, Bouve Coll Hlth Sci, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA.; Laprairie, RB (corresponding author), Univ Saskatchewan, Coll Pharm & Nutr, 104 Clin Pl, Saskatoon, SK S7N 2Z4, Canada.; Laprairie, RB (corresponding author), Dalhousie Univ, Fac Med, Dept Pharmacol, 5850 Coll St, Halifax, NS B3H 4R2, Canada.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Cannabinoid 1 receptor (CB1R) allosteric ligands hold a far-reaching therapeutic promise. We report the application of fluoro- and nitrogen-walk approaches to enhance the drug-like properties of GAT211, a prototype CB1R allosteric agonist-positive allosteric modulator (ago-PAM). Several analogs exhibited improved functional potency (cAMP, beta-arrestin 2), metabolic stability, and aqueous solubility. Two key analogs, GAT591 (6r) and GAT593 (6s), exhibited augmented allosteric-agonist and PAM activities in neuronal cultures, improved metabolic stability, and enhanced orthosteric agonist binding (CP55,940). Both analogs also exhibited good analgesic potency in the CFA inflammatory-pain model with longer duration of action over GAT211 while being devoid of adverse cannabimimetic effects. Another analog, GAT592 (9j), exhibited moderate ago-PAM potency and improved aqueous solubility with therapeutic reduction of intraocular pressure in murine glaucoma models. The SAR findings and the enhanced allosteric activity in this class of allosteric modulators were accounted for in our recently developed computational model for CB1R allosteric activation and positive allosteric modulation. [GRAPHICS] .

Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Garai, S; Kulkarni, PM; Schaffer, PC; Leo, LM; Brandt, AL; Zagzoog, A; Black, T; Lin, XY; Hurst, DP; Janero, DR; Abood, ME; Zimmowitch, A; Straiker, A; Pertwee, RG; Kelly, M; Szczesniak, AM; Denovan-Wright, EM; Mackie, K; Hohmann, AG; Reggio, PH; Laprairie, RB; Thakur, GA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article A [bmim]Cl-promoted domino protocol using an isocyanide-based [4+1]-cycloaddition reaction for the synthesis of diversely functionalized 3-alkylamino-2-alkyl/aryl/hetero-aryl indolizine-1-carbonitriles under solvent-free conditions WOS:000518019300009 published article about IONIC LIQUID; MULTICOMPONENT SYNTHESIS; EFFICIENT CATALYST; C-C; INDOLIZINES; DERIVATIVES; ALKYNES; ACCESS; AMINES; CYCLIZATION in [Atar, Amol Balu; Kang, Jongmin] Sejong Univ, Dept Chem, Seoul 143747, South Korea; [Jadhav, Arvind H.] Jain Univ, CNMS, Jain Global Campus, Bangalore 562112, Karnataka, India in 2020.0, Cited 63.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A domino protocol involving aldehydes, isocyanides and 2-pyridylacetonitrile in the presence of [bmim]Cl as a promoter and solvent for the synthesis of 3-alkylamino-2-alkyl/arylindolizine-1-carbonitriles is described. A wide range of alkyl, aryl and hetero-aryl aldehydes reacted with 2-pyridylacetonitrile and isocyanides, leading to indolizine derivatives with high selectivity, high atom economy, and good to excellent yields. This straight-forward and highly efficient method allows the synthesis of bis-indolizine-1-carbonitrile derivatives.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Atar, AB; Kang, J; Jadhav, AH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem