Tag: M.W=100-150

Category: pyridine-derivatives. Recently I am researching about ONE-POT SYNTHESIS; FRIEDLANDER SYNTHESIS; NANOPARTICLES; COMPLEX; SURFACE; ACID; NANOCATALYST; DERIVATIVES; QUINOLINES; PHOSPHINE, Saw an article supported by the . Published in SPRINGER in NEW YORK ,Authors: Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe-Cr-Ni oxide alloy, was prepared in a two-step synthesis and characterized with various instrumental methods. Due to magnetic property of the screw (a ferritic-alloy), the resultant nano-belts is magnetic. Magnetic Fe-Cr-Ni alloy nano-belts were applied toward efficient preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild conditions. The catalyst could be readily recovered and recycled for several consecutive runs, while it suffers from a very low metal leaching and subsequently efficiency drop. Graphic abstract

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about TRANSFER HYDROGENATION; CONJUGATE REDUCTION; CYCLIZATION; HYDRODEHALOGENATION; CONSTRUCTION; CHLORIDES; OLEFINS; ESTER; ACID, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21202112, 21738002, 21776148]; Ph.D. Programs Foundation of the Ministry of Education of ChinaMinistry of Education, China [20123201120019]; Suzhou Science and Technology Project [ZXY201435]; PAPD (Priority Academic Program Development of Jiangsu Higher Education Institutions); Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2016BM07]; Key Research & Development Project of Shandong [2018GSF118224]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Liu, Y; Mao, YJ; Hu, YW; Gui, JJ; Wang, L; Wang, W; Zhang, SL. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Recommanded Product: 3-Pyridinecarboxaldehyde

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of alpha, beta-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Liu, Y; Mao, YJ; Hu, YW; Gui, JJ; Wang, L; Wang, W; Zhang, SL or concate me.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Magnetic Fe-Cr-Ni oxide alloy nano-belts prepared from the chemical decomposition of a stainless steel screw (a top-down approach): an efficient and cheap catalyst for multicomponent reactions WOS:000519963900003 published article about ONE-POT SYNTHESIS; FRIEDLANDER SYNTHESIS; NANOPARTICLES; COMPLEX; SURFACE; ACID; NANOCATALYST; DERIVATIVES; QUINOLINES; PHOSPHINE in [Kazemnejadi, Milad; Zeinali, Atefeh; Nasseri, Mohammad Ali] Univ Birjand, Dept Chem, Fac Sci, Birjand 97175615, Iran; [Sharafi, Zeinab] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran; [Mahmoudi, Boshra] Sulaimani Polytech Univ, Res Ctr, Sulaimani 46001, Kurdistan Regio, Iraq in 2020.0, Cited 48.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. HPLC of Formula: C6H5NO

A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe-Cr-Ni oxide alloy, was prepared in a two-step synthesis and characterized with various instrumental methods. Due to magnetic property of the screw (a ferritic-alloy), the resultant nano-belts is magnetic. Magnetic Fe-Cr-Ni alloy nano-belts were applied toward efficient preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild conditions. The catalyst could be readily recovered and recycled for several consecutive runs, while it suffers from a very low metal leaching and subsequently efficiency drop. Graphic abstract

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA or concate me.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents published in 2020.0. Quality Control of 3-Pyridinecarboxaldehyde, Reprint Addresses Taha, M (corresponding author), Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, PO Box1982, Dammam 31441, Saudi Arabia.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Leishmaniasis has affected a wider part of population around the globe. Most often, the existing regiments to battle against leishmaniasis are inadequate and limited. In our ongoing efforts to develop new leishmanicidal agents, we have synthesized a series of novel and symmetrical bis-Schiff base-disulfide hybrids 1-27. Intermediate disulfide was synthesized from corresponding 2-aminothiol followed by reacting the coupled adduct with various aromatic aldehydes. All these compounds showed outstanding inhibition when compared with standard (Table 1). Out of twenty seven analogues, twenty two analogues i.e. 1-5, 7-13, 17-21, 23-27 analogues showed excellent inhibitory potential with EC50 values ranging from 0.010 +/- 0.00 to 0.096 +/- 0.01 mu M while five compounds i.e. 6, 14-16, and 22 showed good inhibitory potential with EC50 values ranging from 0.10 +/- 0.00 to 0.137 +/- 0.01 mu M when compared with the standard Amphotericin B. Structure-activity relationship has been established while molecular docking studies were performed to pin the binding interaction of active molecules. This study will help to develop new antileishmanial lead compounds.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Taha, M; Sain, AA; Ali, M; Anouar, E; Rahim, F; Ismail, NH; Adenan, MI; Imran, S; Al-Harrasi, A; Nawaz, F; Iqbal, N; Khan, KM or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 500-22-1. In 2020.0 CHEM ENG SCI published article about DYNAMIC KINETIC RESOLUTION; ESCHERICHIA-COLI; SUBSTRATE; MECHANISM in [Wang, Li-Chao; Xu, Lian; Su, Bing-Mei; Lin, Juan] Fuzhou Univ, Coll Chem Engn, Fuzhou 350116, Peoples R China; [Wang, Li-Chao; Xu, Lian; Xu, Xin-Qi; Su, Bing-Mei; Lin, Juan] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China in 2020.0, Cited 33.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

L-threonine aldolase (LTA) is a PLP-dependent enzyme that can reversibly catalyze aldol reaction of glycine and acetaldehyde to produce beta-hydroxy-alpha-amino acids. In the present work, a putative Ita gene from Actinocorallia herbida (AhLTA) was mined and over-expressed in Escherichia coli BL21 (DE3). The substrate spectrum assay indicated that AhLTA only used glycine as donor substrate and tolerated a wild range of aromatic aldehydes as acceptor substrates. It was found that the type and position of substituents in the aromatic aldehydes exerted a significant impact on the activity and stereoselectivity at beta-carbon of AhLTA. Among those substrates, AhLTA could catalyze glycine and 4-methylsulphonyl benzaldehyde (14a) to produce L-threo-4-methylsulfonylphenylserine ((2S,3R)-14b) with high conversion (94.4%) and moderate stereoselectivity (19% de). By conditional optimization, the de value of (2S, 3R)-14b was improved to 61% and the conversion was 75%. Taken together, our study suggested that AhLTA might be a promising catalyst for producing chiral beta-hydroxy-alpha-amino acids. (C) 2020 Elsevier Ltd. All rights reserved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, LC; Xu, L; Xu, XQ; Su, BM; Lin, J or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. In 2020.0 J PHYS CHEM C published article about AGGREGATION-INDUCED EMISSION; FLUORESCENCE; DERIVATIVES; MECHANOCHROMISM; LUMINESCENCE; ISOMERS; COLOR in [Li, Ye-Xin; Chen, You-Gui; Yu, Zhen-Feng; Yang, Xiao-Feng; Nie, Yong; Cui, Yu; Sun, Guo-Xin] Jinan Univ, Sch Chem & Chem Engn, Jinan 250022, Peoples R China in 2020.0, Cited 31.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The mechanism of most mechanofluorochromic (MFC) materials is related to a noncovalent change in aggregate packing. It is still a challenge to clarify the respective effects of molecular conformation and intermolecular interaction on the MFC performance. Herein, a new (9-anthryl)vinyl derivative APYB with a polymorph-dependent multicolor-switchable MFC property is reported. APYB has only one torsion unit in the molecule configuration and could form four different crystal phases (APYB-a, APYB-b, APYB-c, and APYB-d). Furthermore, all polymorphs are MFC-active. Therefore, it provides a rare and direct case to correlate the aggregate packing with MFC performance. The solid-state emission could be finely tuned from 465 to 500 nm by virtue of polymorphism. Crystal structure analyses and optical studies reveal that an increasing twist angle could result in a blue shift in the fluorescence spectrum and a high-contrast MFC performance. In contrast, strong intermolecular interactions could lead to high emission efficiency and amorphization difficulty during the mechanical grinding. A tricolor-switchable MFC phenomenon was observed for APYB-a, while both APYB-b and APYB-d display a reversible bicolor-changing MFC behavior. As for APYB-c, mechanical grinding only causes a minor change in the emission spectrum. However, two competitive reverse transformation routes were found when treating the ground sample with organic solvent vapor. XRD analyses show that the MFC mechanism for APYB-a, APYB-c, and APYB-d is a crystal-to-amorphous transformation, while only partial amorphization was observed in the MFC behavior of APYB-b. The acidochromism effects of APYB-a and APYB-b were also investigated. They also display multicolor changes due to the polymorphic nature of APYB. Interestingly, in the deprotonation process, NH3 vapor could induce a different transformation route and color change from NEt3.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Li, YX; Chen, YG; Yu, ZF; Yang, XF; Nie, Y; Cui, Y; Sun, GX or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Van Zandt, MC; Jagdmann, GE; Whitehouse, DL; Ji, M; Savoy, J; Potapova, O; Cousido-Siah, A; Mitschler, A; Howard, EI; Pyle, AM; Podjarny, AD in AMER CHEMICAL SOC published article about BINUCLEAR MANGANESE CLUSTER; CRYSTAL-STRUCTURE; ARGININE; PURIFICATION; METABOLISM; EXPRESSION; TARGET in [Van Zandt, Michael C.; Jagdmann, G. Erik; Whitehouse, Darren L.; Ji, Minkoo; Savoy, Jennifer] New England Discovery Partners, 23 Business Pk Dr, Branford, CT 06405 USA; [Potapova, Olga; Pyle, Anna Marie] Yale Univ, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, 219 Prospect St, New Haven, CT 06511 USA; [Potapova, Olga; Pyle, Anna Marie] Yale Univ, Howard Hughes Med Inst, Dept Chem, 219 Prospect St, New Haven, CT 06511 USA; [Cousido-Siah, Alexandra; Mitschler, Andre; Podjarny, Alberto D.] Univ Strasbourg, INSERM, CNRS, Dept Integrat Biol,IGBMC, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France; [Howard, Eduardo I.] Consejo Nacl Invest Cient & Tecn, Inst Fis Liquidos & Sistemas Biol IFLYSIB, Calle 59 Numero 789, RA-1900 La Plata, Buenos Aires, Argentina in 2019.0, Cited 31.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogues with up to a 1000-fold increase in potency relative to the current standards, 2-amino-6-boronohexanoic acid (ABH) and N-hydroxy-nor-L-arginine (nor-NOHA). The lead candidate, with an N-2-amino-3-phenylpropyl substituent (NED-3238), example 43, inhibits arginase I and II with IC50 values of 1.3 and 8.1 nM, respectively. Herein, we report the design, synthesis, and structure activity relationships for this novel series of inhibitors, along with X-ray crystallographic data for selected examples bound to human arginase II.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Van Zandt, MC; Jagdmann, GE; Whitehouse, DL; Ji, M; Savoy, J; Potapova, O; Cousido-Siah, A; Mitschler, A; Howard, EI; Pyle, AM; Podjarny, AD or concate me.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article 5-endo-dig Cyclization of O-Propargyl Mandelic Acid Amides towards 2,5-Dihydrofurans WOS:000500575800001 published article about MOLECULAR-ORBITAL METHODS; FORMAL 4+1 CYCLOADDITION; GAUSSIAN-TYPE BASIS; STEREOCONTROLLED SYNTHESIS; ALLYLIC SUBSTITUTION; ASYMMETRIC-SYNTHESIS; GOLD CATALYSIS; CYCLOISOMERIZATION; ALCOHOLS; ETHERS in [Ben Gaied, Lilia] Inst Preparatoire Etud Sci & Tech, Lab Physicochim Microstruct & Microsyst, BP 51, Tunis 2070, Tunisia; [Fincias, Nicolas; Garrec, Julian; El Kaim, Laurent] Inst Polytech Paris, LSO, Ecole Polytech, CNRS,ENSTA Paris UMR 7652, 828 Bd Marechaux, F-91128 Palaiseau, France in 2019.0, Cited 71.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

5-endo-dig cyclization of O-propargyloxyamides, obtained through a Passerini reaction mediated by boric acid and subsequent propargylation, affords 2,5-dihydrofurans in the presence of tert-butylate. The mechanism of the reaction was studied by using DFT calculations and the results were compared with the behavior of analogous N-propargylamide derivatives.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ben Gaied, L; Fincias, N; Garrec, J; El Kaim, L or concate me.. Name: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Cell cycle arrest and induction of apoptosis of newly synthesized pyranoquinoline derivatives under microwave irradiation WOS:000464742900005 published article about ANTITUMOR ACTIVITIES; IN-VITRO; CONSTITUENTS; ALKALOIDS; QUINOLINE; ACIDS; ASSAY in [Fouda, Ahmed M.; Youssef, Ayman M. S.] King Khalid Univ, Fac Sci, Chem Dept, Abha 61413, Saudi Arabia; [Youssef, Ayman M. S.] Fayoum Univ, Fac Sci, Chem Dept, Al Fayyum, Egypt; [Afifi, Tarek H.] Taibah Univ, Fac Sci, Chem Dept, Al Madinah Al Munawarah 30002, Saudi Arabia; [Mora, Ahmed; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Nar City 11884, Cairo, Egypt in 2019, Cited 47. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Name: 3-Pyridinecarboxaldehyde

A set of 2-amino-4-aryl-4H-pyrano[3,2-h]quinoline-3-carbonitrile derivatives were prepared via a one-pot, three-component condensation reaction between the substituted hydroxyquinoline derivatives, some aryl and/or hetaryl aldehydes, and malononitrile in an ethanol/piperidine solution in a microwave irradiation environment. The structure of the prepared compounds was instituted on the foundations of their spectral data: IR, H-1 NMR, C-13 NMR, and MS. Four human cancer cell lines, MCF-7, HCT-116, HepG-2, and A549 were utilized to evaluate the antiproliferative properties of the target compounds in comparison to the positive controls, Vinblastine and Colchicine using the MTT viability assay. The cell cycle arrest behavior, detected by propidium iodide as well as the apoptosis induction, which was monitored by the flow cytometer, using the Annexin V-FITC kits, was investigated. The results illustrated that the potent cytotoxic compounds induce cell cycle arrest at the G2/M phases and trigger apoptosis in the different tested cancer cells. Finally, the structure-activity relationship (SAR) study showcases the substitution of some specific groups at the 4-, 6-, and 9-positions in the prepared 2-amino-4H-pyrano[3,2-h]quinoline derivatives, which indicates that the lipophilicity manipulates the ability of these moieties against the diverse cell lines.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Fouda, AM; Youssef, AMS; Afifi, TH; Mora, A; El-Agrody, AM or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, biological evaluation, and structure activity relationship (SAR) study of pyrrolidine amide derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors WOS:000459510800006 published article about RAT MODEL; POTENT; PALMITOYLETHANOLAMIDE; ACTIVATION; DESIGN; ESTERS; FAAH; PPAR in [Zhou, Pan; Ren, Jie; Qiu, Yan] Xiamen Univ, Eye Inst, Xiamen 361102, Fujian, Peoples R China; [Zhou, Pan; Xiang, Lei; Ren, Jie; Qiu, Yan] Xiamen Univ, Med Coll, Xiamen 361102, Fujian, Peoples R China; [Zhao, Dongsheng] Quanzhou Med Coll, Dept Pharm, Tel Quanzhou 362100, Peoples R China; [Li, Yuhang] Chinese Acad Sci, Haixi Inst, Xiamen Inst Rare Earth Mat, Xiamen 361005, Fujian, Peoples R China; [Li, Yuhang] Chinese Acad Sci, Fujian Inst Res Struct Matter, CAS Key Lab Design & Assembly Funct Nanostruct, Beijing, Peoples R China; [Li, Yuhang] Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Prov Key Lab Nanomat, Beijing, Peoples R China in 2019.0, Cited 33.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 500-22-1

N-Acylethanolamine acid amidase (NAAA) is one of the key enzymes involved in the degradation of fatty acid ethanolamides (FAEs), especially for palmitoylethanolamide (PEA). Pharmacological blockage of NAAA restores PEA levels, providing therapeutic benefits in the management of inflammation and pain. In the current work, we showed the structure-activity relationship (SAR) studies for pyrrolidine amide derivatives as NAAA inhibitors. A series of aromatic replacements or substituents for the terminal phenyl group of pyrrolidine amides were examined. SAR data showed that small lipophilic 3-phenyl substituents were preferable for optimal potency. The conformationally flexible linkers increased the inhibitory potency of pyrrolidine amide derivatives but reduced their selectivity toward fatty acid amide hydrolase (FAAH). The conformationally restricted linkers did not enhance the inhibitor potency toward NAAA but improved the selectivity over FAAH. Several low micromolar potent NAAA inhibitors were developed, including 4g bearing a rigid 4-phenylcinnamoyl group. Dialysis and kinetic analysis suggested that 4g inhibited NAAA via a competitive and reversible mechanism. Furthermore, 4g showed high anti-inflammatory activities in lipopolysaccharide (LPS) induced acute lung injury (ALI) model, and this effect was blocked by pre-treatment with the PPAR-a antagonist MK886. We anticipate that 4g (E93) will enable a new agent to treat inflammation and related diseases.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zhou, P; Xiang, L; Zhao, DS; Ren, J; Qiu, Y; Li, YH or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem