Tag: M.W=100-150

An article Preparation and Characterization of Acetic Acid-Functionalized Fe3O4@SiO2 Nanoparticles as an Efficient Nanocatalyst for the Synthesis of Nitrones in Water WOS:000491797300001 published article about MAGNETIC NANOPARTICLES; CYCLOADDITION REACTIONS; CATALYST; GREEN; SHELL; CORE; MICROSPHERES; DERIVATIVES; SYSTEMS in [Shendy, Saeid Ahmadizadeh; Shahverdizadeh, Gholam Hossein; Babazadeh, Mirzaagha; Hosseinzadeh-Khanmiri, Rahim; Es’haghi, Moosa] Islamic Azad Univ, Dept Chem, Tabriz Branch, Tabriz, Iran in 2020.0, Cited 37.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives

Magnetic materials grafted with acetic acid (Fe3O4@SiO2COOH MNPs) were successfully prepared from the incorporation of bromoacetic acid as a functional group on the surface of magnetite silica nanoparticles. The catalyst has been characterized by Fourier transform infrared spectroscopy, X-ray diffraction, elemental analysis, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, scanning electron microscopy and transition electron microscopy. Next, the efficiency of this acid catalyst was examined for the synthesis of the nitrones from diaminoglyoxime in the water at room temperature. The present approach provides several advantages such as environmentally benign, excellent yields, straightforward, short reaction times, good recyclability of catalyst, cost-effective and facile catalyst separation for the preparation of nitrones compounds as an important privileged medicinal scaffold.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Shendy, SA; Shahverdizadeh, GH; Babazadeh, M; Hosseinzadeh-Khanmiri, R; Es’haghi, M or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about STABILIZED PHOSPHONIUM YLIDES; SKIPPED DIENES; C BOND; ALLYLIC ALCOHOLS; CALCIUM; ALLYLATION; CYCLOISOMERIZATION; PHOSPHATES; ALKYLATION; ALDEHYDES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21702108]; State Key Program of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21432009]; Natural Science Foundation of Jiangsu Province, ChinaNatural Science Foundation of Jiangsu Province [BK20160977]; Six Talent Peaks Project in Jiangsu Province [YY-033]; College Students’ Innovation and Open Experimentation Fund Project [2019DC0416]; Nanjing Tech University [39837101]; [MOE2016-T1-002-043 (RG111/16)]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Xie, PZ; Fu, WS; Cai, XY; Sun, ZL; Wu, Y; Li, SS; Gao, CQ; Yang, XB; Loh, TP. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. COA of Formula: C6H5NO

A Ba/Pd cooperative catalysis system was developed to enable the dehydrative cross-coupling of allylic alcohols with P-ylides to occur directly and promote a subsequent Wittig reaction in one pot. A variety of multisubstituted 1,4-dienes were isolated in good to excellent yields with broad P-ylides (stabilized by both ester and ketone carbonyl groups) and aldehyde (aliphatic and aromatic) substrates with excellent E selectivity.

COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Xie, PZ; Fu, WS; Cai, XY; Sun, ZL; Wu, Y; Li, SS; Gao, CQ; Yang, XB; Loh, TP or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. Recently I am researching about AMINO-PHOSPHONATES; 3-COMPONENT SYNTHESIS; ACID-DERIVATIVES; CATALYST; SOLVENT; AMINOPHOSPHONATES; INHIBITION; CHLORIDE; FACILE; KETONES, Saw an article supported by the . Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Patnala, H; Abbo, HS; Potla, KM; Titinchi, SJJ; Chinnam, S. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

An efficient and eco-friendly protocol has been accomplished for a series of novel alpha-diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4,4 ‘-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80 degrees C. All products were obtained in good to excellent yields (80-95%). The identity of the new synthesized compounds was confirmed by IR, H-1, 13C, and 31P NMR, LC-MS and elemental analysis. In vivo anti-viral activity was evaluated against tobacco mosaic virus (TMV). Compounds 4b, 4c, 4j and 4k exhibited the highest anti-viral activities against tobacco mosaic virus (TMV) when compared with the standard drug ningnanmycin. [GRAPHICS] .

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Patnala, H; Abbo, HS; Potla, KM; Titinchi, SJJ; Chinnam, S or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors gamma-aminobutyric acid transporter 1 published in 2019.0. SDS of cas: 500-22-1, Reprint Addresses Wanner, KT (corresponding author), Ludwig Maximilians Univ Munchen, Ctr Drug Res, Dept Pharm, Butenandtstr 7, D-81377 Munich, Germany.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS. By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed. In the present study, oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1. The pK(i) values obtained of the best hits were compared with those of related compounds displaying a guvacine instead of a nipecotic acid subunit as hydrophilic moiety. Amongst the new compounds one of the most affine ligands of mGAT1 known so far (pK(i)= 8.55 +/- 0.04) was found.

SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kern, F; Wanner, KT or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors gamma-aminobutyric acid transporter 1 published in 2019.0. Name: 3-Pyridinecarboxaldehyde, Reprint Addresses Wanner, KT (corresponding author), Ludwig Maximilians Univ Munchen, Ctr Drug Res, Dept Pharm, Butenandtstr 7, D-81377 Munich, Germany.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS. By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed. In the present study, oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1. The pK(i) values obtained of the best hits were compared with those of related compounds displaying a guvacine instead of a nipecotic acid subunit as hydrophilic moiety. Amongst the new compounds one of the most affine ligands of mGAT1 known so far (pK(i)= 8.55 +/- 0.04) was found.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kern, F; Wanner, KT or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about ALKALOIDS; CHEMISTRY; 4-METHYLIDENEISOXAZOLIDIN-5-ONES, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [1407681]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Brar, A; Unruh, DK; Ling, N; Krempner, C. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Name: 3-Pyridinecarboxaldehyde

A method for the generation of 5-isoxazolidi-nones with exocyclic phosphonium ylide functionalities via [2+3] cycloaddition of Ph3PCCO and aldonitrones has been developed and applied in the synthesis of 4-alkylidene-5-isoxazolidinones via Wittig olefination. The reaction proceeds by BPh3 catalysis under mild conditions and with a broad substrate scope. A reaction pathway involving the activation of the aldonitrone via interactions with the Lewis acid BPh3 is proposed.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Brar, A; Unruh, DK; Ling, N; Krempner, C or concate me.. Name: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Sonawane, V; Siddique, MUM; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B in [Sonawane, Vinay; Chaudhuri, Bhabatosh] De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England; [Siddique, Mohd Usman Mohd; Sinha, Barij Nayan; Jayaprakash, Venkatesan] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India; [Jadav, Surender Singh] Indian Inst Chem Technol, CSIR, Hyderabad 500007, Telangana, India published Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy in 2019, Cited 79. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Inhibition of cyclin dependent kinase 4 (Cdk4) prevents cancer cells from entering the early G(0)/G(1) phase of the cell division cycle whereas inhibiting tubulin polymerization blocks cancer cells’ ability to undergo mitosis (M) late in the cell cycle. We had reported earlier that two non-planar and relatively non-toxic fascaplysin derivatives, an indole and a tryptoline, inhibit Cdk4 with IC50 values of 6.2 and 10 mu M, respectively. Serendipitously, we had also found that they inhibited tubulin polymerization. The molecules were efficacious in mouse tumor models. We have now identified Cink4T in a 59-compound quinazolinone library, designed on the basis of ligand-based virtual screening, as a compound that inhibits Cdk4 and tubulin. Its IC50 value for Cdk4 inhibition is 0.47 mu M and >50 mu M for inhibition of Cdk1, Cdk2, Cdk6, Cdk9. Cink4T inhibits tubulin polymerization with an IC50 of 0.6 mu M. Molecular modelling studies on Cink4T with Cdk4 and tubulin crystal structures lend support to these observations. Cancer cell cycle analyses confirm that Cink4T blocks cells at both G(0)/G(1) and M phases as it should if it were to inhibit both Cdk4 and tubulin polymerization. Our results show, for the very first time, that virtual screening can be used to design novel inhibitors that can potently block two crucial phases of the cell division cycle. (C) 2019 Elsevier Masson SAS. All rights reserved.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Sonawane, V; Siddique, MUM; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Pyridinecarboxaldehyde. In 2019 ORG LETT published article about GRIGNARD-REAGENTS; STEREOSELECTIVE-SYNTHESIS; ARYL; ALKYL; PALLADIUM; HALIDES; COMPLEXES; CHLORIDES in [Lu, Xiao-Lin; Peng, Xiao-Shui; Wong, Henry N. C.] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Lu, Xiao-Lin; Peng, Xiao-Shui; Wong, Henry N. C.] Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong, Peoples R China; [Peng, Xiao-Shui; Wong, Henry N. C.] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen Municipal Key Lab Chem Synth Med Organ M, 10 Second Yuexing Rd, Shenzhen 518507, Peoples R China; [Shannon, Mark] Univ Warwick, Dept Chem, Gibbet Hill, Coventry CV4 7AL, W Midlands, England in 2019, Cited 38. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

An efficient synthetic protocol involving iron-catalyzed cross-coupling reactions between organolithium compounds and alkenyl iodides as key coupling partners was achieved. More than 30 examples were obtained with moderate to good yields and high stereospecificity. Gram scale and synthetic applications of this procedure are recorded herein to demonstrate its feasibility and potential utilization.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Lu, XL; Shannon, M; Peng, XS; Wong, HNC or concate me.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about MOLECULAR-ORBITAL METHODS; FORMAL 4+1 CYCLOADDITION; GAUSSIAN-TYPE BASIS; STEREOCONTROLLED SYNTHESIS; ALLYLIC SUBSTITUTION; ASYMMETRIC-SYNTHESIS; GOLD CATALYSIS; CYCLOISOMERIZATION; ALCOHOLS; ETHERS, Saw an article supported by the Ministry of Higher Education and Scientific Research (MHESR)Ministry of Higher Education & Scientific Research (MHESR) [CMCU 17G1207]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Ben Gaied, L; Fincias, N; Garrec, J; El Kaim, L. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. HPLC of Formula: C6H5NO

5-endo-dig cyclization of O-propargyloxyamides, obtained through a Passerini reaction mediated by boric acid and subsequent propargylation, affords 2,5-dihydrofurans in the presence of tert-butylate. The mechanism of the reaction was studied by using DFT calculations and the results were compared with the behavior of analogous N-propargylamide derivatives.

HPLC of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ben Gaied, L; Fincias, N; Garrec, J; El Kaim, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Pyridinecarboxaldehyde. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics published in 2019.0, Reprint Addresses Rivera, DG (corresponding author), Univ Havana, Fac Chem, Ctr Nat Prod Res, Havana 10400, Cuba.; Valiente, PA; Gonzalez-Bacerio, J (corresponding author), Univ Havana, Fac Biol, Ctr Prot Studies, 25 & J, Havana 10400, Cuba.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the development of antimicrobials. Here we describe a solid-phase multicomponent approach which enabled the discovery of potent ePepN inhibitors. The on-resin protocol, developed in the frame of the Distributed Drug Discovery (D3) program, comprises the implementation of parallel Ugi-azide four-component reactions with resin-bound amino acids, thus leading to the rapid preparation of a focused library of tetrazole-peptidomimetics (TPMs) suitable for biological screening. By dose-response studies, three compounds were identified as potent and selective ePepN inhibitors, as little inhibitory effect was exhibited for the porcine ortholog aminopeptidase. The study allowed for the identification of the key structural features required for a high ePepN inhibitory activity. The most potent and selective inhibitor (TPM 11) showed a non-competitive inhibition profile of ePepN. We predicted that both diastereomers of compound TPM 11 bind to a site distinct from that occupied by the substrate. Theoretical models suggested that TPM 11 has an alternative inhibition mechanism that doesn’t involve Zn coordination. On the other hand, the activity landscape analysis provided a rationale for our findings. Of note, compound TMP 2 showed in vitro antibacterial activity against Escherichia coli. Furthermore, none of the three identified inhibitors is a potent haemolytic agent, and only two compounds showed moderate cytotoxic activity toward the murine myeloma P3X63Ag cells. These results point to promising compounds for the future development of rationally designed TPMs as antibacterial agents. (C) 2018 Elsevier Masson SAS. All rights reserved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Mendez, Y; De Armas, G; Perez, I; Rojas, T; Valdes-Tresanco, ME; Izquierdo, M; del Rivero, MA; Alvarez-Ginarte, YM; Valiente, PA; Soto, C; de Leon, L; Vasco, AV; Scott, WL; Westermann, B; Gonzalez-Bacerio, J; Rivera, DG or concate me.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem