Tag: M.W=100-150

An article Straightforward access to complex isoindolinones from the Ugi reaction of o-nitrobenzoic acid derivatives WOS:000498709600013 published article about MULTICOMPONENT REACTIONS; CONVERTIBLE ISOCYANIDE; RAPID ACCESS; CONDENSATION in [Kurva, Mahanandaiah; Kerim, Mansour Dole; El Kaim, Laurent] Ecole Polytech, Inst Polytech Paris, Lab Synth Organ, CNRS,ENSTA Paris,UMR 7652, 828 Bd Marechaux, F-91128 Palaiseau, France; [Kurva, Mahanandaiah; Gamez-Montano, Rocio] Univ Guanajuato, Dept Quim, Noria Alta S-N, Guanajuato 36050, Gto, Mexico in 2019.0, Cited 36.0. HPLC of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The Ugi reaction of 2-nitrobenzoic acid derivatives has been used for a diversity oriented synthesis of complex isoindolinones via a SNAr reaction involving the peptidyl position. When the cyclization is triggered by strong bases such as potassium tert-butylate, the SNAr reaction is followed by a deamidification/oxidation sequence leading to 2-hydroxyisoindolinones. The latter may be further transformed into polycyclic fused isoindolinones via Pictet-Spengler type cyclization or O-alkylation/metathesis sequences.

HPLC of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kurva, M; Kerim, MD; Gamez-Montano, R; El Kaim, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. In 2019.0 J IRAN CHEM SOC published article about MICHAEL-CYCLOCONDENSATION REACTION; EFFICIENT CATALYST; 3-COMPONENT SYNTHESIS; DERIVATIVES; MALONONITRILE; ALDEHYDES; SOLVENTS in [Honarmand, Moones] Birjand Univ Technol, Fac Min Civil & Chem Engn, Dept Chem Engn, Birjand 97175569, Iran; [Tzani, Andromachi; Detsi, Anastasia] Natl Tech Univ Athens, Sch Chem Engn, Organ Chem Lab, Zografou Campus, Athens 15780, Greece in 2019.0, Cited 23.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

2-Hydroxyethyl-1-ammonium 3-hydroxypropane-1-sulfonate HAHS’ was synthesized as a novel ionic liquid and characterized by various techniques. HAHS’ ionic liquid was efficiently applied as a multifunctional promoter for the three-component synthesis of 2-amino-3-cyano-4H-pyrans. The 2-amino-3-cyano-4H-pyrans were produced not only in high to excellent yields but also no toxic solvent or catalyst was used. HAHS’ ionic liquid was recovered and reused four times without the considerable decreasing in its activity. The effect of hydroxyl groups in the structure of HAHS’ ionic liquid on its catalytic activity was studied. Moreover, the biodegradability potential of the ionic liquid was examined using the 5-day biological oxygen demand closed bottle test and the results showed that HAHS’ has remarkable biodegradability potential.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Honarmand, M; Tzani, A; Detsi, A or concate me.. Computed Properties of C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Development of Bronsted Base-Photocatalyst Hybrid Systems for Highly Efficient C-C Bond Formation Reactions of Malonates with Styrenes WOS:000574920200025 published article about CATALYTIC RADICAL-ADDITION; PHOTOCHEMICAL MONOALKYLATION; ALKENES; SUBSTITUTION; REACTIVITY in [Bas, Sebastian; Yamashita, Yasuhiro; Kobayashi, Shu] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan in 2020, Cited 31. HPLC of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Bronsted base-photocatalyst hybrid systems have been developed for reactions of malonates with styrene derivatives. The concept of this process lies in the photo-oxidation of catalytic amounts of the enolate to form reactive radicals that react with alkene double bonds under mild reaction conditions. This is an example of visible-light-activated C-C bond formation reactions of malonates with alkenes to realize high atom economy under very mild reaction conditions without using any transition-metal catalysts.

HPLC of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Bas, S; Yamashita, Y; Kobayashi, S or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. In 2019.0 ACS MED CHEM LETT published article about ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION in [Garner, Philip; Rathnayake, Upendra; Holloran, Nicholas] Washington State Univ, Dept Chem, Pullman, WA 99164 USA; [Cox, Philip B.; Erdman, Paul] AbbVie Inc, Discovery Chem & Technol, 1 North Waukegan Rd, N Chicago, IL 60064 USA in 2019.0, Cited 21.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Fragment-based drug discovery (FBDD) is a well- established technology for lead compound generation in drug discovery. As this technology has evolved, the design of fragments for screening has also evolved to engender not just an understanding of the role of modulating the physicochemical properties of fragments (Rule of Three, Ro3) but also the importance and implications of incorporating shape and, in particular, 3D characteristics into fragments. Herein, we describe the design and synthesis of pyrrolidine-based fragments with good fragment-like (Ro3) physicochemical properties that effectively sample three-dimensional molecular space.

Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Garner, P; Cox, PB; Rathnayake, U; Holloran, N; Erdman, P or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C6H5NO. In 2019.0 J BRAZIL CHEM SOC published article about ONE-POT SYNTHESIS; 3-COMPONENT COUPLING REACTION; MULTICOMPONENT SYNTHESIS; COPPER; ALKYNE; 2-AMINOPYRIDINES; CYCLOADDITION; CYCLIZATION; PALLADIUM; ALDEHYDES in [de Salles, Helena D.; Benvenutti, Edilson, V; Schneider, Paulo H.] Univ Fed Rio Grande do Sul, Inst Quim, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil; [da Silva, Tiago L.] Univ Fed Rio de Janeiro, Inst Quim, Av Athos da Silveira Ramos 149,Bloco A, BR-21941909 Rio de Janeiro, RJ, Brazil; [Radatz, Catia S.] Univ Fed Pelotas UFPeI, CCQFA, BR-96010900 Pelotas, RS, Brazil; [Affeldt, Ricardo F.] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil in 2019.0, Cited 60.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

In this work, we report the preparation of a copper-silica material (Cu/SiO2) by a sol-gel methodology and its characterization concerning composition and textural properties. The Cu/SiO2 material was successfully applied as a Lewis acid heterogeneous catalyst for the A(3)-coupling from 2-aminopyridine, aldehydes and alkynes to imidazo[1,2-a]pyridines (45-82%). which are relevant pharmacological scaffolds. The synthesis shows a number of advantages, such as easy separation from the reaction media and the minimal formation of metal aqueous wastes. Investigation of the mechanism supports the involvement of the formation of reaction intermediates inside the pores of the mesoporous material prior to 5-exo-dig cyclization.

COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact de Salles, HD; da Silva, TL; Radatz, CS; Affeldt, RF; Benvenutti, EV; Schneider, PH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019 CHEM-EUR J published article about CATALYZED REDUCTIVE UMPOLUNG; TITANIUM-INDUCED SYNTHESES; EFFICIENT SYNTHESIS; FACILE SYNTHESIS; BOND FORMATION; LEWIS-ACID; ALDEHYDES; PYRROLES; TOOL; AMINOPYRROLES in [Leijendekker, Leonardus H.; Weweler, Jens; Leuther, Tobias M.; Streuff, Jan] Albert Ludwigs Univ Freiburg, Inst Organ Chem, Albertstr 21, D-79104 Freiburg, Germany; [Kratz, Daniel] Albert Ludwigs Univ Freiburg, Inst Anorgan & Analyt Chem, Albertstr 21, D-79104 Freiburg, Germany in 2019, Cited 121. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Quality Control of 3-Pyridinecarboxaldehyde

The exceptionally mild conditions of a titanium(III)-catalyzed cyclization reaction paired with a convenient acid/base extraction have enabled the straightforward synthesis, isolation, and direct N-functionalization of amino heterocycles such as 3-aminoindoles and -pyrroles. The unprotected heterocycles are ideal building blocks for the installation of aminated indoles and pyrroles into target molecules, but their sensitivity has previously impeded their synthesis by modern catalytic methods. This full paper presents the development and extended scope of the new cyclization methodology. The transformation of the products into fused bis-indoles is also demonstrated along with the discovery of an unusual palladium-catalyzed reductive biphenyl coupling reaction. The titanium(III)-catalyzed cyclization has also been applied to the synthesis of substituted 3-iminoindolines, which are of potential interest for applications in natural product synthesis and exhibit tunable blue-to-green fluorescence properties.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Leijendekker, LH; Weweler, J; Leuther, TM; Kratz, D; Streuff, J or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C6H5NO. Ben Gaied, L; Fincias, N; Garrec, J; El Kaim, L in [Ben Gaied, Lilia] Inst Preparatoire Etud Sci & Tech, Lab Physicochim Microstruct & Microsyst, BP 51, Tunis 2070, Tunisia; [Fincias, Nicolas; Garrec, Julian; El Kaim, Laurent] Inst Polytech Paris, LSO, Ecole Polytech, CNRS,ENSTA Paris UMR 7652, 828 Bd Marechaux, F-91128 Palaiseau, France published 5-endo-dig Cyclization of O-Propargyl Mandelic Acid Amides towards 2,5-Dihydrofurans in 2019.0, Cited 71.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

5-endo-dig cyclization of O-propargyloxyamides, obtained through a Passerini reaction mediated by boric acid and subsequent propargylation, affords 2,5-dihydrofurans in the presence of tert-butylate. The mechanism of the reaction was studied by using DFT calculations and the results were compared with the behavior of analogous N-propargylamide derivatives.

HPLC of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ben Gaied, L; Fincias, N; Garrec, J; El Kaim, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 500-22-1. Recently I am researching about BIOLOGICAL-ACTIVITIES; ASSISTED SYNTHESIS; GLUTAMIC-ACID; IN-SILICO; DESIGN; COMPLEXES; DERIVATIVES; THALIDOMIDE; COPPER(II); TOXICITY, Saw an article supported by the . Published in ELSEVIER in AMSTERDAM ,Authors: Al-Sodies, SA; Aouad, MR; Ihmaid, S; Aljuhani, A; Messali, M; Ali, I; Rezki, N. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Novel task dicationic ionic liquids (Ts-DilLs) 6-29 were designed and synthesized, under both conventional and microwave conditions; through molecular hybridization of the appropriate bispyridines having a hydrazone linkage as spacer with some alkyl functionalized esters forming the counter cations. Beside the synthesized halogenated DilLs 6-11, fluorinated metal anions were introduced via metathesis reaction in order to create new dipyridinium ionic liquid-hydrazone hybrids 12-29. All newly synthesized DilLs were fully characterized using different spectroscopic tools such as H-1, C-13, F-19, P-31, B-11 NMR and Mass experiment. The DNA binding, anticancer and docking studies of the synthesized ionic liquids were also carried out. The DNA binding constants ranged from 4.5 x 10(4) to 7.2 x 10(4) M-1, indicating good DNA binding tendencies. The most active ionic liquids were 28 and 29 with 99.99 and 99.86% anticancer activities, respectively. The docking studies indicated DNA binding in the outer grooves of DNA. The reported ionic liquids may be used as future anticancer drugs. (C) 2020 Elsevier B.V. All rights reserved.

SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Al-Sodies, SA; Aouad, MR; Ihmaid, S; Aljuhani, A; Messali, M; Ali, I; Rezki, N or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. Ju, YW; Du, ZT; Xiao, CH; Li, XF; Li, S in [Ju, Yongwei; Li, Shuang] Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China; [Du, Zhongtian; Xiao, Chuhong; Li, Xingfei] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China published Novel Effect of Zinc Nitrate/Vanadyl Oxalate for Selective Catalytic Oxidation of alpha-Hydroxy Esters to alpha-Keto Esters with Molecular Oxygen: An In Situ ATR-IR Study in 2019.0, Cited 40.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Selective oxidation of alpha-hydroxy esters is one of the most important methods to prepare high value-added alpha-keto esters. An efficient catalytic system consisting of Zn(NO3)(2)/VOC2O4 is reported for catalytic oxidation of alpha-hydroxy esters with molecular oxygen. Up to 99% conversion of methyl DL-mandelate or methyl lactate could be facilely obtained with high selectivity for its corresponding alpha-keto ester under mild reaction conditions. Zn(NO3)(2) exhibited higher catalytic activity in combination with VOC2O4 compared with Fe(NO3)(3) and different nitric oxidative gases were detected by situ attenuated total reflection infrared (ATR-IR) spectroscopy. UV-vis and ATR-IR results indicated that coordination complex formed in Zn(NO3)(2) in CH3CN solution was quite different from Fe(NO3)(3); it is proposed that the charge-transfer from Zn2+ to coordinated nitrate groups might account for the generation of different nitric oxidative gases. The XPS result indicate that nitric oxidative gas derived from the interaction of Zn(NO3)(2) with VOC2O4 could be in favor of oxidizing VOC2O4 to generate active vanadium (V) species. It might account for different catalytic activity of Zn(NO3)(2) or Fe(NO3)(3) combined with VOC2O4. This work contributes to further development of efficient aerobic oxidation under mild reaction conditions.

Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ju, YW; Du, ZT; Xiao, CH; Li, XF; Li, S or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about NUCLEAR TRANSLOCATION; DIMERS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473253, 81602956, 81973368]; National Major Program of China during the 13th Five-Year Plan Period [2018ZX09721001-001-001]. Published in SPRINGER in DORDRECHT ,Authors: Yang, Y; Zhou, YZ; Tao, L; Yang, T; Zhao, YL; Luo, YF. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. COA of Formula: C6H5NO

Aberrant activation of ERK signaling pathway usually leads to oncogenesis, and small molecular agents targeting this pathway are impeded by the emergence of drug resistance due to reactivation of ERK signaling. Compound DEL-22379 has been reported to inhibit ERK dimerization which was unaffected by drug-resistant mechanism reactivating the ERK signaling. Here, we discussed a structure-activity relationship study of DEL-22379. Forty-seven analogues were designed and synthesized. Each synthesized compound was biologically evaluated for their inhibitory rates on several tumor cell lines and compounds with high inhibitory rates were further evaluated for IC50 values. The structure-activity relationship of idolin-2-one scaffold and the impact of Z/E configuration on potency were discussed. Potential safety of two synthesized analogues was investigated and in silico docking study of five compounds was performed to understand the structural basis of ERK dimerization inhibition. [GRAPHICS] .

COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Yang, Y; Zhou, YZ; Tao, L; Yang, T; Zhao, YL; Luo, YF or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem