Tag: M.W:100-200

Related Products of 1074-98-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1074-98-2, name is 3-Methyl-4-nitropyridine 1-oxide, molecular formula is C6H6N2O3, molecular weight is 154.13, as common compound, the synthetic route is as follows.

A suspension of 3-methyl-4-nitropyridine N-oxide (2.0 g, 13 mmol) and palladium hydroxide on carbon (0.4 g) in ethanol (30 mL) was heated to 60 C. Ammonium formate (3.3 g, 52 mmol) was then added portionwise and the mixture heated at 60 C for three hours. The cool reaction mixture was filtered through Arbocel and the filtrate evaporated under reduced pressure to afford the title compound as a colourless oil, 1.81 g. LRMS (APCI+): m/z [M+H]+ 125

The chemical industry reduces the impact on the environment during synthesis 1074-98-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/121094; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 14916-65-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14916-65-5, name is 6-Nitropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a so[ution of 3.50 g (11.2 mmo[) 5,10-dioxo-5H,1OH-diimidazo[1,5-a:1?,S?-d]pyrazine-1,6-dicarbony[ dich[oride (Intermediate 001) in 60 mL THF were added 3.10 g (22.4 mmo[) 6-nitropyridin-3-amine and 5.00 mL N,N-diisopropy[ethy[amine. The resu[ting mixture was stirred for 1 hour at room temperature under an argon atmosphere.

According to the analysis of related databases, 14916-65-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERSTAFF, Jens; WAGNER, Sarah; BASTING, Daniel; GOLZ, Stefan; BENDER, Eckhard; LI, Volkhart Min-Jian; LIENAU, Philip; LIU, Ningshu; SIEGEL, Franziska; BAUSER, Marcus; SUeLZLE, Detlev; HOLTON, Simon; BAIRLEIN, Michaela; BUCHGRABER, Philipp; BALINT, Jozsef; WO2015/150449; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 898746-42-4, name is 6-Fluoro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Computed Properties of C7H5FN2

Preparation 1Synthesis of 6-fluoro-l -methyl- lH-pyrrolo[2,3-b]pyridine.Jf)3 C H3 To a solution of 6-fluoro-lH-pyrrolo[2,3-b]pyridine (250 g, 1.84 mol) in dimethylformamide (2.50 L) is added potassium carbonate (507.6 g; 3.67 mol), followed by methyl iodide (171.6 mL, 2.75 mol). The reaction is stirred at room temperature overnight. The reaction mixture is poured into water (3000 mL) and extracted with Et20(3 x 1500 mL). The organic extracts are combined and washed with water (4 x 1000 mL), then brine, and dried over Na2S04. The solvent is evaporated to give a light brown oil which, on standing, gives clear colorless crystals, with a little mobile liquid on top of the crystals. The liquid is decanted off and discarded to leave the product as a crystalline solid (257.3 g, 1.71 moles). XH-NMR (400MHz, CDC13): delta 7.93 (t, 1H), 7.11 (d, 1H), 6.69 (d, 1H), 6.46 (d, 1H), 3.83 (s, 3H).

The synthetic route of 898746-42-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; LAMAS-PETEIRA, Carlos; RICHARDS, Simon, James; SAPMAZ, Selma; WALTER, Magnus, Wilhelm; WO2012/74769; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 936841-69-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 936841-69-9, name is 4-(Trifluoromethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-(trifluoromethyl)pyridine-2-carbonitrile (500 mg, 3.0 mmol) in 10 ml ethanol was added hydroxylammonium chloride (302 mg, 4.0 mmol) and triethylamine (382 mg, 4.0 mmol) and then the reaction mixture was stirred 13 h at 50 C. After cooling to RT, the solvent was evaporated and the crude was solved in dichloromethane and extracted with water. The organic phase was dried over magnesium sulfate, filtered and evaporated under vacuum to yield the title compound (432 mg, 65 % of theory, 90 % purity). The compound was used without further purification. LC-MS (method 2B): RT = 1.78 min, m/z = 206 (M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 936841-69-9, 4-(Trifluoromethyl)picolinonitrile.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ELLERMANN, Manuel; VALOT, Gaelle; CANCHO GRANDE, Yolanda; HAssFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; BEYER, Kristin; ROeHRIG, Susanne; SPERZEL, Michael; STAMPFUss, Jan; MEYER, Imke; KOeLLNBERGER, Maria; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; HEIERMANN, Joerg; HENGEVELD, Willem Jan; (764 pag.)WO2016/71216; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1033203-41-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1033203-41-6, name is 6-Bromopyridine-3,4-diamine, molecular formula is C5H6BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 6-bromopyridine-3,4-diamine 7 (2 g, 10.6 mmol) in NaNO. (2M, 25 mL) was added Acetic acid (20 mL) and stirred at 0C for 15 min and heated the contents of the reaction at 70C for 1.5 h. The reaction was cooled, poured in crushed ice the precipitated solid was filtered, dried and washed with diethyl ether to get e-bromo-SH-n^.Sltriazolo^S-clpyridine (1.0 g, 47%) as off-white solid. LC-MS (method 23): Rt = 1.26 min; m/z = 201.00 (M+H++2).

According to the analysis of related databases, 1033203-41-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52605-96-6, 2-Chloro-3-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H6ClNO, blongs to pyridine-derivatives compound. Formula: C6H6ClNO

General procedure: To 2-chloropyridine (1.1 mmol) in ethanol (5.0 mL) was added hydrazine hydrate (2 mL) dropwise at room temperature. The mixture was refluxed until completion as monitored by TLC. The reaction mixture was cooled, ethanol was removed by evaporation. Then, the residue was partitioned between ethyl acetate and water. The combined organic phase was dried over anhydrous sodium sulfate and concentrated to give the product, which was used for the following cyclization reaction without purification.

The synthetic route of 52605-96-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Lingfeng; Qiao, Chunhua; Shen, Bei; Xu, Yiwen; Tetrahedron Letters; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 97004-04-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 97004-04-1, name is (6-Chloropyridin-3-yl)methanamine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a Radley reaction carousel tube, add 1 equivalent 1, 1.1 equivalents of the amine, a stir bar, and 5 mL 95% ethanol. Reflux while stirring for 24 hours. After cooling to room temperature the resulting precipitate was collected by vacuum filtration, washing with 10 mL deionized water and 5 mL chloroform.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 97004-04-1, (6-Chloropyridin-3-yl)methanamine.

Reference:
Article; Watkins, Sydney M.; Ghose, Debarati; Blain, Joy M.; Grote, Dakota L.; Luan, Chi-Hao; Clare, Michael; Meganathan; Horn, James R.; Hagen, Timothy J.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 20; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1193-71-1, 4,6-Dimethylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1193-71-1, blongs to pyridine-derivatives compound. SDS of cas: 1193-71-1

A solution of step 1 intermediate of example 14 (301 mg, 951 pmol) in thionyl chloride (3 mL) was heated to 70 C for 4 h. The volatiles were removed under reduced pressure and the residude was dissolved in CH2CI2 (14 mL) and NEt3 (254 pL, 1.79 mmol) and 4,6-dimethylpyridine-3-amine (114 mg, 940 pmol) were consecutively added and the mixture was stirred at rt overnight. The volatiles were removed underreduced pressure and the residue was purified by chromatography (lnterchim cartridge 5OSiHP /12 g,EtOAc/Cy) to yield the title compound of example 19 (136 mg, 36%).LC-MS (Method 2): m/z [Mi-H] = 421.1 (MW calc. = 420.80); R = 0.59 mm.1H-NMR (DMSO-d6): 6 = 9.84 (s, 1H), 8.36 (s, 1H), 7.93 (s, IH), 7.73 (s, 1H), 7.17 (s, 1H), 6.85 (s, 1H),3.77 (s, 3H), 2.43 (s, 3H), 2.21 (s, 3H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-71-1, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 60289-67-0, 1-(Pyridin-3-yl)propan-1-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 60289-67-0, blongs to pyridine-derivatives compound. SDS of cas: 60289-67-0

Example 18 N-(1-Pyridin-3-yl-propyl)-2-(quinoline-8-sulfonylamino)-benzamide The title compound was obtained from 2-(quinoline-8-sulfonylamino)-benzoyl chloride (example 1b) and 1-pyridin-3-ylpropylamine (precursor 3n). MS (ES): 447 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60289-67-0, 1-(Pyridin-3-yl)propan-1-amine, and friends who are interested can also refer to it.

Reference:
Patent; Brendel, Joachim; Bohme, Thomas; Peukert, Stefan; Kleemann, Heinz-Werner; US2003/114499; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89402-42-6 , The common heterocyclic compound, 89402-42-6, name is 2,3-Difluoro-5-(trifluoromethyl)pyridine, molecular formula is C6H2F5N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 1 3-Fluoro-2-phenylthio-5-trifluoromethylpyridine Over a period of 2.5 h, 59.6 g (0.326 mol) of 2,3-difluoro-5-trifluoromethylpyridine were added at 148-156 C. to 37.7 g (0.338 mol) of 98.7% pure thiophenol and 2.1 mg (0.01 mol %) of copper powder, and the mixture was stirred at 156-164 C. for 2 hours. After cooling, the residue was taken up in methylene chloride, washed with 0.5 N of aqueous sodium hydroxide solution and with water, dried over magnesium sulfate and concentrated under reduced pressure. 88.9 g (100% of theory) of the title compound of n24/D=1.5539 were obtained.

The synthetic route of 89402-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF Aktiengesellschaft; US6420314; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem