Brief introduction of 97004-04-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 97004-04-1, (6-Chloropyridin-3-yl)methanamine, other downstream synthetic routes, hurry up and to see.

Related Products of 97004-04-1, Adding some certain compound to certain chemical reactions, such as: 97004-04-1, name is (6-Chloropyridin-3-yl)methanamine,molecular formula is C6H7ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 97004-04-1.

The acid 3-(5-carboxyindol-2-yl)indazole and the 5-(aminomethyl)-2-chloropyridine dissolved in 5 ml of CH2Cl2 are introduced into a 30 ml round-bottomed flask. The EDC and the HOBt dissolved in 5 ml of CH2Cl2 are then added at room temperature under nitrogen. The reaction mixture is stirred at room temperature under nitrogen for 24 hours. A sufficient amount of DMF to fully dissolve the reaction medium is added. A further 0.355 mmol of the reagents EDCI and HOBt are then added. The reaction medium is stirred at room temperature for 5 hours and then poured into water and extracted with EtOAc. After drying and concentrating, 268.5 mg of a yellow oil are thus obtained, which product is purified by chromatography on silica (Biotage), eluting with a 99.5/0.5, 98/2, 95/5, 91/10 CH2Cl2/MeOH mixture by volume. 23.9 mg of 3-(5-(N-(2-chloropyrid-5-yl)methyl)carboxamideindol-2-yl)indazole are thus obtained in the form of a beige-coloured powder. 118.6 mg of a mixture are also obtained, which mixture is repurified by chromatography on a column of 60H silica (12 g), eluting with 99/1, 98/2 CH2Cl2/MeOH by volume. Two fractions of comparable purity of 3-(5-(N-(2-chloropyrid-5-yl)methyl)carboxamideindol-2-yl)indazole are thus obtained (41.8 mg and 49.6 mg, respectively) in the form of whitish powders.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 97004-04-1, (6-Chloropyridin-3-yl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Aventis Pharma S.A.; US2004/242559; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 905563-79-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,905563-79-3, its application will become more common.

Application of 905563-79-3 ,Some common heterocyclic compound, 905563-79-3, molecular formula is C7H6ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(S)-N- [( 1 Z -(2-Chloro-4-methoxypyridin-3 -yDmethylidene] -2-methylpropane-2- sulfmamide (0640) To a solution of 2-chloro-4-methoxypyridine-3-carbaldehyde (15 g, 87.4 mmol) in THF (180 mL) at 0C were added sequentially 2-methylpropane-2-sulfinamide (11.72 g, 96.7 mmol), tripotassium phosphate (56.0 g, 264 mmol) and dipotassium hydrogen phosphate (46.0 g, 264 mmol). The cooling bath was removed and the resultant suspension was stirred at r.t. for 18 h. The reaction mixture was filtered through celite, – – (0641) washing through with EtOAc. The filtrate was diluted with EtOAc (250 mL) and washed with brine (200 mL), then dried over anhydrous sodium sulfate, filtered and evaporated in vacuo. The crude material was purified by flash column chromatography (Si02, 0-50% EtOAc in heptane) to afford the title compound (22.0 g, 94%) as a pale yellow solid. 5H (500 MHz, CDCls) 8.88 (s, 1H), 8.33 (d, J5.8 Hz, 1H), 6.88 (d, J 5.8 Hz, 1H), 3.96 (s, 3H), 1.29 (s, 9H). LCMS Method 1 (ES+) RT 1.51 minutes, 275/277 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,905563-79-3, its application will become more common.

Reference:
Patent; UCB BIOPHARMA SPRL; SANOFI; DELIGNY, Michael Louis Robert; HEER, Jag Paul; (86 pag.)WO2017/167993; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 3-Bromo-6-mercaptopyridine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56673-34-8, 3-Bromo-6-mercaptopyridine.

Electric Literature of 56673-34-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56673-34-8, name is 3-Bromo-6-mercaptopyridine. This compound has unique chemical properties. The synthetic route is as follows.

To MeOH (40 mL) cooled to 0 C with an ice-bath, was added sodium hydride (60% in mineral oil) in portions. The cooling bath was removed and the mixture was stirred at rt for 15 min. 5-bromopyridine-2-thiol (l.Og, 5.3 mmol) was added in one portion and the reaction mixture stirred at rt for 15 min until the solid dissolved. diethyl 2-chloromalonate was added dropwise, and the reaction mixture was stirred at rt for 2 hr. MeOH was removed under reduced pressure and the reaction mixture was diluted with diethyl ether and quenched by the addition of 1.0 N HC1. The resulting mixture was partitioned between water/diethyl ether. The organic layer was collected, washed with brine and dried over sodium sulfate. The residue was purified by flash chromatography (loading in chloroform, 0% to 30% EtOAc in hexane over 18 min using a 120 g silica gel cartridge). The desired fractions were combined and concentrated under reduced pressure to yield 98a (1.3 g, 71% yield) as a clear oil. LCMS (Method M) retention time = 0.96 min, m/z = 349.8 (M+H)+. NMR (500MHz, chloroFORM-d) 8.47 (dd, J=2.3, 0.7 Hz, IH), 7.66 (dd, J=8.5, 2.5 Hz, IH), 7.17 (dd, J=8.5, 0.8 Hz, IH), 4.29 (q, J=7.2 Hz, 4H), 1.31 (t, J=7.2 Hz, 6H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 56673-34-8, 3-Bromo-6-mercaptopyridine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; TORA, George, O.; FINLAY, Heather; JIANG, Wen; MENG, Wei; ZHANG, Xiaojun; (303 pag.)WO2017/218633; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 2-Cyano-5-fluoropyridine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 327056-62-2, 2-Cyano-5-fluoropyridine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 327056-62-2, name is 2-Cyano-5-fluoropyridine. A new synthetic method of this compound is introduced below., name: 2-Cyano-5-fluoropyridine

The mixture of 5-fluoro-pyridine-2-carbonitrile (0.16 g, 1.27 mmol) and Pd/C (0.030 g, 10% wt) in 15 ml of MeOH and 0.50 ml of concentrated HCl was placed under H2 which was provided by a balloon and stirred at RT for 4 h, filtered through Celite, condensed, the residue was purified by flash column chromatography. The titled compound was obtained as a light yellowish solid. MS (ES+): 127.2 (free base)(M+H)+. Calc’d for C6H7FN2 (free base) 126.13.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 327056-62-2, 2-Cyano-5-fluoropyridine.

Reference:
Patent; Amgen Inc.; US2003/225106; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 4-Methoxypicolinaldehyde

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16744-81-3, its application will become more common.

Application of 16744-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16744-81-3 as follows.

To the solution of 4-methoxypyridine-2-carbaldehyde (3.00 g, 21 mmol) in 50 ml of dichloromethane was dropwise added ethylenediamine (23 mmol, 1.6 ml) in an ice-water bath. The mixture was stirred for 1 h. Then N-bromosuccinimide (4.1 g, 23 mmol) was added at 0 °C, The mixture was slowly warmed to room temperature and stirred overnight. Washing the reaction mixture with 5percent NaOH solution (50 mL) and then saturated Na2S2O3 solution (50 mL), drying with Na2S04 and removal of the dichloromethane under vacuum directly gave the desired crude product 2-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxypyridine (3.55 g, yield 95percent), which could be used directly in the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16744-81-3, its application will become more common.

Reference:
Patent; TIGER INSTRUMENTS, LLC; TANG, Weiping; ZHENG, Junrong; (23 pag.)WO2018/194537; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 4-Chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 688782-02-7, 4-Chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine.

Application of 688782-02-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 688782-02-7, name is 4-Chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

Example 21A N-(2-Fluoro-4-nitrophenyl)-3-methyl-1H-pyrrolo[2,3-b]pyridine-4-amine A solution of 8 mg (50 mumol) of 4-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine, 9 mg (60 mumol) of 2-fluoro-4-nitroaniline, 4 mg (5 mmol) of tris(dibenzylideneacetone)dipalladium and 5 mg (10 mumol) of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine and 10 mg (70 mumol) of potassium carbonate in 1.00 ml of degassed tert-butanol is stirred at 100 C. in a sealed pressure vessel for 3 h. After cooling to RT, the mixture is filtered through Celite, the Celite is washed with methanol and the filtrates are concentrated under reduced pressure. The residue is purified by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 1:1). Yield: 12 mg (87% of theory) LC-MS (Method 3): Rt=1.63 nm n. MS (ESI pos.): m/z=287 (M+H)+. 1H-NMR (DMSO-d6, 300 MHz): delta=2.13 (s, 3H), 6.82-6.96 (m, 2H), 7.18 (s, 1H), 7.94 (d, 1H), 8.08-8.18 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 688782-02-7, 4-Chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; Bayer HealthCare AG; US2008/269268; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of N3-Benzylpyridine-3,4-diamine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75115-28-5, N3-Benzylpyridine-3,4-diamine, and friends who are interested can also refer to it.

Related Products of 75115-28-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75115-28-5, name is N3-Benzylpyridine-3,4-diamine. A new synthetic method of this compound is introduced below.

General procedure: The vial containing the crude diaminopyridine was equipped with a magnetic stir bar and sealed with a teflon screw cap. Aldehyde (2 mol eqwith respect to the theoretical yield of the first reaction) and then nBuOH was added via syringe to give a diaminopyridine concentration of 0.3 M based on the theoretical yield of the first reaction. The reaction mixture was stirred at 110 C for 18-24 h with needle inserted in septum to expose reaction to air. The mixture was cooled to room temperature, diluted with ethyl acetate, and poured into aqueous saturated NaHCO3. The organic phase was separated and the aqueous phase was extracted twice more into ethyl acetate. The combined organic phases were driedover Na2SO4. The solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel, typically using EtOAc, 0 ->10% MeOH.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75115-28-5, N3-Benzylpyridine-3,4-diamine, and friends who are interested can also refer to it.

Reference:
Article; Li, Chaomin; Chen, Lily; Steinhuebel, Dietrich; Goodman, Andrew; Tetrahedron Letters; vol. 57; 25; (2016); p. 2708 – 2712;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 100848-70-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100848-70-2, 2-Methoxy-4-methylpyridine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100848-70-2, name is 2-Methoxy-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 100848-70-2

General procedure: Freshly distilled diisopropylamine (1.0 g; 10 mmol) was dissolved in dry THF (1 M). Aftercooling this solution to -78 C a solution of nBuLi (4.0 mL; 2.5 M) in hexanes was slowlyadded. After 15 minutes 4-methylpyridine (0.93 g; 10 mmol) was added dropwise resulting ina colour change to amber. After further 30 minutes the desired arylnitrile (10 mmol, 2 MTHF) was added dropwise. The resulting dark red solution was stirred at -78 C for 1 h priorto warming up to ambient temperature. After 4 h the reaction mixture was carefully quenchedwith saturated aqueous ammonium chloride (20 mL) and extracted (3 × DCM/water). Thecombined organic layers were dried over sodium sulfate, filtered and evaporated underreduced pressure yielding a yellow oil. Column chromatography was used to remove residualstarting material (eluent 20-25% EtOAc/hexanes).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100848-70-2, 2-Methoxy-4-methylpyridine.

Reference:
Article; Baumann, Marcus; Baxendale, Ian R.; Synlett; vol. 27; 1; (2016); p. 159 – 163;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 824-52-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,824-52-2, its application will become more common.

Related Products of 824-52-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 824-52-2 as follows.

In a vial, 5-methyl-1H-[2,3-b]pyridine (126, 1 equivalent) is combined with (5-formyl-3-methoxy-pyridin-2-yl)-(4-methoxy-benzyl)-carbamic acid tert-butyl ester (55, 1.1 equivalents), 5 mL of methanol, and potassium hydroxide (3 equivalents). The reaction is stirred at room temperature overnight, then aqueous 1N hydrochloric acid is added and the mixture is extracted with ethyl acetate. The organic layer is washed with water, brine, then dried over magnesium sulfate, filtered and the filtrate concentrated under vacuum. The resulting material is purified by silica gel column chromatography eluting with methanol and dichloromethane. Appropriate fractions are combined and concentrated under vacuum to provide the desired compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,824-52-2, its application will become more common.

Reference:
Patent; Plexxikon Inc.; Zhang, Jiazhong; Ibrahim, Prabha N.; Bremer, Ryan; Spevak, Wayne; Cho, Hanna; US9096593; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 167884-17-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 167884-17-5, Imidazo[1,2-a]pyridin-5-ylmethanol, other downstream synthetic routes, hurry up and to see.

Application of 167884-17-5 ,Some common heterocyclic compound, 167884-17-5, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

i) Synthesis of 3-(imidazo[1,2-a]pyridin-5-yl)methylthiazolidine-2,4-dione To a suspension of 1.19 g (8.0 mmol) of 5-hydroxymethylimidazo[1,2-a]pyridine in 10 ml of dichloromethane, 4.05 ml (56 mmol) of thionyl chloride was added, followed by stirring at room temperature for 1 hour, after which the solvent was distilled off. To a solution of this residue and 0.94 g (8.0 mmol) of thiazolidine-2,4-dione in 15 ml of N,N-dimethylformamide, 2.40 ml (16.0 mmol) of 1,8-diazabicyclo[5.4.0]-7-undecene was added, followed by stirring at 80 C. for 16 hours. After the reaction mixture was cooled, water was added; the mixture was extracted with ethyl acetate and dried, after which the solvent was distilled off. The residue was purified by recrystallization (solvent, chloroform/ethyl acetate/diethyl ether) to yield 247 mg (12.5%, light brown powder) of the desired product. 1 H-NMR (CDCl3, 200 MHz) delta 4.02 (2H, s), 5.06 (2H, s), 6.98 (1H, d, J=6.6 Hz), 7.18 (1H, dd, J=7.0, 9.0 Hz), 7.66 (1H, d, J=9.0 Hz), 7.70 (1H, d, J=1.0 Hz), 7.89 (1H, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 167884-17-5, Imidazo[1,2-a]pyridin-5-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Chemical Industries Ltd.; US5840732; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem