Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55052-27-2, name is 6-Chloro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 6-Chloro-1H-pyrrolo[2,3-b]pyridine

a) 6-Chloro-7-aza-3,3-dibromooxindole 6-Chloro-7-azaindole was prepared according to the procedure of Minakata et al; Synthesis, 1992, 661-663.. To a stirred solution of 1.32 g (8.7 mmol) of 6-chloro-7-azaindole in tert-butanol (80 ML) was added 9.9 g (28 mmol) of 90% pyridine hydrobromide perbromide resulting in a thick yellow precipitate forming immediately.. The reaction was concentrated and the crude chromatographed on silica gel eluding with hexane to 90% hexane/10% EtOAc gradient to give 2.36 g of the title compound as a white solid, containing about 30% of 5-bromo-6-chloro-7-aza-3,3-dibromooxindole as an inseparable impurity. 1H NMR (CDCl3) delta 7.16 (d, J=8.0 Hz, 1H), 7.81 (d, J=8.0 Hz, 1H), 9.0 (bs, 1H).. (5-Bromo-6-chloro-7-aza-3,3-dibromooxindole, 8.05 (s, 1H), 9.0 (bs, 1H).

The synthetic route of 55052-27-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Glaxo Wellcome Inc.; US6350747; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 83393-46-8, Adding some certain compound to certain chemical reactions, such as: 83393-46-8, name is 1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone,molecular formula is C9H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83393-46-8.

A solution of 6.89 g (43.0 mmol) of 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone in 50 ml of DMF is added dropwise under nitrogen to a suspension of 1.25 g (52.0 mmol) of sodium hydride in 100 ml of DMF. The mixture is stirred at room temperature for one hour and then cooled to 0. A solution of 9.92 g (52.0 mmol) of toluene-4-sulfonyl chloride in 50 ml of DMF is added dropwise, and the reaction mixture is stirred at 0 for 2 hours. The reaction mixture is partitioned between ethyl acetate and water. The organic phase is dried over sodium sulfate, evaporated, and the residue is stirred with water. The residue is filtered off with suction and dried in vacuo: 1-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]ethanone as colourless crystals; ESI 315, m.p. 187-189.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 83393-46-8, 1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dorsch, Dieter; Sirrenberg, Christian; Mueller, Thomas; US2010/173923; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 17075-15-9, 4-(Methylsulfonyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 17075-15-9, blongs to pyridine-derivatives compound. HPLC of Formula: C6H7NO2S

EXAMPLE 1A 4-[2-[4-[4-(trifluoromethyl)phenoxy]phenyl]ethoxy]pyridine (Compound 1A) To a suspension of 0.2 g of 60% NaH (as an oil dispersion, 0.005 m) in 5 mL of DMF was added 1.41 g (0.005 m) of 2-[4-[4-(trifluoromethyl)phenoxy]phenyl]ethanol. The mixture was stirred at room temperature for 30 minutes, until hydrogen evolution ceased. To the mixture was then added 0.79 g (0.005 m) of 4-(methylsulfonyl)pyridine, and the mixture was stirred overnight at room temperature. Excess DMF was then removed in vacuo. The resulting material was diluted with water, and the product was extracted into CH2 Cl2. The CH2 Cl2 layer was separated and filtered through phase separating paper, then concentrated. The residue was adsorbed onto silica gel and chromatographed, eluding with CH2 Cl2 ?30% EtOAc/CH2 Cl2. The resulting material was rechromatographed over fine-particle silica gel, eluding with CH2 Cl2 ?50% EtOAc/CH2 Cl2. Yield 0.5 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17075-15-9, its application will become more common.

Reference:
Patent; DowElanco; US5399564; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 19230-55-8 ,Some common heterocyclic compound, 19230-55-8, molecular formula is C6H6ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 81 COMPOUND 81: N1-(3-chloro-5-methyl-pyridin-2-ylmethyl)-N1-(3-isopropyl-pyridin-2-ylmethyl)-butane-1,4-diamine (HBr salt) At -78 C., under N2, BuLi (2.5 M in hexanes, 0.80 mL, 2.0 mmol) was added to a solution of TMEDA (0.30 mL, 2.0 mmol) in dry Et2O (20 mL). After addition the mixture was warmed to room temperature. After stirred at room temperature for 30 min the mixture was cooled to -78 C., and added to a solution of 3-chloro-5-methyl-pyridine (0.255 g, 2.00 mmol) (Bushby et al. J. Chem. Soc. Perkin Trans. 11978, 1578) in dry Et2O (10 mL) pre-cooled at -78 C. The mixture was stirred at -78 C. for 30 min and then warmed to room temperature for 1 h. Water (15 mL) was added, and the mixture was extracted with Et2O (3*40 mL). The organic extracts were combined and dried over anhydrous Na2SO4. After filtration the solvent was removed by evaporation under vacuum, and the residue was purified by flash chromatography on a silica gel column (CH2Cl2) to afford 3-chloro-5-methyl-pyridine-2-carbaldehyde (0.096 g, 31%). 1H NMR (CDCl3) delta 2.44 (s, 3H), 7.65 (s, 1H), 8.54 (s, 1H), 10.28 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19230-55-8, its application will become more common.

Reference:
Patent; Bridger, Gary; McEachern, Ernest J.; Skerlj, Renato; Schols, Dominique; US2004/209921; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 84487-03-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84487-03-6, name is 6-Chloro-5-nitropyridin-2-amine, molecular formula is C5H4ClN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 6-chloro-5-nitropyridin-2-amine(0.26 g, 1.50 mmol), benzylmercaptan (0.19mL, 1.65 mmol), K2CO3 (0.25 g, 1.83 mmol) and DMF (2.1 mL) was stirred at 80 C for 3.5 h. The mixture was poured into water and extracted with CH2CI2 (3×15 mL). The combined organic layers were dried over anhydrous Na2S04 and concentrated. The residue was dissolved in CH2CI2, and the product was precipitated by addition of hexane to give the sub-title compound (0.32 g, 83 %).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 84487-03-6, 6-Chloro-5-nitropyridin-2-amine.

Reference:
Patent; OBLIQUE THERAPEUTICS AB; PELCMAN, Benjamin; SUNA, Edgars; STAFFORD, William; PRIEDE, Martins; (90 pag.)WO2018/146472; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 121643-44-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 121643-44-5 as follows.

Preparation Example 36 2-Methoxy-3-(trifluoromethyl)pyridine (8 g), 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (17 g), and trifluoroacetic acid (32 mL) were mixed, followed by stirring at room temperature for 22 hours. The reaction mixture was concentrated under reduced pressure, and to the residue was added diisopropyl ether. The precipitated solid was separated by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine (9.4 g) as an oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,121643-44-5, its application will become more common.

Reference:
Patent; Astellas Pharma Inc.; TAKAHASHI, Taisuke; KOIKE, Takanori; NEGORO, Kenji; TANAKA, Hiroaki; MAEDA, Jun; YOKOYAMA, Kazuhiro; TAKAMATSU, Hajime; (146 pag.)EP3153511; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 89510-90-7, 2-Chloro-5-fluoro-4-pyridinamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H4ClFN2, blongs to pyridine-derivatives compound. Formula: C5H4ClFN2

4th Step Morpholine (3 ml) was added to 2-chloro-5-fluoropyridin-4-amine (262 mg) obtained in the 2nd step, followed by microwave irradiation (Initiator, 235 C., 2 hours, 2.45 GHz, 0-240 W). A saturated ammonium chloride aqueous solution was added to the reaction solution, followed by extraction with ethyl acetate. The organic layers were washed with a saturated ammonium chloride aqueous solution and saturated saline and dried over anhydrous sodium sulfate. Next, the solvent was distilled away under reduced pressure and a light brown solid of 5-fluoro-2-morpholinopyridin-4-amine (311 mg) was thus obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89510-90-7, 2-Chloro-5-fluoro-4-pyridinamine, and friends who are interested can also refer to it.

Reference:
Patent; FUJIFILM Corporation; FUJIWARA, Hideyasu; MIZUMOTO, Shinsuke; KUBO, Yohei; NAKATA, Hiyoku; HAGIWARA, Shinji; BABA, Yasutaka; TAMURA, Takashi; KUNIYOSHI, Hidenobu; MASHIKO, Tomoyuki; YAMAMOTO, Mari; US2014/309225; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 628691-93-0 ,Some common heterocyclic compound, 628691-93-0, molecular formula is C6H3ClFNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3.72. Compound 73: (lR,2R)-N-(6-((2-Cyano-5-ethyl-3-fluoropyridin-4-yl)(methyl)amino)-l-methyl- lH-imidazo[4,5-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide 3.72.1. Step i: Carbamic acid, N-(2-chloro-3-fluoro-4-pyridinyl)-l,l-dimethylethyl ester To a mixture of 2-chloro-3-fluoronicotinic acid (3.55 g, 20.2 mmol, 1.0 eq), TEA (8.4 mL, 60.6 mmol, 3.0 eq) in a mixture of dry toluene (40 mL) and dry T^uOH (40 mL) under nitrogen, is added diphenylphosphoryl azide (DPPA) (6.51 mL, 30.1 mmol, 1.5 eq). The reaction is heated to 110C for 2 h. The reaction is diluted with water and the compound is extracted with DCM. The organic layer is dried over Na2S04, filtered and removed the solvent under vacuum. The residue is purified by silica chromatography (ethyl acetate/DCM, from 0-20% in 15CV) to give the desired product as transparent oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,628691-93-0, its application will become more common.

Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; MAMMOLITI, Oscar; QUINTON, Evelyne; JOANNESSE, Caroline, Martine, Andree-Marie; DE BLIECK, Ann; BLANC, Javier; (263 pag.)WO2017/12647; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 105252-99-1, Adding some certain compound to certain chemical reactions, such as: 105252-99-1, name is 4-Amino-6-fluoropyridin-2(1H)-one,molecular formula is C5H5FN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 105252-99-1.

Step a: A suspension of 4-ammno-6-fluoropyridin-2(1H)-one (570 mg, 4.45 mmol), K2C03 (922 mg, 6.67 mmol), and Mel (278 jiL, 4.45 mmol) in EtOH (15 mL) was stirred for 15 h at 70 C. After cooling to RT, the reaction mixture was filtered and rinsed with EtOH. The filtrate was suspended in water (40 mL) and extracted with EtOAc (2 x 40 mL) and trifluoroethanol (10% in DCM, 8 x 40 mL). The combined organic extracts were dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 10% gradient of MeOH/DCM) to give 4-amino-6-fluoro- 1-methylpyridin-2(1H)-one (356 mg, 2.51 mmol) as a white solid. MS m/z 142.8 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105252-99-1, 4-Amino-6-fluoropyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 113293-70-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 113293-70-2 as follows.

NaH (613 mg, 15.4 mmol) was added portion wise to stirred anhydrous DMSO (10 mL). The mixture was heated to 80C until evolution of gas ceased and then cooled to 0C. A solution of (carbethoxymethyl)- triphenylphosphonium bromide (3.29 g, 7.74 mmol) in DMSO (5 mL) was then added and the mixture stirred at r.t for 30 min. The mixture was cooled to 0C and a solution of 2,6-dichloroisonicotinaldehyde (1 .35 g, 7.74 mmol) in DMSO (5 mL) was added and the mixture was stirred at r.t for 1 h. The mixture was then poured into aqueous 1 M HCI and extracted into DCM (3 x 50 mL). The organics were combined and washed with H2O (3 x 100 mL) and brine (2 x 100 mL), separated, dried (MgSO ) and concentrated. Purification by flash silica column chromatography (gradient elution /’-hex to 20% EtOAc in /-hex) gave the title compound as a yellow solid (1 .25 g, 66%). LCMS (ES+) 247 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113293-70-2, its application will become more common.

Reference:
Patent; CHDI FOUNDATION, INC.; LUCKHURST, Christopher A.; HAUGHAN, Alan F.; BRECCIA, Perla; STOTT, Andrew J.; BURLI, Roland W.; HUGHES, Samantha J.; MUNOZ-SANJUAN, Ignacio; DOMINGUEZ, Celia; MANGETTE, John E.; WO2012/103008; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem