Tag: M.W=150-200

Maiden, Tracy M. M. published the artcileSynthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction, Recommanded Product: Ethyl 6-chloropicolinate, the main research area is oxazolylpyridine functionalized preparation rhodium silver catalyzed amidation; azaquinazoline scaffold preparation; pyridopyrimidinone preparation; nicotinamide derivative preparation heterocyclization; picolinamide derivative preparation heterocyclization.

The 1st Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.

Organic Letters published new progress about Amidation. 21190-89-6 belongs to class pyridine-derivatives, name is Ethyl 6-chloropicolinate, and the molecular formula is C8H8ClNO2, Recommanded Product: Ethyl 6-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Young, Ian S. published the artcilePalladium-Catalyzed Site-Selective Amidation of Dichloroazines, Synthetic Route of 132097-09-7, the main research area is dichloroazine amide amidation palladium; chloroazinyl amide regioselective preparation; palladium amidation catalyst.

A highly site-selective amidation reaction of substituted 2,4-dichloroazines is reported. Palladium acetate/1,1′-bis(diphenylphosphino)ferrocene (dppf) was identified as the optimal catalyst system, producing >99:1 C-2/C-4 selectivity for most examples. The generality of this transformation was demonstrated through a survey of a diverse amide/substituted 2,4-dichloroazine scope, leading to the preparation of the desired C-2 amidated products in good to excellent yields.

Organic Letters published new progress about Amidation. 132097-09-7 belongs to class pyridine-derivatives, name is 2,4-Dichloro-3-methylpyridine, and the molecular formula is C6H5Cl2N, Synthetic Route of 132097-09-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ishida, Yoshiyuki published the artcileSequence selective dual-emission detection of (i, i + 1) bis-phosphorylated peptide using diazastilbene-type Zn(ii)-Dpa chemosensor, COA of Formula: C7H6ClNO2, the main research area is sequence selective dual emission bisphosphorylated peptide diazastilbene zinc chemosensor.

This paper describes a new fluorescent chemosensor for phosphorylated peptide, which comprises a rigid trans-4,4′-diazastilbene and two Zn(II)-Dpa (2,2′-dipicolylamine) units; this chemosensor sequence-selectively binds to a (i, i + 1) bis-phosphorylated peptide and displays a dual-emission fluorescence change.

Chemical Communications (Cambridge, United Kingdom) published new progress about Affinity. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, COA of Formula: C7H6ClNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ashworth, Ian W. published the artcileProcess Development of a Suzuki Reaction Used in the Manufacture of Lanabecestat, HPLC of Formula: 917471-30-8, the main research area is lanabecestat preparation; Suzuki coupling diethanolamine alkynylpyridinylboronate bromodispirocyclohexaneindaneimidazole key step; hydrolysis kinetics diethanolamine alkynylpyridinylboronate; effect diethanolamine removal palladium lanabecestat.

A process for preparation of the potential anti-Alzheimer’s agent lanabecestat was developed by coupling of an alkynylpyridinylboronic acid diethanolamine ester with a bromodispirocyclohexaneindaneimidazole in the presence of Pd(AmPhos)2Cl2 and K3PO4 in EtOH/H2O; the new process reduced the need for solvent changes and difficult isolation steps and decreased the amount of palladium detected in the final product without the use of solid-phase extractants. The kinetics of hydrolysis of the diethanolamine boronate and the free boronic acid was determined; diethanolamine generated in the hydrolysis decreased the rate of coupling but likely improved the purge of palladium from the product.

Organic Process Research & Development published new progress about Hydrolysis. 917471-30-8 belongs to class pyridine-derivatives, name is (5-(Prop-1-yn-1-yl)pyridin-3-yl)boronic acid, and the molecular formula is C8H8BNO2, HPLC of Formula: 917471-30-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Puszko, A. published the artcile13C NMR spectra of 2,4-dihalopicolines and their N-oxides and IR spectra of 2-halopicoline N-oxides, 2,4-dihalopicoline N-oxides and 2-halo-4-nitropicoline N-oxides, Safety of 2,4-Dichloro-3-methylpyridine, the main research area is NMR IR spectra halopicoline; picoline halo NMR IR spectra; substituent effect NMR IR spectra halopicoline.

The 13C NMR and IR spectra of the title compounds were recorded and their spectral parameters assigned. The influence of electronic properties of the substituents on the direction of chem. shifts and νN-O values is discussed. The ratio between a substituted heterocyclic compound and its parent and the identically substituted benzene derivatives has been determined

Polish Journal of Chemistry published new progress about IR spectra. 132097-09-7 belongs to class pyridine-derivatives, name is 2,4-Dichloro-3-methylpyridine, and the molecular formula is C6H5Cl2N, Safety of 2,4-Dichloro-3-methylpyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mayer, Joachim M. published the artcileDeviations in the log P (partition coefficient) of protonated arylalkylamines and in their apparent log P, COA of Formula: C7H11ClN2, the main research area is amine aryl protonated partition coefficient; pyridylamine partition coefficient; phenylalkylamine partition coefficient.

Partition coefficients of monoprotonated phenyl- and 2-, 3-, and 4-pyridyl-substituted alkylamines show unpredictable but consistent trends. The coefficients of the Me, Bu, and pentyl homologs in each series are linearly related, while the Et and Pr derivatives appear too lipophilic. Thus, these partition coefficients are affected by perturbative effects, e.g., hydration or ion pairing. Also, the phosphate buffers yield abnormally low partition coefficient values.

European Journal of Medicinal Chemistry published new progress about Additivity. 84359-16-0 belongs to class pyridine-derivatives, name is 2-(Pyridin-3-yl)ethanamine hydrochloride, and the molecular formula is C7H11ClN2, COA of Formula: C7H11ClN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shibata, Katsumi published the artcileNiacin activity of 3-cyanopyridine, pyridine 3-sulfonic acid, nicotinic acid N-oxide, and 6-hydroxynicotinic acid in rats, Application In Synthesis of 636-73-7, the publication is Bitamin (1995), 69(7), 357-64, database is CAplus.

Niacin activity of the niacin related compounds such as 3-cyanopyridine, pyridine 3-sulfonic acid, nicotinic acid N-oxide, and 6-hydroxynicotinic acid was investigated using rats. 3-Cyanopyridine, pyridine-3-sulfonic acid, and 6-hydroxynicotinic acid had not only niacin activity but also the antagonistic activity. Nicotinic acid N-oxide had niacin activity and the relative niacin activity to nicotinic acid was about 1/2 in molar ratio.

Bitamin published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C14H10O4S2, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Surov, O. V. published the artcileEnthalpies of Fusion, sublimation and vaporization of some hydrazones, Quality Control of 2215-33-0, the publication is Physical Chemistry: An Indian Journal (2017), 12(1), 1-15, database is CAplus.

Enthalpies of melting, sublimation and vaporization were determined for some hydrazones. The validity of thermogravimetric procedure for measuring enthalpy of vaporization of the compounds under investigation was demonstrated. Exploring packing modes and intermol. interactions in mol. crystals of the hydrazones using Hirshfeld surfaces was carried out.

Physical Chemistry: An Indian Journal published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C5H10Cl3O3P, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vecchio-Sadus, Angelica M. published the artcileElectrosynthesis and magnetic behavior of neutral cobalt(II) complexes of pyridine-2-carbaldehyde pyridin-2′-ylhydrazone (papyH) and its analogs, Category: pyridine-derivatives, the publication is Transition Metal Chemistry (London) (1995), 20(1), 38-45, database is CAplus.

Neutral cobalt(II) complexes with the tridentate N-heterocyclic ligand pyridine-2-carbaldehyde pyridin-2′-ylhydrazone (papyH) and its analogs were prepared by the electrochem. oxidation of cobalt in an acetone solution of the hydrazone. [Co(papy)₂] were obtained as red-green dichroic microcrystals due to the extended π-conjugation system in the anionic ligand. The magnetic moments of the octahedral cobalt(II) chelates decrease continuously from μ_eff = 1.81-4.63 μB at room temperature to 1.7-4.08 μB at ∼90 K. The changes in magnetic moment were accounted for by a ⁴T₁ ↔ ²E spin crossover system.

Transition Metal Chemistry (London) published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C4Br2N2O4S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vecchio-Sadus, Angelica M. published the artcileElectrochemical synthesis of neutral transition metal(II) (Fe, Co, Ni, Cu, Zn) complexes of pyridine-2-carbaldehyde pyridine-2′-ylhydrazone and several analogs, SDS of cas: 2215-33-0, the publication is Transition Metal Chemistry (London) (1995), 20(3), 256-61, database is CAplus.

Neutral transition metal(II) complexes of pyridine-2-carbaldehyde pyridine-2′-ylhydrazone (papyH) and several analogs were prepared by electrochem. synthesis. [M(papy)₂] (M = Fe, Co, Ni, Cu or Zn) were obtained mostly as red-green dichroic substances as a result of the extended π-conjugation system in the anionic hydrazone. Vibrational and electronic spectra confirm the presence of the anionic hydrazone and its tridentate coordination to the metal center.

Transition Metal Chemistry (London) published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C4Br2N2O4S, SDS of cas: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem