Tag: M.W=150-200

Watanabe, Takashi published the artcileOrganic synthesis unit process-thiochemicals and heterocyclic compounds: heterocyclic compounds (part 1), Quality Control of 636-73-7, the publication is Fain Kemikaru (2013), 42(8), 53-66, database is CAplus.

Unit processes of various heterocyclic compounds including furan derivatives, THF or its derivatives, chroman, thiophene or its derivatives, tetrahydrothiophene, pyrrole or its derivatives, pyrrolidine or its derivatives, indole derivative, pyridine derivatives, piperidine derivatives, and quinoline or its derivatives are described. Thus, 2,6-dibromo-4-nitrophenol 8, glycerin 20, and concentrated H₃PO₄ 12 g were charged to a 3-neck flask fitted with a stirrer, a reflux condenser, and a thermometer, cooled, treated slowly with concentrated H₂SO₄ with stirring well, heated in a oil bath at 150-160° for 3 h with gentle refluxing, and cooled. Water (∼150 mL) was added to the flask content solidified, throughly pulverized, and filtered to sep. the insoluble residue and the filtrate. The insoluble residue was immersed in warm 5% aqueous HCl solution and left to be cooled to readily precipitate colorless needle crystals which were filtered off. The filtrate was concentrated to give addnl. crystalline salt. The combined crystalline salt (3.55 g) was added to slightly acidic aqueous Na₂CO₃ solution, throughly stirred, left to stand for ∼20 min, and the free amine formed (2.87 g) was filtered off and recrystallized from acetone to give 7-bromo-6-hydroxyquinoline. The filtrate from the aqueous Na₂CO₃ solution was neutralized with Na₂CO₃, followed by filtering off the precipitated free amine (0.72 g) and recrystallization from acetone to give 7-bromo-6-hydroxyquinoline in ∼62% as crude product.

Fain Kemikaru published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C4H7BN2O2, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Anderegg, Giorgio published the artcilePyridine derivatives as complexing agents. IX. Stability constants of complexes with 2-aminomethylpyridine, 6-methyl-2-aminomethylpyridine, 2-pyridylhydrazine, 2,2′-dipyridylamine, and 1-(α-pyridylmethylene)-2-(α’-pyridyl)hydrazine, COA of Formula: C11H10N4, the publication is Helvetica Chimica Acta (1971), 54(2), 509-12, database is CAplus.

The stability constants for the Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Hg(II), Cd(II), and Ag(I) complexes of 2-aminomethylpyridine, 6-methyl-2-aminomethylpyridine, 2-pyridylhydrazine, 2,2′-dipyridylamine, 1-(2-pyridylmethylene)-2-(2′-pyridyl)hydrazine are reported. In all cases logK1 > logK2.

Helvetica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Anonymous published the artcilePreparation of new nitrogen-bridged heterocycles. 72. A new approach to 1-acyl-3-(substituted methylthio)thieno[3′,4′:4,5]imidazo[1,5-a]pyridine derivatives [Erratum to document cited in CA154:284193], Application In Synthesis of 17281-59-3, the publication is Chemical & Pharmaceutical Bulletin (2010), 58(12), 1672, database is CAplus.

On page 1502 the title contains an error; the correct title is given. On page 1509 in the right column, lines 3,8 and 7 and in the left column, lines 8 and 7, imidazo[1,5-α]pyridine is incorrect; the correction is given. On page 1510 in the left column, lines 3 and 17, imidazo[1,5-α]pyridine is incorrect; the correction is given. On page 1510, a reference should be added; the reference is given.

Chemical & Pharmaceutical Bulletin published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Application In Synthesis of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chiswell, B. published the artcilePlatinum complexes of some deprotonatable tridentate ligands, Related Products of pyridine-derivatives, the publication is Australian Journal of Chemistry (1968), 21(8), 1997-2001, database is CAplus.

Pt(II) and Pt(IV) complexes of 1,3-bis(2-pyridyl)-1,2-diazaprop-2-ene and ligands of similar structure, but with Me “blocking groups” adjacent to the pyridine N atoms, were studied. In neutral solution, these ligands lose a proton upon interaction with either Pt(II) or Pt(IV) salts to yield highly colored complexes soluble in organic solvents. Protonated compounds of both oxidation states can be obtained, but such compounds are unstable in neutral solution and readily yield deprotonated complexes.

Australian Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

El Ali, Bassam published the artcileRh₆(CO)₁₆-H₃PW₁₂O₄₀-catalyzed one pot hydroformylation-cyclotrimerization of cyclohexene and cyclopentene to 2,4,6-trisubstituted 1,3,5-trioxanes, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Journal of Molecular Catalysis A: Chemical (2003), 203(1-2), 53-58, database is CAplus.

One-pot hydroformylation-cyclotrimerization of cyclopentene and cyclohexene was selectively catalyzed by Rh₆(CO)₁₆ and H₃PW₁₂O₄₀·xH₂O (HPA-W₁₂) in THF at 40 atm (CO/H₂ = 1/1) and afforded 2,4,6-tris(cycloalkyl)-1,3,5-trioxanes as major products along with the corresponding aldehydes.

Journal of Molecular Catalysis A: Chemical published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guven, Alaattin published the artcileAcidity study on 3-substituted pyridines, Recommanded Product: Pyridine-3-sulfonic acid, the publication is International Journal of Molecular Sciences (2005), 6(11), 257-275, database is CAplus.

A comprehensive theor. study for the protonation of some 3-substituted pyridines has been carried out in aqueous solution (ε=78.4) by semi empirical AM1 method in MOPAC2000 and PM5 method in MOPAC2002. Solvent effect was accounted for implicitly by means of the conductor like screening model (COSMO). The acidity constants of these pyridine derivatives have been calculated The tautomeric and/or conformational equilibrium for these compounds, where available, were also taken into account to find out the mol fractions of the species in aqueous media. The results obtained from the calculations were compared with the available exptl. values, and the results indicate a considerable agreement with available exptl. data.

International Journal of Molecular Sciences published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lombardini, John B. published the artcileEffects of taurine and taurine analogs on the phosphorylation of a 44 kDa protein present in a mitochondrial subfraction of the rat heart: partial characterization of the 44 kDa phosphoprotein, Quality Control of 636-73-7, the publication is Journal of Molecular and Cellular Cardiology (1994), 26(12), 1675-89, database is CAplus and MEDLINE.

Recent studies suggest that taurine (2-aminoethanesulfonic acid) is involved in the regulation of protein phosphorylation in excitable tissues such as the retina, brain and heart. To determine the structural requirements for the effect of taurine on the phosphorylation of a 44 kDa protein(s), a series of taurine analogs were tested in an in vitro assay using a subcellular mitochondrial fraction of rat heart. Inhibitors of the phosphorylation of the 44 kDa protein include taurine and close structural analogs of taurine such as aminoethylhydrogen sulfate and α-sulfo-β-alanine. Secondary amines with the taurine structure partially locked into a saturated 5-membered ring such as (±)piperidine-3-sulfonic acid and 1,2,3,4-tetrahydroquinoline-8-sulfonic acid also possess inhibitory activity. Sulfone analogs of taurine such as 2-aminoethylmethylsulfone, a non-restricted taurine analog with maximal conformational flexibility about its amino and sulfone moieties, and (±)3-aminotetrahydrothiopyran-1,1-dioxide, an analog containing the sulfone moiety in a six-membered ring structure, were more potent inhibitors of phosphorylation than taurine despite the fact that the sulfone moiety is neither an isosteric nor isoelectronic substitution for the sulfonic acid moiety. The results of this study indicate that the inhibition of the phosphorylation of the 44 kDa protein in a rat heart mitochondrial fraction is relatively specific for the taurine structure. Two analogs of taurine with unsaturated rings containing a primary sulfonic acid and a secondary amine. Pyridine-3-sulfonic acid and quinoline-8-sulfonic acid, were observed to be stimulators of the phosphorylation of the 44 kDa protein. In addition, 2-aminobenzenesulfonic acid also stimulated phosphorylation. Phase separation experiments with Triton X-114 suggest that the 44 kDa phosphoprotein is a soluble protein and not an integral membrane protein of the mitochondria. Phosphate incorporation into specific amino acids was determined by two-dimensional electrophoresis on celluloses plates and was found exclusively in the serine residues.

Journal of Molecular and Cellular Cardiology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lombardini, John B. published the artcileQuantitative analysis of the combination dose-effects of taurine and taurine analogs on the phosphorylation of an ∼44-Kd protein present in a mitochondrial subfraction of rat heart, COA of Formula: C5H5NO3S, the publication is Journal of Cardiovascular Pharmacology (1996), 28(1), 107-114, database is CAplus and MEDLINE.

Combinations of taurine and analogs of taurine that partially contain the N-C-C-S moiety within a semirigid saturated ring structure were tested for their effects on the phosphorylation of an ∼44-Kd protein present in the mitochondrial fraction of rat heart. (±)-Piperidine-3-sulfonic acid (PiP), an inhibitor of the phosphorylation of the ∼44-Kd protein with activity approx. similar to that of taurine, was observed to be mutually exclusive with taurine, i.e., to have a similar mode of action. The combination of taurine plus PiP in a fixed ratio mixture of 1:1 was slightly antagonistic at all concentrations (±)-Aminotetrahydrothiopyran-1,1-dioxide (APS), a sulfone derivative of taurine with a net pos. charge, also has approx. the same inhibitory activity as taurine. However, APS was mutually nonexclusive with taurine when tested in combination and thus appears to act independently of taurine. Taurine plus APS in a fixed ratio mixture of 3:1 was highly antagonistic at low concentrations of the mixture, approached an additive relation at 50% saturation, and became synergistic at high concentrations of the mixture Three analogs of taurine, pyridine-3-sulfonic acid (PyS), quinoline-8-sulfonic acid (QS), and 2-aminobenzenesulfonic acid (ABS), that have the basic taurine structure (N-C-C-S) partially in a semirigid unsaturated ring structure stimulate the phosphorylation of the ∼44-Kd protein. Due to the unsaturated ring structure, these analogs of taurine have a net neg. charge at physiol. pH and are not zwitterions. When PyS, QS, or ABS was titrated in the presence of a fixed concentration of taurine (10 mM), there was a competitive relation even through their electronic nature is quite different than that of taurine. The combination of QS plus PyS (1:5) appears to progress through a transition from being synergistic at low concentrations of the fixed ratio mixture, additive at 50% saturation, and finally antagonistic at high concentration of the fixed ratio mixture

Journal of Cardiovascular Pharmacology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, COA of Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Melo, Eduardo Borges de published the artcileA structure-activity relationship study of the toxicity of ionic liquids using an adapted Ferreira-Kiralj hydrophobicity parameter, Related Products of pyridine-derivatives, the publication is Physical Chemistry Chemical Physics (2015), 17(6), 4516-4523, database is CAplus and MEDLINE.

The Ferreira-Kiralj hydrophobicity parameter W_c is a number fraction of hydrophobic carbon atoms and can be regarded as a constitutional descriptor since its calculation depends only on the number of polar and nonpolar carbons in a compound Hydrophobicity is important to the toxicity of ionic liquids (ILs), which are salts by nature. Herein, a descriptor for this property was calculated using a simple adaptation of the type of polar carbon atoms included (W_cAdap) to explore the possibility of its use in quant. structure-activity relationship (QSAR) studies of ILs. The resulting model was tested using a database of ILs with toxicity against the Leukemia rat cell line IPC-81. Two other models were constructed using Crippen log P and Mannhold log P descriptors, which are both available in the free program PaDEL. The use of W_cAdap led to a better and more indicative model. Thus, W_cAdap may be a suitable mol. descriptor for the hydrophobicity of ILs in QSAR studies.

Physical Chemistry Chemical Physics published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mihkelson, A. E. published the artcileReactions of palladium(II) with a series of potentially tridentate nitrogen ligands. II. Solution studies, Application In Synthesis of 2215-33-0, the publication is Journal of Inorganic and Nuclear Chemistry (1981), 43(1), 127-36, database is CAplus.

Potentiometric and conductometric titrations of Pd²⁺ and pyridine-2-carboxaldehyde 2′-pyridylhydrazone (HL) in aqueous solution showed that only 1 mol of L coordinates with each Pd in solution There was no evidence for PdL₂ formation in aqueous solution Equilibrium constants were estimated for a model system using Job’s method of continuous variations. Proton NMR of PdL₂ and PdL¹OAc (HL¹ = 6-methylpyridine-2-carboxaldehyde 2′-pyridylhydrazone) showed that the ligand undergoes isomerization about the imine bond.

Journal of Inorganic and Nuclear Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem