Tag: M.W=150-200

In 2019.0 ORG CHEM FRONT published article about 1,2,3-BENZOTRIAZIN-4-ONE DERIVATIVES; NEMATOCIDAL ACTIVITIES; CORROSION-INHIBITORS; SELECTIVE SYNTHESIS; BENZOTRIAZOLE; HETEROCYCLES; THERMOLYSIS; CYCLIZATION; ANNULATION; HYDRAZONES in [Cai, Yue-Ming; Zhang, Xin; An, Cui; Yang, Ye-Fei; Liu, Wei; Gao, Wen-Xia; Huang, Xiao-Bo; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China in 2019.0, Cited 37.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Computed Properties of C12H9NO

We disclose a catalyst-free method to synthesize 1,2,3-triazoles rapidly via an oxidative N-N coupling strategy. Of particular note is that the one-step synthesis route to access [1,2,3] triazolo[1,5-a] pyridines from pyridin-2-ylmethanamine has been reported for the first time. This approach features no use of catalyst, extremely mild conditions and excellent efficiency.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Cai, YM; Zhang, X; An, C; Yang, YF; Liu, W; Gao, WX; Huang, XB; Zhou, YB; Liu, MC; Wu, HY or concate me.. Computed Properties of C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Lapier, M; Ballesteros-Garrido, R; Guzman-Rivera, D; Gonzalez-Herrera, F; Aguilera-Venegas, B; Moncada-Basualto, M; Ballesteros, R; Abarca, B; Pesce, B; Kemmerling, U; Olea-Azar, C; Maya, JD in FUTURE SCI LTD published article about CELL-PROLIFERATION; STRUCTURAL-BASIS; DRUG CANDIDATES; CHOLESTEROL; 14-ALPHA-DEMETHYLASE; INHIBITION; INSIGHTS; BINDING; CYP51; CHAIN in [Lapier, Michel; Guzman-Rivera, Daniela; Gonzalez-Herrera, Fabiola; Pesce, Barbara; Maya, Juan D.] Univ Chile, Fac Med, Inst Ciencias Biomed ICBM, Clin & Mol Pharmacol Program, Independencia 1027, Santiago 1027, Chile; [Ballesteros-Garrido, Rafael; Ballesteros, Rafael; Abarca, Belen] Univ Valencia, Fac Pharm, Dept Organ Chem, Avda Vicent Andres Estelles S-N, E-46100 Valencia, Spain; [Aguilera-Venegas, Benjamin; Moncada-Basualto, Mauricio; Olea-Azar, Claudio] Univ Chile, Fac Chem & Pharmaceut Sci, Free Rad & Antioxidants Lab, Inorgan & Analyt Dept, Santos Dumt 964, Santiago, Chile; [Moncada-Basualto, Mauricio] Univ Santiago Chile, Fac Chem & Biol, Dept Environm Sci, Santiago, Chile; [Kemmerling, Ulrike] Univ Chile, Fac Med, Inst Ciencias Biomed ICBM, Anat & Dev Biol Program, Independencia 1027, Santiago, Chile in 2019, Cited 38. Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Aim: To study a new series of [1,2,3] triazolo[1,5-alpha] pyridine derivatives as trypanocidal agents because current antichagasic pharmacologic therapy is only partially effective. Materials & methods: The effect of the series upon Trypanosoma cruzi epimastigotes and murine macrophages viability, cell cycle, cell death and on the metabolites of the sterol biosynthesis pathway was measured; also, docking in 14 alpha-demethylase was analyzed. Results: Compound 16 inhibits 14 alpha-demethylase producing an imbalance in the cholesterol/ergosterol synthesis pathway, as suggested by a metabolic control and theoretical docking analysis. Consequently, it prevented cell proliferation, stopping the cellular cycle at the G2/M phase, inducing cell death. Conclusion: Although the exact cell death mechanism remained elusive, this series can be used for the further rational design of novel antiparasitic molecules.

Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Lapier, M; Ballesteros-Garrido, R; Guzman-Rivera, D; Gonzalez-Herrera, F; Aguilera-Venegas, B; Moncada-Basualto, M; Ballesteros, R; Abarca, B; Pesce, B; Kemmerling, U; Olea-Azar, C; Maya, JD or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 SYNTHESIS-STUTTGART published article about STEREOSELECTIVE ADDITION; DIMETHYLPHOSPHINE OXIDE; SYNERGISTIC EXTRACTION; CARBONYL-COMPOUNDS; PHOSPHORUS; ALKENES; CHALCOGENIDES; METHODOLOGY; ABSORPTION; COMPLEXES in [Gusarova, Nina K.; Ivanova, Nina I.; Khrapova, Kseniya O.; Volkov, Pavel A.; Telezhkin, Anton A.; Larina, Lyudmila I.; Afonin, Andrei V.; Pavlov, Dmitry V.; Trofimov, Boris A.] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, 1 Favorsky Str, Irkutsk 664033, Russia in 2020.0, Cited 69.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Quality Control of Phenyl(pyridin-2-yl)methanone

Tertiary alpha-hydroxyphosphine oxides have been synthesized via the catalyst- and solvent-free reaction between available secondary phosphine oxides and aliphatic, aromatic and heteroaromatic ketones at 20-62 degrees C in near to 96-98% yield. The developed method meets the requirements of green chemistry and the PASE (pot, atom, step economy) paradigm. According to quantum-chemical calculations at the B3LYP/6-311++G(d,p) level, the synthesized hydroxyphosphine oxides feature a weak (approximate to 3 kcal center dot mol(-1)) O-H center dot center dot center dot O=P intramolecular hydrogen bond.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gusarova, NK; Ivanova, NI; Khrapova, KO; Volkov, PA; Telezhkin, AA; Larina, LI; Afonin, AV; Pavlov, DV; Trofimov, BA or concate me.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020 J MOL STRUCT published article about BIOLOGICAL-PROPERTIES; NITRIC-OXIDE; CRYSTAL; DRUG; CANCER in [Rechitskaya, E. D.; Kuratieva, N., V; Lider, E., V; Eremina, J. A.; Kostin, G. A.] Nikolaev Inst Inorgan Chem SB RAS, Lavrentieva 3, Novosibirsk, Russia; [Rechitskaya, E. D.; Kuratieva, N., V; Lider, E., V; Eremina, J. A.; Eltsov, I., V; Kostin, G. A.] Novosibirsk State Univ, Pirogova 2, Novosibirsk, Russia; [Klyushova, L. S.] Inst Mol Biol & Biophys, Subdiv FRC FTM, 2-12 Timakova Str, Novosibirsk 630060, Russia; [Klyushova, L. S.] Sci Inst Clin & Expt Lymphol, Branch ICG SB RAS, 2 Timakova Str, Novosibirsk 630117, Russia in 2020, Cited 37. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6. SDS of cas: 614-18-6

Three novel ruthenium nitrosyl complexes [Ru(NO)Cl-3(InicMe)(2)] (1b), [RuNOCl3(NicEt)(2)] (1c) and [RuNOCl3(NicMe)(2)] (1d) (InicMe = methyl isonicotinate, NicEt = ethyl nicotinate, NicMe = methyl nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD analysis. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: pi(arene)-pi(arene) and pi(COO)-pi(arene) stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)(2)Cl-3] (L = Py, gamma-Pic, beta-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex. (C) 2020 Elsevier B.V. All rights reserved.

SDS of cas: 614-18-6. About Ethyl nicotinate, If you have any questions, you can contact Rechitskaya, ED; Kuratieva, NV; Lider, EV; Eremina, JA; Klyushova, LS; Eltsov, IV; Kostin, GA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C12H9NO. In 2019.0 ACS CATAL published article about C BOND FORMATION; ALLYLIC ALCOHOLS; CATALYZED TRIFLUOROMETHYLATION; EFFICIENT SYNTHESIS; 1,2-ARYL MIGRATION; DIFUNCTIONALIZATION; 1,4-DIKETONES; CYCLIZATION; ARYL; 1,2-DIFUNCTIONALIZATION in [Ngai, Ming-Yu] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA; SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11794 USA in 2019.0, Cited 80.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

We report the development of a photocatalytic strategy for the synthesis of beta-functionalized unsymmetrical 1,4-, 1,6-, and 1,7-diketones from aroyl chlorides and unactivated alkenes at room temperature. The mild reaction conditions not only tolerate a wide range of functional groups and structural moieties, but also enable migration of a variety of distal groups including (hetero)arenes, nitrile, aldehyde, oxime derivative, and alkene. The efficiency of chirality transfer, factors that control the distal-group migration, and synthesis of carbocycles and heterocycles from the diketones are also described. Mechanistic studies suggest a reaction pathway involving a photocatalytic radical aroylation of unactivated alkenes followed by a distal-group migration, oxidation, and deprotonation to afford the desired diketones.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Sarkar, S; Banerjee, A; Yao, W; Patterson, EV; Ngai, MY or concate me.. Computed Properties of C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Huang, C; Qiao, J; Ci, RN; Wang, XZ; Wang, Y; Wang, JH; Chen, B; Tung, CH; Wu, LZ in CELL PRESS published article about SP(3) C-H; LIGHT PHOTOREDOX CATALYSIS; TRANSITION-METAL; FUNCTIONALIZATION; ALLYLATION; CARBONYL; PHOTOCATALYSIS; SELECTIVITY; ACTIVATION; ALDEHYDES in [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China; [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Univ Chinese Acad Sci, Beijing 100190, Peoples R China; [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China in 2021, Cited 67. Safety of Ethyl nicotinate. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

Direct alkylation and arylation of allylic C(sp3)-H bonds are straight-forward approaches for accessing allylic C-C products. However, the engagement of allylic C-C bond- forming reaction without introducing extraneous functional groups and stoichiometric oxidant or reductant has proved difficult. Here, we report a general and mild strategy using semiconductor quantum dots (QDs) as photocatalysts for coupling a broad range of available allylic C(sp(3))-H bonds with alpha- amino C-H bonds or heteroarenes, respectively, under sunlight irradiation (> 85 examples). The protocol bypasses stoichiometric oxidant or reductant and pre-functionalization of both the coupling partners and produces hydrogen (H-2) as the byproduct. The outstanding efficiency and selectivity and step- and atom-economy represents the first direct alkylation and arylation of allylic C(sp(3))-H bonds with hydrogen evolution powered by solar energy.

About Ethyl nicotinate, If you have any questions, you can contact Huang, C; Qiao, J; Ci, RN; Wang, XZ; Wang, Y; Wang, JH; Chen, B; Tung, CH; Wu, LZ or concate me.. Safety of Ethyl nicotinate

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Patil, SG; Jadhav, JS; Sankpal, ST in [Patil, Suhas G.] St Rawool Maharaj Mahavidyalaya, Kudal 416520, MS, India; [Jadhav, Jagannath S.] Shivaji Univ, Dept Chem, Kolhapur 416004, MS, India; [Patil, Suhas G.; Sankpal, Sagar T.] ASP Coll, Dept Chem, Ratnagiri 415804, MS, India published Mg3N2-assisted one-pot synthesis of 1,3-disubstituted imidazo[1,5-a]pyridine in 2020.0, Cited 58.0. Safety of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A novel Mg3N2-assisted one-pot annulation strategy has been developed via cyclo-condensation reaction of 2-pyridyl ketones with alkyl glyoxylates or aldehydes, allowing the formation of imidazo[1,5-a]pyridines exclusively with an exellent yield.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Patil, SG; Jadhav, JS; Sankpal, ST or concate me.. Safety of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 ORG LETT published article about MANNICH-TYPE REACTIONS; BOND FORMATION; ARYL HALIDES; ALPHA-AMINO; ASYMMETRIC HYDROGENATION; BENZOPHENONE IMINE; DIRECT ACCESS; SCHIFF-BASES; DERIVATIVES; ACTIVATION in [Kondo, Yuta; Kadota, Tetsuya; Hirazawa, Yoshinobu; Morisaki, Kazuhiro; Morimoto, Hiroyuki; Ohshima, Takashi] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan; [Morisaki, Kazuhiro] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan in 2020.0, Cited 67.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. COA of Formula: C12H9NO

N-Unprotected ketimines are useful substrates and intermediates for synthesizing valuable nitrogen-containing compounds, but their potential applicability is limited by the available synthetic methods. To address this issue, we report a scandium(III) triflate catalyzed direct synthesis of N-unprotected ketimines. Using commercially available reagents and Lewis acid catalysts, ketones were directly transformed into the corresponding N-unprotected ketimines in high yields with broad functional group tolerance, even in multigram scales. The reactions were readily applicable for one-pot synthesis of important compounds such as a glycine Schiff base without isolation of N-unprotected ketimine intermediates. Preliminary mechanistic studies to clarify the reaction mechanism are also described.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Kondo, Y; Kadota, T; Hirazawa, Y; Morisaki, K; Morimoto, H; Ohshima, T or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Metal-free oxidative C(sp(3))-H functionalization: a facile route to quinoline formaldehydes from methyl-azaheteroarenes published in 2020.0. SDS of cas: 91-02-1, Reprint Addresses Zhu, YP; Sun, YY; Meng, QG (corresponding author), Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Shandong, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

A facile protocol for the synthesis of quinoline formaldehydes via direct oxidative C-H bonds functionalization of methyl-azaheteroarenes in the presence of I-2-DMSO has been described. This method is metal-free and easy to operate. This reaction provided a convenient route for the preparation of a range of important quinoline formaldehydes.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Weng, WZ; Guo, JS; Liu, KX; Shao, TQ; Song, LQ; Zhu, YP; Sun, YY; Meng, QG or concate me.. SDS of cas: 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Phenyl(pyridin-2-yl)methanone. I found the field of Chemistry very interesting. Saw the article Triazole-based ligands functionalized silica: Effects of ligand denticity and donors on catalytic oxidation activity of Pd nanoparticles published in 2019.0, Reprint Addresses Sangtrirutnugul, P (corresponding author), Mahidol Univ, Ctr Excellence Innovat Chem PERCH CIC, Ctr Catalysis, Dept Chem,Fac Sci, 272 Rama VI Rd, Bangkok 10400, Thailand.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem