Tag: M.W=150-200

Safety of Phenyl(pyridin-2-yl)methanone. In 2019.0 ACTA CRYSTALLOGR C published article about SUPEROXIDE-DISMUTASE ACTIVITY; DOT-N INTERACTIONS; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE in [Araujo, Vinicius Oliveira; Schwade, Vania Denise] Fundacao Univ Fed Grande Dourados, Fac Ciencias Exatas & Tecnol, Rodovia Dourados Itahum,Km 12, BR-79804970 Dourados, MS, Brazil; [Tirloni, Brbara] Univ Fed Santa Maria, Dept Quim, Ave Roraima 1000, BR-97105900 Santa Maria, RS, Brazil; [Streit, Livia] Univ North Georgia, Dept Chem & Biochem, 3820 Mundy Mill Rd, Oakwood, GA 30566 USA in 2019.0, Cited 22.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Semicarbazones can exist in two tautomeric forms. In the solid state, they are found in the keto form. This work presents the synthesis, structures and spectroscopic characterization (IR and NMR spectroscopy) of four such compounds, namely the neutral molecule 4-phenyl-1-[phenyl(pyridin-2-yl)methylidene] semicarbazide, C19H16N4O, (I), abbreviated as HBzPyS, and three different hydrated salts, namely the chloride dihydrate, C19H17N4O+center dot Cl-center dot 2H(2)O, (II), the nitrate dihydrate, C19H17N4O+center dot NO3-center dot 2H(2)O, (III), and the thiocyanate 2.5-hydrate, C19H17N4O+center dot SCN-center dot 2.5H(2)O, (IV), of 2-[phenyl({[(phenylcarbamoyl) amino]imino})methyl]pyridinium, abbreviated as [H(2)BzPyS](+)center dot X-center dot nH(2)O, with X = Cl- and n = 2 for (II), X= NO3- and n = 2 for (III), and X = SCN- and n = 2.5 for (IV), showing the influence of the anionic form in the intermolecular interactions. Water molecules and counter-ions (chloride or nitrate) are involved in the formation of a two-dimensional arrangement by the establishment of hydrogen bonds with the N-H groups of the cation, stabilizing the E isomers in the solid state. The neutral HBzPyS molecule crystallized as the E isomer due to the existence of weak pi-pi interactions between pairs of molecules. The calculated IR spectrum of the hydrated [H(2)BzPyS](+) cation is in good agreement with the experimental results.

Safety of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Araujo, VO; Tirloni, B; Streit, L; Schwade, VD or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Oncology; Pharmacology & Pharmacy very interesting. Saw the article Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis published in 2020.0. Quality Control of Phenyl(pyridin-2-yl)methanone, Reprint Addresses Jin, JF (corresponding author), Guilin Med Univ, Affiliated Hosp, Lab Hepatobiliary & Pancreat Surg, Guilin 541001, Guangxi, Peoples R China.; Huang, ZQ (corresponding author), Guilin Med Univ, Dept Pathol, Affiliated Hosp, 15 Lequn Rd, Guilin 541001, Guangxi, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Objective: To overcome the disadvantages of cisplatin, numerous platinum (Pt) complexes have been prepared. However, the anticancer activity and mechanism of Pt(II) complexed with 2-benzoylpyridine [Pt(II)-Bpy]: [PtCl2(DMSO)L] (DMSO = dimethyl sulfoxide, L = 2-benzoylpyridine) in cancer cells remain unknown. Methods: Pt(II)-Bpy was synthesized and characterized by spectrum analysis. Its anticancer activity and underlying mechanisms were demonstrated at the cellular, molecular, and in vivo levels. Results: Pt(II)-Bpy inhibited tumor cell growth, especially HepG2 human liver cancer cells, with a half-maximal inhibitory concentration of 9.8 +/- 0.5 mu M, but with low toxicity in HL-7702 normal liver cells. Pt(H)Bpy induced DNA damage, which was demonstrated through a marked increase in the expression of cleaved-poly (ADP ribose) polymerase (PARP) and gamma-H2A histone family member X and a decrease in PARP expression. The interaction of Pt(II)-Bpy with DNA at the molecular level was most likely through an intercalation mechanism, which might be evidence of DNA damage. Pt(II)-Bpy initiated cell cycle arrest at the S phase in HepG2 cells. It also caused severe loss of the mitochondria( membrane potential; a decrease in the expression of caspase-9 and caspase-3; an increase in reactive oxygen species levels; the release of cytochrome c and apoptotic protease activation factor; and the activation of caspase-9 and caspase-3 in HepG2 cells, which in turn resulted in apoptosis. Meanwhile, changes in p53 and related proteins were observed including the upregulation of p53, the phosphorylation of p53, p21, B-cell lymphoma-2-associated X protein, and NOXA; and the down-regulation of B-cell lymphoma 2. Moreover, Pt(II)-Bpy displayed marked inhibitory effects on tumor growth in the HepG2 nude mouse model. Conclusion: Pt(II)-Bpy is a potential candidate for cancer chemotherapy.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Li, YL; Gan, XL; Zhu, RP; Wang, XH; Liao, DF; Jin, JF; Huang, ZQ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: Ethyl nicotinate. Authors Liu, JJ; Chen, JY; Li, SS; Tian, WN; Wu, HG; Han, BZ in TAYLOR & FRANCIS INC published article about in [Liu, Jingjing; Li, Shuangshi; Tian, Weina] Beijing Polytech, Sch Bioengn, Dept Food Technol, Beijing, Peoples R China; [Chen, Jingyu; Han, Beizhong] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Lab Food Qual & Safety, Beijing, Peoples R China; [Wu, Haigang] Henan Univ, Sch Life Sci, Kaifeng, Henan, Peoples R China in 2021, Cited 32. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

Sufu is a pleasant-tasting, traditional Chinese fermented soybean food that is rich in nutrients. In this study, the changes of volatile and nonvolatile metabolites in sufu fermented by bacillus licheniformis, were investigated. The results indicated that a total of 55 kinds of nonvolatile compounds were detected, including 2 carbohydrates, 4 alcohols, 17 amino acids, 18 organic acids, 6 biogenic amines, and 8 other substances. Furthermore, a total of 58 volatile compounds identified were composed of 11 esters, 16 alcohols, 10 acids, and 21 miscellaneous compounds. Inoculation of bacillus licheniformis enriched the metabolite pro?le of sufu and improved its functionality and safety of edibility. It was observed that the pure fermented starter resulted in controlled acceleration of sufu maturation.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of Phenyl(pyridin-2-yl)methanone. Authors Pischedda, S; Stoccoro, S; Zucca, A; Sciortino, G; Ortu, F; Clarkson, GJ in ROYAL SOC CHEMISTRY published article about in [Pischedda, Sara; Stoccoro, Sergio; Zucca, Antonio] Univ Sassari, Dipartimento Chim & Farm, Via Vienna 2, I-07100 Sassari, Italy; [Pischedda, Sara; Stoccoro, Sergio; Zucca, Antonio] Consorzio Interuniv Reatt Chim & Catalisi CIRCC, Bari, Italy; [Sciortino, Giuseppe] Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain; [Ortu, Fabrizio] Univ Leicester, Sch Chem, Univ Rd, Leicester LE1 7RH, Leics, England; [Ortu, Fabrizio] Univ Manchester, Dept Chem, Oxford Rd, Manchester M13 9PL, Lancs, England; [Clarkson, Guy J.] Univ Warwick, Dept Chem, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England in 2021.0, Cited 77.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Several palladium(ii) and platinum(ii) complexes (1-20) of general formula [M(L-n)(X)(Y)] [M = Pd, X = Y = Cl (1-Cl-4-Cl), X = Y = OAc (1-OAc-4-OAc); M = Pt: X = Y = Cl (5-8); M = Pd, X = Cl, Y = CH3 (9-12); M = Pt, X = Cl, Y = CH3 (13-16) or X = Y = CH3 (17-20); n = 1-4] have been synthesized by reaction of different Pd(ii) and Pt(ii) derivatives with various 3-substituted 1-(2-pyridyl)-imidazo[1,5-a]pyridines; i.e.L-n = 1-(2-pyridyl)-3-arylimidazo[1,5-a]pyridine (aryl = Phenyl, L-1; 2-o-Tolyl, L-2; Mesityl, L-3) and 1-(2-pyridyl)-3-benzylimidazo[1,5-a]pyridine (L-4). Detailed spectroscopic investigation (including IR, mono- and bi-dimensional H-1 NMR) and elemental analysis has been performed for all these species, allowing their complete characterization. L-n act as N,N-bidentate ligands and coordinate the metal centers in a chelate fashion through the pyridyl (N-py) and the pyridine-like nitrogen atom of the imidazo[1,5-a]pyridine group (N-im). The X-ray structural analysis performed on two of Pd(ii) and three Pt(ii) complexes, namely [Pd(L-2)(CH3)Cl] (10), [Pd(L-3)(CH3)Cl] (11) and [Pt(L-1)Cl-2] (5), [Pt(L-4)Cl-2] (8), [Pt(L-2)(CH3)Cl] (14) confirmed the spectroscopic and analytical data. Finally DFT studies unveiled the structural reasons behind the inertia of the synthesised compounds toward metalation, identified as the higher angle steric strain in comparison with the analogous bipyridine complexes.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Pischedda, S; Stoccoro, S; Zucca, A; Sciortino, G; Ortu, F; Clarkson, GJ or concate me.. Safety of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of Phenyl(pyridin-2-yl)methanone. Gharami, S; Aich, K; Ghosh, P; Patra, L; Murmu, N; Mondal, TK in [Gharami, Saswati; Aich, Krishnendu; Patra, Lakshman; Mondal, Tapan Kumar] Jadavpur Univ, Dept Chem, Kolkata 700032, India; [Ghosh, Paramita; Murmu, Nabendu] Chittaranjan Natl Canc Inst, Dept Signal Transduct & Biogenis Amines STBA, Kolkata 700026, India published A simple coumarin based fluorescent On probe for the selective detection of Al3+ along with its application in live cell imaging via AGS cell line in 2020.0, Cited 37.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A new coumarin based fluorescent switch (HCBP) has been fabricated which displays high selective sensing towards Al3+ among other metal cations at physiological pH. On gradual addition of Al3+ specifically, HCBP shows a brilliant turn-on emission enhancement of about similar to 13-fold with about 50 nm red shift at 481 nm in MeOH/H2O (1/1, v/v) solution. The fluorescent switch is proven to be a reversible probe by addition of EDTA gradually into the HCBP-Al3+ solution. Detection limit as well as Binding constant values have been calculated and found to be in the order of 10(-9) M and 10(3) M-1 respectively. DFT and TDDFT studies are conducted with the probe to establish a similarity between theoretical and experimental outcomes. We can also use this new fluorescent switch as a biomarker kit as it has shown a brilliant potential in the application of live cell imaging using gastric cancer cell (AGS cell).

Safety of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gharami, S; Aich, K; Ghosh, P; Patra, L; Murmu, N; Mondal, TK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Gharami, S; Aich, K; Ghosh, P; Patra, L; Murmu, N; Mondal, TK in ELSEVIER SCIENCE SA published article about TURN-ON; AQUEOUS-MEDIUM; ALUMINUM; SENSOR; DIARYLETHENE; WATER; IONS in [Gharami, Saswati; Aich, Krishnendu; Patra, Lakshman; Mondal, Tapan Kumar] Jadavpur Univ, Dept Chem, Kolkata 700032, India; [Ghosh, Paramita; Murmu, Nabendu] Chittaranjan Natl Canc Inst, Dept Signal Transduct & Biogenis Amines STBA, Kolkata 700026, India in 2020.0, Cited 37.0. Computed Properties of C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A new coumarin based fluorescent switch (HCBP) has been fabricated which displays high selective sensing towards Al3+ among other metal cations at physiological pH. On gradual addition of Al3+ specifically, HCBP shows a brilliant turn-on emission enhancement of about similar to 13-fold with about 50 nm red shift at 481 nm in MeOH/H2O (1/1, v/v) solution. The fluorescent switch is proven to be a reversible probe by addition of EDTA gradually into the HCBP-Al3+ solution. Detection limit as well as Binding constant values have been calculated and found to be in the order of 10(-9) M and 10(3) M-1 respectively. DFT and TDDFT studies are conducted with the probe to establish a similarity between theoretical and experimental outcomes. We can also use this new fluorescent switch as a biomarker kit as it has shown a brilliant potential in the application of live cell imaging using gastric cancer cell (AGS cell).

Computed Properties of C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gharami, S; Aich, K; Ghosh, P; Patra, L; Murmu, N; Mondal, TK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Reaction of Pyridine-N-Oxides with Tertiary sp(2)-N-Nucleophiles: An Efficient Synthesis of Precursors for N-(Pyrid-2-yl)-Substituted N-Heterocyclic Carbenes WOS:000585614500001 published article about ONE-STEP CONVERSION; METAL-COMPLEXES; MILD; CATALYSIS; GOLD(I); SALTS; HETEROATOM; IMIDAZOLO; LIGANDS; ROUTE in [Bugaenko, Dmitry, I; Yurovskaya, Marina A.; Karchava, Alexander, V] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia in 2020, Cited 61. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6. Safety of Ethyl nicotinate

N-(Pyrid-2-yl)-substituted azolium and pyridinium salts, precursors for hybrid NHC-containing ligands, were obtained with excellent regioselectivity, employing a deoxygenative CH-functionalization of pyridine-N-oxides with substituted imidazoles, thiazoles, and pyridine. Unlike the traditional SNAr-based methods, this approach provides high yields for substrates bearing substituents of different electronic nature. The utility of azolium and pyridinium salts thus prepared was also highlighted by the synthesis of pyridyl-substituted imidazolyl-2-thione, benzodiazepine as well as 2-aminopyridines.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about GOLD-BASED DRUGS; CRYSTAL-STRUCTURE; ANTICANCER AGENTS; 2-SUBSTITUTED PYRIDINES; SOLUTION CHEMISTRY; CARBENE COMPLEXES; CYTOTOXICITY; REACTIVITY; DERIVATIVES; INHIBITION, Saw an article supported by the University of Kentucky; UK Igniting Research Collaboration (IRC). Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gukathasan, S; Parkin, S; Awuah, SG. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

The synthesis of a novel class of cyclometalated gold(III) complexes supported by benzoylpyridine, benzylpyridine, and (1R,2R)-(+)-1,2-diaminocyclohexane (DACH) ligands, along with their crystal structures, is reported. These compounds provide a new scaffold to investigate biological properties of gold(III) complexes. The six complexes were prepared and characterized, following reactions of (C,N) cyclometalated gold(III) scaffolds, [Au(C boolean AND N)Cl-2] with DACH, which yielded a new series of cyclometaled gold(III), 3-5, of the type [Au(C boolean AND NH)(DACH)(2)](+) and the nitrogen substituted cyclometalated Au(III), 6-8, of the type [Au-(C boolean AND N)(DACH)](2+). Antiproliferative activity of these complexes in a panel of cancer cells showed promising results with IC50 in the micromolar range and selectivity over normal epithelial cells, MRCS. Whereas 8 shows minimal interaction with superhelical DNA except at high gold concentrations of 500 mu M, complex 5 does not show interaction even at 1000 mu M. The complexes display significant uptake in OVCAR8 cancer cells within 200-1200 pmol/million cells with the exception of complex 4. Differential cellular uptake was observed for the complexes; for example, while 3 and 8 display significant uptake, 4 showed minimal uptake. The compounds proved to be stable under physiological conditions and were minimally affected by either glutathione or sodium ascorbate. Cell cycle studies reveal a G1 arrest induced by representative complexes. The results reveal that enhanced Au(III) stabilization promoted by combined cyclometalated and DACH ligands may offer ligand tuning insights for novel anticancer drug design.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of Phenyl(pyridin-2-yl)methanone. Boubakri, L; Al-Ayed, AS; Mansour, L; Harrath, AA; Al-Tamimi, J; Ozdemir, I; Yasar, S; Hamdi, N in [Boubakri, L.; Hamdi, N.] Univ Carthage, Higher Inst Environm Sci & Technol, Res Lab Environm Sci & Technol LR16ES09, Hammam Lif, Tunisia; [Al-Ayed, Abdullah S.; Hamdi, N.] Qassim Univ, Coll Arts & Sci, Dept Chem, Al Rass, Saudi Arabia; [Mansour, L.; Harrath, A. A.; Al-Tamimi, J.] King Saud Univ, Coll Sci, Dept Zool, POB 2455, Riyadh 11451, Saudi Arabia; [Ozdemir, I.; Yasar, S.] Inonu Univ, Fac Sci & Art, Dept Chem, Malatya, Turkey published In situ palladium/N-heterocyclic carbene complex catalyzed carbonylative cross-coupling reactions of arylboronic acids with 2-bromopyridine under CO pressure: efficient synthesis of unsymmetrical arylpyridine ketones and their antimicrobial activities in 2019.0, Cited 86.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

The carbonylative Suzuki cross-coupling of 2-bromopyridine with various boronic acids to prepare unsymmetrical arylpyridine ketones has been carried out using palladium/N-heterocyclic carbene complexes as catalysts prepared in situ. The selectivity and the rate of these reactions are highly dependent on the conditions, i.e., nature of the palladium catalyst precursor, solvent, temperature and CO pressure. The main side-products arise from direct, non-carbonylative cross-coupling. Under the optimum conditions, arylpyridine ketones are recovered in high yields (60-88%). The antibacterial activities of the corresponding benzimidazole salts 2 were tested against Gram positive and negative bacteria using the agar dilution procedure, and their IC50 values have been determined.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 ORG LETT published article about ONE-POT SYNTHESIS; N-TOSYLHYDRAZONES; CATALYZED TRANSANNULATION; ASYMMETRIC HYDROGENATION; ETHYL DIAZOACETATE; C(SP(3))-H BONDS; DIAZO-COMPOUNDS; ARYLATION; DISCOVERY; NITRILES in [Dong, Chao; Wang, Xin; Pei, Zibo; Sheno, Ruwei] Nanjing Tech Univ, Coll Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 211800, Jiangsu, Peoples R China in 2019.0, Cited 84.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Safety of Phenyl(pyridin-2-yl)methanone

Pyridotriazoles are utilized as robust building blocks to access alpha-secondary and alpha-tertiary pyridines via the development of a simple yet practically useful metal-free denitrogenative C-C cross-coupling with boronic acids. The reaction shows a high level of functional tolerance, broad substrate scope, and facile scalability. The synthetic potential of the method is demonstrated by the strurctural modification of a bioactive molecule and concise synthesis of pheniramine analogs.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem