Tag: M.W:200-300

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. 69045-84-7

Into a 500 mL autoclave, 51.2 g (0.2348 mol, 99%, 1.0 eq) of 2,3-dichloro-5-trifluoromethylpyridine and 160 mL of tetrahydrofuran were placed, and the autoclave was closed.Nitrogen was replaced three times at normal temperature, and 20.0 g (1.174 mol, 5.0 eq) of liquid ammonia was passed through the system, and the pressure in the system was about 0.6 MPa.The temperature was raised to 100 C to maintain the pressure reaction for 28 h.The system pressure was reduced from 1.6Mpa to 1.2Mpa, and the reaction of the raw material in the bottom tube sampling HPLC was complete. After the system is lowered to normal temperature, the pressure is released to normal pressure.The ammonia gas released is absorbed by tetrahydrofuran.The reaction solution was taken out, filtered, and rinsed with an appropriate amount of tetrahydrofuran, and the mother liquid was subjected to the next step of deamination.

Statistics shows that 69045-84-7 is playing an increasingly important role. we look forward to future research findings about 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Patent; Dalian Jiu Xin Fine Chemical Co., Ltd.; Inner Mongolia Jiaruimi Fine Chemical Co., Ltd.; Wang Rongliang; Wang Junchun; (10 pag.)CN110143916; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

571188-59-5, A common compound: 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate,molecular formula is C14H22N4O2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

In a 2L four-neck round bottom flask,Add 100 g of 2-chloro-4-cyclopentyl-N,N-dimethyl-7H-pyrrole[2,3-d]pyrimidine-6-carboxamide (Formula 2), 104.6 g of 4-(6-aminopyridine- 3-yl) piperazine-1-carboxylic acid tert-butyl ester (formula 1),155.8 g of cesium carbonate, after replacing three times with nitrogen, 800 g of 4-methyl-2-pentanone was added.1.534 g of palladium acetate, 6.38 g of BINAP. After the addition is completed, under a nitrogen atmosphere,The temperature was raised to 90 to 100 C and the reaction was carried out for 3 hours. Cool down to 65 C, add 800g water, 270g n-heptane,10 ml of propylenediamine, cooled to room temperature, filtered, and the filter cake was washed once with 500 g of water.Rinse once with 160g of 4-methyl-2-pentanone/270g of n-heptane mixed solvent.Drying at 60 C gives 4-(6-(7-cyclopentyl-6-(dimethylaminoformyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)aminopyridin-3-yl Piperazine-1-carboxylic acid tert-butyl ester) (Formula 3) 168 g. The yield is 92.2%.Determined by HPLC (area normalization method),4-(6-(7-Cyclopentyl-6-(dimethylaminoformyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)aminopyridin-3-yl)piperidyl The purity of the tert-butyl ester of azine-1-carboxylate was 98.8%.

With the rapid development of chemical substances, we look forward to future research findings about 571188-59-5.

Reference:
Patent; Chongqing San Sheng Industrial Co., Ltd.; Wu Ke; He Wei; Peng Lei; Wang Longlin; Jiang Guangding; Yang Fan; (7 pag.)CN109400612; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

571188-59-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, molecular formula is C14H22N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a nitrogen environment at about 25¡À2 C., mix 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbamide and 4-(6-aminopyyrol-3-yl)piperazin-1-carboxyl tert-butylate into tetrahydrofuran THF) added with lithium bis(trimethyl)amine (LiHMDS) and stir for about 1 h to obtain the intermediate 4-[6-[[7-cyclopentyl-6-[(dimethylamino)carbonyl]-7H-pyrrolo[2,3-pyrimidine-2-yl]amino]-3-pyridine]-1-piperazinecarboxyl 1,1-dimethylethylate. Cool the mixture to about 8¡À2 C. and keep the mixture at this temperature while an aqueous hydrogen chloride solution is subsequently added slowly and mixed into the mixture. After that, using a separatory funnel and ethyl acetate as an extracting agent, perform an extraction process in duplicate to acquire the aqueous phase. When the extracted solution is cooled to about 5 C. or lower, slowly add an aqueous sodium hydroxide solution until the pH reaches 12.5. Heat the solution to 25 C. and stir for about 16 h. Next, filter the solution to obtain the solid matter (or filter cake), and rinse the filter cake with DD water until the pH of the rinsing liquid is equal to or lower than 9. Lastly, dry the filter cake at about 55¡À5 C. to yield yellowish brown solids, which are 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, whose molar recovery rate can be 98% or higher, with 98% or higher purity.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO. LTD.; Kamani, Satyanarayana; Lu, Tzu-Chiang; Chang, Hsin-Yun; Mai, Chin-Cheng; (30 pag.)US10336763; (2019); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 624-28-2, name is 2,5-Dibromopyridine, the common compound, a new synthetic route is introduced below. 624-28-2

To a solution of 2,5-dibromopyridine (10.50 g, 44 mmol) in 210 mL of pyridine was added hydrazine hydrate (80%, 8.85 g, 176.4 mmol), and the mixture was heated to 110 C. and stirred further for 2 hours, then cooled to rt, and concentrated in vacuo. The residue was diluted with DCM (1500 mL). The resulted mixture was washed with aqueous NaOH solution (1 M, 350 mL), dried over anhydrous Na2SO4, and concentrated in vacuo to give the title compound as a gray solid (7.87 g, 94.8%). MS (ESI, pos. ion) m/z: 188.0[M+H]+; 1H NMR (600 MHz, DMSO-d6): delta 8.03 (d, J=2.3 Hz, 1H), 7.67 (s, 1H), 7.59 (dd, J=8.9, 2.5 Hz, 1H), 6.69 (d, J=8.9 Hz, 1H), 4.16 (s, 2H).

Statistics shows that 624-28-2 is playing an increasingly important role. we look forward to future research findings about 2,5-Dibromopyridine.

Reference:
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 624-28-2, name is 2,5-Dibromopyridine. This compound has unique chemical properties. The synthetic route is as follows. 624-28-2

A mixture of 2,5-dibromopyridine (12.2 g, 51.5 mmol) and (S)-hydroxypyrrolidine (2.80 g, 32.1 mmol) in toluene (50 mL) was heated to reflux overnight. The mixture was allowed to cool to rt, and the solvents were removed under reduced pressure. The residue was dissolved with EtOAc (150 mL), and the mixture was washed with aq. 10% K2CO3. The org. layer was dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane?heptane/EtOAc 1:2) yielded the title compound (3.62 g, 46%). LC-MS: tR=0.48 min; ES+: 243.15.

Statistics shows that 624-28-2 is playing an increasingly important role. we look forward to future research findings about 2,5-Dibromopyridine.

Reference:
Patent; Actelion Pharmaceuticals Ltd.; US2009/62342; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

571188-59-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

1) Replace the reaction flask three times with inert gas N2,Add 1140g of toluene to the reaction flask.Then, 93 g of 4-(6-aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester was added.Cool down to 20 C,Add 140g of isopropylmagnesium chloride,After the addition is completed within 1 hour,Activated for 30 minutes;Continue to add 95 g of 6-bromo-2-chloro-8-cyclopentyl-5-methyl-pyrido[2,3-D]pyrimidin-7(8H)-one, and complete the addition within 1 hour;Continue to add 140g of isopropylmagnesium chloride,After the addition is completed within 1 hour,The temperature was raised to 60 C for 30 minutes.Until the end of the reaction,By adding dropwise a mixture of acetic acid/tetrahydrofuran (mass ratio of acetic acid to tetrahydrofuran: 1:10), the pH of the solution was adjusted to precipitate a solid, and the temperature was lowered to 0 C, filtered, and the filter cake was dried to obtain a yellow solid powder intermediate I141 g, yield 87%. . The HPLC chromatogram of the obtained Pabsini intermediate I is shown in Fig. 2. As can be seen from Fig. 2, the purity of the intermediate I is99.45%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate.

Reference:
Patent; Chongqing San Sheng Industrial Co., Ltd.; Wen Jiandong; Peng Lei; He Wei; Yang Zhikun; Fan Jun; Yang Huan; (11 pag.)CN109336886; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

571188-59-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, the common compound, a new synthetic route is introduced below.

In the nitrogen atmosphere, the 6-acetyl-8-cyclopentyl-5-methyl-2-chlorine-pyrido[2,3-d]pyrimidin-7(8H)-one (VI) (1.53 g, 5 mmol), 4-(6-amino-3-pyridinyl)-1- piperazinecarboxylic acid 1,1-dimethylethyl ester (VII) (2.78 g, 10 mmol), Lithium bis(trimethylsilyl)amide (2.0 g, 10 mmol) and methylbenzene of 50 mL were added into the reaction bulb. They were heated up to 50-55 C. and react for 2-3 hours, and then cooled down to the room temperature after the completion of TLC detection reaction. The organic layer was separated out by pouring the reaction mixture into icy water, extraction was conducted for the water layer with methylbenzene for two times, and organic phases were combined. The organic layer was washed with water and saline solution respectively, and dried and concentrated to dry with anhydrous sodium sulfate. The residues obtained were dissolved into the dichloromethane of 50 mL, which was added with the concentrated hydrochloric acid of 5 mL and stirred in the room temperature for 12 hours. The organic phase was separated out and washed with water and solution of 10% sodium bicarbonate. The solvent was recycled under normal pressure and added with diethyl ether to separate solids. The crude products obtained were recrystallized with normal hexane and ethyl acetate, and off-white solid Palbociclib (I) of 1.85 g was obtained; yield: 82.6%; mass spectrometry (EI): m/z 448(M+H).

Statistics shows that 571188-59-5 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate.

Reference:
Patent; SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD.; XU, Xuenong; (8 pag.)US2017/247380; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

69045-84-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

(R) -2- (4-hydroxyphenoxy) propionic acid (3 g),DMF (35 ml), slowly adding K2CO3 (4.55 g),Heating up to 70 ~ 80 ,Stir for 1h,Was added dropwise 2,3-dichloro-5-trifluoromethylpyridine (3.56 g)Keep at 70 ~ 80 for 8h,Stop the reaction,Naturally cooled to room temperature,The mixture was poured into ice water (200 mL)The pH was adjusted to 4 to 5 using dilute hydrochloric acid, extracted with ethyl acetate,Organic phase washed,dry,(R) -2- [4- (5-trifluoromethyl-3-chloropyridin-2-yloxy) phenoxy]Propionic acid brown liquid 5.03 g,Yield 84.4%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; China Three Gorges University; Liu Qixing; Zhou Haifeng; Lu Guoren; Peng Yuqi; (9 pag.)CN106632293; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 624-28-2, name is 2,5-Dibromopyridine, molecular formula is C5H3Br2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 1 5-BROMO-PYRIDIN-2-YL-HYDRAZINE A 12 L three-necked round-bottomed flask equipped with a mechanical stirrer and a condenser, connected on top with a nitrogen bubbler and a thermometer, was charged with 2,5-dibromopyridine (442 g, 1.87 moles), hydrazine hydrate (55% wt., 1057 ml, 18.7 moles), poly(ethylene glycol) (average Mn about 300, 1.87 L), 2-butanol (373 ml) and water (1.87 L). The mixture was heated at reflux for 29 hours. The heating source was removed and the mixture was stirred for an additional 20 hours. To the resulting slurry, cold water (2.2 L) was added. The slurry was stirred for an additional 30 minutes and filtered. The cake was washed with cold water (3¡Á200 ml) and dried in a vacuum-oven (40 C.) for 48 hours. The title compound was obtained as off-white flakes (305 g, yield 87%). [0186] GCMS(m/z): 187 (M+). H1 NMR (400 MHz, CDCl3): delta 8.14 (d, J=2.0 Hz, 1H), 7.55 (dd, J=8.7/2.0 Hz, 1H), 6.66 (d, J=8.7 Hz, 1H), 5.89 (brs, 1H), 3.65 (brs, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc; US2004/87615; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 624-28-2, name is 2,5-Dibromopyridine. A new synthetic method of this compound is introduced below.

2,5-Dibromopyridine (10 g, 35.2 mmol) is dissolved in dry toluene (200 mL) under a nitrogen atmosphere and cooled to -78 C. n-Butyllithium (2.5M in hexanes, 2.5 mL, 38.7 mmol) is added at -78 C. over 20 minutes. The reaction mixture is stirred at -78 C. for 20 minutes. Oxetane-3-one (2.79 g, 38.7 mmol) in toluene (100 mL) is added then stirred at -78 C. for 30 minutes. Saturated aqueous ammonium chloride solution (50 mL) is added. The mixture extracted with ethyl acetate (2¡Á200 mL), separated, washed with brine solution (50 mL) and the solvent evaporated under reduced pressure. The crude material is purified using flash chromatography (35% ethyl acetate in hexane) to give the title compound (4.2 g): 1H NMR (400 MHz, DMSO-d6): delta 4.64 (2H, d), 4.87 (2H, d), 6.68 (1H, s), 7.55 (1H, d), 8.06 (1H, dd), 8.76 (1H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ZOETIS LLC; Billen, Denis; Curtis, Michael; Ewin, Richard Andrew; Goodwin, Richard M.; Johnson, Paul D.; Johnson, Timothy Allan; Kyne, Graham M.; Maddux, Todd M.; Sheehan, Susan Mary Kult; Vairagoundar, Rajendran; US2014/88046; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem