Tag: M.W=250-300

Almutairi, Zainab M. published the artcileComparative genomics of HORMA domain-containing proteins in prokaryotes and eukaryotes, Application of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, the publication is Cell Cycle (2018), 17(23), 2531-2546, database is CAplus and MEDLINE.

In eukaryotes, critical regulation of cell cycle is required to ensure the integrity of cell division. HORMA-containing proteins include various proteins that contain HORMA domain and play important role in the regulation of cell cycle in eukaryotes. Many types of HORMA-containing proteins are found in eukaryotes, but their role in prokaryotes has not been proven. Therefore, we conduct an extensive search in GenBank for HORMA-containing proteins in prokaryotes to compare HORMA domain structure and architecture across eukaryotes and prokaryotes. Strikingly, genome sequencing for many prokaryotic organisms reveals that HORMA domain is present in many bacterial genomes and only two archaeal genomes. We perform sequence alignment and phylogenetic anal. to trace the evolutionary link between HORMA domain in prokaryotes and eukaryotes. HORMA domain in prokaryotes appears to vary in sequence and architecture. Interestingly, seven bacterial HORMA-containing proteins and the two archaeal HORMA-containing proteins showed close relationships with eukaryotic HORMA-containing proteins. Addnl., we uncovered remarkable close relationships between HORMA-containing protein from Chlamydia trachomatis and eukaryotic MAD2 proteins. Our results provide insights into evolutionary relationships between prokaryotic and eukaryotic systems, which facilitate our understanding of the evolution of cell cycle regulation mechanisms.

Cell Cycle published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Application of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Almutairi, Zainab M. published the artcileComparative genomics of HORMA domain-containing proteins in prokaryotes and eukaryotes, Application of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, the publication is Cell Cycle (2018), 17(23), 2531-2546, database is CAplus and MEDLINE.

In eukaryotes, critical regulation of cell cycle is required to ensure the integrity of cell division. HORMA-containing proteins include various proteins that contain HORMA domain and play important role in the regulation of cell cycle in eukaryotes. Many types of HORMA-containing proteins are found in eukaryotes, but their role in prokaryotes has not been proven. Therefore, we conduct an extensive search in GenBank for HORMA-containing proteins in prokaryotes to compare HORMA domain structure and architecture across eukaryotes and prokaryotes. Strikingly, genome sequencing for many prokaryotic organisms reveals that HORMA domain is present in many bacterial genomes and only two archaeal genomes. We perform sequence alignment and phylogenetic anal. to trace the evolutionary link between HORMA domain in prokaryotes and eukaryotes. HORMA domain in prokaryotes appears to vary in sequence and architecture. Interestingly, seven bacterial HORMA-containing proteins and the two archaeal HORMA-containing proteins showed close relationships with eukaryotic HORMA-containing proteins. Addnl., we uncovered remarkable close relationships between HORMA-containing protein from Chlamydia trachomatis and eukaryotic MAD2 proteins. Our results provide insights into evolutionary relationships between prokaryotic and eukaryotic systems, which facilitate our understanding of the evolution of cell cycle regulation mechanisms.

Cell Cycle published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Application of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sadler, Scott A. published the artcileIridium-catalyzed C-H borylation of pyridines, Formula: C11H14BCl2NO2, the publication is Organic & Biomolecular Chemistry (2014), 12(37), 7318-7327, database is CAplus and MEDLINE.

The iridium-catalyzed C-H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodol. for the preparation of pyridyl and related azinyl boronates can be challenged by low reactivity and propensity for rapid protodeborylation, particularly for a boronate ester ortho to the azinyl nitrogen. Competition experiments have revealed that the low reactivity is due to inhibition of the active catalyst through coordination of the azinyl nitrogen lone pair at the vacant site on the iridium. This effect can be overcome through the incorporation of a substituent at C-2. Moreover, when this is sufficiently electron-withdrawing protodeborylation is sufficiently slowed to permit isolation and purification of the C-6 boronate ester. Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring.

Organic & Biomolecular Chemistry published new progress about 1622217-00-8. 1622217-00-8 belongs to pyridine-derivatives, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 2,4-Dichloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, and the molecular formula is C11H14BCl2NO2, Formula: C11H14BCl2NO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Raftery, Declan P. published the artcileIdentification of hydrogen peroxide as the autoxidation product of N-phenyl-2-propyl-3,5-diethyl-1,2-dihydropyridine, Name: 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, the publication is Analytical Communications (1996), 33(10), 375-379, database is CAplus.

Recently, dihydropyridines were used as autoxidizable materials in novel air-activated adhesives. The dihydropyridines react with air to produce peroxide species, which are capable of initiating free radical polymerization of methacrylates. Probably N-phenyl-2-propyl-3,5-diethyl-1,2-dihydropyridine undergoes autoxidation in the presence of glacial acetic acid, yielding a pyridinium ion and an unknown peroxide product. Employing a variety of anal. techniques, including polarog., spectrophotometry and an enzyme-based biosensor, it was shown conclusively that hydrogen peroxide is generated in the autoxidation of this dihydropyridine. An aqueous extraction procedure was used to remove the hydrogen peroxide from an organic matrix and also to eliminate any interference from the dihydropyridine in the anal. procedure.

Analytical Communications published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Name: 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Krow, Grant published the artcileReinvestigation of 1,2-dihydropyridine formation by condensation of aldehydes with aniline. Revision of a structural assignment, Formula: C18H25N, the publication is Tetrahedron Letters (1971), 3653-6, database is CAplus.

The product of the HOAc catalyzed condensation of 3:1 PrCHO-PhNH2 was established by uv and NMR spectra as I. The reaction of I with maleic anhydride gave II, via a concerted π2s+π4s addition The structure and stereochemistry of II was determined by its NMR spectrum in the presence of Eu(DPM)3. In this abstract DPM=(tert-BuCO)2C-H.

Tetrahedron Letters published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Formula: C18H25N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kelly, Terence A. published the artcileNovel Non-Nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase. 6. 2-Indol-3-yl- and 2-Azaindol-3-yldipyridodiazepinones, Quality Control of 192189-15-4, the publication is Journal of Medicinal Chemistry (1997), 40(15), 2430-2433, database is CAplus and MEDLINE.

Modification of the non-nucleoside inhibitor of HIV-1 reverse transcriptase nevirapine (Viramune) by incorporation of a 2-indolyl substituent confers activity against several mutant forms of the enzyme.

Journal of Medicinal Chemistry published new progress about 192189-15-4. 192189-15-4 belongs to pyridine-derivatives, auxiliary class Other Aromatic Heterocyclic,Bromide,Amide, name is tert-Butyl 3-bromo-1H-pyrrolo[3,2-b]pyridine-1-carboxylate, and the molecular formula is C12H13BrN2O2, Quality Control of 192189-15-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Fang-tao published the artcileSynthesis of aldehyde-amines type sulfide 808 and DHP, Safety of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, the publication is Yingyong Huagong (2013), 42(4), 765-767, database is CAplus.

Aniline reacted with n-butyraldehyde under different conditions afforded condensation products 808 and DHP (808HP). By using gas chromatog., products were verified by compared to standard samples, and purity was decent. This process achieved improved yield and simplified operations, reduced costs, and provided a new approach in industrial production

Yingyong Huagong published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Safety of 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zeng, Rong published the artcileRh-Catalyzed Decarbonylative Coupling with Alkynes via C-C Activation of Isatins, Name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine, the publication is Journal of the American Chemical Society (2015), 137(4), 1408-1411, database is CAplus and MEDLINE.

Herein we report a [5 + 2 – 1] transformation though catalytic decarbonylative coupling between isatins and alkynes, which provides a unique way to synthesize 2-quinolinone derivs I [R¹ = H, 6-Me; R² = Me, Bn; R³ = Ph, Bu, 4-Me-C₆H₄, etc; R⁴ = Me, Ph, CO₂Me, etc; DG= pyridin-2-yl, 3-Me-pyridin-2-yl]. A broad range of alkynes can be coupled efficiently with high regioselectivity. This reaction is proposed to go through C-C activation of isatins, followed by decarbonylation and alkyne insertion. Directing group (DG) plays a critical role in this transformation. Assisted by the DG, the C-C cleavage of isatins occurs at room temperature

Journal of the American Chemical Society published new progress about 1644629-23-1. 1644629-23-1 belongs to pyridine-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C28H29NO4, Name: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Silva, Allan R.; Polo, Ellen C.; Martins, Nelson C.; Correia, Carlos Roque D. published the artcile< Enantioselective Oxy-Heck-Matsuda Arylations: Expeditious Synthesis of Dihydrobenzofuran Systems and Total Synthesis of the Neolignan (-)-Conocarpan>, Computed Properties of 1416819-91-4, the main research area is aryldiazonium salt styrenic olefin palladium Oxy Heck Matsuda arylation; dihydrobenzofuran stereoselective preparation.

This work discloses the first examples of an effective enantioselective oxy-Heck-Matsuda reaction using a variety of styrenic olefins to generate chiral dihydrobenzofurans I (R1 = 6-NO2, 5-NO2, 5-Me, etc.; R2 = 4-OMe, 4-OH, 2,4-OMe, etc.; R3 = Me, i-Pr). The reaction proceeds in moderate to good yields, with high trans diastereoselectivity (up to 20:1) in enantioselectivities up to 90:10 using the N,N-ligand pyrimidine-bisoxazoline (PyriBox). The oxy-Heck-Matsuda reactions were carried out under mild conditions and rather low catalyst loadings. The feasibility and practicality of the process is demonstrated by a concise total synthesis of the neolignan (-)-conocarpan. X-ray diffraction of an advanced brominated intermediate in the route to (-)-conocarpan has allowed the unequivocal assignment of the absolute stereochem. of the oxy-Heck-Matsuda aryldihydrobenzofuran products. A rationale for the mechanism operating in these enantioselective oxy-Heck-Matsuda reactions is also presented.

Advanced Synthesis & Catalysis published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation) (Dihydro). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Computed Properties of 1416819-91-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pezzetta, Cristofer; Bonifazi, Davide; Davidson, Robert W. M. published the artcile< Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach>, Product Details of C13H15F3N2O, the main research area is benzylic heterocycle preparation enantioselective; heterocyclic carboxylic acid aryl bromide decarboxylative cross coupling; nickel photoredox dual catalysis.

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common com. material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Product Details of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem