Mochida, Kazuhiko’s team published research in Marine Pollution Bulletin in 64 | CAS: 971-66-4

Marine Pollution Bulletin published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, SDS of cas: 971-66-4.

Mochida, Kazuhiko published the artcileUse of species sensitivity distributions to predict no-effect concentrations of an antifouling biocide, pyridine triphenylborane, for marine organisms, SDS of cas: 971-66-4, the publication is Marine Pollution Bulletin (2012), 64(12), 2807-2814, database is CAplus and MEDLINE.

We used species sensitivity distributions (SSDs) and a Bayesian statistical model to carry out a primary risk assessment for pyridine triphenylborane (PTPB) in Hiroshima Bay, Japan. We used SSDs derived from toxicity values, such as EC50 and LC50, obtained from this study and previous work to calculate hazardous concentrations that should protect 95% and 99% of species (HC5 and HC1) and demonstrated that the medians of the HC5 and HC1 were 0.78 and 0.17 μg/L, resp. We also used liquid chromatog./mass spectrometry to investigate the occurrence of PTPB in seawater from several coastal sites of Hiroshima Bay and detected PTPB at concentrations of 4.8-21 pg/L. Comparison of environmental concentrations to the HC values suggests that the current ecol. risk posed by PTPB in Hiroshima Bay is low. This is the first report of the detection of PTPB in the natural marine environment.

Marine Pollution Bulletin published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, SDS of cas: 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Loh, Yean Chun’s team published research in Biomedicine & Pharmacotherapy in 150 | CAS: 21829-25-4

Biomedicine & Pharmacotherapy published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Loh, Yean Chun published the artcileThe predominance of endothelium-derived relaxing factors and beta-adrenergic receptor pathways in strong vasorelaxation induced by 4-hydroxybenzaldehyde in the rat aorta, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Biomedicine & Pharmacotherapy (2022), 112905, database is CAplus and MEDLINE.

4-Hydroxybenzaldehyde (4HB), known as ρ-hydroxybenzaldehyde, is commonly present in traditional Chinese medicine herb, most frequently used for hypertension treatment. This research aims to determine the potency of 4HB’s vasorelaxant action. In the study, the vasodilation effect of 4HB was evaluated using in vitro isolated rat aortic rings assay. The aortic rings were pre-incubated with resp. antagonists before being pre-contracted with phenylephrine (PE) and challenged with various concentrations of 4HB for mechanistic action studies. Rmax (maximal vasodilation) and pEC50 (neg. logarithm of half-maximal effective concentration) values of each experiment were determined for comparison purposes. 4HB caused vasodilation on endothelium-intact aortic rings which pre-contracted with PE (pEC50 = 3.53 ± 0.05, Rmax = 100.95 ± 4.25%) or potassium chloride (pEC50 = 2.96 ± 0.13, Rmax = 72.13 ± 4.93%). The vasodilation effect of 4HB was significantly decreased in the absence of an endothelium (pEC50 = 2.21 ± 0.25, Rmax = 47.96 ± 4.16%). The atropine, 4-aminopyridine, Nω-nitro–arginine Me ester, glibenclamide, and propranolol significantly reduced the vasorelaxation effect of 4HB. Besides that, 4HB blocked the voltage-operated calcium channel (VOCC) and regulated the intracellular Ca2+ release from the sarcoplasmic reticulum (SR) in the aortic ring. Thus, the results indicated that 4HB exerted its vasodilatory effect via cGMP and β2 pathways, M3-dependent PLC/IP3 pathways, and potassium and calcium channels.

Biomedicine & Pharmacotherapy published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sazonova, V. A.’s team published research in Zhurnal Obshchei Khimii in 26 | CAS: 971-66-4

Zhurnal Obshchei Khimii published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, SDS of cas: 971-66-4.

Sazonova, V. A. published the artcileReaction of tetraphenylborocopper with oxo compounds, SDS of cas: 971-66-4, the publication is Zhurnal Obshchei Khimii (1956), 3440-5, database is CAplus.

cf. C.A. 50, 1644d. To 2.25 g. Et benzalacetoacetate in MePh was added at 80° 5 g. pyridine salt of PH4BCu (I); after filtration, treatment with 10% AcOH, then 10% NaOH and H2O, there was formed on evaporation 70% Et α-benzhydrylacetoacetate, m. 83-4°, also formed under N in 70% yield. The precipitate formed in the reaction was 96% Cu. Similarly benzalacetylacetone gave 61% α-benzhydryl-α-acetylacetone, m. 115.5°, Et benzalbenzoylacetate gave 98% Et benzhydrylbenzoylacetate, m. 135°, Et α-ethylideneacetoacetate gave over 100% Et α-phenethylacetoacetate, b4.5 125.5-6°, nD20 1.4990; benzalacetophenone gave 29% β,β-diphenylpropiophenone, m. 96-6.5°, and dibenzalacetone and I heated to 160° gave 42% α-benzhydryl-α-benzalacetone, m. 136-6.5°. To 1.14 g. BzH in MePh was added at 80° 5 g. I yielding 0.71 g. Ph2; a similar failure to add was noted for Ph2CO and dibenzoylethylene. Addition of 7.5 g. I at 75° under N in CCl4 gave a brown precipitate containing Ph3B pyridine salt and Cu salts; evaporation of the filtrate and heating with H2O 2 hrs. with Ca(OH)2 and powd. Fe gave BzOH. The brown precipitate extracted with Me2CO gave on extraction with Me2CO and treatment of the insoluble part with aqueous KI, a precipitate of CuI and iodine; the filtrate gave triphenylboron pyridine salt, m. 212-18° (decomposition).

Zhurnal Obshchei Khimii published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, SDS of cas: 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ettel, Viktor’s team published research in Chemicke Listy pro Vedu a Prumysl in 51 | CAS: 971-66-4

Chemicke Listy pro Vedu a Prumysl published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Product Details of C23H20BN.

Ettel, Viktor published the artcileLocal anesthetics derived from acylaminoacridine, Product Details of C23H20BN, the publication is Chemicke Listy pro Vedu a Prumysl (1957), 1906-8, database is CAplus.

Preparing Xylocaine analogs of the type RNHCOCH2NEt2 (I) where R is acridine or its derivatives gave compounds with biol. activity approximating that of Procaine but with considerably lower toxicity. Adding 3 g. ClCH2COCl to 9.7 g. 9-aminoacridine in 400 ml. Me2CO, boiling the mixture shortly under reflux, filtering while hot, and evaporating Me2CO gave 13.3 g. crude 9-(chloroacetylamino)acridine (II), m. 212° (decomposition, from EtOH). Adding 4 g. NHEt2 to suspension of 5.4 g. II in 250 ml. PhMe, refluxing the mixture 8 hrs., separating the precipitated HCl-salt, evaporating the solution, extracting the base with dilute HCl, and precipitating with aqueous NH4OH gave 5.5 g. I (R = 9-acridyl), m. 132° (C6H6); dihydrochloride, m. 220° (decomposition). Adding MeONa solution from 8 g. Na and 200 ml. MeOH to suspension of 22.6 g. tetrahydroacridine-9-carboxylamide in 45 ml. MeOH, dropping into the mixture with stirring at 20° 28.5 g. Br in 1 hr., raising the temperature to boiling in 1 hr., boiling shortly, cooling down, neutralizing with AcOH, distilling the MeOH, diluting with an equal volume of H2O, separating the precipitated urethan, decomposing by heating with excess 30% H2SO4 1 hr. on an H2O-bath, filtering, and precipitating the base with NaOH gave 15 g. 9-amino-1,2,3,4-tetrahydroacridine (III), m. 178° (EtOH). III (20 g.) heated in a sealed tube with 17 g. ClCH2COCl 4 hrs. to 130-5°, the reaction mixture dissolved in H2O, the solution filtered with C, and the product precipitated with NH4OH gave 25 g. 9-(chloroacetylamino)-1,2,3,4-tetrahydroacridine (IV), m. 207° (EtOH). IV (5.5 g.) allowed to react with 4.0 g. NHEt2 in 250 ml. PhMe gave 6.6 g. I [R = 9-(1,2,3,4-tetrahydroacridyl)], m. 80° (aqueous EtOH); dihydrochloride, m. 235°. Reducing the preceding base (7.7 g.) in boiling EtOH by adding portionwise 200 g. 4% Na-Hg in the presence of NaHCO3 in a stream of CO2, cooling the mixture, separating Hg, and distilling EtOH in vacuo gave 7.2 g. I [R = 9-(1,2,3,4,9,10,11,12-octahydroacridyl)], m. 50°.

Chemicke Listy pro Vedu a Prumysl published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Product Details of C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

van Winden, Tijn M S’s team published research in BMC pregnancy and childbirth in 22 | CAS: 21829-25-4

BMC pregnancy and childbirth published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C9H12O, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

van Winden, Tijn M S published the artcileTocolysis with nifedipine versus atosiban and perinatal outcome: an individual participant data meta-analysis., Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is BMC pregnancy and childbirth (2022), 22(1), 567, database is MEDLINE.

BACKGROUND: Worldwide, nifedipine and atosiban are the two most commonly used tocolytic agents for the treatment of threatened preterm birth. The aim of this study was to evaluate the effectiveness of nifedipine and atosiban in an individual participant data meta-analysis (IPDMA). METHODS: We investigated the occurrence of adverse neonatal outcomes in women with threatened preterm birth by performing an IPDMA, and sought to identify possible subgroups in which one treatment may be preferred. We searched PubMed, Embase, and Cochrane for trials comparing nifedipine and atosiban for treatment of threatened preterm birth between 240/7 and 340/7 weeks’ gestational age. Primary outcome was a composite of perinatal mortality and neonatal morbidities including respiratory distress syndrome, intraventricular haemorrhage, periventricular leucomalacia, necrotising enterocolitis, and sepsis. Secondary outcomes included NICU admission, prolongation of pregnancy and GA at delivery. For studies that did not have the original databases available, metadata was used. This led to a two-stage meta-analysis that combined individual participant data with aggregate metadata. RESULTS: We detected four studies (Nâ€?â€?91 women), of which two provided individual participant data (Nâ€?â€?50 women). The composite neonatal outcome occurred in 58/364 (16%) after nifedipine versus 69/359 (19%) after atosiban (OR 0.76, 95%CI 0.47-1.23). Perinatal death occurred in 14/392 (3.6%) after nifedipine versus 7/380 (1.8%) after atosiban (OR 2.0, 95%CI 0.80-5.1). Nifedipine results in longer prolongation of pregnancy, with a 18 days to delivery compared with 10 days for atosiban (HR 0.83 (96% CI 0.69-0.99)). NICU admission occurred less often after nifedipine (46%) than after atosiban (59%), (OR 0.32, 95%CI 0.14-0.75). The sensitivity analysis revealed no difference in prolongation of pregnancy for 48 hours (OR 1.0, 95% CI 0.73-1.4) or 7 days (OR 1.3, 95% CI 0.85-5.8) between nifedipine and atosiban. There was a non-significant higher neonatal mortality in the nifedipine-exposed group (OR 1.4, 95% CI 0.60-3.4). CONCLUSIONS: In this IPDMA, we found no differences in composite outcome between nifedipine and atosiban in the treatment of threatened preterm birth. However, the non-significant higher mortality after administering nifedipine warrants further investigation of the use of nifedipine as a tocolytic drug. STUDY REGISTRATION: We conducted this study according to a prospectively prepared protocol, registered with PROSPERO (the International Prospective Register of Systematic Reviews) under CRD42016024244.

BMC pregnancy and childbirth published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C9H12O, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dong, Yifan’s team published research in Nature Communications in | CAS: 971-66-4

Nature Communications published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, COA of Formula: C23H20BN.

Dong, Yifan published the artcileOrientation dependent molecular electrostatics drives efficient charge generation in homojunction organic solar cells, COA of Formula: C23H20BN, the publication is Nature Communications, database is CAplus and MEDLINE.

Organic solar cells usually utilize a heterojunction between electron-donating (D) and electron-accepting (A) materials to split excitons into charges. However, the use of D-A blends intrinsically limits the photovoltage and introduces morphol. instability. Here, we demonstrate that polycrystalline films of chem. identical mols. offer a promising alternative and show that photoexcitation of α-sexithiophene (α-6T) films results in efficient charge generation. This leads to α-6T based homojunction organic solar cells with an external quantum efficiency reaching up to 44% and an open-circuit voltage of 1.61 V. Morphol., photoemission, and modeling studies show that boundaries between α-6T crystalline domains with different orientations generate an electrostatic landscape with an interfacial energy offset of 0.4 eV, which promotes the formation of hybridized exciton/charge-transfer states at the interface, dissociating efficiently into free charges. Our findings open new avenues for organic solar cell design where material energetics are tuned through mol. electrostatic engineering and mesoscale structural control.

Nature Communications published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, COA of Formula: C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Okamura, H.’s team published research in Bulletin of Environmental Contamination and Toxicology in 71 | CAS: 971-66-4

Bulletin of Environmental Contamination and Toxicology published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application of Triphenyl(pyridin-1-ium-1-yl)borate.

Okamura, H. published the artcilePhytotoxic effects of antifouling compounds on nontarget plant species, Application of Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Bulletin of Environmental Contamination and Toxicology (2003), 71(5), 881-886, database is CAplus and MEDLINE.

A battery of bioassays was employed to assess the phytotoxic effects of eight antifouling compounds, i.e., copper pyrithione, Disulfiram, Diuron, KH 101, Sea-Nine 211, Thiram, zinc pyrithione (ZnPT) and Ziram, using non-target freshwater species. The microalga was the most susceptible organism, followed by duckweed and lettuce. The test compounds inhibited algal growth in the following order: Diuron > KH101 > ZnPT > Thiram > Disulfiram > CuPT > Ziram > Sea-Nine 211.

Bulletin of Environmental Contamination and Toxicology published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application of Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wei, Ningyi’s team published research in Zhongguo Yaopin Biaozhun in 12 | CAS: 54856-23-4

Zhongguo Yaopin Biaozhun published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C7H13NO2, SDS of cas: 54856-23-4.

Wei, Ningyi published the artcileImprovement and suggestion on the problems existing in the betahistine mesilate monograph, SDS of cas: 54856-23-4, the publication is Zhongguo Yaopin Biaozhun (2011), 12(5), 384-386, database is CAplus.

A method for determination of water in betahistine mesilate that was of hygroscopicity and thermal instability was established. HPLC, TLC, DSC purity, and hygroscopicity under varying relative humidity conditions were determined Loss on drying influenced on purity of betahistine mesilate. Determination of water by Karl Fischer should be instead of loss on drying in vacuum at 70 degree method. Loss on drying makes betahistine mesilate degraded. The Karl Fischer method is simple, accurate, and suitable for determination of water.

Zhongguo Yaopin Biaozhun published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C7H13NO2, SDS of cas: 54856-23-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Krossing, Ingo’s team published research in European Journal of Inorganic Chemistry in | CAS: 971-66-4

European Journal of Inorganic Chemistry published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Formula: C23H20BN.

Krossing, Ingo published the artcileBis(tetramethylpiperidino)aluminum halide adducts tmp2AlX.Do and tetrahaloaluminates of tricoordinated aluminum cations [tmp2Al(Do)]AlX4, Formula: C23H20BN, the publication is European Journal of Inorganic Chemistry (1998), 927-939, database is CAplus.

Upon treatment with Lewis bases Do (Do = pyridine bases or THF), the Lewis acids tmp2AlX (X = Cl, Br, I) are converted exclusively to the monoadducts tmp2AlX.Do. Crystal and mol. structure of these monoadducts were determined The Al-X bonds of these addition compounds are considerably elongated, indicating a tendency towards the formation of ionic species [tmp2Al(Do)]X. Due to the steric requirements of the bulky tmp ligands, addition of an excess of the Lewis base does not force these compounds to form tetracoordinated Al cations [tmp2Al(Do)2]+ or pentacoordinated adducts tmp2AlX.Do2. Attempts to prepare ionic representatives by reaction of tmp2AlX.Do with “ate” complexes of comparatively low nucleophilicity [MY = NaBP4, AgBPh4, LiB(C6F5)4, AgBF4, AgOtos] result in phenylation products (e.g. tmp2AlPh and BPh3.py) or tetracoordinated addition compounds tmp2AlY.Do (Y = anion). However, addition of 1 equivalent of AlX3 (X = Br, I) initiates halide abstraction with formation of the ionic [tmp2Al(Do)]AlX4 species, as indicated by 27Al-NMR data and conductivity measurements. Solid [tmp2Al(py)]AlI4 decomposes readily into tmpAlI2 and tmpAlI2.py. Addition of non-polar aliphatic solvents to solutions of [tmp2Al(Do)]AlX4 leads to slow decomposition into tmp2AlX and AlX3.Do. This also occurs in polar donor solvents, where compounds AlX3.Do are favored due to the formation of penta- or hexacoordinated species AlX3.Do.Solvn (n = 1, 2). Semiempirical AM1 calculations reveal the gas-phase stability of the tricoordinated bis(tmp)aluminum cation in the salt [tmp2AlPy]AlCl4 as the only representative in a series of calculated Al cations [(R2N)2A1Py]AlCl4 (R2N = Me2N, Et2N, iPr2N, tmp). According to these calculations, the stability of a given cation increases when tetrachloroaluminate is replaced by tetraiodoaluminate. Ab initio calculations were performed on 2 cations [(H2N)2Al(Do)]+ (Do = NH3, py) and indicate very short Al-N bond lengths owing to ionic bonding contributions.

European Journal of Inorganic Chemistry published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Formula: C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kikuchi, Daisuke’s team published research in Hypertension Research in 45 | CAS: 21829-25-4

Hypertension Research published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Kikuchi, Daisuke published the artcileAntihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Hypertension Research (2022), 45(9), 1441-1446, database is CAplus and MEDLINE.

Abstract: Hypertensive disorders of pregnancy cause maternal organ damage. Therefore, appropriate management with antihypertensive medication is required from the first trimester. We aimed to clarify the antihypertensive drug prescription trends in pregnant women with hypertension in Japan. The administrative data of pregnant outpatients aged 16-49 years who visited acute hospitals between 2013 and 2020 were included. The annual antihypertensive drug prescription trends were evaluated based on their prescription proportions. The most prescribed drug in 2020 was nifedipine, followed by methyldopa and amlodipine. The proportion of nifedipine prescriptions significantly increased from 33.5 to 40.8% during the study period, whereas that of methyldopa significantly decreased from 16.6 to 11.6%. There was no change in the prescription trend of amlodipine. Dihydropyridine calcium channel blockers were the most commonly prescribed drug for pregnant women with hypertension.

Hypertension Research published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem