Tag: M.W=300-350

Yang, Wan-jing published the artcileEffect of vestibular rehabilitation training combined with betahistine mesylate on elderly patients with benign paroxysmal positional vertigo, Category: pyridine-derivatives, the publication is Huanan Guofang Yixue Zazhi (2016), 30(1), 71-72, database is CAplus.

Objective To investigate the effect of vestibular rehabilitation training combined with betahistine mesylate on elderly patients with benign positional paroxysmal vertigo (BPPV). Methods 120 elderly patients with BPPV were randomized into three groups: group A was treated with vestibular rehabilitation training, group B was treated by oral administration of betahistine mesylate, and group C was treated by vestibular rehabilitation training combined with oral administration of betahistine mesylate. Results The total effective rate of group C was significantly higher than that of group A and group B (χ²=11.61, P<0.05), and the total effective rate of group B was significantly higher than that of group A (χ²=8.90, P<0.05). The incidence of adverse reactions of group C was significantly lower than that of group A and group B (χ²=4.50, P<0.05), and the incidence of adverse reactions of group B was significantly lower than that of group A (χ²=3.53, P<0.05). The recurrence rate of group C was significantly lower than that of group A and group B (χ²=6.13, P<0.05), and the recurrence rate of group B was significantly lower than that of group A (χ²=5.00, P<0.05). Conclusion Vestibular rehabilitation training combined with betahistine mesylate had obvious effect for treating elderly patients with BPPV, which could effectively shorten treatment period and decrease recurrence rate.

Huanan Guofang Yixue Zazhi published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C18H23N3O4S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cao, Jingyi published the artcilePreparation and property of environmental friendly copper-free self-polishing antifouling coatings, COA of Formula: C23H20BN, the publication is Tuliao Gongye (2015), 45(3), 33-36, database is CAplus.

Title coatings were prepared from zinc-acrylate polymer as matrix, pyrithione zinc (ZnPT) and pyridine tri-Ph borane (PK) as biocides and other pigments. The basic properties of the antifouling coatings with different organic biocides are studied. Meanwhile, the antifouling property of the prepared coatings has been compared with that of the similar imported product via offshore immersion test. The title coatings comprising ZnPT and PK at mass ratio of 6:4 can exhibit excellent antifouling property.

Tuliao Gongye published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, COA of Formula: C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Yi-Lin published the artcileCellular mechanism underlying the facilitation of contractile response induced by tumor necrosis factor-α in mouse tracheal smooth muscle, Product Details of C17H18N2O6, the publication is American Journal of Pathology (2022), 192(1), 104-111, database is CAplus and MEDLINE.

The proinflammatory cytokine tumor necrosis factor-α (TNF-α) augments intracellular Ca2+ signaling and contractile responses of airway smooth muscles, leading to airway hyperresponsiveness. However, the underlying mechanism has not been fully elucidated. This study aimed to investigate the cellular mechanism of the potentiated contraction of mouse tracheal smooth muscle induced by TNF-α. The results showed that TNF-α triggered facilitation of mouse tracheal smooth muscle contraction in an epithelium-independent manner. The TNF-α-induced hypercontractility could be suppressed by the protein kinase C inhibitor GF109203X, the tyrosine kinase inhibitor genistein, the Src inhibitor PP2, or the L-type voltage-dependent Ca2+ channel blocker nifedipine. Following TNF-α incubation, the α1C L-type Ca2+ channel (CaV1.2) was up-regulated in cultured primary mouse tracheal smooth muscle cells. Pronounced phosphotyrosine levels were observed in mouse tracheas. In conclusion, this study shows that TNF-α enhanced airway smooth muscle contraction via protein kinase C-Src-CaV1.2 pathways, which provides novel insights into the pathol. role of proinflammatory cytokines in mediating airway hyperresponsiveness.

American Journal of Pathology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C14H10O4S2, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liao, Jun published the artcileEfficacy of vestibular rehabilitation training combined with medication in treatment of vestibular neuritis, Computed Properties of 54856-23-4, the publication is Sichuan Yixue (2017), 38(3), 332-334, database is CAplus.

Objective: To observe and evaluate the clin. effect of vestibular rehabilitation training combined with drug therapy in the treatment of vestibular neuritis. Methods: 30 cases of vestibular neuritis diagnosed during hospital stay between Sept. 2014 and Sept. 2015 in our department were included. 15 patients in exptl. group received vestibular rehabilitation training combined with drug therapy and 15 patients in control group only received drug therapy. Dizziness Handicap Inventory (DHI) scores on admission and 4 wk after onset of exptl. group and control group were compared. Results: Difference of DHI scores on admission between the two groups was not statistically significant (P>0.05). Both in two groups, differences of DHI scores before and after treatment were statistically significant (P<0.05). After 1 mo of treatment, comparing the differences of DHI scores in the two groups, the difference being statistically significant (P<0.05). Conclusion: Vestibular rehabilitation training combined with drug therapy can improve the prognosis of patients with vestibular neuritis.

Sichuan Yixue published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Computed Properties of 54856-23-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Jianbing published the artcileMarine environmental risk assessment method for active substances used in antifouling systems on ships in China, Category: pyridine-derivatives, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2014), 962-972, database is CAplus.

A Chinese risk assessment procedure was developed to address active substances used in biol. active (biocidal) antifouling paints. The priority was to promote the use of environmentally friendly, tech. and economically viable alternatives to DDT/TBT (dichlorodiphenyltrichloroethane/tributyltin) in the control of marine fouling organisms. The procedure was based upon European Union Biocide Product Directive (EU-BPD) and International Standard Organization (ISO) method for the Environmental risk assessment of antifouling systems. In order to focus on Chinese national conditions, international templates were adapted to address regional differences. In the Chinese method, persistence, bioaccumulation and toxicity information is assessed on a step by step basis, allowing an antifouling substance to be defined as either “Risk of high concern” or “Relatively low risk” at the end of the decision making process. 4,5-Dichloro-2-n-Octyl-3-Isothiazolinone (DCOIT, Sea-nine), triphenylborane pyridine (TPBP), 8-methyl-N-vanillyl-6-nonenamide (Capsaicin) and Zinc ethylene(bis) dithiocarbamate (Zineb), popularly used in China as active substance of antifouling paints, were reviewed according to the developed procedure. The preliminary results indicate that Sea-nine use in antifouling products can be considered low risk, whereas TPBP, Capsaicin and Zineb failed the screening procedure on the basis of bioaccumulation potential, persistence and an unacceptable risk ratio, resp. Data availability was determined to be a critical factor in the assessments due to the application of Safety Factors for data-poor substances.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C17H14F3N3O2S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Takahashi, Kazunobu published the artcileDetermination of release rate of pyridine-triphenylborane (PTPB) from copper-free antifouling paints, COA of Formula: C23H20BN, the publication is Shikizai Kyokaishi (2005), 78(2), 50-57, database is CAplus.

Pyridine-triphenylborane (PTPB) is one of the alternative tin-free antifoulants in marine antifouling paints and was used widely in com. copper-free self-polishing antifouling paints in Japan. Anal. method for determination of PTPB at low ppb level in seawater was developed by HPLC with UV detection at 220 nm after pre-concentration with C18 solid-phase extraction (SPE). PTPB leached from an antifouling paint film was extracted from artificial seawater using a C18 solid-phase extraction (SPE) cartridge, and eluted with acetonitrile/pyridine (99:1). The recoveries of PTPB (25 μg/1 and 50 μg/l) spiked into artificial seawater were 96% and 97%, resp. The limit of determination of PTPB using 100 mL of artificial seawater was 0.5 μg/l for this anal. method. The HPLC-UV using SPE was applied onto measurement of the release rate (μg/cm²/day) of PTPB from copper-free antifouling paints containing PTPB according to both ISO 15181-1 and 15181-2.

Shikizai Kyokaishi published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C6H12N2O, COA of Formula: C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kaburaki, Soyoko published the artcileHepatic drug metabolism in older people with body composition changes., Related Products of pyridine-derivatives, the publication is Geriatrics & gerontology international (2022), 22(5), 449-454, database is MEDLINE.

AIM: Dosage adjustment is essential in older individuals because they are prone to experience a decline in liver function and changes in body composition. However, quantitative tests or equations for evaluating the activity of hepatic drug metabolism have not yet been clearly established. We examined hepatic drug metabolism activities in older individuals, focusing on changes in body composition parameters. METHODS: Lansoprazole and nifedipine, substrates of the metabolic enzymes cytochrome P450 (CYP) 2C19 and 3A4, respectively, were selected to study hepatic drug metabolism. Residual samples from blood test for older patients were evaluated to determine drug metabolism. The body composition of relevant patients was determined by analyzing characteristic parameters of skeletal muscle mass index (SMI), handgrip strength (HGS) and hepatic steatosis index (HSI). The differences in hepatic drug metabolism were studied statistically among categories in terms of the cut-off value of these parameters. RESULTS: Older male patients receiving lansoprazole and nifedipine in the low SMI (<7.0 kg/m² ) category showed an 85-90% reduction in respective CYP2C19 and CYP3A4 metabolic activities compared with the normal SMI category. For the female patients, CYP2C19 and CYP3A4 metabolic activities showed no significant correlation with SMI and HGS. Fatty liver disease (HSI ≥36) was found to reduce CYP2C19 metabolic activity particularly in older female patients. CONCLUSIONS: Low CYP2C19 metabolic activity was statistically correlated with low SMI in male patients and high HSI in female patients, whereas low CYP3A4 metabolic activity was statistically correlated with low HGS in male patients. Geriatr Gerontol Int 2022; 22: 449-454.

Geriatrics & gerontology international published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Naito, Yasuyuki published the artcileConstructing vascularized hepatic tissue by cell-assembled viscous tissue sedimentation method and its application for vascular toxicity assessment, Safety of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Acta Biomaterialia (2022), 275-288, database is CAplus and MEDLINE.

In vitro Construction of the liver sinusoidal structure using artificial tissue is an important but worthwhile challenge, particularly for assessing the risk of diseases such as sinusoidal obstruction syndrome (SOS). Current models are unsuitable for evaluating the toxicity because of lacking sinusoidal capillary. In this study, we developed a vascularized hepatic tissue (VHT) using a unique tissue engineering technique, the cell assembled viscous tissue by sedimentation (CAViTs) method. The “viscous bodies” created using the CAViTs method exhibited significant self-assembly within 6 h after seeding, promoting cell-cell interaction. The level of albumin secreted by the VHT was four times higher than that of 2D-coculture and maintained for 1 mo. The gene expression pattern of the VHT was closer to that of total human liver, compared with the 2D system. Quant. evaluations of the vascular structure of VHT treated with two typical SOS-inducing compounds, monocrotaline and retrorsine, revealed higher sensitivity (IC50 = 40.35μM), 19.92 times higher than the cell-viability assay. Thus, VHT represents an innovative in vitro model that mimics the vessel network structure and could become a useful tool for the early screening of compounds associated with a risk of vascular toxicity. Mimicking sinusoidal structures in in vitro liver model is important to consider from the perspective of predicting hepatotoxicity such like sinusoidal obstruction syndrome (SOS). However, it was difficult to reconstruct the vascular structure within the hepatocyte-rich environment. In this study, we constructed a vascularized hepatic tissue in a high-throughput manner by a unique method using collagen and heparin, and evaluated its applicability to toxicity assessment. Vessel morphol. anal. of the model treated by monocrotaline, which is a well-known SOS-inducing compound, could predict the toxicity with higher sensitivity. To the best of our knowledge, this is the first report to provide vascularized hepatic tissues using sinusoidal endothelial cells at least for demonstrating applicability to the evaluation of SOS induction risk.

Acta Biomaterialia published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Safety of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hong, Bing published the artcileSedimentary spectrum and potential ecological risks of residual pharmaceuticals in relation to sediment-water partitioning and land uses in a watershed, Quality Control of 21829-25-4, the publication is Science of the Total Environment (2022), 152979, database is CAplus and MEDLINE.

Pharmaceutical residues in river surficial sediment are prone to anthropogenic impacts and environmental factors in watershed, but the mechanisms remain unclear. This study attempted to reveal surficial sediment-water pseudo-partitioning and anthropogenic (land use) patterns of pharmaceutical residues in surficial sediment among 23 subwatersheds of Jiulong River, southeast China with a gradient of urban land use percentile in dry and wet seasons. Thirty-eight out of target 86 compounds from six-category pharmaceuticals were quantified and ranged from below the quantification limits (0.001 mg kg^-1 dry mass) up to 8.19 mg kg^-1 dry mass (chlortetracycline) using a developed SPE-HPLC-MS/MS protocol. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) collectively dominated sedimentary pharmaceutical residues for 34.5-99.8% of the total quantified compounds (median at 92%). Land uses in subwatersheds showed high consistency with sedimentary pharmaceutical residues in the dry season rather than the wet season, especially for human use only and veterinary use only compounds Surficial sediment-water partitioning of pharmaceutical compounds influenced their sedimentary residues regardless of season, which were determined by properties of compound and surficial sediment interactively. All tetracycline compounds, trimethoprim (sulfonamides synergist), caffeine (central nervous system drug), and oxfendazole (antiparasitic drug) were quantified to pose high potential ecol. risks to aquatics. Findings of this study suggest that pseudo-persistent legacy of human and veterinary pharmaceuticals requires a wider coverage of pharmaceutical compounds for a comprehensive ecol. assessment in the environment and more involvement of anthropogenic impacts and socioeconomic factors in the future studies.

Science of the Total Environment published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Quality Control of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fukushi, Keiichi published the artcileSimultaneous determination of a pyridine-triphenylborane anti-fouling agent and its estimated degradation products using capillary zone electrophoresis, Application of Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Journal of Chromatography A (2010), 1217(14), 2187-2190, database is CAplus and MEDLINE.

A com. organoborane compound, pyridine-triphenylborane (PTPB), is often applied to ship hulls as an anti-fouling agent. The authors developed capillary zone electrophoresis (CZE) with direct UV detection for the simultaneous determination of PTPB and its estimated degradation products: diphenylborinic acid (DPB), phenylboronic acid (MPB), and phenol. The limits of detection (LODs) for PTPB, DPB, MPB, and phenol were, resp., 25, 30, 50, and 29 μg/L at a signal-to-noise ratio of three. At concentrations of 0.5 mg/L, values of the relative standard deviation (relative standard deviation, n = 6, intra-day) of peak area were obtained, resp., for PTPB, DPB, MPB, and phenol, as 4.1%, 4.1%, 4.7%, and 3.4% for peak heights 3.6%, 3.2%, 1.7%, and 1.4%, and for migration times 1.1%, 1.1%, 1.0%, and 0.73%. The analytes were detected within 14 min. Simple photodegradation experiments were conducted to verify the usefulness of the proposed method for addnl. PTPB degradation studies.

Journal of Chromatography A published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application of Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem