Tag: M.W=300-350

Shirkhedkar, Atul A. published the artcileExploring an experimental combination of analytical quality by design and green analytical chemistry approaches for development of HPTLC densitometric protocol for the analysis of barnidipine hydrochloride, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Biomedical Chromatography (2022), 36(1), e5244, database is CAplus and MEDLINE.

An exptl. combination of anal. quality by design and green anal. chem. approaches is introduced to develop an high-performance thin-layer chromatog. (HPTLC) approach to quantify barnidipine hydrochloride in the pharmaceutical matrix. The anal. quality by design approach was introduced to green anal. chem. to enhance protocol knowledge while ensuring efficiency and reducing environmental impacts, energy consumption and analyst visibility. This anal. approach was systematically addressed by exploring failure mode effect anal., risk assessment and optimization design. Subsequently, a screening of primary variables was performed to select the aptest proportion of solvents in the mobile phase resulting from the principles of green anal. chem. Failure mode effect anal. and a risk assessment study were attempted to estimate the critical method parameters (CMPs). The influence of the CMPs on critical anal. attributes, i.e. retention factor and peak area, was assessed through a screening design. A response surface methodol. was then executed for the critical anal. attributes as a concern of the determined CMPs, and the conditions for excellent resolution were determined using a desirability procedure. The established protocol was validated in compliance with the International Conference on Harmonization guideline Q2(R1) and showed excellent specificity and sensitivity.

Biomedical Chromatography published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C12H10O4S, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yuan, Yanbing published the artcileRapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy., Related Products of pyridine-derivatives, the publication is Analytical sciences : the international journal of the Japan Society for Analytical Chemistry (2022), 38(2), 359-368, database is MEDLINE.

Nifedipine is an antihypertensive chemical. The illegal addition of this chemical into Chinese traditional patent medicine (CTPM) is unstandardized and lacks regulation. It could bring serious side effects to patients, causing various symptoms. Therefore, accurate detection of nifedipine is very important for human health and the prevention of illegal additives. Surface-enhanced Raman spectroscopy (SERS) is a fast and sensitive fingerprint spectroscopic technique, which has been shown to be promising in drug detection. In this study, nifedipine in CTPM was determined qualitatively and quantitatively with SERS. Linear relationships between the concentrations of nifedipine and the intensities of the characteristic peaks were established. The results showed a linear relationship within the concentration range of 0.5-10 mg/L, and the lowest detectable concentration of nifedipine in CTPM was 0.1 mg/L (equivalent to 0.03% doping of nifedipine in CTPM). This method has shown a great potential in the detection of drugs illegally added to CTPM.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C12H9N3O4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yakun published the artcileAntifouling behavior of self-renewal acrylate boron polymers with pyridine-diphenylborane side chains, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is New Journal of Chemistry (2018), 42(24), 19908-19916, database is CAplus.

Currently, most high-performance tributyltin (TBT)-free antifouling paints contain cuprous oxide (Cu₂O) in their formulations, leading to a serious challenge to the marine environment and ecosystem. In this study, non-metal acrylate boron polymers (ABPs) were synthesized using acrylate acid polymers (AAPs) as the backbone and a pyridine-Ph borane compound as the side chain with hydrolyzable functional groups. The antifouling mechanism of ABPs researched by XPS and EDS indicated that the antifouling performance of ABPs was realized by the hydrolysis of hydrophobic di-Ph borane pyridine side groups. The results of diatom anti-setting test showed that fewer or no algae cells were attached on the surfaces of ABPs with higher contents of hydrophobic di-Ph borane pyridine side groups. The growth rates of algae suspension solutions containing ABPs were close to that of the blank solution without ABPs. Antifouling paints made of ABPs showed excellent antifouling performances in the Yellow Sea of China. This study provides new insights into the development of ABPs with desirable antifouling properties and environmental friendliness.

New Journal of Chemistry published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yakun published the artcileFabrication and antifouling behavior research of self-healing lubricant impregnated films with dynamic surfaces, Related Products of pyridine-derivatives, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2019), 123865, database is CAplus.

To repel the unwanted fouling organisms, various strategies were developed. During these methods, most static antifouling surfaces can not effectively deter the adhesion of marine biofouling in the long term. In this study, self-healing acrylate boron fluorinated polymer films (SABFPs) with dynamic surfaces were facilely prepared by mixing perfluoropolyether (PFPE) lubricant with acrylate boron fluorinated polymer (ABFP) by ultrasonic dispersion. The self-healing mechanism was investigated by analyzing the film thickness change and the distribution of elements under different conditions. Weight loss measurement demonstrated the self-replenishing lubricant and self-polishing polymer surfaces constitute the dynamic surfaces, which reduce the adhesion of fouling organisms in a significant extent. Moreover, the prepared samples exhibited outstanding abrasion performance. Advantageously, this study provided a simple method for preparing marine antifouling films under environmentally friendly conditions.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yakun published the artcileSynthesis of Amphiphilic Acrylate Boron Fluorinated Polymers with Antifouling Behavior, Category: pyridine-derivatives, the publication is Industrial & Engineering Chemistry Research (2019), 58(19), 8016-8025, database is CAplus.

We constructed two kinds of amphiphilic acrylate boron fluorinated polymers (ABFPs) with backbones comprising acrylate fluorinated polymers (AFPs) and side chains comprising hydrolyzable pyridine-phenylborane functional groups. We determined the hydrolysis rates of the ABFPs by measuring their weight loss ratios. The ABFPs with shorter fluorinated side chains had higher rates of hydrolysis. We investigated and confirmed the amphiphilic and antifouling behavior of the ABFPs, using XPS and surface wettability analyses. During immersion for 90 days in the Bohai Sea of China, the ABFP coatings exhibited good antifouling performance. We also assessed the environmental characteristics of the ABFP coatings by determining the COD (COD) and growth rate of diatoms on their surfaces. The present study provides new insight into the development of environmentally friendly ABFPs with desirable antifouling properties.

Industrial & Engineering Chemistry Research published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Zixu published the artcileGuanidine-functionalized graphene to improve the antifouling performance of boron acrylate polymer, Formula: C23H20BN, the publication is Progress in Organic Coatings (2021), 106396, database is CAplus.

A series of antifouling composite coatings based on guanidine-functionalized graphene (GNG) and self-polishing boron acrylate polymer (BAP) were prepared Compared to graphene oxide, GNG had more wrinkles on its surface and was more uniformly distributed in the interior and on the surface of BAP, resulting in the tight binding of inorganic and organic compounds at the interface. The BAP/GNG composite coatings exhibited excellent algae anti-adhesion performance. Specifically, the inhibition rate of Phaeodactylum tricornutum reached 99.2%, and high antibacterial rates of up to 94.2% and 95% were obtained for Escherichia coli and Staphylococcus aureus, resp. This performance is ascribed to the polishing of BPA, exposing the guanidine-functionalized graphene on the surface. On one hand, as a filler, the prepared guanidine-functionalized graphene improved the antifouling ability by adjusting the hydrolysis rate of the antifouling coating. On the other hand, the exposure of guanidine-functionalized graphene and the hydrolysis of the polymer matrix enhanced the antifouling capability. BAP/GNG shows promise as an antifouling coating with potential applications in marine antifouling.

Progress in Organic Coatings published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C9H9ClN2, Formula: C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Urtaeva, Zh. Kh. published the artcileElectrochemical properties of organoboron compounds, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Doklady Akademii Nauk SSSR (1986), 286(3), 671-4 [Phys. Chem.], database is CAplus.

The electrochem. properties were studied of trimethyl-, tri-n-butyl-, triphenyl-, tri-α-naphthyl-, and trimesitylborons, as well as their complexes with NH₃ and pyridine. Cyclic voltammograms of the oxidation of trimethylboron in a supporting electrolyte of 0.1M NaBF₄ in MeCN at 25° are shown. The electrochem. oxidation of several organoboron compounds and their complexes on a Pt disk electrode by cyclic voltammetry is also shown, using a supporting electrolyte of Bu₄NBF₄ in MeCN. The polarog. reduction of 10^-3M triarylborons and their complexes in 0.1M Et₄NClO₄ is also described. The simplest organoboron compounds are electrochem. oxidized with difficulty, and the value of their half-wave oxidation potentials cannot be used for evaluating their reactivities with respect to O and other chem. oxidizing agents; the formation of complexes with NH₃ and pyridine rarely increases the capability of the organoboron compounds to be electrochem. oxidized.

Doklady Akademii Nauk SSSR published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C7H5Br2F, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Urtaeva, Zh. Kh. published the artcileElectrochemical behavior of organoboron compounds, Category: pyridine-derivatives, the publication is Zhurnal Obshchei Khimii (1986), 56(6), 1294-9, database is CAplus.

The electrochem. oxidation of R₃B (I; R = Me, Bu, Ph, 1-naphthyl, mesityl) was difficult, and the anodic peak potentials did not reflect the reactivity of I toward O₂. Complexation with NH₃ or pyridine facilitated the electrochem. oxidation of I. Polarog. reduction of I (R = Ph, 1-naphthyl, mesityl) gave the anion radicals, which dimerized at a rate governed by the solvating ability of the solvent.

Zhurnal Obshchei Khimii published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C7H12ClNO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Duffaut, N. published the artcilePreparation of some organosilicon compounds derived from ω-undecylenic alcohol, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Revue Francaise des Corps Gras (1957), 69-73, database is CAplus.

Reduction of Me 10-undecenoate gave the corresponding alc. which with SOCl₂ in presence of PhNMe₂ gave 80% Cl(CH₂)₉CH:CH₂ (I). I added HSiCl₃ quantitatively to give Cl(CH₂)₁₁SiCl₃ (II), b₁₆ 189°, n_D²⁰ 1.4688, d₂₀ 1.1204. With C₆H₆ and AlCl₃ II furnishes 1-phenyl-11-trichlorosilylundecane, b₁₆ 216-18°, n_D²⁰ 1.4955 d₂₀ 1.0788, and further, by methylation, 1-phenyl-11-trimethylsilylundecane, b₃ 176-7, n_D²⁰ 1.4822, d₂₀ 0.8618, ν 698 and 759 cm.^-1 II in ether gave with MeOH 1-chloro-11-trimethoxysilylundecane (III), b₁₆ 187°, n_D²⁰ 1.4426, d₂₀ 0.9855. The Br analog (IV) was obtained, b₁₆ 196°, n_D²⁰ 1.4559, d₂₀ 1.1192. III and IV gave very small amounts of amine by replacing the halogen by NEt₂. From I Me₃Si(CH₂)₉CH: CH₂ (V) was prepared, b₁₆ 131-2°, n_D²⁰ 1.4417, d₂₀ 0.8021, which with Cl₃CCO₂Et gave about 30% addition product, C₁₈H₃₅O₂Cl₃Si, b_2.5 215-16°, n_D²⁰ 1.4700, d₂₀ 1.0521.

Revue Francaise des Corps Gras published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gao, Zongming published the artcileAn In Vitro Dissolution Method for Testing Extended-Release Tablets Under Mechanical Compression and Sample Friction, SDS of cas: 21829-25-4, the publication is Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) (2022), 111(6), 1652-1658, database is CAplus and MEDLINE.

The release and dissolution of an active pharmaceutical ingredient (API) from the solid oral formulation into the gastrointestinal (GI) tract is critical for the drug′s absorption into systemic circulation. Extended-release (ER) solid oral dosage forms are normally subjected to phys. shear and grinding forces as well as pressure exerted by peristaltic movements when passing through the GI tract. The complex phys. contraction and sample friction exerted by the GI tract are not simulated well by compendial dissolution methods. These limitations render traditional in vitro dissolution testing unable to discriminate and predict a product′s in vivo performance. The objective of this study was to develop a dissolution method that better simulates the GI environment that products are subject to when taken by patients. A newly designed Mech. Apparatus under GI Conditions (MAGIC) was assembled with a dissolution platform and mech. capabilities to allow in vitro dissolution testing under sample contractions and friction. The dissolution platform, with medium flow-through configuration, was manufactured by 3D printing. A 60 mg polymer matrix-based ER nifedipine product was tested. To simulate GI physiol. conditions during the dissolution testing, the flow rate of the medium, and a combination of mech. compression with rotation induced sample friction at various rotation frequencies were explored. The polymer matrix-based nifedipine ER formulation used here failed its controlled release functionality in the simulated GI environment under mech. compression and sample friction. The results showed that the MAGIC system, with flow-through configuration under compression and sample friction, has advantages over compendial methods in testing ER solid oral formulations.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, SDS of cas: 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem