Tag: M.W=300-400

Nishiyama, Hisao; Park, Soon-Bong; Haga, Masaaki; Aoki, Katsuyuki; Itoh, Kenji published the artcile< Ruthenium(II)Cl2-bis(oxazolinyl)bipyridine complex. Its structure and reactivity>, Electric Literature of 147409-41-4, the main research area is crystal structure ruthenium oxazolinylbipyridine complex; catalyst dimerization cyclopropanation ruthenium oxazolinylbipyridine complex.

A mixture of [RuCl2(p-cymene)]2 and 6,6′-bis(oxazolinyl)-2,2′-bipyridine (L) was heated in EtOH at 70° to produce RuCl2L, of which structure was clarified by x-ray anal. to show that L coordinates as a tetradentate ligand. Its catalytic activities for transformations of diazoacetates in dimerization and cyclopropanation with styrene were examined and its spectroelectrochem. was studied.

Chemistry Letters published new progress about Crystal structure. 147409-41-4 belongs to class pyridine-derivatives, and the molecular formula is C22H26N4O2, Electric Literature of 147409-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chebotarev, Alexander N.; Pliuta, Konstantin V.; Snigur, Denys V. published the artcile< Determination of Carmoisine onto Carbon-Paste Electrode Modified by Silica Impregnated with Cetylpyridinium Chloride>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is carmoisine carbon electrode silica cetylpyridinium chloride soft drinks analysis.

In this paper a simple, cheap and sensitive electrochem. sensor for determination of Carmoisine in soft drinks was developed. Carmoisine is a synthetic azo dye which is used in food products. In this work effective voltammetric sensor based on carbon-paste electrode modified by silica impregnated with cetylpyridinium chloride to increase the sensitivity of Carmoisine detection was proposed. The voltammetric behavior of Carmoisine, the number of protons and electrons involved in the oxidation process were studied. The probable mechanism of Carmoisine oxidation on the developed sensor was suggested. The optimal conditions for the square-wave voltammetric determination of Carmoisine onto developed sensor were found to be: pH=2; Eads=400 mV; tads=300s; A=50 mV; ν=25 Hz, υ=100 mV/s. The calibration curve was linear in the range of Carmoisine concentrations 0,08-1μM. The proposed method was successfully tested in the anal. of Carmoisine in soft drinks with RSD not more than 5%.

ChemistrySelect published new progress about Carbonated beverages. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Funk, Bernhard; Kirmayer, David; Sahar-Heft, Sharonit; Gati, Irith; Friedman, Michael; Steinberg, Doron published the artcile< Efficacy and potential use of novel sustained release fillers as intracanal medicaments against Enterococcus faecalis biofilm in vitro>, HPLC of Formula: 123-03-5, the main research area is Enterococcus cetylpyridinium chloride vancomycin biofilm solidification; Cetylpyridinium chloride; E. faecalis biofilm; Intracanal medication; Sustained release.

Enterococcus faecalis is a bacterium frequently isolated after failed root canal therapy. First, the solidification capability was tested by introducing liquid SRF into phosphate buffered saline, followed by 30 s of vortexing. The antimicrobial effects of SRF-CPC against static monospecies biofilms were analyzed with a metabolic assay. Inhibition of biofilm formation was tested by exposing daily refreshed E. faecalis suspensions to SRF-CPC for 9 wk. To evaluate the effects of SRF-CPC against preformed biofilms, biofilms were grown for 1, 3 and 7 days, and then treated with SRF-CPC for 24 h. Biofilm kill time was tested by applying SRF-CPC to a 3-day-old biofilm and measuring its viability at different time points. All experiments were compared to Placebo SRFs and to untreated control biofilms. Data were analyzed with two-way ANOVA followed by Tukey’s test. Results were considered significant at P < 0.05. The liquid SRF solidified within seconds and no structural changes were observed after 30 s of vortexing at maximum speed. SRF-CPC inhibited E. faecalis biofilm formation for 7 wk and significantly reduced its viability in weeks 8 and 9. Mature biofilms grown for 1, 3 and 7 days were destructed by SRF-CPC in less than 24 h. Fifty percent of a 3-day-old biofilm was destructed in 2 h and complete destruction occurred in less than 12 h. SRF-CPC's phys. properties and long-lasting anti-biofilm effects make it a promising coadjuvant medication for endodontic therapy. BMC Oral Health published new progress about Biofilms (microbial), schmutzdecke. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, HPLC of Formula: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chutvirasakul, Boonta; Nuchtavorn, Nantana; Macka, Mirek; Suntornsuk, Leena published the artcile< Distance-based paper device using polydiacetylene liposome as a chromogenic substance for rapid and in-field analysis of quaternary ammonium compounds>, Formula: C21H38ClN, the main research area is paper device polydiacetylene liposome chromogenic substance quaternary ammonium compound; Distance-based microfluidic paper-based device; In-field analysis; Polydiacetylene; Quaternary ammonium compounds.

This work presents an affordable distance-based microfluidic paper-based device (μPAD), using polydiacetylene (PDA) liposome as a chromogenic substance with a smartphone-based photo editor, for rapid and in-field anal. of quaternary ammonium compounds (QACs) (e.g., didecyldimethylammonium chloride (DDAC), benzyldimethyltetradecyl ammonium chloride (BAC), and cetylpyridinium chloride (CPC)). In-field anal. of these compounds is important to ensure their antimicrobial activity and user safety since they are widely used as disinfectants in households and hospitals. The μPAD featured a thermometer-like shape consisting of a sample reservoir and a microchannel as the detection zone, which was pre-deposited with PDA liposome. The color change from blue to red appeared in the presence of QACs and the color bar lengths were proportional to the QAC concentrations Reactions of QACs with the PDA required a specific pH range (from pH 4.0 to 10.0) and a readout time of 7 min. Anal. performance characteristics of the device were tested with DDAC, BAC, and CPC showing acceptable specificity, accuracy (96.1-109.4%), and precision (%RSDs ≤ 9.3%). Limits of detection and quantitation were at 20-80 and 70 to 250μM, resp. Feasibility of the newly developed device was demonstrated for in-field anal. of QACs in fumigation solution providing comparable results with those obtained from a colorimetric assay (P > 0.05). The proposed device shows potentials for further applications of other analytes since it offers speed, simplicity, and affordability for in-field anal., especially in remote areas where expertise, resources, and infrastructures are limited.

Analytical and Bioanalytical Chemistry published new progress about Colorimetry. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Doan, Viet Sang; Saingam, Prakit; Yan, Tao; Shin, Sangwoo published the artcile< A Trace Amount of Surfactants Enables Diffusiophoretic Swimming of Bacteria>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is surfactant bacteria diffusionphoresis; bacteria; biofilms; diffusiophoresis; surface charge; surfactants.

From birth to health, surfactants play an essential role in the authors’ lives. Due to the importance, their environmental impacts are well understood. One of the aspects that has been extensively studied is their impact on bacteria, particularly on their motility. Here, the authors uncover an alternate chemotactic strategy triggered by surfactants-diffusiophoresis. Even a trace amount of ionic surfactants, down to a single ppm level, can promote the bacterial diffusiophoresis by boosting the surface charge of the cells. Because diffusiophoresis is driven by the surface-solute interactions, surfactant-enhanced diffusiophoresis is observed regardless of the types of bacteria. Whether Gram-pos. or -neg., flagellated or nonflagellated, the surfactants enable fast migration of freely suspended bacteria, suggesting a ubiquitous locomotion mechanism that has been largely overlooked. The authors also demonstrate the implication of surfactant-enhanced bacterial diffusiophoresis on the rapid formation of biofilms in flow networks, suggesting environmental and biomedical implications.

ACS Nano published new progress about Bacteria. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fontaine, Fanny; Hequet, Arnaud; Voisin-Chiret, Anne-Sophie; Bouillon, Alexandre; Lesnard, Aurelien; Cresteil, Thierry; Jolivalt, Claude; Rault, Sylvain published the artcile< First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump>, Synthetic Route of 832735-54-3, the main research area is boron compound transport protein NorA Staphylococcus.

Overexpression of efflux pumps is an important mechanism of bacterial resistance that results in the extrusion of antimicrobial agents outside the bacterial cell. Inhibition of such pumps appears to be a promising strategy that could restore the potency of existing antibiotics. The NorA efflux pump of Staphylococcus aureus confers resistance to a wide range of unrelated substrates, such as hydrophilic fluoroquinolones, leading to a multidrug-resistance phenotype. Here, 150 heterocyclic boronic species were evaluated for their activity against susceptible and resistant strains of S. aureus. Twenty-four hit compounds, although inactive when tested alone, were found to potentiate ciprofloxacin activity by a 4-fold increase at concentrations ranging from 0.5 to 8 μg/mL against S. aureus 1199B, which overexpresses NorA. Boron-free analogs showed no biol. activity, thus revealing that the boron atom is crucial for biol. activity. This work describes the first reported efflux pump inhibitory activity of boronic acid derivatives

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Synthetic Route of 832735-54-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Acharjee, Animesh; Rakshit, Atanu; Chowdhury, Suman; Datta, Indukamal; Barman, Milan Krishna; Ali, Ansar Md.; Saha, Bidyut published the artcile< Micellar catalysed oxidation of hydrophobic fatty alcohol in aqueous medium>, Synthetic Route of 123-03-5, the main research area is octanol micellar catalyst oxidation mechanism kinetics.

Oxidation of a hydrophobic fatty alc. was carried out under pseudo 1st order reaction condition in aqueous micellar medium efficiently. In addition to the dissolution of alc. micelles are found to catalyze the oxidation reaction. Use of promoters further enhanced the rate of the reaction with almost instant completion of the reaction via the formation of active oxidants (AO+). The product was confirmed by IR and NMR study. Fluorescence studies and DLS measurements were done to confirm the formation of AO+. NMR studies were carried out to establish the interaction between the surfactants and 1-Octanol. Calculated activation parameters (ΔH≠, ΔS≠) also support the exptl. findings.

Journal of Molecular Liquids published new progress about Activation enthalpy. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Synthetic Route of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Raut, Prakash; Weller, Sasha R.; Obeng, Bright; Soos, Brandy L.; West, Bailey E.; Potts, Christian M.; Sangroula, Suraj; Kinney, Marissa S.; Burnell, John E.; King, Benjamin L.; Gosse, Julie A.; Hess, Samuel T. published the artcile< Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is cetylpyridinium chloride antiviral agent PIP2 influenza virus infection zebrafish; Cetylpyridinium chloride; Influenza; Phosphatidylinositol 4,5-bisphosphate; Quaternary ammonium compound; Super-resolution microscopy; Zebrafish.

The COVID-19 pandemic raises significance for a potential influenza therapeutic compound, cetylpyridinium chloride (CPC), which has been extensively used in personal care products as a pos.-charged quaternary ammonium antibacterial agent. CPC is currently in clin. trials to assess its effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity. Two published studies have provided mouse and human data indicating that CPC may alleviate influenza infection, and here we show that CPC (0.1 μM, 1 h) reduces zebrafish mortality and viral load following influenza infection. However, CPC mechanisms of action upon viral-host cell interaction are currently unknown. We have utilized super-resolution fluorescence photoactivation localization microscopy to probe the mode of CPC action. Reduction in d. of influenza viral protein hemagglutinin (HA) clusters is known to reduce influenza infectivity: here, we show that CPC (at non-cytotoxic doses, 5-10 μM) reduces HA d. and number of HA mols. per cluster within the plasma membrane of NIH-3T3 mouse fibroblasts. HA is known to colocalize with the neg.-charged mammalian lipid phosphatidylinositol 4,5-bisphosphate (PIP2); here, we show that nanoscale co-localization of HA with the PIP2-binding Pleckstrin homol. (PH) reporter in the plasma membrane is diminished by CPC. CPC also dramatically displaces the PIP2-binding protein myristoylated alanine-rich C-kinase substrate (MARCKS) from the plasma membrane of rat RBL-2H3 mast cells; this disruption of PIP2 is correlated with inhibition of mast cell degranulation. Together, these findings offer a PIP2-focused mechanism underlying CPC disruption of influenza and suggest potential pharmacol. use of this drug as an influenza therapeutic to reduce global deaths from viral disease.

Toxicology and Applied Pharmacology published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khatouri, M.; Lemaalem, M.; Ahfir, R.; El Khaoui, S.; Derouiche, A.; Filali, M. published the artcile< Sol/gel transition of oil/water microemulsions controlled by surface grafted triblock copolymer dodecyl-PEO227-dodecyl: molecular dynamics simulations with experimentally validated interaction potential>, Synthetic Route of 123-03-5, the main research area is soluble gel transition microemulsion copolymer mol dynamic simulation.

We studied a large range of identical spherical oil/water microemulsion (O/W-MI) volume fractions. The O/W-MIs are stabilized by cetylpyridinium chloride ionic surfactant (CpCl) and octanol cosurfactant and dispersed in salt water. We grafted different numbers of dodecyl-(polyEthylene oxide)227-dodecyl triblock copolymer that we note (n(D-PEO227-D)), where n varies from 0 to 12. We accomplished the grafting process by replacing a small amount of CpCl and octanol with the appropriate n(D-PEO227-D). The aim is to determine the interaction/structure relationship of the covered microemulsions. Precisely, we are interested in a quant. investigation of the influence of volume fraction Φ, temperature (T), and n(D-PEO227-D) on the microemulsion sol/gel transition. To this end, we first study the uncoated microemulsion structure depending only on Φ. Second, we determine the coated microemulsions structure as a function of n(D-PEO227-D) for different Φ. Third, we examine the effect of temperature on the uncoated and coated microemulsion. We show that the sol/gel transition is controlled by the three main parameters, Φ, T, and n(D-PEO227-D). Accordingly, the uncoated microemulsion sol/gel transition, at ambient temperature, occurred for Φ ≃ 33.65%. By increasing Φ, the O/W-MIs show a glass state, which occurs, along with the gel state, at Φ ≃ 37% and arises clearly at Φ ≃ 60%. The coated O/W-MI sol/gel transition is found to be linearly dependent on n(D-PEO227-D) and takes place for Φ ≃ 26.5% for n(D-PEO227-D) = 12. Ordinarily, the decrease in temperature leads to gel formation of microemulsions for low Φ. Addnl., in this work, we found that the gelation temperature increases linearly with n(D-PEO227-D). Thus, the parameter n(D-PEO227-D) can control the sol/gel transition of the O/W-MIs at ambient temperature and moderate Φ.

RSC Advances published new progress about Clusters. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Synthetic Route of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sakac, Nikola; Markovic, Dean; Sarkanj, Bojan; Madunic-Cacic, Dubravka; Hajdek, Krunoslav; Smoljan, Bozo; Jozanovic, Marija published the artcile< Direct potentiometric study of cationic and nonionic surfactants in disinfectants and personal care products by new surfactant sensor based on 1,3-dihexadecyl-1H-benzo[d]imidazol-3-ium>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is dihexadecyl benzo imidazolium sensor cationic nonionic surfactant disinfectant; cationic surfactants; disinfectants; ionophore; nonionic surfactants; nose drops; personal care products; potentiometry; sensor.

A novel, simple, low-cost, and user-friendly potentiometric surfactant sensor based on the new 1,3-dihexadecyl-1H-benzo[d]imidazol-3-ium-tetraphenylborate (DHBI-TPB) ion-pair for the detection of cationic surfactants in personal care products and disinfectants is presented here. The new cationic surfactant DHBI-Br was successfully synthesized and characterized by NMR (NMR), Fourier transform IR (FTIR) spectrometry, liquid chromatog.-mass spectrometry (LC-MS) and elemental anal. and was further employed for DHBI-TPB ion-pair preparation The sensor gave excellent response characteristics for CTAB, CPC and Hyamine with a Nernstian slope (57.1 to 59.1 mV/decade), whereas the lowest limit of detection (LOD) value was measured for CTAB (0.3 x 10-6 M). The sensor exhibited a fast dynamic response to dodecyl sulfate (DDS) and TPB. High sensor performances stayed intact regardless of the employment of inorganic and organic cations and in a broad pH range (2-11). Titration of cationic and ethoxylated (EO)-nonionic surfactant (NSs) (in Ba2+) mixtures with TPB revealed the first inflexion point for a cationic surfactant and the second for an EO-nonionic surfactant. The increased concentration of EO-nonionic surfactants and the number of EO groups had a neg. influence on titration curves and signal change. The sensor was successfully applied for the quantification of tech.-grade cationic surfactants and in 12 personal care products and disinfectants. The results showed good agreement with the measurements obtained by a com. surfactant sensor and by a two-phase titration A good recovery for the standard addition method (98-102%) was observed

Molecules published new progress about Alcohols, tallow, ethoxylated Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses) (Genapol T 110, Genapol T 080). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem