Tag: M.W=300-400

Matsuo, Kenya; Yoshihara, Kumiko; Nagaoka, Noriyuki; Makita, Yoji; Obika, Hideki; Okihara, Takumi; Matsukawa, Akihiro; Yoshida, Yasuhiro; Van Meerbeek, Bart published the artcile< Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite>, Electric Literature of 123-03-5, the main research area is cetylpyridinium chloride montmorillonite antimicrobial adhesive formulation; Adhesive; Antibacterial; Cetylpyridinium chloride (CPC); Montmorillonite; Recharge; S. mutans.

Long-term anti-bacterial effect is a desired ability of any dental material in combating tooth caries as one of the most common and widespread persistent diseases today. Among several cationic quaternary ammonium compounds with antiseptic properties, cetylpyridinium chloride (CPC) is often used in mouthrinses and toothpastes. In this study, we incorporated CPC in a soft phyllosilicate mineral (clay), referred to as montmorillonite (Mont), to enable gradual CPC release with rechargeability. Besides measuring CPC release and recharge, we examined the anti-bacterial effect, cytotoxicity and bonding effectiveness of five exptl. adhesive formulations, prepared by adding 1 and 3 wt% CPC_Mont, 3 wt% Mont (without CPC), and 1 and 3 wt% CPC (without Mont) to the com. adhesive Clearfil S3 Bond ND Quick (C-S3B; Kuraray Noritake). Strong inhibition of Streptococcus mutans biofilm formation by CPC_Mont adhesives was confirmed by optical d. and SEM. CPC release from CPC_Mont adhesives was higher and lasted longer than from CPC adhesives, while CPC_Mont adhesives could also be recharged with CPC upon immersion in 2 wt% CPC. In conclusion, CPC_Mont technol. rendered adhesives anti-bacterial properties with recharge ability, this without reducing its bonding potential, neither increasing its cytotoxicity. Dental caries is one of the most prevalent chronic diseases in the population worldwide and is the major cause of tooth loss. In this study, we developed cetylpyridinium chloride (CPC) loaded montmorillonite (CPC-Mont) with a long-term antibacterial efficacy to prevent caries. CPC is an antibacterial agent approved by FDA, used as an OTC drug and contained in oral hygiene aids. CPC-Mont was incorporated in a dental adhesive to gradually release CPC. CPC_Mont technol. rendered adhesives anti-bacterial properties with rechargeability, this without reducing its bonding potential, neither increasing its cytotoxicity.

Acta Biomaterialia published new progress about Adhesives. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sinwat, Nuananong; Witoonsatian, Kriangkrai; Chumsing, Suksan; Suwanwong, Monticha; Kankuntod, Somyod; Jirawattanapong, Pichai; Songserm, Thaweesak published the artcile< Antimicrobial Resistance Phenotypes and Genotypes of Salmonella spp. Isolated from Commercial Duck Meat Production in Thailand and Their Minimal Inhibitory Concentration of Disinfectants>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is Salmonella disinfectant antimicrobial resistance phenotype genotype duck meat; Salmonella enterica; antimicrobial resistance; disinfectant resistance; meat-type ducks.

Salmonella is an important foodborne bacterium that has become increasingly resistant to critical antimicrobial and disinfectant agents. The aim of this study was to characterize antimicrobial and disinfectant resistance of Salmonella spp. isolated from ducks raised for meat in Nakhon Pathom province, Thailand. A total of 694 fecal samples from ducks were collected in 2018. Of which, 85 samples were pos. for Salmonella (12.2%), and 12 Salmonella serovars were identified from 125 Salmonella isolates. The Altona serovar was the predominant serotype found in this study (36.5%). All isolates showed resistance to at least one class of antimicrobial, and 23.2% displayed multidrug resistance (MDR) phenotype. The blaTEM, aadA2, strA, and dfrA12 genes were detected in antibiotic-resistant strains of Salmonella, whereas the genes within a plasmid-borne qnr family that presented in fluoroquinolone-susceptible Salmonella strains were qnrB (3.8%) and qnrS (1.5%). The min. inhibitory concentrations of benzalkonium chloride (BKC), cetylpyridium chloride (CPC), and hexadecyltrimethyl ammonium bromide (CTAB) ranged between 128 and 512μgg/mL, while that of didecyldimethylammonium chloride (DDAC) was between 32 and 128μg/mL. The presences of qacEΔ1, mdfA, sugE(c), sugE(p), and ydgE genes were less prevalent (0.8-1.6%). Taken together, our results indicate that duck is an important source of Salmonella with antimicrobial resistance in food-producing animals. Active surveillance programs for antimicrobial and disinfectant resistance in duck production are needed for an early detection of resistance strains of public health importance.

Microbial Drug Resistance (New Rochelle, NY, United States) published new progress about Antimicrobial agent resistance. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Robke, Lucas; Rodrigues, Tiago; Schroeder, Peter; Foley, Daniel J.; Bernardes, Goncalo J. L.; Laraia, Luca; Waldmann, Herbert published the artcile< Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors>, Reference of 832735-54-3, the main research area is dimethoxy pyridine derivative preparation autophagy inhibitor structure.

Autophagy is a catabolic process, which mediates degradation of cellular components and has important roles in health and disease. Therefore, small mol. modulators of autophagy are in great demand. Herein, we describe a phenotypic high-content screen for autophagy inhibitors, which led to the discovery of a dimethoxypyridine-based class of autophagy inhibitors, which derive from previously reported, natural product-inspired MAP4K4 inhibitors. Comprehensive structure-activity relationship studies led to a potent compound, and biol. validation experiments indicated that the mode of action was upstream or independent of mTOR.

Tetrahedron published new progress about Apoptosis. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Reference of 832735-54-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Assis, Ellen Lima; Silveira, Felipe Dantas; da Ponte, Alan Victor Araujo; Regis, Romulo Rocha published the artcile< A Systematic Review of the Potential Effects of Lippia sidoides on Dental Plaque and Periodontal Diseases>, Formula: C21H38ClN, the main research area is Lippia sidoides dental plaque periodontal disease potential effect.

Lippia sidoidesis a typical shrub from Brazil that has been used in traditional medicine. This is a systematic review on the effect of L. sidoidesfor controlling dental plaque, gingivitis, and periodontitis. A database search through May 2021 in Medline/PubMed, SCOPUS, BVS, and Web of Science identified 711 reports of which 17 met our inclusion criteria. Five randomized controlled trials and three animal studies were included that compared L. sidoides-based products (toothpaste, mouthrinse, and gel) to cetylpyridinium chloride, chlorhexidine, and placebo products. Among the human studies, a significant antiplaque effect after treatment with L. sidoides-based products was observed in three studies and an antigingivitis effect in two studies, similar to chlorhexidine-based products. One study found superior dental plaque reduction compared to cetylpyridinium chloride mouthrinse. Only one study testing a L. sidoidesgel found no antiplaque effect. Among the animal studies, an L. sidoidesmouthrinse significantly reduced calculus in two studies, inflammatory infiltrate in one study, and plaque bacteria and gingivitis in one study. An L. sidoidesgel significantly reduced alveolar bone loss and inflammatory response in one study in which mice were submitted to ligature-induced periodontal disease. In general, L. sidoides-based products were effective in reducing dental plaque and calculus formation, as well as clin. signs of gingivitis. As most studies present methodol. limitations, these results should be interpreted carefully. Further clin. trials with greater methodol. accuracy and control of biases are necessary for the use of L. sidoides-based products in humans to be viable in clin. practice.

Planta Medica published new progress about Alveolar bone. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jalba, Angela; Regnier, Noemie; Ollevier, Thierry published the artcile< Enantioselective Aromatic Sulfide Oxidation and Tandem Kinetic Resolution Using Aqueous H2O2 and Chiral Iron-Bis(oxazolinyl)bipyridine Catalysts>, Application In Synthesis of 147409-41-4, the main research area is aromatic sulfoxide sulfone enantioselective preparation; arylsulfide enantioselective oxidation iron chiral ligand catalyst.

An efficient method for the oxidation of aromatic sulfides has been developed by using aqueous H2O2, catalyzed by the in situ generated chiral Fe/6,6′-bis(4-isopropyloxazolin-2-yl)-2,2′-bipyridine (bipybox-iPr) complex. The corresponding sulfoxides were obtained with high enantioselectivities (up to 98.5:1.5 er) and in good yields (up to 61 %) when the mono-oxidation of the sulfides was performed in combination with the kinetic resolution of the sulfoxide into the sulfone.

European Journal of Organic Chemistry published new progress about Amino alcohols, chiral Role: RCT (Reactant), RACT (Reactant or Reagent). 147409-41-4 belongs to class pyridine-derivatives, and the molecular formula is C22H26N4O2, Application In Synthesis of 147409-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kmentova, Iveta; Sutherland, Hamish S.; Palmer, Brian D.; Blaser, Adrian; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Denny, William A.; Thompson, Andrew M. published the artcile< Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)>, Related Products of 832735-54-3, the main research area is imidazooxazine aza diazabiphenyl analog preparation physicochem lipophilicity; microsomal stability pharmacokinetic property; tuberculosis antituberculosis structure activity; Suzuki Leibeskind Srogl cross coupling.

New heterocyclic analogs of the potent biphenyl class derived from antitubercular drug I were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both Ph groups by pyridine, pyridazine, pyrazine, or pyrimidine, in order to reduce lipophilicity. For para-linked biaryls, hydrophilicities (ClogP) correlated with measured solubilities, but highly soluble bipyridine analogs displayed weak antitubercular activities. A terminal pyridine or proximal heterocycle allowed retention of potency and provided solubility improvements, particularly at low pH, with examples from the latter classes displaying the better in vivo efficacies, high metabolic stabilities, and excellent pharmacokinetics. Five such compounds were >100-fold better than the parent drug in a mouse model of acute Mycobacterium tuberculosis infection, and two orally bioavailable pyridine analogs (3-4-fold more soluble than the parent at low pH) were superior to antitubercular drug II in a chronic infection model.

Journal of Medicinal Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Related Products of 832735-54-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mao, Xiaojun; Auer, David L.; Buchalla, Wolfgang; Hiller, Karl-Anton; Maisch, Tim; Hellwig, Elmar; Al-Ahmad, Ali; Cieplik, Fabian published the artcile< Cetylpyridinium chloride: mechanism of action, antimicrobial efficacy in biofilms, and potential risks of resistance>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is review cetylpyridinium chloride antibacterial resistance biofilm biocide antiseptic; CPC; adaptation; antiseptic; biocide; cetylpyridinium chloride; oral; resistance.

A review. Antimicrobial resistance is a serious issue for public health care all over the world. While resistance toward antibiotics has attracted strong interest among researchers and the general public over the last 2 decades, the directly related problem of resistance toward antiseptics and biocides has been somewhat left untended. In the field of dentistry, antiseptics are routinely used in professional care, but they are also included in lots of oral care products such as mouthwashes or dentifrices, which are easily available for consumers over-the-counter. Despite this fact, there is little awareness among the dental community about potential risks of the widespread, unreflected, and potentially even needless use of antiseptics in oral care. Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which was first described in 1939, is one of the most commonly used antiseptics in oral care products and included in a wide range of over-the-counter products such as mouthwashes and dentifrices. The aim of the present review is to summarize the current literature on CPC, particularly focusing on its mechanism of action, its antimicrobial efficacy toward biofilms, and on potential risks of resistance toward this antiseptic as well as underlying mechanisms. Furthermore, this work aims to raise awareness among the dental community about the risk of resistance toward antiseptics in general.

Antimicrobial Agents and Chemotherapy published new progress about Antibacterial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cieplik, Fabian; Kara, Esra; Muehler, Denise; Enax, Joachim; Hiller, Karl-Anton; Maisch, Tim; Buchalla, Wolfgang published the artcile< Antimicrobial efficacy of alternative compounds for use in oral care toward biofilms from caries-associated bacteria in vitro>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is chlorhexidine digluconate streptococcus actinomyces biofilms propidium iodide polymicrobial; antimicrobial; biofilm; cetylpyridinium chloride; chlorhexidine; citrus extract; dental caries.

For caries-active patients, antimicrobial measures may be useful in addition to mech. biofilm removal. The aim of this study was to investigate the antimicrobial efficacy of alternative compounds for use in oral care from two main categories (i.e., preservatives and natural compounds) toward biofilms from caries-associated bacteria as compared to oral care gold-standards chlorhexidine digluconate (CHX), Streptococcus mutans (CPC), and zinc. Compounds were screened in initial Streptococcus mutans biofilms. Then, the most effective compounds were further investigated in mature S. mutans and polymicrobial biofilms comprising Actinomyces naeslundii,Actinomyces odontolyticus, and S. mutans. Biofilms were visualized by SEM and bacterial membrane damage was evaluated by means of flow cytometry and staining with SYBR Green and propidium iodide. Citrus extract was the only compound exhibiting similar antimicrobial efficacy in initial S. mutans biofilms (>5 log10) as compared to CHX and CPC, but its effect was clearly inferior in mature S. mutans and polymicrobial biofilms. From all alternative compounds investigated in this study, citrus extract exhibited the highest antimicrobial efficacy toward in vitro biofilms from caries-associated bacteria, but still was less effective than oral care gold-standard antiseptics CHX and CPC. Nevertheless, citrus extract may be a valuable antimicrobial compound for use in oral care for caries-active patients.

MicrobiologyOpen published new progress about Actinomyces naeslundii. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catarineu, Noelle R.; Schoedel, Alexander; Urban, Philipp; Morla, Maureen B.; Trickett, Christopher A.; Yaghi, Omar M. published the artcile< Two Principles of Reticular Chemistry Uncovered in a Metal-Organic Framework of Heterotritopic Linkers and Infinite Secondary Building Units>, COA of Formula: C18H22BNO3, the main research area is zinc MOF heterotritopic benzoate benzosemiquinonate oxidopyridine linker solvothermal preparation; crystal structure zinc MOF heterotritopic benzoate benzosemiquinonate oxidopyridine linker; helicity zinc MOF heterotritopic benzoate benzosemiquinonate oxidopyridine linker.

Structural diversity of metal-organic frameworks (MOFs) was largely limited to linkers with at most two different types of coordinating groups. MOFs constructed from linkers with three or more nonidentical coordinating groups were not explored. Here, the authors report a robust and porous crystalline MOF, Zn3(PBSP)2 or MOF-910, constructed from a novel linker PBSP (phenylyne-1-benzoate, 3-benzosemiquinonate, 5-oxidopyridine) bearing three distinct types of coordinative functionality. The MOF adopts a complex and previously unreported topol. termed tto. The authors’ study suggests that simple, sym. linkers are not a necessity for formation of crystalline extended structures and that new, more complex topologies are attainable with irregular, heterotopic linkers. This work illustrates two principles of reticular chem.: first, selectivity for helical over straight rod secondary building units (SBUs) is achievable with polyheterotopic linkers, and second, the pitch of the resulting helical SBUs may be fine-tuned based on the metrics of the polyheterotopic linker.

Journal of the American Chemical Society published new progress about Crystal structure. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, COA of Formula: C18H22BNO3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Salipante, Paul F.; Dharmaraj, Vishnu L.; Hudson, Steven D. published the artcile< Entrance effects and high shear rate rheology of shear-banding wormlike micelle fluids in a microcapillary flow>, Formula: C21H38ClN, the main research area is cetylpyridinium chloride sodium salicylate micelle fluid shear rate viscosity.

The viscosity of a shear-banding wormlike micelle solution at high shear rates is investigated by capillary rheol. and particle streak velocimetry. Measurements of the flow profile and pressure gradient show an extended entrance region, which exceeds a length to diameter ratio of 100, to reach a fully developed flow. We characterized this entrance region for capillaries with different cross sections and used the results to select a downstream portion of the capillary, where viscosity measurements can be made on fully developed flow. Measurements from this portion of the channel show a shear-thinning power-law behavior for all channel geometries from shear rates of 1000-120000s-1. Varying the surfactant concentration shows two distinct power-law behaviors that depend on both the shear rate and the concentration and are an indication of change in the micelle length. (c) 2020 American Institute of Physics.

Journal of Rheology (Melville, NY, United States) published new progress about Elasticity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem