Tag: M.W=300-400

Rincon, A.; Kumar, S.; Ritz, C. W.; Jackson, J. S.; Jackson, C. R.; Frye, J. G.; Hinton, A. Jr.; Singh, M.; Cosby, D. E.; Cox, N. A.; Thippareddi, H. published the artcile< Antimicrobial interventions to reduce Salmonella and Campylobacter populations and improve shelf life of quail carcasses>, Reference of 123-03-5, the main research area is Coturnix Campylobacter shelf life carcass; Campylobacter; Salmonella; antimicrobial; quail carcass; shelf life.

Quail (Coturnix japonica) is processed and marketed as fresh meat, with limited shelf life. The objective of this study was to evaluate the efficacy of antimicrobial interventions during slaughter on reducing Salmonella and Campylobacter contamination and to determine the microbiol. shelf life of quail during refrigerated (4°C) storage. Three antimicrobials, peracetic acid (400 ppm; PAA), Citrilow (pH 1.2), and Cecure (cetylpyridinium chloride [CPC], 450 ppm), along with a water and no-treatment control were evaluated. Quail carcasses (n = 75) were inoculated with a cocktail of nalidixic acid-resistant Salmonella Typhimurium and gentamicin-resistant Campylobacter coli. After 30 min of attachment time, quail carcasses were submerged in each antimicrobial solution for 20 s with air agitation. Noninoculated quail carcasses (n = 25) were similarly treated, packaged, and stored under refrigeration (4°C). Aerobic plate counts (APC), psychrotroph counts (PC), Enterobacteriaceae counts (ENT), total coliform counts (TCC), and Escherichia coli counts on quail carcasses were determined on 1, 4, 7, and 10 d. Salmonella and Campylobacter populations were determined by plating on Petrifilm APC supplemented with 200-ppm nalidixic acid and Campy Cefex agar supplemented with 200-ppm gentamycin, resp. No significant reductions in (P > 0.01 log cfu/mL) in APC, PC, ENT, TCC, and E. coli counts were observed on carcasses submerged in water. However, treatments with PAA, Citrilow, and CPC significantly reduced (P ≤ 0.05) Salmonella and Campylobacter coli contamination. Citrilow showed greater (P ≤ 0.05) reduction in Salmonella and Campylobacter population (1.90 and 3.82 log cfu/mL reduction, resp.) to PAA and CPC. Greater (P ≤ 0.05) reductions in APC, PC, ENT, TCC, and E. coli counts (2.22, 1.26, 1.47, 1.52, and 1.59 log cfu/mL, resp.) were obtained with the application of CPC. Application of antimicrobial interventions resulted in a reduction in Campylobacter and Salmonella, APC, PC, and ENT populations after treatments (day 0) and throughout the storage period (day 10). Use of antimicrobial interventions after slaughter can improve the microbiol. safety and shelf life of quail.

Poultry Science published new progress about Animal carcass. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Simmons, Bryan J.; Hoffmann, Marie; Champagne, Pier Alexandre; Picazo, Elias; Yamakawa, Katsuya; Morrill, Lucas A.; Houk, K. N.; Garg, Neil K. published the artcile< Understanding and Interrupting the Fischer Azaindolization Reaction>, Reference of 832735-54-3, the main research area is Fischer Azaindolization Reaction mechanism.

Exptl. and computational studies pertaining to the Fischer azaindolization reaction are reported. These studies explain why pyridylhydrazines are poorly reactive in Fischer indolization reactions, in addition to the origin of hydrazine substituent effects. Addnl., an interrupted variant of Fischer azaindolization methodol. is disclosed, which provides a synthetic entryway into fused azaindoline scaffolds.

Journal of the American Chemical Society published new progress about Fischer indole synthesis. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Reference of 832735-54-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nishiyama, Hisao published the artcile< Synthesis and reactivity of organometallic complexes with C2-symmetrical optically active nitrogen-ligands. Asymmetric catalytic oxidation>, Name: 6,6′-Bis(4-(S)-isopropyl-2-oxazolinyl)-2,2′-bipyridine, the main research area is ruthenium oxazolinyl pyridine catalyst asym oxidation; oxazolinyl bipyridine ruthenium catalyst asym oxidation.

Two types of optically active nitrogen-ligands having C2-symmetry, bis(oxazolinyl)pyridine (Pybox) and bis(oxazolinyl)bipyridine (Bipymox), were developed for asym. catalytic reactions. The nitrogen ligands gave stable complexes by the reaction with ruthenium(II) chloride complex. The structures of the Pybox- and Bipymox-ruthenium complexes were analyzed by x-ray and electrochem. Their complexes of ruthenium(II) exhibited strong activities of oxidation of secondary alcs. and epoxidation of olefins with asym. induction. During this study, highly efficient enantioselective hydrosilylation of ketones and cyclopropanation reaction were discovered.

Asahi Garasu Zaidan Josei Kenkyu Seika Hokoku published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 147409-41-4 belongs to class pyridine-derivatives, and the molecular formula is C22H26N4O2, Name: 6,6′-Bis(4-(S)-isopropyl-2-oxazolinyl)-2,2′-bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fizer, Maksym; Fizer, Oksana; Sidey, Vasyl; Mariychuk, Ruslan; Studenyak, Yaroslav published the artcile< Experimental and theoretical study on cetylpyridinium dipicrylamide - A promising ion-exchanger for cetylpyridinium selective electrodes>, SDS of cas: 123-03-5, the main research area is exptl theor cetylpyridinium dipicrylamide ion exchanger; cetylpyridinium phthalate ion selective electrode.

The cetylpyridinium (CP) dipicrylamide (DPA) ion pair was synthesized and characterized by the FTIR and NMR (1H and 13C) spectroscopy, theor. studied and tested as ion-exchanger for cetylpyridinium selective electrodes. The mol. dynamics and further DFT optimization indicate face-to-face π-π stacking interaction between pyridinium and 2,4,6-trinitrophenyl rings. The presence of weak interactions between hydrogens of cetyl chain and oxygens of nitro groups of DPA anion was confirmed by RDG function anal. Numeric reactivity descriptors computed at the B3LYP/6-31+G(d,p) level of theory show that CP-DPA has electrophilic character and can readily react with bases. Two fabricated electrodes with the CP-DPA ion-exchanger showed near-Nernstian responses towards CP chloride in the concentration range from 1 × 10-2 to 1 × 10-5 mol/L. In the case where di-Bu phthalate was used as plasticizer, the slope is 57.2 ± 1.3 mV/decade, whereas for the case of dioctyl phthalate the slope is 61.6 ± 1.2 mV/decade.

Journal of Molecular Structure published new progress about Density functional theory, B3LYP. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jeon, So Mi; Lim, Je Sun; Kim, Hyung-Ryong; Lee, Jong-Ho published the artcile< PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells>, Electric Literature of 123-03-5, the main research area is human dental pulp stem cell odontogenic differentiation PFK activation; Aerobic glycolysis; Differentiation; Human dental pulp stem cell; Odontoblast; PFK.

Dental pulp stem cells (DPSCs) can differentiate into diverse cell lineages, including odontogenic cells that are responsible for dentin formation, which is important in pulp repair and tooth regeneration. While glycolysis plays a central role in various cellular activities in both physiol. and pathol. conditions, its role and regulation in odontogenic differentiation are unknown. Here, we show that aerobic glycolysis is induced during odontoblastic differentiation from human DPSCs. Importantly, we demonstrate that during odontoblastic differentiation, protein expression levels of phosphofructokinase 1 muscle isoform (PFKM) and PFK2, but not other glycolytic enzymes, are mainly upregulated by AKT activation, resulting in increased total PFK enzyme activity. Increased PFK activity is essential to enhance aerobic glycolysis, which plays an important role in the odontoblastic differentiation of human DPSCs. These findings underscore that PFK activation-induced aerobic glycolysis accompanies, and participates in, human DPSCs differentiation into odontogenic lineage, and could play a role in the regulation of dental pulp repair.

Biochemical and Biophysical Research Communications published new progress about Dental pulp. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alvarez, Diana M.; Duarte, Luisa F.; Corrales, Nicolas; Smith, Patricio C.; Gonzalez, Pablo A. published the artcile< Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts>, Reference of 123-03-5, the main research area is cetylpyridinium chloride antiviral gingival fibroblast herpes simplex virus infection; Antiviral; Cetylpyridinium chloride, CPC; Fibroblasts; Herpes simplex viruses; NF-κB.

Infections with herpes simplex viruses are lifelong and highly prevalent worldwide. Individuals with clin. symptoms elicited by HSVs may suffer from occasional or recurrent herpetic lesions in the orofacial and genital areas. Despite the existence of nucleoside analogs that interfere with HSV replication, such as acyclovir, these drugs are somewhat ineffective in treating skin lesions as topical formulations only reduce in one or few days the duration of the herpetic ulcers. Cetylpyridinium chloride (CPC) is a quaternary ammonium compound present in numerous hygiene products, such as mouthwashes, deodorants, aphtae-treating formulations and oral tablets as an anti-septic to limit bacterial growth. Some reports indicate that CPC can also modulate host signaling pathways, namely NF-κB signaling. Because HSV infection is modulated by NF-κB, we sought to assess whether CPC has antiviral effects against HSVs. Using wild-type HSV-1 and HSV-2, as well as viruses that are acyclovir-resistant or encode GFP reporter genes, we assessed the antiviral capacity of CPC in epithelial cells and human gingival fibroblasts expanded from the oral cavity and its mechanism of action. We found that a short, 10-min exposure to CPC added after HSV entry into the cells, significantly limited viral replication in both cell types by impairing viral gene expression. Interestingly, our results suggest that CPC blocks HSV replication by interfering with the translocation of NF-κB into the nucleus of HSV-infected cells. Taken together, these findings suggest that formulations containing CPC may help limit HSV replication in infected tissues and consequently reduce viral shedding.

Antiviral Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frolov, Nikita; Detusheva, Elena; Fursova, Nadezhda; Ostashevskaya, Irina; Vereshchagin, Anatoly published the artcile< Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is clin strains biofilms microbiologica novel bis quaternary ammonium compound; antibacterial activity; antibiofilm activity; antiseptics; bacterial resistance; biocides; disinfectants; pyridinium salts; quaternary ammonium compounds.

This work is devoted to the investigation of biocidal properties of quaternary ammonium compounds (QACs) based on pyridine structures with aromatic spacers, and their widely known analogs, against clin. significant microorganisms. This study is focused on investigating their antimicrobial activity (min. inhibitory concentrations (MICs) and min. bactericidal concentrations (MBCs)), antibiofilm properties (min. biofilm inhibitory concentrations (MBICs) and min. biofilm eradication concentrations (MBECs)), synergetic effect with different alcs. in antiseptic formulations, and bacterial resistance development. It was shown that all combined analog preparations had a higher level of antibacterial activity against the tested bacterial strains, with a 16- to 32-fold reduction in MICs and MBCs compared to previously used antiseptic preparations Moreover, hit-QACs demonstrated a stable effect against Gram-neg. E. coli, K. pneumoniae, and A. baumannii within a month of incubation. Overall results indicated a high level of antibacterial activity of pyridine-based QACs.

Pharmaceuticals published new progress about Acinetobacter baumannii. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghosh, Kajari; Molla, Rostam Ali; Iqubal, Asif Md.; Islam, S. M. published the artcile< A mesoporous organosilica grafted Pd catalyst (MOG-Pd) for efficient base free and phosphine free synthesis of tertiary butyl esters via tertiary-butoxycarbonylation of boronic acid derivatives without using carbon monoxide>, Category: pyridine-derivatives, the main research area is silica palladium preparation alkoxycarbonylation catalyst green chem.

A mesoporous organosilica grafted palladium(II) catalyst was synthesized and characterized using various spectroscopic techniques. Its catalytic activity was evaluated for the synthesis of tert-Bu esters by tert-butoxycarbonylation of boronic acid derivatives The tert-Bu esters were obtained directly from boronic acid pinacol esters and di-tert-Bu dicarbonate. The reaction was optimized by varying the bases, temperatures and solvents (green chem. method). The catalyst was very stable and could be facilely recovered and reused six times with no significant decrease in its activity and selectivity. The synthesis of the target compounds was achieved using mesoporous-silica-supported furanmethanimine-palladium diacetate (i.e., Schiff-base-imine-palladium complex) as a catalyst. The starting materials included dicarbonic acid 1,3-bis(1,1-dimethylethyl) ester and 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine derivatives, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile (nitrile), 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarboxylic acid ester (pyridine), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline, 4,4,5,5-tetramethyl-2-(2-methylphenyl)-1,3,2-dioxaborolane derivatives, 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane (thiophene derivative). The title compounds thus formed included 2-pyridinecarboxylic acid 1,1-dimethylethyl ester, 3-pyridinecarboxylic acid 1,1-dimethylethyl ester, 4-pyridinecarboxylic acid 1,1-dimethylethyl ester, 3,5-pyridinedicarboxylic acid 3-(1,1-dimethylethyl) 5-Et ester, 4-quinolinecarboxylic acid 1,1-dimethylethyl ester, benzoic acid 1,1-dimethylethyl ester derivatives

Green Chemistry published new progress about Alkoxycarbonylation. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mhanna, Ramona; Lee, Jonghun; Narayanan, Suresh; Reich, Daniel H.; Leheny, Robert L. published the artcile< Phase-dependent shear-induced order of nanorods in isotropic and nematic wormlike micelle solutions>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is gold nanorod hexagonal wormlike micelle solution.

Small angle X-ray scattering with in situ shear was employed to study the assembly and ordering of dispersions of gold nanorods within wormlike micelle solutions formed by the surfactant cetylpyridinium chloride (CPyCl) and counter-ion sodium salicylate (NaSal). Above a threshold CPyCl concentration but below the isotropic-to-nematic transition of the micelles, the nanorods self-assembled under quiescent conditions into isotropically oriented domains with hexagonal order. Under steady shear at rates between 0.5 and 7.5 s-1, the nanorod assemblies acquired macroscopic orientational order in which the hexagonal planes were coincident with the flow-vorticity plane. The nanorods could be re-dispersed by strong shear but re-assembled following cessation of the shear. In the nematic phase of the micelles at higher surfactant concentration, the nanorods did not acquire hexagonal order but instead formed smectic-like layers in the gradient-vorticity plane under shear. Finally, at still higher surfactant concentration, where the micelles form a hexagonal phase, the nanorods showed no translational ordering but did acquire nematic-like order under shear due to alignment in the flow. Depletion forces mediated by the wormlike micelles are identified as the driving mechanism for this sequence of nanorod ordering behaviors, suggesting a novel mechanism for controlled, reconfigurable assembly of nanoparticles in solution

Nanoscale published new progress about Aggregation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pal, Amalendu; Punia, Renu published the artcile< Mixed micellization behaviour of tri-substituted surface active ionic liquid and cationic surfactant in aqueous medium and salt solution: Experimental and theoretical study>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is tetradecyldimethylimidazolium cetyltrimethylammonium sodium bromide aqueous medium micellization physiochem property.

The aim of the present study is to investigate the mixed micellization behavior of trisubstituted surface active ionic liquid (SAIL) 1-tetradecyl-2,3-dimethylimidazolium bromide and cationic surfactant CTAB in aqueous solution and in the presence of inorganic salt, NaBr using the conductivity, steady-state fluorescence and 1H NMR measurements. The degree of counter-ion dissociation (g), critical micelle concentration (cmc), various thermodn. parameters of micellization (ΔG0m, ΔH0m and ΔS0m) have been evaluated from conductivity measurements. The aggregation number (Nagg) of mixed micelle has been ascertained from steady-state fluorescence quenching indicate that the contribution of CTAB was always more than that of SAIL. Various mixed micellar parameters such as ideal cmc (cmc*), activity coefficients (f1 and f2), micellar mole fraction of CTAB in mixed and ideal state (Xm1andXideal1), interaction parameter (βm) and excess Gibbs free energy of micellization (ΔGex) have been calculated at temperatures of (298.15, 308.15 and 318.15) K. Mixed micellar parameters (cmc*, Xm1, and ΔGex) reveal non-ideal behavior of the mixed system and magnitude of interaction parameter (βm) becomes more neg. in the presence of salt. 1H NMR shed light on the electrostatic interactions between CTAB and SAIL in mixed state.

Journal of Molecular Liquids published new progress about Electric conductivity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem