Tag: M.W=300-400

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Basicity Enhancement by Multiple Intramolecular Hydrogen Bonding in Organic Superbase N,N ‘,N ”,N ”’-Tetrakis(3-(dimethylamino)propyl)triaminophosphazene

With the synthesis of N,N’,N ”,N”’-tetrakis(3-(dimethylamino)propyl)triaminophosphazene (TDMPP, 1), we present the first phosphazene superbase with enhanced basicity through the effect of multiple intramolecular hydrogen bonding (IHB). Due to intramolecular solvation of four NH protons, the proton affinity is even higher than that of second-order phosphazene (dma)P-2-tBu. X-ray structural proof, NMR titration experiments, and computational investigations provide a more detailed quantitative description of the IHB influence on the superbasicity of 1 in solid-state, solution, and the gas-phase.

If you are hungry for even more, make sure to check my other article about 503615-03-0, HPLC of Formula: C15H17N3O4.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 117977-21-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 117977-21-6, Name is 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole, SMILES is COCCCOC1=C(C(=NC=C1)CSC2=NC3=C([NH]2)C=CC=C3)C, belongs to pyridine-derivatives compound. In a article, author is Yin, Sanmao, introduce new discover of the category.

Synthesis of terpyridine-containing Pd(II) complexes and evaluation of their catalytic activity

Herein, we prepare two terpyridine-containing Pd(II) complexes, [PdClL1]center dot solvent (A(1)) and [PdClL2] center dot 2H(2)O (A(2)) (L-1 = 4′-(4-carboxyl-phenyl)-2,2′:6′,2 ”-terpyridine, L-2 = 2,6-bis(2-pyrazinyl)-4-(4-carboxyl-phenyl)pyridine), from 4′-(4-cyanophenyl)-2,2′:6′,2 ”-terpyridine(L-1a)/2,6-bis(2-pyrazinyl)-4-(4-cyanophenyl)pyridine (L-2a) and Pd(II) acetate and characterise them by several instrumental techniques. A(1) and A(2) are shown to be good catalysts for the coupling of 2-iodobiphenyl with iodobenzenes to afford triphenylenes, which is known to involve dual C-H bond activation and double C-C bond formation. The obtained data suggest that the mechanism of A(1)-and A(2)-mediated coupling may be similar to the reference Pd catalysts, A(1) and A(2) are also suitable catalysts for this cyclization process. Study on this kind of complexes is of importance to the development of novel Pd-based catalysts and triphenylene synthesis techniques. (C) 2019 Elsevier B.V. All rights reserved.

Reference of 117977-21-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 117977-21-6.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 503615-03-0, Name is 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one, molecular formula is C15H17N3O4, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Chen, Qiong, once mentioned the new application about 503615-03-0, Safety of 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one.

Two new pyridine derivatives and two new furan derivatives from Irpex lacteus

Two undescribed disubstituted pyridine derivatives irpexidines A and B (1 and 2) and two undescribed alkylfuran derivatives irpexins K and L (3 and 4) were isolated from fermentation broth of Irpex lacteus. Their structures were established by extensive spectroscopic methods. The pyridine derivatives from this fungus were reported for the first time. The new compounds were evaluated for their cytotoxicity against Hela cancer cell and inhibitory activity on NO production.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 503615-03-0. The above is the message from the blog manager. Safety of 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Benkovics, Gabor, once mentioned the application of 545445-44-1, Quality Control of 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one, Name is 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one, molecular formula is C20H25N3O3, molecular weight is 355.4308, MDL number is MFCD19440881, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

Facile synthesis of per(6-O-tert-butyldimethylsilyl)-alpha-, beta-, and gamma-cyclodextrin as protected intermediates for the functionalization of the secondary face of the macrocycles

Per(6-O-tert-butyldimethylsilyl)-alpha-, beta- and gamma-cyclodextrin derivatives are well-known as synthetic intermediates that enable the selective mono-, partial, or perfunctionalization of the secondary face of the macrocycles. Although silylation of the primary rim is readily achieved by treatment with tert-butyldimethylsilyl chloride in the presence of pyridine (either alone or mixed with a co-solvent), the reaction typically results in a mixture containing both under- and oversilylated byproducts that are difficult to remove. To address this challenge in preparing a pure product in high yield, we describe an approach that centers on the addition of a controlled excess of silylating agent to avoid the presence of undersilylated species, followed by the removal of oversilylated species by column chromatography elution with carefully designed solvent mixtures. This methodology works well for 6-, 7-, and 8-member rings (alpha-, beta-, and gamma-cyclodextrins, respectively) and has enabled us to repeatedly prepare up to x2053;35 g of >= 98% pure product (as determined by HPLC) in 3 d. We also provide procedures for lower-scale reactions, as well as an example of how the beta-cyclodextrin derivative can be used for functionalization of the secondary face of the molecule.

Interested yet? Read on for other articles about 545445-44-1, you can contact me at any time and look forward to more communication. Quality Control of 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, 103577-40-8, Name is 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, SMILES is FC(F)(F)COC1=C(C)C(CSC2=NC3=CC=CC=C3N2)=NC=C1, belongs to pyridine-derivatives compound. In a document, author is Bryleva, Yuliya A., introduce the new discover.

Ln(III) complexes with a chiral 1H-pyrazolo[3,4-b]pyridine derivative fused with a (-)-alpha-pinene moiety: synthesis, crystal structure, and photophysical studies in solution and in the solid state

Chiral lanthanide(iii) complexes, [LnL(2)(NO3)(3)]center dot MeCN (Ln = Sm (1), Eu (2), Tb (3)), containing an optically active 1H-pyrazolo[3,4-b]pyridine derivative fused with a natural monoterpene (-)-alpha-pinene moiety (L) have been synthesized and structurally characterized. The mononuclear complexes 1-3 are isostructural and crystallize in the non-centrosymmetric space group P2(1)2(1)2. The lanthanide ions are ten-coordinated with three bidentate chelating nitrate ions and two bidentate N,N-donor ligands L. Complexes 1-3 show metal-centered luminescence at room temperature in solution and in the solid state. The solid-state and solution-phase luminescence quantum yields increase in the order 1 < 2 < 3. Complex 3 possesses a very high luminescence quantum yield both in acetonitrile solution (phi(f) = 0.736) and in the solid state (phi(f) = 0.890), indicating efficient energy transfer from two ligands L to the Ln center. The luminescence quantum yields of complexes 1 and 2 in the acetonitrile solutions are almost two and four times higher, respectively, than those in the solid state. DFT and TD-DFT studies were carried out to explore geometry and electronic structure of L and to gain insight into its absorption properties. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 103577-40-8. Recommanded Product: 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 152460-09-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 152460-09-8 as follows.

N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine (35 g, 0.114 mol) and stannous chloride dihydrate (128.5 g, 0.569 mol) were dissolved in a solvent mixture of ethyl acetate and ethanol (250 ml, 10/1, v/v), and the reaction solution was refluxed for 4 hours. The solution was cooled to room temperature, washed with 10% aqueous sodium hydroxide solution, and concentrated to give N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine (35 g). Rf=0.45 (Methylene chloride_Methanol=9:1). 1H-NMR(DMSO-d6)=2.04(s, 3H), 6.30-6.34(m, 1H), 6.76-6.77(m, 1H), 6.84-6.87 (d, 1H), 7.34-7.35(m, 1H), 7.50-7.56(m, 1H), 8.38-8.47(m, 1H), 8.53-8.57(m, 2H), 8.66-8.70(m, 1H), 9.23-9.24(d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,152460-09-8, its application will become more common.

Reference:
Patent; IL YANG PHARM. CO., LTD.; US2004/248918; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 571189-16-7, name is tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

A nitrogen-flushed, 2.5 L heavy-wall Parr bottle (pressure rated to 60 psi) is charged with 68 g (0.22 mol,) of tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate, (A2a), 6.8 g of 10% palladium on carbon, 50% water wet catalyst and 807 g (1020 mL) of methanol. The reaction vessel is inerted three times with nitrogen (ca. 30 psi), evacuating the atmosphere above the reaction mixture each time. The vessel is pressurized twice with hydrogen (ca. 30 psi), evacuating the atmosphere above the reaction mixture each time. The reaction vessel is pressurized to 45 psi with hydrogen. The shaker motor is started. The reaction is exothermic. A temperature rise from 19 to 54 C. over 15 min is observed after which time the hydrogen uptake stops. The mixture is allowed to cool to 30 C. over 1 h at which point the shaker is stopped. The hydrogen atmosphere is replaced with nitrogen as described above (Inert the reaction vessel). The catalyst is removed by filtration through a 10 g pad of filter cel. This entire process is repeated once more, both filtrates are combined and charged to a clean 3 L 4-neck round bottom flask.; The filtrates from Step 2.3 is stirred and concentrated under reduced pressure (50 mbar, 40 C. internal MAXIMUM.) to a thick paste. 190 g (250 mL) of tert-butyl methyl ether is charged to the residue. The sample is again stirred and concentrated under reduced pressure (50 mbar, 30 C. internal MAXIMUM.) to a thick paste. 342 g (500 mL) of heptane is charged to the residue and the resulting suspension is stirred for 15 min at 22+/-3 C. The solids are filtered and the filter cake is washed with 68 g (100 mL) of heptane. Dry the solids at 50 C. for 16 h, to afford 112.3 g (93.4%) of Compound A2 as tan plates, mp 124-126 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 571189-16-7, tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate.

Reference:
Patent; Calienni, John Vincent; Chen, Guang-Pei; Gong, Baoqing; Kapa, Prasad Koteswara; Saxena, Vishal; US2012/115878; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 113975-31-8 ,Some common heterocyclic compound, 113975-31-8, molecular formula is C10H13IN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Manufacturing Example 1-2-3: 3-lodo-pyridin-2-ylamine N-(3-lodo-pyridin-2-yl)-2,2-dimethyl-propionamide (66.2 g, 218 mmol) described in Manufacturing Example 1-2-2, a 5 N aqueous solution (200 mL) of sodium hydroxide, and methanol (200 mL) were stirred under reflux for 1 hour and 20 minutes. The reaction solution was returned to room temperature, and then water was added thereto, which was extracted with ethyl acetate three times. The ethyl acetate layers were combined, which was washed once with saturated brine, and then dried over sodium sulfate. The sodium sulfate was removed by filtration, and the solvent was evaporated under a reduced pressure to obtain the titled compound (41 g). 1H-NMR spectrum (DMSO-d6) delta (ppm): 6.00 (2H, brs), 6.32 (1 H, dd, J = 4.8 Hz, 7.2 Hz), 7.87 (1 H, d, J = 7.2 Hz), 7.92 (1 H, d, J = 4.8 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113975-31-8, its application will become more common.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2065377; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 757978-18-0, name is 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H4BrIN2

Step 1: Synthesis of 5-bromo-3-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine 2.30 g (11.67 mmol) of 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine was dissolved in 90 ml of anhydrous THF under nitrogen. An excess of sodium hydride was added at room temperature and subsequently 3 ml of tri-iso-propylsilyl chloride were added. The reaction mixture was allowed to stir at ambient temperature for 4 h. The mixture was distributed between ethyl acetate and a saturated aqueous solution of ammonium chloride. The aqueous phase was extracted three times with ethyl acetate and the organic phases were combined, washed with brine, dried over sodium sulfate and evaporated. The crude material was purified by flash chromatorgraphy on silica gel using a gradient of ethyl acetate in hexanes to afford 3.493 g (7.235 mmol, 62% yield) of -bromo-3-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine as a crystalline solid. 1H-NMR (d6-DMSO): (58.34 (d, J=1.9 Hz, 1H), 7.88 (d, J=2.0 Hz, 1H), 7.72 (s, 1H), 1.86 (m, 3H), 1.05 (d, J=7.8 Hz, 18H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 757978-18-0, 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; SGX Pharmaceuticals, Inc.; US2006/30583; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 757978-18-0 ,Some common heterocyclic compound, 757978-18-0, molecular formula is C7H4BrIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

60% NaH in oil (150 mg, 3.74 mmol) was added to a solution of 5-bromo-3-iodo-lH- pyrrolo[2,3-b]pyridine (1.0 g, 3.12 mmol) in dry DMF (6 mL) at 00C. The reaction mixture was allowed to warm to rt over 1 h and cooled again to 0 0C. 2-(chloromethoxy)ethyl)trimethylsilane (661 uL, 3.74 mmol) was then added and the reaction was maintained for 1.5 h. The reaction was then quenched with water and the mixture was concentrated in vacuo. The resulting crude solid was dissolved in EtOAc (75 mL) and washed sequentially with water (2 X 25 mL), aqueous 2.0 M HCl (50 mL), water (25 mL), and then brine (50 mL). The solution was dried (Na2SO^ and concentrated to yield 1.48 g of 5-bromo-3-iodo-l-((2-(trimethylsilyl)ethoxy)methyl)-lH-pyrrolo[2,3,-delta]pyridine:LCMS (m/z): 455.0 (MH+), tR= 1.47 min .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 757978-18-0, 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; WO2009/115572; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem