Tag: M.W=300-400

145100-50-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, molecular formula is C7H4F6N2O4S2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of sodium bis(trimethylsilyl)amide (1.12 g, 6.13 mmol) in 16.2 mL of THF was cooled to -78C and a solution of ethyl 4-(2,2-dimethyl-4-oxo-thiochroman-6- ylethynyl)-benzoate (1.86 g, 5.10 mmol) in 15.0 mL was added slowly. After 30 minutes a solution of 2-[N,N-bis(trifluoromethanesulfonyl)amino]-5-pyridine (2.40 g, 6.13 mmol) in 10 mL of THF was added. After 5 minutes the solution was warmed to room temperature and stirred overnight. The reaction was quenched by the addition of saturated aqueous NH4CI and extracted with EtOAc. The combined organic layers were washed with 5% aqueous NaOH and H2O before being dried (MgSO4) and concentrated under reduced pressure. Ethyl 4-((2,2-dimethyl-4-trifluoromethanesulfonyloxy-(2H)- thiochromen-6-y-l)ethynyl)-benzoate, 1.53 g (61%), was isolated by column chromatography (2% EtOAc/hexanes) as a yellow solid. 1H NMR (300 MHz, CDCl3) delta: 8.03 (2H, d, J=8.4 Hz), 7.61 (IH5 d, J=I.8 Hz), 7.59 (2H, d, J=8.4 Hz), 7.41 (IH, dd, J=1.8, 8.1 Hz), 7.29 (IH, d, J=8.1 Hz), 5.91 (IH, s), 4.39 (2H, q, J=7.1 Hz), 1.53 (6H, s), 1.41 (3H, t, J=7. I Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; WO2007/136653; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 145100-50-1, blongs to pyridine-derivatives compound. 145100-50-1

General procedure: Either (2S)-13 or (2R)-13 was dissolved in anhydrous DCM, and1.5 equivalents of 2-Pyridyltriflimide were added. The flask was placedunder N2 atmosphere and cooled to -78 C. 3.0 equivalents of N,Ndiisopropylethylaminewere added and the reaction slowly warmed toroom temperature and stirred for 20 h. Saturated aqueous ammoniumchloride was added, and extraction done with DCM. Organic fractionswere dried over sodium sulfate and purification was done by flashchromatography 98:2 (DCM:MeOH). TLC eluents used (95:5Dichloromethane: MeOH).

With the rapid development of chemical substances, we look forward to future research findings about 145100-50-1.

Reference:
Article; Perry, Charles K.; Casey, Austen B.; Felsing, Daniel E.; Vemula, Rajender; Zaka, Mehreen; Herrington, Noah B.; Cui, Meng; Kellogg, Glen E.; Canal, Clinton E.; Booth, Raymond G.; Bioorganic and Medicinal Chemistry; vol. 28; 3; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

102625-64-9 , The common heterocyclic compound, 102625-64-9, name is 5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, molecular formula is C16H15F2N3O3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

At room temperature, 10.0 G of 5-DIFLUOROMETHOXY-2- [ (3, 4-DIMETHOXY-2-PYRIDINYL) METHYLTHIO]-1H- benzimidazole and 1.05 G of (+) -L-tartaric acid bis- (N-pyrrolidinamide) (0.15 eq. ) are suspended in 72 ML of methyl isobutyl ketone. The suspension is heated at 40-45C and 12 ml of MIBK are distilled off for azeotropic removal of water present in the mixture. At this temperature, 0.53 G of zirconium (IV) ISOPROPOXIDE-ISOPROPANOL (0.05 eq. ) is added and the mixture is stirred for 1 hour. After cooling to 30C, 0.16 mi of N-ETHYIDIISOPROPYLAMINE is added. 5.5 g of cumene hydroperoxide (80% in cumene) are then slowly metered in. Stirring is continued at 30C until the exothermic oxidation process has ended (20 hours, monitored by TLC or HPLC). HPLC of the reaction shows 82% of title compound in an optical purity of > 95%.

The synthetic route of 102625-64-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALTANA PHARMA AG; WO2004/52881; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

145100-50-1 ,Some common heterocyclic compound, 145100-50-1, molecular formula is C7H4F6N2O4S2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-[iV,lambdar-Bis(trifluoromethansulfonyl)amino]pyridine (13.2 g, 37.0 mmol) was added to a stirred solution ofi-3d-OH (15.6 g, 37.9 mmol), triethylamine (6.50 rnL546.6 mmol) and DMAP (256 mg, 2.10 mmol) in DCM (270 mL) at 0 “C. After approximately 2 h, the reaction mixture was poured into saturated aqueous sodium bicarbonate and extracted three times with EtOAc. The combined organic extracts were washed with saturated aqueous sodium bicarbonate and brine, dried (sodium sulfate) and concentrated in vacuo. The crude residue was purified by flash chromatography on silica gel (gradient elution; 30%-80% EtOAc/hexanes as eluent) to afford i-3d. m/z (ES) 545 (MH)+. 1HNMR (500 MHz, CDCl3): delta 8.97 (s, 2H)5 8.61 (d, IH, J= 3.0 Hz), 7.57 (d, 2H, J= 8.4 Hz), 7.53 (m, IH), 7.53 (d, 2H3 J- 8.0 Hz), 7.37 (d, IH, J= 8.7 Hz)5 5.95 (s, 2H), 3.15 (m, IH), 2.41 (s, 6H)5 1.78 (s, 3H), 0.89 (d, 3H, J= 6.7 Hz), 0.86 (d5 3H, J= 6.9 Hz).

According to the analysis of related databases, 145100-50-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2008/30369; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

641569-94-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 641569-94-0, name is 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid. A new synthetic method of this compound is introduced below.

The compound of formula VI (3.5 g), Toluene (35 ml),Thionyl chloride (14 ml) was added to the reaction flask, The temperature was raised to 80 C for 5 h. The reaction solution was spin-dried, A solution of 3- (4-ethyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline (2.0 g) Acetonitrile (70 ml), The temperature was raised to 80 C for 7 h. The reaction solution was concentrated, To give a black oil, The black oil was separated and purified on a silica gel column, The eluent is dichloromethane: Methanol = 30: 1, Collect products, Concentration gave 2.9 g of the compound of formula II, The molar yield was 69% and the HPLC purity was 98.40%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 641569-94-0, 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Guo Qi; Huang Junjie; Liao Mingyi; (7 pag.)CN106905298; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide. This compound has unique chemical properties. The synthetic route is as follows. 145100-50-1

(101c) Triethylamine (115 mL, 7.8 eq) was added to a suspension of 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (14.95 g, 3 eq) and the phenol from reaction 101b (3.53 g, 13.88 mmol) in CH2Cl2 (50 mL). After stirring at room temperature for 2 h, the mixture was concentrated and re-dissolved in EtOAc (200 mL), washed with 1 N HCl (2¡Á1100 mL), brine (20 mL), dried (MgSO4) and concentrated. Silica gel chromatography (30% EtOAc-hexanes) gave the desired triflate (3.97 g, 74%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/185056; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem