Tag: M.W=350-400

Feller, Moran published the artcileMononuclear Rh(II) PNP-Type Complexes. Structure and Reactivity, Product Details of C23H43NP2, the publication is Inorganic Chemistry (2007), 46(25), 10479-10490, database is CAplus and MEDLINE.

The Rh(II) mononuclear complexes [(PNP^tBu)RhCl][BF₄] (2), [(PNP^tBu)Rh(OC(O)CF₃)] (4), and [(PNP^t-Bu)Rh(acetone)][BF₄]₂ (6), where PNP^tBu = 2,6-bis(di-tert-butylphosphinomethyl)pyridine, were synthesized by oxidation of the corresponding Rh(I) analogs with silver salts. However, treatment of (PNP^tBu)RhCl with AgOC(O)CF₃ led only to chloride abstraction, with no oxidation 2 And 6 were characterized by x-ray diffraction, EPR, cyclic voltammetry, and dipole moment measurements. 2 And 6 react with NO gas to give diamagnetic [(PNP^tBu)Rh(NO)Cl][BF₄] (7) and [(PNP^tBu)Rh(NO)(acetone)][BF₄]₂ (8), resp. 6 Is reduced to Rh(I) in the presence of phosphines, CO, or isonitriles to give the Rh(I) complexes [(PNP^tBu)Rh(PR₃)][BF₄] (11, 12) (R = t, Ph), [(PNP^tBu)Rh(CO)][BF₄] (13) and [(PNP^tBu)Rh(L)][BF₄] (15, 16) (L = tert-Bu isonitrile or 2,6-dimethylphenyl isonitrile), resp. However, 2 disproportionates to Rh(I) and Rh(III) complexes in the presence of acetonitrile, or CO. 2 Is also reduced by triethylphosphine and water to Rh(I) complexes [(PNP^tBu)RhCI] (1) and [(PNP^tBu)Rh(PEt₃)][BF₄] (11). When triphenylphosphine and water were used, the reduced Rh(I) complex reacts with a proton, which is formed in the redox reaction to give a Rh(III) complex with a coordinated BF₄, [(PNP^tBu)Rh(Cl)(H)(BF₄)] (9).

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Product Details of C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Feller, Moran published the artcileCationic, Neutral, and Anionic PNP Pd^II and Pt^II Complexes: Dearomatization by Deprotonation and Double-Deprotonation of Pincer Systems, Synthetic Route of 338800-13-8, the publication is Inorganic Chemistry (2010), 49(4), 1615-1625, database is CAplus and MEDLINE.

Cationic, neutral, and anionic Pd^II and Pt^II PNP (PNP = 2,6-bis(di-tert-butylphosphinomethyl)pyridine) complexes were synthesized. The neutral, dearomatized complexes [(PNP^*)MX] (PNP^* = deprotonated PNP; M = Pd, Pt; X = Cl, Me) were prepared by deprotonation of the PNP methylene group of the corresponding cationic complexes [(PNP)MX][Cl] with 1 equiv of base (KN(SiMe₃)₂ or ^tBuOK), while the anionic complexes [(PNP^**)MX]^–Y⁺ (PNP^** = double-deprotonated PNP; Y = Li, K) were prepared by deprotonation of the two methylene groups of the corresponding cationic complexes with either 2 equiv of KN(SiMe₃)₂ or an excess of MeLi. While the reaction of [(PNP)PtCl][Cl] with an excess of MeLi led only to the anionic complex without chloride substitution, reaction of [(PNP)PdCl][Cl] with an excess of MeLi led to the methylated anionic complex [(PNP^**)PdMe]^–Li⁺. NMR studies, x-ray structures, and d. functional theory (DFT) calculations reveal that the neutral complexes have a broken aromatic system with alternating single and double bonds, and the deprotonated arm is bound to the ring by an exocyclic C:C double bond. The anionic complexes are best described as a π system comprising the ring carbons conjugated with the exocyclic double bonds of the deprotonated arms. The neutral complexes are reversibly protonated to their cationic analogs by H₂O or MeOH. The thermodn. parameters ΔH, ΔS, and ΔG for the reversible protonation of the neutral complexes by MeOH were obtained.

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Synthetic Route of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Feller, Moran published the artcileCO₂ activation by metal-ligand-cooperation mediated by iridium pincer complexes, Formula: C23H43NP2, the publication is Journal of Coordination Chemistry (2018), 71(11-13), 1679-1689, database is CAplus.

Herein we report the reversible activation of CO₂ by the dearomatized complex [(^tBuPNP*)Ir(COE)] and by the aromatized complex [(^tBuPNP)Ir(C₆H₅)] via metal-ligand cooperation (MLC) (^tBuPN = 2,6-bis-(di-tert-butylphosphinomethyl)pyridine; ^tBuPNP* = deprotonated PNP; COE = cyclooctadiene). The [1,3]-addition of CO₂ to both complexes is reversible at ambient temperature While the dearomatized complex reacts readily at ambient temperature with CO₂ in THF or benzene, the aromatized complex reacts with CO₂ upon heating in benzene at 80 °C or at ambient temperature in THF. The novel aromatized complex [(^tBuPNP)IrCl] does not react with CO₂. Based on the reactivity patterns of these complexes with CO₂, we suggest that CO₂ activation via MLC takes place only via the dearomatized species, and that in the case of [(^tBuPNP)Ir(C₆H₅)], THF plays a role as a polar solvent in facilitating formation of the dearomatized hydrido Ph complex intermediate.

Journal of Coordination Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Formula: C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Prechtl, Martin H. G. published the artcileSynthesis and characterisation of nonclassical ruthenium hydride complexes containing chelating bidentate and tridentate phosphine ligands, Product Details of C23H43NP2, the publication is Chemistry – A European Journal (2007), 13(5), 1539-1546, database is CAplus and MEDLINE.

The synthesis and characterization of nonclassical Ru hydride complexes containing bidentate diphosphine and tridentate PCP (1,3-bis(di-tert-butylphosphinomethyl)benzene) and PNP (1,6-bis(di-tert-butylphosphinomethyl)pyridine) pincer-type ligands are described. The mononuclear and dinuclear Ru complexes presented were synthesized in moderate to high yields by the direct hydrogenation route (1-pot synthesis) or in a two-step procedure. In both cases [Ru(cod)(metallyl)₂] served as a readily available precursor. The influences of the coordination geometry and the ligand framework on the structure, binding, and chem. properties of the M-H₂ fragments were studied by x-ray crystal structure anal., spectroscopic methods, and reactivity towards N₂, D₂, and deuterated solvents.

Chemistry – A European Journal published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Product Details of C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rayder, Thomas M. published the artcileEngineering Second Sphere Interactions in a Host-Guest Multicomponent Catalyst System for the Hydrogenation of Carbon Dioxide to Methanol, Product Details of C23H43NP2, the publication is Journal of the American Chemical Society (2021), 143(3), 1630-1640, database is CAplus and MEDLINE.

Many enzymes utilize interactions extending beyond the primary coordination sphere to enhance catalyst activity and/or selectivity. Such interactions could improve the efficacy of synthetic catalyst systems, but the supramol. assemblies employed by biol. to incorporate second sphere interactions are challenging to replicate in synthetic catalysts. Herein, a strategy is reported for efficiently manipulating outer-sphere influence on catalyst reactivity by modulating host-guest interactions between a noncovalently encapsulated transition-metal-based catalyst guest and a metal-organic framework (MOF) host. This composite consists of a ruthenium PNP pincer complex encapsulated in the MOF UiO-66 that is used in tandem with the zirconium oxide nodes of UiO-66 and a ruthenium PNN pincer complex to hydrogenate carbon dioxide to methanol. Due to the method used to incorporate the complexes in UiO-66, structure-activity relationships could be efficiently determined using a variety of functionalized UiO-66-X hosts. These investigations uncovered the beneficial effects of the ammonium functional group (i.e., UiO-66-NH₃⁺). Mechanistic experiments revealed that the ammonium functionality improved efficiency in the hydrogenation of carbon dioxide to formic acid, the first step in the cascade. Isotope effects and structure-activity relationships suggested that the primary role of the ammonium functionality is to serve as a general Bronsted acid. Importantly, the cooperative influence from the host was effective only with the functional group in close proximity to the encapsulated catalyst. Reactions carried out in the presence of mol. sieves to remove water highlighted the beneficial effects of the ammonium functional group in UiO-66-NH₃⁺ and resulted in a 4-fold increase in activity. As a result of the modular nature of the catalyst system, the highest reported turnover number (TON) (19 000) and turnover frequency (TOF) (9100 h^-1) for the hydrogenation of carbon dioxide to methanol are obtained. Moreover, the reaction was readily recyclable, leading to a cumulative TON of 100 000 after 10 reaction cycles.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Product Details of C23H43NP2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Wanyi published the artcileEfficacy of felodipine and enalapril in the treatment of essential hypertension with coronary artery disease and the effect on levels of Salusin-β, Apelin, and PON1 gene expression in patients., Computed Properties of 72509-76-3, the main research area is .

This study aimed to analyze the effect of felodipine combined with enalapril in the treatment of patients with essential hypertension and coronary artery disease. Also, the effect of these medicines was evaluated on the peripheral blood Salusin-β, Apelin levels, and PON1 gene expression. For this purpose, 110 patients with essential hypertension combined with coronary heart disease, admitted to the hospital from January 2019 to January 2021, were selected and randomly divided into two groups. The control group was given felodipine treatment alone, and the study group was treated with combined application of felodipine and enalapril. The treatment effect, peripheral blood Salusin-β, Apelin, PON1 gene expression, and the safety of medication were compared between the two groups. The results showed that the post-treatment systolic blood pressure in the study group was 119.77 ± 5.23 mm Hg and diastolic blood pressure was 86.84 ± 5.42 mm Hg, both of which were significantly lower than those in the control group (127.81 ± 6.92 mm Hg and 95.13 ± 6.08 mm Hg), with statistically significant differences (p<0.05). The effective rates of the study group and the control group were 92.73% and 74.54% respectively, with statistically significant differences (P<0.05). The post-treatment peripheral blood Salusin-βlevel in the study group was 3.77±0.53mmol/L, and Apelin was 1.94±0.58μg/L, with statistically significant differences compared to the control group (P<0.05). The PON1 gene expression in the study group was higher than those in the control group after treatment (P<0.05). Also, the results showed that there was no statistical difference in adverse reactions between the two groups (P>0.05). According to these results, the combination of felodipine and enalapril in patients with essential hypertension combined with coronary artery disease can effectively lower the patients’ blood pressure and improve their peripheral blood Salusin-β, Apelin levels, and PON1 gene expression, thus enhancing the patients’ therapeutic effect with few adverse effects and high safety.

Cellular and molecular biology (Noisy-le-Grand, France) published new progress in MEDLINE about 72509-76-3, 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Computed Properties of 72509-76-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kinoshita, Eriko published the artcileSynthesis and Catalytic Activity of Molybdenum-Nitride Complexes Bearing Pincer Ligands, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is European Journal of Inorganic Chemistry (2015), 2015(10), 1789-1794, database is CAplus.

Mo-nitride complexes, e.g., [Mo(N)(Cl)(L)][OTf] (L = N,N’-bis(di-tert-butylphosphino)-2,6-diaminopyridine), bearing pincer ligands were designed, prepared, and characterized spectroscopically. The synthetic method described in this paper provides a convenient and useful approach to the preparation of cationic Mo(V)-nitride complexes that may act as catalysts for the formation of NH₃ from mol. dinitrogen under ambient reaction conditions.

European Journal of Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kuriyama, Shogo published the artcileCatalytic Formation of Ammonia from Molecular Dinitrogen by Use of Dinitrogen-Bridged Dimolybdenum-Dinitrogen Complexes Bearing PNP-Pincer Ligands: Remarkable Effect of Substituent at PNP-Pincer Ligand, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Journal of the American Chemical Society (2014), 136(27), 9719-9731, database is CAplus and MEDLINE.

A series of dinitrogen-bridged dimolybdenum-dinitrogen complexes bearing 4-substituted PNP-pincer ligands are synthesized by the reduction of the corresponding molybdenum trichloride complexes under 1 atm of mol. dinitrogen. In accordance with a theor. study, the catalytic activity is enhanced by the introduction of an electron-donating group to the pyridine ring of PNP-pincer ligand, and the complex bearing 4-methoxy-substituted PNP-pincer ligands is found to work as the most effective catalyst, where 52 equiv of ammonia are produced based on the catalyst (26 equiv of ammonia based on each molybdenum atom of the catalyst), together with mol. dihydrogen as a side-product. Time profiles for the catalytic reactions indicate that the rates of the formation of ammonia and mol. dihydrogen depend on the nature of the substituent on the PNP-pincer ligand of the complexes. The formation of ammonia and mol. dihydrogen is complementary in the reaction system.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kuriyama, Shogo published the artcileNitrogen fixation catalyzed by ferrocene-substituted dinitrogen-bridged dimolybdenum-dinitrogen complexes: unique behavior of ferrocene moiety as redox active site, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Chemical Science (2015), 6(7), 3940-3951, database is CAplus and MEDLINE.

A series of dinitrogen-bridged dimolybdenum-dinitrogen complexes bearing metallocene-substituted PNP-pincer ligands is synthesized by the reduction of the corresponding monomeric molybdenum-trichloride complexes under 1 atm of mol. dinitrogen. Introduction of ferrocene as a redox-active moiety to the pyridine ring of the PNP-pincer ligand increases the catalytic activity for the formation of ammonia from mol. dinitrogen, up to 45 equivalent of ammonia being formed based on the catalyst (22 equivalent of ammonia based on each molybdenum atom of the catalyst). The time profile for the catalytic reaction reveals that the presence of the ferrocene unit in the catalyst increases the rate of ammonia formation. Electrochem. measurement and theor. studies indicate that an interaction between the Fe atom of the ferrocene moiety and the Mo atom in the catalyst may play an important role to achieve a high catalytic activity.

Chemical Science published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Javed, Arslan published the artcileDevelopment of Simple Dissolution Methods for Felodipine and Combined Amlodipine Besylate-Indapamide Extended Release Tablets without Stationary (Felodipine) Basket., Synthetic Route of 72509-76-3, the main research area is Felodipine basket; amlodipine besylate; dissolution; felodipine; indapamide; similarity factor; stationary hanging basket.

BACKGROUND: The dissolution method for certain drugs needs specialized conditions. Dissolution testing for felodipine extended release (ER) tablets (Plendil® 5 mg) and amlodipine-indapamide fixed dose (Natrilam®, 5/1.5 mg) ER tablets requires the use of a stationary (felodipine) basket in USP Apparatus II. OBJECTIVE: The study aimed to develop simple methods for Plendil® and Natrilam® without the use of a felodipine basket. METHODS: The dissolution profiles obtained from different media and paddle speeds were used to compute miscellaneous dissolution parameters and were compared to those obtained from standard (existing) methods using a felodipine basket. RESULTS: The f1, f2, and bootstrap f2 (5th % percentile) values for Plendil® 2.47, 88.17, and 54.62, respectively, and all other dissolution factors revealed similarity between standard and the selected test method with 1% Tween 20 at 50 rpm. For Natrilam®, f1 and f2 and bootstrap f2 5.13, 72.92, and 62.67, respectively, and all other dissolution parameters showed similarity of the standard and selected test method using 0.1N HCl media having 0.38 gm/L EDTA with a sinker at 100 rpm. Release of products assumed zero-order and Weibull model, respectively. CONCLUSION: Test dissolution methods for Plendil® and Natrilam® tablets produced equivalent dissolution profiles compared to their respective standard methods with stationary basket USP Apparatus II.

Current pharmaceutical design published new progress about Felodipine basket; amlodipine besylate; dissolution; felodipine; indapamide; similarity factor; stationary hanging basket. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Synthetic Route of 72509-76-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem