Tag: M.W=500-600

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bollenbach, Maud; Lecroq, William; Wagner, Patrick; Fessard, Thomas; Schmitt, Martine; Salome, Christophe researched the compound: 5-(di-tert-Butylphosphino)-1′,3′,5′-triphenyl-1’H-1,4′-bipyrazole( cas:894086-00-1 ).Product Details of 894086-00-1.They published the article 《On water N-arylation of oxetanylamines for the preparation of N-aryl-oxetanylamines; potentially useful aryl-amide isosteres》 about this compound( cas:894086-00-1 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: aryl oxetanylamine preparation water surfactant tocopherol methoxypolyethylene glycol succinate; oxetanylamine aryl halide palladium cross coupling. We’ll tell you more about this compound (cas:894086-00-1).

A Pd cross-coupling approach for the synthesis of N-aryl-oxetanylamines I (R = 2-Me, 3-F, 3-MeO etc.) has been developed. This method provides new building blocks potentially useful in medicinal chem. as amide bioisosteres. The reactions are conducted in water employing the renewable feedstock surfactant TPGS-750-M ( DL-α-Tocopherol methoxypolyethylene glycol succinate).

Here is a brief introduction to this compound(894086-00-1)Product Details of 894086-00-1, if you want to know about other compounds related to this compound(894086-00-1), you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1374639-78-7, tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate, blongs to pyridine-derivatives compound. Application In Synthesis of tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate

To the solution of tert-butyl 4-(6- { [7-cyclopentyl-6-(dimethylcarbamoyl)-7H- pyrrolo[2, 3 -d]pyrimidin-2-yl] amino } pyridin-3 -yl)piperazine- 1 -carboxylate (6.0 g)in 15 ml of DCM was added TFA (15 ml) at 5-10C. The solution was stirred over3-4 hrs at 20-30C. To this was added methyl tertiary butyl ether (60 ml) and stirred for 2-3 hrs at 15-25C. The solid was collected by filtration followed by drying at 40-50C to give crystalline form I of 4-(6-{[7-cyclopentyl-6- (dimethylcarbamoyl)-7H-pyrrolo[2,3 -d]pyrimidin-2-yl] amino } pyridin-3 -yl)piperazin- 1 -ium-trifluoro acetate (100 g).Yield: 99.0 %; HPLC Purity: 99.8%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1374639-78-7, tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; FRESENIUS KABI ONCOLOGY LTD.; SOKHI, Sarbjot Singh; SINGH, Govind; LAHIRI, Saswata; PANDEY, Maneesh Kumar; TIWARI, Raj Narayan; SHUKLA, Sonu; MUSMADE, Sachin; DUA, Heena; CABRI, Walter; (70 pag.)WO2019/82143; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1229006-21-6, name is Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate, molecular formula is C26H26F2N2O7, molecular weight is 516.4907, as common compound, the synthetic route is as follows.Application In Synthesis of Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate

Example 2e Methyl 5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-1-[2-hydroxy-2-(methyloxy)ethyl]-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate (in equilibrium with the corresponding aldehyde) Methyl 1-[2,2-bis(methyloxy)ethyl]-5-({[(2,4-difluorophenyl)methyl]amino}carbonyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate 25 (11.6 g) was treated with 90% formic acid (250 mL) at 40 C. for ?12 hours (monitored by LC-MS). After the solvents were evaporated at <40 C., the residue was re-dissolved in EtOAc (?1 L) and the resulting solution was washed with NaHCO3 and brine. The organic phase was then dried over Na2SO4. After evaporation of solvents, the titled compounds 26 and 27 were obtained as an approximate 80/20 equillibrium mixture (10.57 g). 1H NMR (400 MHz, DMSO-d6) 5 ppm 10.3 (m, 1H), 9.47 (s, aldehyde-H. ?0.2H)), 8.4 (m, 1H), 7.3 (s, 6H), 7.2 (m, 1H), 7.0 (m, 1H), 6.3 (m, 2H), 5.1 (s, 3H), 4.9 (m, 1H), 4.5 (m, 3H), 3.9 (m, 2H), 3.8 (s, 3H). LC-MS, for 26 (M+H+), calcd 503, obsd 503; for 27 (M+H2O+H+), cald 489, obsd 489. At the same time, in my other blogs, there are other synthetic methods of this type of compound,1229006-21-6, Methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate, and friends who are interested can also refer to it. Reference:
Patent; SHIONOGI & CO., LTD.; ViiV Healthcare Company; Kawasuji, Takashi; Nagamatsu, Daiki; (30 pag.)US9242986; (2016); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.88150-62-3, name is Phthaloylamlodipine, molecular formula is C28H27ClN2O7, molecular weight is 538.98, as common compound, the synthetic route is as follows.Computed Properties of C28H27ClN2O7

Example (1)100 g (0.185 mol) of phthaloyl amlodipine and toluene (1-1.5 L) were charged to 2 L autoclave. Methylamine gas was purged to the above reaction mass at room temperature. The reaction mass was stirred at 40-70 C for 8-10 hrs. and then at room temperature (25 C) for 8-12 hrs to complete the reaction. The completion of the reaction was monitored by TLC. After completion of the reaction, IPA (400 mL) was added to the reaction mixture and further stirred for 10-20 min. The reaction mixture was washed with 2 x 400 mL of water. The organic layer was separated and the volume was reduced to 100-150 mL by evaporation under vacuum. Hexane (1-1.5 L) was added slowly (20-30 min) to the above concentrated mass at 40-50 C. The solid obtained was filtered and dried at 45-50 C for 10-15 hrs. to obtain 55-70 g of amlodipine free base as the product.Example (2)100 g (0.185 mol) of phthaloyl amlodipine and isopropyl alcohol (1L) were charged to a 2 L autoclave. Methylamine gas was purged to the above reaction mass at room temperature. The reaction mass was stirred at 50 C for 4-8 hrs. and then at room temperature for 8-12 hrs for the reaction to complete. The completion of the reaction was monitored by TLC. The reaction mass was filtered and the filtrate was concentrated to syrupy mass at reduced pressure and at bath temperature of about 40- 50 C. To the above residue toluene (600 mL) was added and was stirred for 20-40 min. The reaction mixture was washed with 3 x 300 mL of water. The organic layer was separated, dried over sodium sulfate and was evaporated under vacuum to near completion by maintaining the bath temperature at 50-60 C. Hexane (1-1.5 L) was added slowly (20-30 min) to the above concentrated mass at 40-50 C. The solid obtained was filtered and dried at 45-50 C for 10-15 hours to obtain 55-70 g of amlodipine free base as the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,88150-62-3, Phthaloylamlodipine, and friends who are interested can also refer to it.

Reference:
Patent; ORCHID CHEMICALS & PHARMACEUTICALS LIMITED; WO2007/96724; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1374639-78-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1374639-78-7, name is tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate, molecular formula is C28H38N8O3, molecular weight is 534.65, as common compound, the synthetic route is as follows.

In a nitrogen environment at about 25±2 C., mix 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbamide and 4-(6-aminopyyrol-3-yl)piperazin-1-carboxyl tert-butylate into tetrahydrofuran THF) added with lithium bis(trimethyl)amine (LiHMDS) and stir for about 1 h to obtain the intermediate 4-[6-[[7-cyclopentyl-6-[(dimethylamino)carbonyl]-7H-pyrrolo[2,3-pyrimidine-2-yl]amino]-3-pyridine]-1-piperazinecarboxyl 1,1-dimethylethylate. Cool the mixture to about 8±2 C. and keep the mixture at this temperature while an aqueous hydrogen chloride solution is subsequently added slowly and mixed into the mixture. After that, using a separatory funnel and ethyl acetate as an extracting agent, perform an extraction process in duplicate to acquire the aqueous phase. When the extracted solution is cooled to about 5 C. or lower, slowly add an aqueous sodium hydroxide solution until the pH reaches 12.5. Heat the solution to 25 C. and stir for about 16 h. Next, filter the solution to obtain the solid matter (or filter cake), and rinse the filter cake with DD water until the pH of the rinsing liquid is equal to or lower than 9. Lastly, dry the filter cake at about 55±5 C. to yield yellowish brown solids, which are 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, whose molar recovery rate can be 98% or higher, with 98% or higher purity.

The chemical industry reduces the impact on the environment during synthesis 1374639-78-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO. LTD.; Kamani, Satyanarayana; Lu, Tzu-Chiang; Chang, Hsin-Yun; Mai, Chin-Cheng; (30 pag.)US10336763; (2019); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1374639-78-7, name is tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate, molecular formula is C28H38N8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C28H38N8O3

A solution of tert-butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-l-carboxylate (Ila) (50 g) in toluene (300 mL) was cooled to 10 C. Hydrochloric acid (6N, 100 mL) was added to the above solution in drop wise at 15 C. The reaction mass was stirred for 1 hour at 25-30 C. Hydrochloric acid (IN, 200 mL) was added to the above reaction mass at 25-30 C and stirred for 10 minutes at the same temperature. The reaction mass was then filtered and washed with toluene (1 x 50 mL) followed by hydrochloric acid (IN, 50 mL). Organic layer was separated and aqueous layer was cooled to 15 C. pH of aqueous layer was adjusted to pH=12.0-12.5 using saturated solution of sodium hydroxide (50% w/w) and stirred for 1 hour at 15-20 C. The resulted precipitate was then filtered, washed with water (3 chi 80 mL) and dried at 50 C for 6 hours to provide the title compound. (0169) Yield: 35.1 g; Purity by HPLC: 99.31 %

With the rapid development of chemical substances, we look forward to future research findings about 1374639-78-7.

Reference:
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; ORUGANTI, Srinivas; KANDAGATLA, Bhaskar; DAS GUPTA, Shirshendu; (39 pag.)WO2018/51280; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 88150-62-3, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 88150-62-3, Name is Phthaloylamlodipine, SMILES is O=C(C1=C(COCCN(C(C2=C3C=CC=C2)=O)C3=O)NC(C)=C(C(OC)=O)C1C4=CC=CC=C4Cl)OCC, belongs to pyridine-derivatives compound. In a article, author is He, Hui, introduce new discover of the category.

The impacts of nitrogen doping on the electrochemical hydrogen storage in a carbon

Activated carbon materials doped with different nitrogen contents and nitrogen functional groups were synthesized. Nitrogen doping can improve the electrochemical hydrogen storage activity as well as the hydrophilicity of the carbon materials. Synthesized with the optimal synthesis conditions, the N-doped activate carbon demonstrated the hydrogen storage capacity of 148.4 mAh g(-1) under 100 mA g(-1) rate, and 84.3% capacity retention at a high current density of 1000 mA g(-1). 73.4% hydrogen could be preserved after a 24 hours rest at open potential. The main nitrogen functional groups on this carbon material were found to be pyrrole N, pyridine N oxide and nitro N. The density functional theory (DFT) calculations revealed that the H adsorption energy on pyridine N and pyrrole N was larger than that of pyridine N, while graphite N had no advantage in improving the H adsorption energy of carbon materials.

Reference of 88150-62-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 88150-62-3.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.88150-62-3, Name is Phthaloylamlodipine, SMILES is O=C(C1=C(COCCN(C(C2=C3C=CC=C2)=O)C3=O)NC(C)=C(C(OC)=O)C1C4=CC=CC=C4Cl)OCC, belongs to pyridine-derivatives compound. In a document, author is Lu, Kang, introduce the new discover, Quality Control of Phthaloylamlodipine.

The synergetic effect of acid and nickel sites on bifunctional MWW zeolite catalysts for ethylene oligomerization and aromatization

Corresponding H- and Ni-form MWW zeolites were synthesized and compared to investigate the influences of the acidity strength and the synergetic effect of bifunctional sites on the catalytic performance for ethylene oligomerization and aromatization. The acidities of ERB-1 and MCM-22 zeolites with an MWW structure were adjusted via deboronation and desilication to synthesize MCM-56 and ITQ-1. The physicochemical properties of the catalysts were measured via XRD, EDS, EPMA, N-2 sorption, SEM, FT-IR, pyridine adsorption FT-IR, NH3-TPD, XPS and H-2-TPR studies. The effects of the acid strength and Ni/acid site ratio on the product distribution were studied at 523 and 723 K, which are two typical optimal reaction temperatures for oligomerization and aromatization, respectively. According to the characterization and catalytic performance results from this series of catalyst zeolites with similar structures and different acid sites, a fundamental mechanism involving different elementary steps for ethylene oligomerization and aromatization was proposed to explain the synergetic effect of acid and Ni sites on bifunctional MWW zeolites. The synergetic effect impact relating to different acid strength MWW zeolite structures shows that Ni ions on weak acidity zeolites are superior for ethylene conversion and determine the Anderson-Schultz-Flory product distribution at 523 K, and strong acid sites on MCM-22 are preponderant for ethylene conversion and dominate the product distribution at 723 K. Ni species are not only favorable for the dimerization of alpha-olefins at 523 K, but also for dehydrogenation, leading to the generation of aromatics at 723 K. Increasing zeolite acidity strength produces an obviously positive effect on the production of aromatics.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 88150-62-3 is helpful to your research. Quality Control of Phthaloylamlodipine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 88150-62-3, Name is Phthaloylamlodipine, SMILES is O=C(C1=C(COCCN(C(C2=C3C=CC=C2)=O)C3=O)NC(C)=C(C(OC)=O)C1C4=CC=CC=C4Cl)OCC, in an article , author is Gemeinhardt, Max E., once mentioned of 88150-62-3, Product Details of 88150-62-3.

Direct C-13 Hyperpolarization of C-13-Acetate by MicroTesla NMR Signal Amplification by Reversible Exchange (SABRE)

Herein, we demonstrate direct C-13 hyperpolarization of C-13-acetate via signal amplification by reversible exchange (SABRE). The standard SABRE homogeneous catalyst [Ir-IMes; [IrCl(COD)(IMes)], (IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene)] was first activated in the presence of an auxiliary substrate (pyridine) in alcohol. Following addition of sodium 1-C-13-acetate, parahydrogen bubbling within a microtesla magnetic field (i.e. under conditions of SABRE in shield enables alignment transfer to heteronuclei, SABRE-SHEATH) resulted in positive enhancements of up to approximate to 100-fold in the (CNMR)-C-13 signal compared to thermal equilibrium at 9.4T. The present results are consistent with a mechanism of direct transfer of spin order from parahydrogen to C-13 spins of acetate weakly bound to the catalyst, under conditions of fast exchange with respect to the C-13 acetate resonance, but we find that relaxation dynamics at microtesla fields alter the optimal matching from the traditional SABRE-SHEATH picture. Further development of this approach could lead to new ways to rapidly, cheaply, and simply hyperpolarize a broad range of substrates (e.g. metabolites with carboxyl groups) for various applications, including biomedical NMR and MRI of cellular and in vivo metabolism.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Related Products of 88150-62-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 88150-62-3, Name is Phthaloylamlodipine, SMILES is O=C(C1=C(COCCN(C(C2=C3C=CC=C2)=O)C3=O)NC(C)=C(C(OC)=O)C1C4=CC=CC=C4Cl)OCC, belongs to pyridine-derivatives compound. In a article, author is Chen, Hongyun, introduce new discover of the category.

Synthesis, spectroscopic and DFT studies of copper(I) complexes inserting the electron-donating groups into pyridine-imidazole ligands vis an acetylide linker

The three Cu(I) complexes [Cu(POP)(N<^>N)]PF6, N<^>N = 2-(1H-imidazol-2-yl)-5-(p-tolylethynyl)pyridine (P1), 2-(1H-imidazol-2-yl)-5-((4-methoxyphenyl)ethynyl)pyridine (P2), 4-((6-(1H-imidazol-2-yl)pyridin-3-yl)ethynyl)-N,N-diphenylaniline (P3), were prepared and characterized. The different electron-donating groups such as methylphenyl, methoxyphenyl, and diphenylamine substituents were functionalized onto the pyridine ring part of the diimine ligands through an acetylide linker to enhance the light-absorption abilities, giving the larger light-absorption ability and red-shifted absorption bands for the investigated Cu(I) complexes. Yellow emissions in the range of 579-590 nm with quantum yields of 8.40-15.1% can be observed for all complexes at room temperature. The photophysical properties were further explained by DFT and TDDFT methods.

Related Products of 88150-62-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 88150-62-3 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem