《Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine-Based Palladacycle》 was written by Takale, Balaram S.; Thakore, Ruchita R.; Casotti, Gianluca; Li, Xaiohan; Gallou, Fabrice; Lipshutz, Bruce H.. Category: pyridine-derivativesThis research focused onwater Stille coupling triphenylphosphine palladacycle catalyst pharmaceutical preparation; Stille couplings; cross-coupling; green chemistry; nanostructures; palladium. The article conveys some information:
An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500-1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Category: pyridine-derivatives