Tamang, Sem Raj; Singh, Arpita; Bedi, Deepika; Bazkiaei, Adineh Rezaei; Warner, Audrey A.; Glogau, Keeley; McDonald, Corey; Unruh, Daniel K.; Findlater, Michael published the artcile< Polynuclear lanthanide-diketonato clusters for the catalytic hydroboration of carboxamides and esters>, Category: pyridine-derivatives, the main research area is amine preparation; carboxamide hydroboration lanthanide diketonato cluster catalyst; tetramethyl dioxaborolane preparation.
The direct deoxygenation of carboxamides RC(O)N(R1)R2 [R = H, Ph, thiophen-2-yl, naphthalen-2-yl, etc.; R1 = H, Me, Et, (CH2)4CH3, iso-Pr, Ph, benzyl; R2 = H, Me, Et, isopropyl; R1R2 = (CH2)5, (CH2)2O(CH2)2] using earth-abundant lanthanum catalysts in the presence of HBpin presents good to excellent yields with broad substrate scope and functional group/heteroatom tolerance. Moreover, this method is also effective in catalyzing the hydroboration of esters R3C(O)OR4 [R3 = Ph, cyclohexyl, (CH2)6CH3, pyridin-3-yl, etc.; R4 = Me, Et, naphthalen-2-yl, 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl, etc.]. Finally, selective cleavage of the amide group bonds (C-N vs. C-O) could be achieved based on the nature of the nitrogen substituents. Catalytic reduction of carboxamides into their corresponding amines RCH2N(R1)R2 is attractive but extremely challenging transformation, which often meets with limited success; the valuable amine products drive ongoing research in this area.
Nature Catalysis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Category: pyridine-derivatives.